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Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma

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Current Medical Science 2024年第2期44卷 309-327页

作者： Xiao-jun WANG jia-ping CHEN Xin-wei qiao Wang-yang MENG Yang-wei WANG Yun-chong MENG Rong ZHAO Wei LIN Yong-de LIAO Han XIAO Pei-yuan MEI Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Thoracic Surgery Shandong Provincial Hospital Afiliated to Shandong First Medical UniversityJinan 250021China

Objective:Lung squamous cell carcinoma(LUSC)is associated with a low survival rate.Evidence suggests that bone morphogenetic proteins(BMPs)and their receptors(BMPRs)play crucial roles in tumorigenesis and progression.However,a comprehensive analysis of their role in LUSC is lacking.Our study aimed to explore the relationship between BMPs/BMPRs expression levels and the tumorigenesis and prognosis of LUSC.Methods:The“R/Limma”package was utilized to analyze the differential expression characteristics of BMPs/BMPRs in LUSC,using data from TCGA,GTEx,and GEO databases.Concurrently,the“survminer”packages were employed to investigate their prognostic value and correlation with clinical features in LUSC.The core gene associated with LUSC progression was further explored through weighted gene correlation network analysis(WGCNA).LASSO analysis was conducted to construct a prognostic risk model for LUSC.Clinical specimens were examined by immunohistochemical analysis to confirm the diagnostic value in LUSC.Furthermore,based on the tumor immune estimation resource database and tumor-immune system interaction database,the role of the core gene in the tumor microenvironment of LUSC was explored.Results:GDF10 had a significant correlation only with the pathological T stage of LUSC,and the protein expression level of GDF10 decreased with the tumorigenesis of LUSC.A prognostic risk model was constructed with GDF10 as the core gene and 5 hub genes(HRASLS,HIST1H2BH,FLRT3,CHEK2,and ALPL)for LUSC.GDF10 showed a significant positive correlation with immune cell infiltration and immune checkpoint expression.Conclusion:GDF10 might serve as a diagnostic biomarker reflecting the tumorigenesis of LUSC and regulating the tumor immune microenvironment to guide more effective treatment for LUSC.

关键词： lung squamous cell carcinoma tumorigenesis bone morphogenetic protein GDF10 tumor immune microenvironment

Emerging WS_(2)/WSe_(2)@graphene nanocomposites: synthesis and electrochemical energy storage applications

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Rare Metals 2024年第1期43卷 1-19页

作者： Yu-Meng Gao Yong Liu Kai-jia Feng Jun-Qing Ma Ying-Jie Miao Bin-Rui Xu Kun-Ming Pan Osaka Akiyoshi Guang-Xin Wang Ke-Ke Zhang qiao-Bao Zhang National Joint Engineering Research Center for Abrasion Control and Molding of Metal Materials Henan Key Laboratory of Non-Ferrous Materials Science and Processing TechnologySchool of Materials Science and EngineeringHenan University of Science and TechnologyLuoyang 471023China Provincial and Ministerial Co-Construction of Collaborative School of Electrical Engineering Henan University of Science and TechnologyLuoyang 471023China Biomaterials Laboratory Faculty of EngineeringOkayama UniversityTsushima-NakeOkayama-Shi 700-8530Japan Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005China Fujian Key Laboratory of Surface and Interface Engineering for High Performance Materials Xiamen UniversityXiamen 361005China

In recent years, tungsten disulfide(WS_(2)) and tungsten selenide(WSe_(2)) have emerged as favorable electrode materials because of their high theoretical capacity, large interlayer spacing, and high chemical activity;nevertheless, they have relatively low electronic conductivity and undergo large volume expansion during cycling, which greatly hinder them in practical applications. These drawbacks are addressed by combining a superior type of carbon material, graphene, with WS_(2) and WSe_(2) to form a WS_(2)/WSe_(2)@graphene nanocomposites.These materials have received considerable attention in electro-chemical energy storage applications such as lithium-ion batteries(LIBs), sodium-ion batteries(SIBs),and supercapacitors. Considering the rapidly growing research enthusiasm on this topic over the past several years, here the recent progress of WS_(2)/WSe_(2)@graphene nanocomposites in electrochemical energy storage applications is summarized. Furthermore, various methods for the synthesis of WS_(2)/WSe_(2)@graphene nanocomposites are reported and the relationships among these methods, nano/microstructures, and electrochemical performance are systematically summarized and discussed. In addition, the challenges and prospects for the future study and application of WS_(2)/WSe_(2)@graphene nanocomposites in electrochemical energy storage applications are proposed.

关键词： WS_(2)/WSe_(2)@graphene nanocomposites Liion batteries(LIBs) Na-ion batteries(SIBs) Supercapacitors Electrochemical performance

Combining network pharmacology， molecular docking， and experimental verification to investigate the anti-rheumatoid arthritis effect and mechanism of Baeckea frutescens leaves

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Food Science and Human Wellness 2024年

作者： Xueyang Guo Mengyao Zhang Haixia Cai Xinyue jiang Siyuan Zhou Wen Gong Zijiao Wei Weili qiao Beixi jia Department of Pharmacognosy School of Pharmaceutical Science Zhengzhou University Department of Pharmacy Henan Provincial People's Hospital

The aromatic Baeckea frutescens leaves (BFL) known as “Gang-Song-Cha” is a popular drink (Tea) in South China. To explore the healthcare value， a systematic and in-depth study on BFL alleviating rheumatoid arthritis (RA) was carried out by integrating network pharmacology， molecular docking， and experimental verification. The efficacy was first evaluated， and the BFL extract could ameliorate RA by inhibiting articular swelling， lowering immune organ index， improving the ankle pathologies， and regulating serum levels of TNF-α， IL-6， and IL-10 in CIA rats. Then the anti-RA mechanism of BFL was investigated by leveraging the high-content and active component 5-hydroxy-7-methoxy-2-isopropylchromone (Chro.)， and the potential signaling pathway and related target proteins for Chro. acting on RA were analyzed by KEGG enrichment and docking simulation. Finally， the experimental validations were conducted on RA-FLS cells， and compound Chro. could inhibit cell invasion and migration， block cell cycle at G2/M phase and induce apoptosis， and reduce the secretion of inflammatory cytokines by suppressing the PI3K-Akt pathway. These results provided pharmacological basis for the folk usage of “Gang-Song-Cha (Tea)” for intervening RA.

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原子氧和紫外辐射效应对空间光学系统沸石分子筛吸附性能的影响

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航空材料学报 2024年第3期44卷 35-42页

作者：乔佳胡旺旺江苏海洋大学电子工程学院江苏连云港222000

针对低轨空间环境下分子筛材料吸附能力变弱造成高精度、超低温光学仪器或者其他精密探测仪器的探测质量和使用寿命受到严重影响的问题,研究低轨环境中,ZSM-5、ZSM-22、MCM-41和SAPO-11四种沸石分子筛辐照前后样品的外观和对水的吸附性... 详细信息

针对低轨空间环境下分子筛材料吸附能力变弱造成高精度、超低温光学仪器或者其他精密探测仪器的探测质量和使用寿命受到严重影响的问题,研究低轨环境中,ZSM-5、ZSM-22、MCM-41和SAPO-11四种沸石分子筛辐照前后样品的外观和对水的吸附性能。结果表明:原子氧对四种材料吸附性能几乎没有影响;紫外会严重降低MCM-41吸附性能,吸收比率降低约2.44%,SAPO-11吸收比率增加1.6%,而ZSM-5、ZSM-22吸收比率增加的幅度非常小,可以忽略;与紫外单独辐照相比,原子氧与紫外同时辐照对MCM-41影响不大,而对SAPO-11、ZSM-5影响较大,可以显著增强其吸附能力,吸收比率增加约为1.7%;对四种材料进行烘烤,加热后MCM-41吸收比率恢复为原样品的吸收比率,表明紫外辐照后造成的网络破坏可以通过烘烤修复。

关键词：沸石分子筛原子氧紫外辐射吸附性能

Converting intercalation-type cathode in spent lithium-ion batteries into conversion-type cathode

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Nano Research 2024年第5期17卷 4602-4609页

作者： Dingding Zhu Yong Su Jingzhao Chen Xiangze Ou Xuedong Zhang Wen Xie Yuyan Zhou Yunna Guo Qiushi Dai Peng jia Jitong Yan Lin Geng Baiyu Guo Liqiang Zhang Yongfu Tang qiao Huang jianyu Huang School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Clean Nano Energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066000China

The widespread applications of lithium-ion batteries(LIBs)generate tons of spent LIBs.Therefore,recycling LIBs is of paramount importance in protecting the environment and saving the resources.Current commercialized LIBs mostly adopt layered oxides such as LiCoO_(2)(LCO)or LiNi_(x)Co_(y)Mn_(1-x-y)O_(2)(NMC)as the cathode materials.Converting the intercalation-type spent oxides into conversion-type cathodes(such as metal fluorides(MFs))offers a valid recycling strategy and provides substantially improved energy densities for LIBs.Herein,two typical Co-based cathodes,LCO and LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NMC622),in spent LIBs were successfully converted to CoF_(2) and(Ni_(x)Co_(y)Mn_(z))F_(2) cathodes by a reduction and fluorination technique.The as converted CoF_(2) and(Ni_(x)Co_(y)Mn_(z))F_(2) delivered cell energy densities of 650 and 700 Wh/kg,respectively.Advanced atomic-level electron microscopy revealed that the used LCO and NMC622 were converted to highly phase pure Co metal and Ni_(0.6)Co_(0.2)Mn_(0.2) alloys in the used graphite-assisted reduction roasting,simultaneously producing the important product of Li_(2)CO_(3) using only environment friendly solvent.Our study provided a versatile strategy to convert the intercalation-type Co-based cathode in the spent LIBs into conversion-type MFs cathodes,which offers a new avenue to recycle the spent LIBs and substantially increase the energy densities of next generation LIBs.

关键词： spent lithium-ion batteries recycling energy densities conversion-type cathode

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正颌外科虚拟手术规划研究现状

中华整形外科杂志 2024年第1期40卷 124-128页

作者：李磊乔嘉牛峰中国医学科学院北京协和医学院整形外科医院颅颌面整形一科北京100144

正颌手术是治疗牙颌面畸形的经典手术。由于牙颌面解剖结构的复杂性, 术前通常需要进行详细而准确的手术规划。随着近年来医学成像技术和手术规划软件的快速发展, 虚拟手术规划(VSP)越来越多地被用于正颌外科, 以提供准确、高效、可预... 详细信息

正颌手术是治疗牙颌面畸形的经典手术。由于牙颌面解剖结构的复杂性, 术前通常需要进行详细而准确的手术规划。随着近年来医学成像技术和手术规划软件的快速发展, 虚拟手术规划(VSP)越来越多地被用于正颌外科, 以提供准确、高效、可预测的规划和模拟。正颌外科VSP的设计和发展涉及图像采集和复合头部模型构建、三维参考框架定义、虚拟咬合设置、虚拟截骨和手术模拟、软组织预测、转移工具等几个方面, 该文对相关步骤的研究进行了总结, 以为临床提供参考。

关键词：外科手术计算机辅助虚拟手术规划正颌外科手术

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前进接触线薄液膜结构与运移机制

物理学报 2024年第1期73卷 277-284页

作者：刘乔黄家宸王昊邓亚骏中国石化石油勘探开发研究院北京102206 北京大学工学院北京100871 深圳技术大学聚龙学院深圳518118

气-液-固三相接触线薄液膜微观结构认识不清使得动态接触角预测问题始终存在争议.本文通过大规模分子动力学模拟研究液滴动态润湿过程,获得了完全浸润液滴前进接触线区域的前驱液膜结构、部分浸润液滴前进接触线区域的纳米级凸起结构.... 详细信息

气-液-固三相接触线薄液膜微观结构认识不清使得动态接触角预测问题始终存在争议.本文通过大规模分子动力学模拟研究液滴动态润湿过程,获得了完全浸润液滴前进接触线区域的前驱液膜结构、部分浸润液滴前进接触线区域的纳米级凸起结构.首次在模拟中获得了微观接触角与宏观接触角随时间的动态演变规律.分子轨迹追踪揭示了接触线薄液膜区域流体在固体表面摩擦作用下,随速度增大从滑动为主向滚动为主的模式转变,进而在底层出现气体裹挟导致滑移、发生溅射的机制.本研究为进一步构建普适的动态接触角预测模型提供了关键物理依据.

关键词：接触线薄液膜润湿界面分子模拟

不确定环境下的航空发动机装配线适应性调度方法

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控制与决策 2024年第5期39卷 1629-1635页

作者：王怡琳刘鹃乔非张家谔同济大学电子与信息工程学院上海201800 中国航空制造技术研究院北京100020

航空发动机装配是航空发动机制造过程的关键环节,其工序多,流程复杂,生产过程中扰动频发,如装配时间波动、不合格返工等.针对不确定环境下的航空发动机装配线的调度问题,提出一种基于门控循环神经网络(GRU)的适应性调度方法.该调度方法... 详细信息

航空发动机装配是航空发动机制造过程的关键环节,其工序多,流程复杂,生产过程中扰动频发,如装配时间波动、不合格返工等.针对不确定环境下的航空发动机装配线的调度问题,提出一种基于门控循环神经网络(GRU)的适应性调度方法.该调度方法包含扰动识别和调度规则调整两个部分:扰动识别模块以滑动时间窗口为周期,利用GRU神经网络进行渐近型扰动的识别;调度规则调整模块以扰动识别的结果为触发,通过构建基于GRU神经网络的调度规则决策模型,输出适配当前生产状态的新的调度规则,用以指导生成更新的调度方案.最后,以某航空发动机装配线为研究案例,对所提出适应性调度方法进行验证分析.对比实验结果表明,所提出方法能够有效提升装配线的设备利用率、日均生产率等性能.

关键词：适应性调度扰动识别深度学习门控循环神经网络航空发动机装配调度规则

O2O外卖价格促销策略对消费者购买意愿的影响研究

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中国管理科学 2024年第2期32卷 254-264页

作者：钟琦曲冠桥唐加福东北财经大学管理科学与工程学院辽宁大连116025 国际商业机器全球服务(大连)有限公司辽宁大连116044

O2O外卖行业如何通过差异化促销策略提升用户体验、提高购买意愿,是O2O外卖平台和餐饮商家十分关注的问题。O2O外卖常见的价格促销方式有13种,本文将其梳理归纳为三类促销策略:优惠券类、折扣类和附加服务费优惠类。基于刺激-机体-反应... 详细信息

O2O外卖行业如何通过差异化促销策略提升用户体验、提高购买意愿,是O2O外卖平台和餐饮商家十分关注的问题。O2O外卖常见的价格促销方式有13种,本文将其梳理归纳为三类促销策略:优惠券类、折扣类和附加服务费优惠类。基于刺激-机体-反应模型(SOR模型),引入感知促销价值因素,建立O2O外卖价格促销策略对消费者购买意愿影响机制的理论模型;通过问卷星在线收集567份样本数据并进行结构方程模型分析,针对不同价格促销策略对潜在消费者购买意愿的影响路径和作用机制进行实证检验,并验证感知促销利益和感知促销成本的中介效应。研究结果表明,在三类价格促销策略中,优惠券类促销策略对潜在消费者购买意愿的影响最大;附加服务费优惠类促销策略对于O2O外卖消费者的购买意愿影响不大;与优惠券类促销策略直接促使消费者做出购买决策不同,折扣类促销策略下消费者需要对感知促销成本和感知促销利益进行权衡后做出最终购买决策。研究结论为O2O外卖平台和餐饮商家改进现有促销策略提供理论依据和参考。

关键词： O2O外卖价格促销策略 SOR模型购买意愿