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灵管蓟马亚科系统发育关系研究——基于形态和生物学数据

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环境昆虫学报 2018年第2期40卷 363-373页

作者：党利红乔格侠陕西理工大学生物科学与工程学院陕西汉中723000 中国科学院动物研究所北京100101

基于对国家动物博物馆、澳大利亚联邦科工组织国家昆虫标本馆、英国自然历史博物馆、德国森根堡博物馆、日本东京农业大学、台湾农业试验所的所有灵管蓟马亚科物种玻片标本的检视,本研究选取了88个形态特征和1个生物学特征,以蓟马科的... 详细信息

基于对国家动物博物馆、澳大利亚联邦科工组织国家昆虫标本馆、英国自然历史博物馆、德国森根堡博物馆、日本东京农业大学、台湾农业试验所的所有灵管蓟马亚科物种玻片标本的检视,本研究选取了88个形态特征和1个生物学特征,以蓟马科的花蓟马Franklinnell aintonsa,以及管蓟马科Phlaeothripidae管蓟马亚科Phlaeothripinae的波密滑管蓟马Liothrips bomiensis和黄角滑管蓟马***为外群,灵管蓟马亚科Idolothripinae 2.属2.种作为内群,建立了形态特征矩阵,依据最大简约法,利用TNT v1.1软件重建了灵管蓟马亚科属间的系统发育树,结果中灵管蓟马族的单系性得到了支持,与Mound and Palmer(1983)的结论一致;但臀管蓟马族Pygothripini并非单系,该结果与Buckman等(2.13)基于分子数据的研究结果相似。

关键词：灵管蓟马亚科形态数据支序系统学系统发育

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酒石酸溴莫尼定体内外微透析回收率的研究

中国药学杂志 2018年第19期53卷 1676-1681页

作者：夏志芳汤湛王领王俏冯海浙江工业大学药学院杭州310014 浙江省医学科学院药物研究所杭州310013

目的研究酒石酸溴莫尼定浓度、流速对体内外自制微透析探针回收率的影响,为进一步的眼部微透析药动学试验提供依据。方法以酒石酸溴莫尼定为模型药物,分别测定微透析探针在不同药物浓度、不同灌流速度时,体外正向、反向回收率及体内反... 详细信息

目的研究酒石酸溴莫尼定浓度、流速对体内外自制微透析探针回收率的影响,为进一步的眼部微透析药动学试验提供依据。方法以酒石酸溴莫尼定为模型药物,分别测定微透析探针在不同药物浓度、不同灌流速度时,体外正向、反向回收率及体内反向回收率。结果微透析探针体内外回收率与药物浓度无关,与流速成反比。探针体外正向、反向回收率在1. 0μL·min^(-1)时有差异,在2. 0、3. 0μL·min^(-1)时无明显差异;且均大于体内反向回收率。结论自制微透析探针回收率稳定,可用于酒石酸溴莫尼定的眼部药动学研究。

关键词：酒石酸溴莫尼定微透析探针回收率体外体内眼

A visible-light-assisted Pd/TiO_(2.gas sensor with carbon nanotubes electrodes for trace formaldehyde detection

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Rare Metals 2024年第1期43卷 257-266页

作者： Can Liu qiao-qiao Zou Bin Liu Yong Zhang School of Physics and Optoelectronics Xiangtan UniversityXiangtan 411105China Hunan Institute of Advanced Sensing and Information Technology Xiangtan UniversityXiangtan 411105China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China

Owing to the ppb-level detection standard toward the toxic and harmful gas,the detection of trace gases has become an important subject in the field of indoor environment ***,the traditional resistive gas sensors hardly meet the requirement due to the weak signal generated by trace gas molecules that are difficult to ***,a visible-light-assisted Pd/TiO_(2.gas sensor is proposed to endow the effective detection of trace formaldehyde(HCHO)gas without heating *** from the enhanced photocatalytic properties of TiO_(2.by Pd decoration,the visible-light-assisted Pd/TiO_(2.gas sensor can detect the HCHO gas as low as80×10^(–9)at room *** successful preparation of nanoscale TiO_(2.sensing layer is facilitated by the ultrathin carbon nanotube interdigital electrode in the gas sensor,which avoids the discontinuity of the sensing layer caused by the excessive thickness of the traditional metal *** addition,the whole preparation process of the Pd/TiO_(2.gas sensor with carbon nanotube electrodes is compatible with mainstream CMOS fabrication technology,which is expected to realize the batch fabrication and micro-integrated application of gas *** is expected that our work can provide a new strategy for the batch preparation of high-performance trace HCHO gas sensors and their future applications in portable electronic devices such as smartphones.

关键词： Visible-light-assisted gas sensor Pd/TiO_(2. Trace HCHO detection Carbon nanotubes electrodes

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mTOR抑制剂抗动脉粥样硬化的研究进展

基础医学与临床 2017年第2期37卷 265-269页

作者：刘丽乔王群南昌大学基础医学院生物化学与分子生物学教研室江西南昌330006 南昌大学第一附属医院心胸外科江西南昌330006

雷帕霉素靶蛋白(m TOR)是哺乳动物细胞中的Ser/Thr激酶,存在m TORC1和m TORC2.种复合体,调控细胞增殖、迁移及血管生成。大环内酯类免疫抑制剂雷帕霉素(RAPA)及其衍生物(rapalogs)可抑制m TORC1的功能,减缓动脉粥样硬化(AS)的发生发展... 详细信息

雷帕霉素靶蛋白(m TOR)是哺乳动物细胞中的Ser/Thr激酶,存在m TORC1和m TORC2.种复合体,调控细胞增殖、迁移及血管生成。大环内酯类免疫抑制剂雷帕霉素(RAPA)及其衍生物(rapalogs)可抑制m TORC1的功能,减缓动脉粥样硬化(AS)的发生发展。然而长期应用rapalogs会导致m TORC1抵抗及m TORC2.制,产生血脂异常等。临床上采取联合用药、间歇性给药或低剂量给药等措施应对。

关键词：动脉粥样硬化雷帕霉素靶蛋白雷帕霉素雷帕霉素衍生物

ROS-responsive hydrogels with spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs for the repair of MRSA-infected wounds

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Regenerative Biomaterials 2024年第1期3卷 119-131页

作者： Bowen qiao Jiaxin Wang Lipeng qiao Aziz Maleki Yongping Liang Baolin Guo Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Mechanical Behavior of Materials Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Zanjan Pharmaceutical Nanotechnology Research Center(ZPNRC) Zanjan 45139-56184Iran Department of Orthopaedics The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061People’s Republic of China

For the treatment of MRSA-infected wounds,the spatiotemporally sequential delivery of antibacterial and anti-inflammatory drugs is a promising *** this study,ROS-responsive HA-PBA/PVA(HPA)hydrogel was prepared by phenylborate ester bond cross-linking between hyaluronic acid-grafted 3-amino phenylboronic acid(HA-PBA)and polyvinyl alcohol(PVA)to achieve spatiotemporally controlled release of two kinds of drug to treat MRSA-infected *** hydrophilic antibiotic moxifloxacin(M)was directly loaded in the *** hydrophobic curcumin(Cur)with anti-inflammatory function was first mixed with Pluronic F12.(PF)to form Cur-encapsulated PF micelles(Cur-PF),and then loaded into the HPA *** to the different hydrophilic and hydrophobic nature of moxifloxacin and Cur and their different existing forms in the HPA hydrogel,the final HPA/M&Cur-PF hydrogel can achieve different spatiotemporally sequential delivery of the two *** addition,the swelling,degradation,self-healing,antibacterial,anti-inflammatory,antioxidant property,and biocompatibility of hydrogels were ***,in the MRSA-infected mouse skin wound,the hydrogel-treated group showed faster wound closure,less inflammation and more collagen *** experiments further confirmed that the hydrogel promoted better repair by reducing inflammation(TNF-a)and promoting vascular(VEGF)*** conclusion,this HPA/M&CurPF hydrogel that can spatiotemporally sequential deliver antibacterial and anti-inflammatory drugs showed great potential for the repair of MRSA-infected skin wounds.

关键词： MRSA-infected wounds spatiotemporally sequential delivery antibacterial anti-inflammatory

Data-Driven Direct Adaptive Risk-Sensitive Control of Stochastic Systems

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Journal of Systems Science & Complexity 2024年第4期37卷 1446-1469页

作者： qiao Nan LI Tao School of Mathematical Sciences East China Normal UniversityShanghai 200241China Shanghai Key Laboratory of Pure Mathematics and Mathematical Practice School of Mathematical SciencesEast China Normal UniversityShanghai 200241China

The authors propose a data-driven direct adaptive control law based on the adaptive dynamic programming(ADP) algorithm for continuous-time stochastic linear systems with partially unknown system dynamics and infinite horizon quadratic risk-sensitive *** authors use online data of the system to iteratively solve the generalized algebraic Riccati equation(GARE) and to learn the optimal control law *** the case with measurable system noises,the authors show that the adaptive control law approximates the optimal control law as time goes *** the case with unmeasurable system noises,the authors use the least-square solution calculated only from the measurable data instead of the real solution of the regression equation to iteratively solve the *** authors also study the influences of the intensity of the system noises,the intensity of the exploration noises,the initial iterative matrix,and the sampling period on the convergence of the ADP ***,the authors present two numerical simulation examples to demonstrate the effectiveness of the proposed algorithms.

关键词： Adaptive dynamic programming direct adaptive control generalized algebraic Riccati equation risk-sensitive control

Supercoiled DNA Minicircles under Double-strand Breaks

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Chinese Journal of Polymer Science 2024年第9期42卷 1353-1359,I0007页

作者： Ye-Peng qiao Chun-Lai Ren National Laboratory of Solid State Microstructures and Department of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China

Understanding how supercoiled DNA releases intramolecular stress is essential for its functional ***,the molecular mechanism underlying the relaxation process remains insufficiently *** we employed MD simulations based on the oxDNA2.model to investigate the relaxation process of a 336-base pair supercoiled minicircular DNA under double-strand breaks with two fixed *** simulations show that the conformational changes in the DNA occur continuously,with intramolecular stress release happening abruptly only when the DNA chain traverses the breakage *** relaxation process is influenced not only by the separation distance between the fixed ends but also their ***,we observe an inhibitory effect on the relaxation characterized by small angles,where short terminal loops impede DNA conformational adjustments,preserving the supercoiled *** findings elucidate the intricate interplay between DNA conformational change,DNA motion and intramolecular stress release,shedding light on the mechanisms governing the relaxation of supercoiled DNA at the molecular level.

关键词： Supercoiled DNA DNA minicircle DNA relaxation oxDNA model MD simulation

The spectrum and stability of travelling pulses in a coupled FitzHugh-Nagumo equation

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Science China Mathematics 2024年第5期67卷 975-1010页

作者： Qi qiao Xiang Zhang School of Mathematical Sciences Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Scientific and Engineering Computing(Ministry of Education) and Shanghai Frontier Science Center of Modern Analysis(CMA-Shanghai)Shanghai Jiao Tong UniversityShanghai 200240China

For a coupled slow-fast FitzHugh-Nagumo(FHN)equation derived from a reaction-diffusionmechanics(RDM)model,Holzer et al.(2.13)studied the existence and stability of the travelling pulse,which consists of two fast orbit arcs and two slow ones,where one fast segment passes the unique fold point with algebraic decreasing and two slow ones follow normally hyperbolic critical curve *** and Zhang(2.2.)obtained the existence of the travelling pulse,whose two fast orbit arcs both exponentially decrease,and one of the slow orbit arcs could be normally hyperbolic or not at the ***,we characterize both the nonlinear and spectral stability of this travelling pulse.

关键词： coupled FitzHugh-Nagumo equation singular perturbation travelling pulse spectrum nonlinear stability spectral stability

Spin Resolved Zero-Line Modes in Minimally Twisted Bilayer Graphene from Exchange Field and Gate Voltage

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Chinese Physics Letters 2024年第7期41卷 111-116页

作者： Sanyi You Jiaqi An Zhenhua qiao International Centre for Quantum Design of Functional Materials CAS Key Laboratory of Strongly Coupled Quantum Matter Physicsand Department of PhysicsUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China

The reliance on spin-orbit coupling or strong magnetic fields has always posed significant challenges for the mass production and even laboratory realization of most topological materials. Valley-based topological zero-line modes have attracted widespread attention due to their substantial advantage of being initially realizable with just an external electric field. However, the uncontrollable nature of electrode alignment and precise fabrication has greatly hindered the advancement in this field. By utilizing minimally twisted bilayer graphene and introducing exchange fields from magnetic substrates, we successfully realize a spin-resolved, electrode-free topological zeroline mode. Further integration of electrodes that do not require alignment considerations significantly enhances the tunability of the system's band structure. Our approach offers a promising new support for the dazzling potential of topological zero-line mode in the realm of low-energy-consumption electronics.

关键词： structure field topological