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原发于胃的嗜酸细胞性神经内分泌肿瘤临床病理学分析

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中华病理学杂志 2025年第2期54卷 162-164页

作者：佘欣远赵莎化宏金郑宇李海王前玉江苏省人民医院宿迁医院(宿迁市第一人民医院)病理科宿迁江苏省人民医院(南京医科大学第一附属医院)病理科南京

目的探讨原发于胃的嗜酸细胞性神经内分泌肿瘤的临床病理学特征、免疫组织化学及鉴别诊断要点。方法收集并观察3例发生于胃的伴有显著嗜酸细胞性特征的神经内分泌肿瘤病例的临床、病理组织形态学特点及免疫组织化学结果, 并复习相关文...

目的探讨原发于胃的嗜酸细胞性神经内分泌肿瘤的临床病理学特征、免疫组织化学及鉴别诊断要点。方法收集并观察3例发生于胃的伴有显著嗜酸细胞性特征的神经内分泌肿瘤病例的临床、病理组织形态学特点及免疫组织化学结果, 并复习相关文献进行分析。结果例1男, 50岁, 因上腹部不适2年入院, 肿瘤位于胃体;例2女, 47岁, 有甲状腺功能亢进病史, 长期服用甲巯咪唑, 肿瘤位于窦体交界;例3男, 54岁, 因上腹烧灼样疼痛2年入院, 肿瘤位于胃体。例1、2肿瘤均位于黏膜固有层, 例3肿瘤大部位于黏膜固有层, 局灶可见黏膜下侵犯。瘤细胞胞质丰富、嗜酸性, 细胞核偏位类似于嗜酸细胞样的印戒细胞癌, 并且核具有一定多形性;免疫组织化学肿瘤细胞弥漫表达上皮及神经内分泌标志物, 包括突触素、嗜铬粒素A、胰岛素相关蛋白1, Ki-67阳性指数分别为2%、5%和7%。结论原发于胃的嗜酸细胞性神经内分泌肿瘤罕见, 临床病理实践中需要与胃腺癌包括印戒细胞癌、壁细胞癌、泌酸腺肿瘤、颗粒细胞瘤等多种肿瘤相鉴别。并且其早期阶段即有较高的增殖活性, 认识该罕见亚型的存在结合相关免疫组织化学检查有助于其诊断与鉴别诊断。

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Synergistic injection of the thermosensitive hydrogel and Bi-based alloy bone cement for orthopaedic repair

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Science China(Technological Sciences) 2024年第7期67卷 2153-2163页

作者： LIU SiCong LI Lei JIANG ChanYuan wang qianyu DENG ZhongShan Key Laboratory of Cryogenic Science and Technology Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Department of Cleft Lip and Palate Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100144China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

Low-melting-point alloys have the advantages of good biocompatibility, plasticity, and near-bone mechanical strength, making them suitable as bone defect-filling materials for direct injection into defective bone sites. However, using low-melting-point alloys for orthopedic implants poses the challenge of causing thermal damage to the surrounding bone tissue during injection. In this study, a thermosensitive hydrogel is prepared and synergistically injected into the bone defect site with BiInSn. BiInSn solidifies and releases heat during injection, while the thermosensitive hydrogel absorbs heat and transforms into a gel state,encapsulating BiInSn. Therefore, the surrounding bone tissue is effectively protected from thermal damage. When BiInSn and the thermosensitive hydrogel were injected synergistically, in vitro thermal experiments revealed that the maximum temperature of the surrounding bone tissue reached 42℃. This temperature is below the 47℃ threshold, which causes permanent damage to bone tissues. In vivo experiments demonstrated that rats in the BiInSn-thermosensitive hydrogel group exhibited better recovery at the bone defect sites. These results suggest that the synergistic injection of Bi-based alloy and thermosensitive hydrogel is beneficial in reducing thermal damage to bone tissue, guiding bone tissue growth, and effectively facilitating the repair of bone defects.

关键词： bone defects thermosensitive hydrogel thermal damage to tissue bismuth-based alloy bone cement

维普期刊数据库

Magnetic activated carbon for the removal of methyl orange from water via adsorption and Fenton-like degradation

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Particuology 2024年第11期94卷 314-326页

作者： qianyu wang Yuming Zhang Yuhua Zheng Emmanuel Oluwaseyi Fagbohun Yanbin Cui State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing102249China State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Laboratory for Nanomaterials and Molecular Plasmonics Department of Chemistry and BiologyToronto Metropolitan University350 Victoria StTorontoONM5B2K3Canada

Water pollution caused by organic dyes is a critical environmental *** activated carbon(AC)is commonly used for dye adsorption,its effectiveness is limited by challenges in separation and *** address these limitations,a convenient recyclable magnetic activated carbon(MAC)was fabricated via co-precipitation and calcination method,serving as adsorbent and catalyst for methyl orange(MO)removal through a Fenton-like degradation *** techniques,including XRD,FTIR,SEM and TEM,confirmed that Fe_(3)O_(4) nanoparticles(10–20 nm)were uniformly dispersed on AC *** MAC maintaining a high surface area(997 m^(2)/g)and pore volume(0.795 cm^(3)/g)and exhibited superparamagnetic properties with a saturated magnetization of 5.52 emu/g,enabling effective separation from aqueous solutions by *** adsorption studies revealed that MO adsorption onto MAC followed pseudo-second-order kinetic and Freundlich isotherm model,with a maximum adsorption capacity of 205 mg/g at 25℃.Thermodynamic analysis showed that the adsorption process was spontaneous and *** degradation of MO and in-situ regeneration of MAC were achieved via Fenton-like reaction using sodium persulfate(PS).Under a PS concentration of 9 mmol/L,the MO removal efficiency near 95%after 60 min,with a total organic carbon(TOC)reduction of 83.1%.The reaction of Fe_(3)O_(4) and oxygen functional groups on AC surface with PS facilitated the generation of SO_(4)^(·-),thereby enhancing catalytic degradation of *** degradation efficiency improved as the temperature increased from 25℃ to 45℃.Cycle tests demonstrated that the MO removal efficiency of MAC remained above 90%after 5 cycles of ***,this study highlights the potential of MAC for efficient removal of organic dyes from water through the coupling of adsorption and Fenton-like degradation,providing a promising solution for addressing water pollution challenges.

关键词： Magnetic activated carbon Methyl orange Adsorption Sodium persulfate Fenton-like degradation

The combination of DNA methylation and positive regulation of anthocyanin biosynthesis by MYB and bHLH transcription factors contributes to the petal blotch formation in Xibei tree peony

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Horticulture Research 2023年第7期10卷 69-86页

作者： Jin Zhu Yizhou wang qianyu wang Bing Li Xiaohan wang Xian Zhou Hechen Zhang Wenzhong Xu Shanshan Li Liangsheng wang Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093 China University of Chinese Academy of Sciences Beijing 100049China Horticulture Research Institute Henan Academy of Agricultural SciencesZhengzhou 450002China

Xibei tree peony is a distinctive cultivar group that features red–purple blotches in ***,the pigmentations of blotches and non-blotches are largely independent of one *** underlying molecular mechanism had attracted lots of attention from investigators,but was still *** present work demonstrates the factors that are closely related to blotch formation in Paeonia rockii‘Shu Sheng Peng Mo’.Non-blotch pigmentation is prevented by the silencing of anthocyanin structural genes,among which PrF3H,PrDFR,and PrANS are the three major *** characterized two R2R3-MYBs as the key transcription factors that control the early and late anthocyanin biosynthetic ***1,which belongs to MYB subgroup 7(SG7)was found to activate the early biosynthetic gene(EBG)PrF3H by interacting with SG5 member PrMYBa2 to form an‘MM’*** SG6 member PrMYBa3 interacts with two SG5(IIIf)bHLHs to synergistically activate the late biosynthetic genes(LBGs)PrDFR and PrANS,which is essential for anthocyanin accumulation in petal *** comparison of methylation levels of the PrANS and PrF3H promoters between blotch and non-blotch indicated a correlation between hypermethylation and gene *** methylation dynamics of PrANS promoter during flower development revealed a potential early demethylating reaction,which may have contributed to the particular expression of PrANS solely in the blotch *** suggest that the formation of petal blotch may be highly associated with the cooperation of transcriptional activation and DNA methylation of structural gene promoters.

关键词： belongs synergistic pigment

Chemical Mechanism of Flower Color Microvariation in Paeonia with Yellow Flowers

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Horticultural Plant Journal 2020年第3期6卷 179-190页

作者： Yong Yang Bing Li Chengyong Feng Qian Wu qianyu wang Shanshan Li Xiaonan Yu Liangsheng wang Key Laboratory of Plant Resources/Beijing Botanical Garden Institute of BotanyChinese Academy of SciencesBeijing 100093China Beijing Key Laboratory of Ornamental Plants Germplasm Innovation and Molecular Breeding National Engineering Research Center for FloricultureCollege of Landscape ArchitectureBeijing Forestry UniversityBeijing 100083China University of Chinese Academy of Sciences Beijing 100049China

Paeonia species are important ornamental plants,including three types:tree peony,herbaceous peony,and Itoh hybrid *** with yellow color is desired and becoming ***,the chemical mechanism of the formation of yellow flowers in Paeonia is still *** this study,14 representative samples were selected:four samples of three species of Paeonia,four herbaceous peony cultivars,three lutea hybrid tree peony cultivars,and three Itoh hybrid peony *** petal extracts of the samples were determined by HPLC-DAD and HPLCQ-TOF-MS/*** total,29 flavonoids were isolated and identified,including 28 flavonol glycosides and one chalcone *** were significant differences in the composition and content of flavonoids in petals of different cultivars(species).The total content of flavonoids was between 19.430 and 143.043 mg·g^−1 *** glycosides were detected in all *** 2′-O-glucoside was detected from one herbaceous peony cultivar‘Golden Wheel’lutea hybrid tree peony cultivars,and Itoh peony *** content of chalconaringenin 2′-O-glucoside in the samples was more than 43% of total *** pigment type and content of lutea hybrid tree peonies and Itoh hybrid peonies are *** flavonoids,especially quercetin 3-O-galloylglucoside and chalconaringenin 2′-O-glucoside contribute greatly to the formation of yellow flowers of *** results of this study provide a comprehensive understanding of the chemical mechanism for yellow flower coloration of Paeonia,and lay the foundation for yellow flower breeding of Paeonia.

关键词： Paeonia Yellow flower HPLC Flavonoid composition Breeding

维普期刊数据库

Improved thermal conductivity of styrene acrylic resin with carbon nanotubes, graphene and boron nitride hybrid fillers

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Carbon Resources Conversion 2021年第1期4卷 190-196页

作者： Fuhua Jia Emmanuel Oluwaseyi Fagbohun qianyu wang Duoyin Zhu Jianling Zhang Bin Gong Yanbin Cui State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China College of Mechanical and Power Engineering Shenyang University of Chemical TechnologyShenyang 110142China University of Chinese Academy of Sciences Beijing 100049 China

In the process of printing and copying,the volatilization of toner produces tiny particles and harmful gases that are detrimental to the human ***-temperature printing and copying can reduce harmful gas *** acrylic resin is the main component of toner and the thermal conductivity of toner can be improved by increasing the thermal conductivity of styrene acrylic *** this paper,hexagonal boron nitride(h-BN),carboxyl modified multi-walled carbon nanotubes(MWCNTs-COOH)and graphene hybrid fillers were added into styrene acrylic resin to improve the thermal conductivity of resin composite by forming a connected thermal conductivity network in *** experimental result shows that the thermal conductivity of the h-BN/styrene acrylic resin composite increases with the increase in h-BN filler content(0-20wt%).When 20.0 wt%h-BN is added into styrene acrylic resin,the thermal conductivity is increased by 83.63%.Hybrid fillers(MWCNTs-COOH/graphene and 3.0 wt%h-BN)were added in styrene acrylic resin and the thermal conductivity of the composite is almost the same or higher than that of 20.0 wt%h-BN/styrene acrylic resin *** thermal conductivity of styrene acrylic resin composites improved by 69.57%and 87.14%via adding 1.5wt%CNTs-3 wt%h-BN and 1.0wt%graphene-3 wt%***-COOH or graphene can bridge isolated h-BN aggregates to form a thermally conductive network in styrene acrylic resin,while the addition of graphene improves the thermal conductivity of resin composite higher than that of MWCNTs-COOH.

关键词： Styrene acrylic resin Boron nitride Carbon nanotubes Graphene Thermal conductivity

Synthesis ofγ-MnS/nanoporous carbon/reduced graphene oxide composites for high-performance supercapacitor

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Carbon Resources Conversion 2022年第3期5卷 222-230页

作者： Abiola Ganiyat Olatoye Jie Zhang qianyu wang Erping Cao Wenli Li Emmanuel Oluwaseyi Fagbohun Yanbin Cui State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

In the present work,nanoporous carbon(NPC)was prepared from a metal-organic framework(zeolite imidazolate framework 8,ZIF-8).Different concentrations of graphene oxide(GO)were used to make NPC/reduced graphene oxide(NPC/rGO-x,x=0.5,1.0,1.5,and 2.0)composites,and thenγ-MnS/NPC/rGO-1 composite was synthesized via a simple hydrothermal *** electrochemical characteristics of porous carbon composites(NPC/rGO-x)andγ-MnS/NPC/rGO-1 electrodes were investigated by galvanostatic charge and discharge,cyclic voltammetry,and electrochemical impedance ***/rGO-1 showed the highest specific capacitance of 207 F/g at 0.5 A/***,theγ-MnS/NPC/rGO-1 electrode demonstrates exceptional electrochemical performance with a high specific capacitance of 300 F/g at 0.5 A/g and impressive cyclic stability of 70%capacitance retention after 10,000 cycles at 1 A/*** a result,this study demonstrates thatγ-MnS/NPC/rGO-1 electrode can be considered a promising candidate for high-performance supercapacitors.

关键词： Metal-organic framework Nanoporous carbon Reduced graphene oxide γ-MnS Supercapacitor

One-Dimensional Metal-Organic Framework for High-Efficiency Electrocatalytic Reduction of CO_(2)to CO

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Chinese Journal of Chemistry 2024年第22期42卷 2788-2794页

作者： Jie Lu qianyu wang Zhikai Jin Yang Xiao Bi-Hong Huang Cai-Hong Zhang Gui-Zeng Yang Yi Zhou Fu-Sheng Ke Hubei Key Laboratory of Electrochemical Power Sources Hubei Key Lab on Organic and Polymeric Opto-Electronic MaterialsCollege of Chemistry and Molecular SciencesWuhan UniversityWuhanHubei 430072China

Electrocatalytic reduction of CO_(2)to valuable products possesses huge potential to alleviate environmental and energy *** is well known that Ag favors the conversion of CO_(2)to CO but the exposed active sites and stability are still rather *** this study,a novel one-dimensional Ag-based metal-organic framework(1D Ag-NIM-MOF)was successfully synthesized and used in the electrocatalytic CO_(2)reduction reaction(CO_(2)RR)for the first *** a result,the Faradaic efficiency of CO achieved 94.5%with current density of 12.5 mA·cm^(-2)in an H-type cell and 98.2%with current density of 161 mA·cm^(-2)in a flow cell at–1.0 V(***),which stands as a new benchmark of Ag-based MOFs in the electrocatalytic CO_(2)*** excellent performance of 1D Ag-NIM-MOF is attributed to its peculiar one-dimensional structure,which is beneficial for diffusion of reactants and products,and exposure of much more catalytic *** to commercial Ag nanoparticles,1D Ag-NIM-MOF exhibits superior electrocatalytic CO_(2)RR performance with higher catalytic activity and stability.

关键词： Metal-organic frameworks Ag-based catalyst One-dimensional material Crystal engineering Electrocatalysis CO_(2)reduction

GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4667-4682页

作者： Xu Chen Qingnan Wu Wei Gong Shaolong Ju Jiawen Fan Xiaohan Gao Xingyang Liu Xiao Lei Siqi Liu Xiangdong Ming qianyu wang Ming Fu Yongmei Song Yan wang Qimin Zhan State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College100021BeijingChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital&Institute100142BeijingChina Peking University-Yunnan Baiyao International Medical Research Center 100191BeijingChina Center for Infection and Immunity The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhaiChina Department of Biochemistry and Biophysics School of Basic Medical SciencesPeking University Health Science CenterBeijingChina Research Unit of Molecular Cancer Research Chinese Academy of Medical SciencesBeijingChina Soochow University Cancer Institute Suzhou215000China

Cachexia,which affects 50–80%of cancer patients,is a debilitating syndrome that leads to 20%of cancer-related deaths.A key feature of cachexia is adipose tissue atrophy,but how it contributes to the development of cachexia is poorly ***,we demonstrate in mouse models of cancer cachexia that white adipose tissue browning,which can be a characteristic early-onset manifestation,occurs prior to the loss of body weight and skeletal muscle *** analysing the proteins differentially expressed in extracellular vesicles derived from cachexia-inducing tumours,we identified a molecular chaperone,Glucose-regulated protein 75(GRP75),as a critical mediator of adipocyte ***,GRP75 binds adenine nucleotide translocase 2(ANT2)to form a GRP75–ANT2 ***,stabilized ANT2 enhances its interaction with uncoupling protein 1,leading to elevated expression of the latter,which,in turn,promotes adipocyte *** with withanone,a GRP75 inhibitor,can reverse this browning and alleviate cachectic phenotypes in ***,our findings reveal a novel mechanism by which tumour-derived GRP75 regulates white adipose tissue browning during cachexia development and suggest a potential white adipose tissue-centred targeting approach for early cachexia intervention.

关键词： cancer elevated white