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pH-Sensitive nanoscale materials as robust drug delivery systems for cancer therapy

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Chinese Chemical Letters 2020年第6期31卷 1345-1356,F0003页

作者： Zhaoqing Shi qianqian li lin Mei School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Tsinghua Shenzhen International Graduate School.Tsinghua University Shenzhen 518055China

Cancer is one of the diseases that have the highest mortality,which threatens the human *** functions as the most widely used strategy in clinic to treat cancer,still exists urgent problems,like lacking selectivity and causing severe side *** to detailed researches on the metabolism,functions and histology of cancer tissues,many different features of cancer are uncovered,like lower pH in microenvironment,abnormal redox level in intracellular compartments and elevated expression level of several enzymes and ***,the development of smart nanoparticles that response to tumor specific microenvironment has lighted up hope for selective cancer ***,this review mainly focuses on pH-sensitive nano scale materials for anti-cancer drug *** summarized the formation progress of acidic tumor microenvironment,the mechanism of pHresponsive drug delivery system and nanomaterials that responsive to acidic pH in tumor microenvironment.

关键词： Cancer therapy Drug delivery systems Nanoparticles pH-sensitive material

Marine Ranching Engineering Collaborative Innovation from the Perspective of Ecological Environment

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Journal of Ocean University of China 2023年第4期22卷 1151-1163页

作者： WAN Xiaole ZHANG Guixian li qianqian Management College Ocean University of ChinaQingdao 266100China Marine Development Studies Institute of Ocean University of China Key Research Institute of Humanities and Social Sciences at UniversitiesMinistry of EducationQingdao 266100China

As a resource development model with both economic and ecological functions,the environmental friendliness of marine ranching products meets the environmental needs of ***,the lack of technological innovation ability limits the development of marine ***,this research builds a marine ranching collaborative innovation system with multi-agent *** game theory is used to analyze strategic choices of all parties and the conditions of system equilibrium,and numerical simulation is used to analyze the effect of relevant *** paper integrates the benefits from the improvement of environmental friendliness into the payoff matrix,and explains the significance of collaborative innovation to the development of marine ranching from the perspective of ecological *** results showed:the participation willingness of marine ranching enterprises is positively related to open innovation subject,while the participation willingness of the other two parties is negatively related to the government;The incentive effect of collaboration is negatively correlated with the government’s will,positively correlated with the other two parties;The incentive effect of government subsidies positively affects the willingness of the three parties to ***,suggestions are provided for each participant to maintain the strategic choice of marine ranching collaborative innovation system.

关键词： marine ranching engineering ecological environment collaborative innovation evolutionary game numerical simulations

基于Web of Science的癌症相关认知功能障碍研究热点及可视化分析

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全科护理 2024年第4期22卷 607-613页

作者：李倩倩李洪丽庄丽安然中国人民武装警察部队第一机动总队医院 073000 中南大学湘雅医院临床护理学教研室 410008

目的:分析癌症相关认知功能障碍(cancer-related cognitive impairment, CRCI)研究领域的研究现状、热点及前沿。方法:以Web of Science核心合集数据库为数据来源,检索建库至2022年12月31日CRCI的相关文献,利用CiteSpace和VOSviewer软... 详细信息

目的:分析癌症相关认知功能障碍(cancer-related cognitive impairment, CRCI)研究领域的研究现状、热点及前沿。方法:以Web of Science核心合集数据库为数据来源,检索建库至2022年12月31日CRCI的相关文献,利用CiteSpace和VOSviewer软件对相关文献的国家、机构及关键词等进行分析。结果:共纳入2 093篇相关文献,发文量总体呈逐年增长趋势,美国、中国、荷兰是该领域发文量较多的国家,美国的加州大学系统、得克萨斯大学系统和哈佛大学是主要的研究机构,研究方向主要是肿瘤学和神经科学与神经病学,研究热点集中在CRCI病人认知功能与生活质量的研究、CRCI的发生机制、CRCI与疲乏及抑郁等症状负担的关系研究。研究前沿是CRCI的影响因素及评估方式。结论:近年来CRCI领域研究关注度逐年提高,以知识图谱的形式展示CRCI的研究热点及前沿趋势,可为今后国内相关研究提供借鉴。

关键词：癌症相关认知功能障碍文献计量学 CiteSpace软件知识图谱研究热点

同方期刊数据库博看期刊评论

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基于“五水共治”的浙江省水安全评价研究

环境污染与防治 2024年第1期46卷 111-116,122页

作者：申开丽孔蕾李倩倩姜利杰欧健浙江水利水电学院测绘与市政工程学院浙江杭州310018 浙江省海洋科学院浙江杭州310012 浙江省生态环境科学设计研究院浙江杭州310007

基于驱动力-压力-状态-影响-响应-管理(DPSIRM)模型,结合浙江省“五水共治”工作实践,建立了包括6个准则层、42个评价指标的浙江省水安全评价指标体系,并结合障碍度诊断模型,对2006—2020年浙江省水安全的障碍因子进行了诊断分析。结果... 详细信息

基于驱动力-压力-状态-影响-响应-管理(DPSIRM)模型,结合浙江省“五水共治”工作实践,建立了包括6个准则层、42个评价指标的浙江省水安全评价指标体系,并结合障碍度诊断模型,对2006—2020年浙江省水安全的障碍因子进行了诊断分析。结果表明:(1)浙江省的水安全状况总体呈逐年上升趋势;(2)除驱动力子系统外,各子系统水安全指数基本呈波动上升趋势;(3)不同时段的主要障碍度因子各不相同,2006—2013年,压力和响应子系统是水安全的主要制约因素。2016年起,状态和驱动力子系统成为制约水安全的主要障碍。

关键词：水安全 DPSIRM模型障碍度 “五水共治” 浙江省

Icosahedral quasicrystal structure of the Mg_(40)Zn_(55)Nd_(5) phase and its thermodynamic stability

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International Journal of Minerals,Metallurgy and Materials 2022年第8期29卷 1543-1550页

作者： Shuai Zhang qianqian li Hongcan Chen Qun Luo Qian li State Key Laboratory of Advanced Special Steels Shanghai Key Laboratory of Advanced FerrometallurgySchool of Materials Science and EngineeringShanghai UniversityShanghai 200444China Materials Genome Institute Shanghai UniversityShanghai 200444China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

The quasicrystal phase is beneficial to increasing the strength of magnesium ***,its complicated structure and unclear phase relations impede the design of alloys with good mechanical *** this paper,the Mg_(40)Zn_(55)Nd_(5) icosahedral quasicrystal(I-phase)structure is discovered in an as-cast Mg-58Zn-4Nd alloy by atomic resolution high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM).A cloud-like morphology is observed with Mg_(41.6)Zn_(55.0)Nd_(3.4) *** selected area electronic diffrac-tion(SAED)analysis shows that the icosahedral quasicrystal structure has 5-fold,4-fold,3-fold,and 2-fold symmetry zone *** thermo-dynamic stability of the icosahedral quasicrystal is investigated by differential scanning calorimetry(DSC)in the annealed *** an-nealed above 300℃,the Mg_(40)Zn_(55)Nd_(5) quasicrystal is found to decompose into a stable ternary phase Mg_(35)Zn_(60)Nd_(5),a binary phase MgZn,andα-Mg,suggesting that the quasicrystal is a metastable phase in the Mg-Zn-Nd system.

关键词： icosahedral quasicrystal crystal structure thermodynamic stability Mg-Zn-Nd alloys

Investigation on Reduction of Pressure Fluctuation for a Double-Suction Centrifugal Pump

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Chinese Journal of Mechanical Engineering 2021年第1期34卷 181-198页

作者： qianqian li Shiyang li Peng Wu Bin Huang Dazhuan Wu College of Energy Engineering Zhejiang UniversityHangzhou 310058China Zhejiang Zhixin Technology Co. LtdShaoxing 312000China Ocean College Zhejiang UniversityZhoushan 310021China The State Key Laboratory of Fluid Power Tran smission and Control Hangzhou 310058China

Double-suction centrifugal pumps have been applied extensively in many areas,and the significance of pressure fluctuations inside these pumps with large power is becoming increasingly *** this study,a double-suction centrifugal pump with a high-demand for vibration and noise was redesigned by increasing the flow uniformity at the impeller discharge,implemented by combinations of more than two ***,increasing the number of the impeller blades was intended to enhance the bounding effect that the blades imposed on the ***,increasing the radial gap between the impeller and volute was applied to reduce the rotor-stator ***,the staggered arrangement was optimized to weaken the efficacy of the interference *** on numerical simulation,the steady and unsteady characteristics of the pump models were *** the fluctuation analysis in the frequency domain,the dimensionless pressure fluctuation amplitude at the blade passing frequency and its harmonics,located on the monitoring points in the redesigned pumps(both with larger radial gap),are reduced a ***,in the volute of the model with new impellers staggered at 12°,the average value for the dimensionless pressure fluctuation amplitude decreases to 6%of that in prototype *** dimensionless rootmean-square pressure contour on the mid-span of the impeller tends to be more uniform in the redesigned models(both with larger radial gap);similarly,the pressure contour on the mid-section of the volute presents good uniformity in these models,which in turn demonstrating a reduction in the pressure fluctuation *** results reveal the mechanism of pressure fluctuation reduction in a double-suction centrifugal pump,and the results of this study could provide a reference for pressure fluctuation reduction and vibration performance reinforcement of doublesuction centrifugal pumps and other pumps.

关键词： Double-suction centrifugal pump Pressure fluctuation Flow uniformity Numerical simulation

2017—2020年内蒙古自治区肉及肉制品中食源性致病菌污染分析

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生物加工过程 2024年第1期22卷 113-118页

作者：李茜茜乌伊罕曲琳内蒙古科技大学包头医学院公共卫生学院内蒙古包头014000 内蒙古综合疾病预防控制中心内蒙古呼和浩特010000

为了了解2017—2020年内蒙古自治区肉及肉制品中食源性致病菌污染状况,评估其存在的主要危害因素,笔者于2017—2020年在内蒙古自治区12个盟市随机采集市售肉及肉制品,依据《国家食品污染物和有害因素风险监测工作手册》、GB 4789—2016... 详细信息

为了了解2017—2020年内蒙古自治区肉及肉制品中食源性致病菌污染状况,评估其存在的主要危害因素,笔者于2017—2020年在内蒙古自治区12个盟市随机采集市售肉及肉制品,依据《国家食品污染物和有害因素风险监测工作手册》、GB 4789—2016和GB 4789.9—2014进行沙门氏菌、单核细胞增生李斯特氏菌、金黄色葡萄球菌、致泻大肠埃希氏菌(含大肠埃希氏菌O157:H7)和空肠弯曲菌检测。共采集餐饮服务、流通、养殖、屠宰环节肉及肉制品7 380份,检出378株阳性菌株,致病菌总检出率为5.12%,其中空肠弯曲菌污染率最高,检出率为22.85%,致泻大肠埃希氏菌次之,检出率为7.43%,沙门氏菌、单核细胞增生李斯特菌和金黄色葡萄球菌检出率分别为4.35%、3.55%和0.10%,未检出大肠埃希氏菌O157:H7。各类食品中致病菌总检出率介于0.21%~12.56%,其中,生禽肉检出率最高,熟肉制品最低。综上,内蒙古自治区市售肉及肉制品存在不同程度食源性致病菌污染,且污染持续多年存在,相关部门应针对性地对污染率高的食品长期持续监测,加强生产源头和流通过程的监督与管理,切断感染源及传播途径,预防食源性疾病的发生。

关键词：肉制品食源性致病菌食源性疾病污染状况食品安全

黄河流域城市经济韧性的时空分异及其驱动因素

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资源开发与市场 2024年第2期40卷 240-253页

作者：梁静波李倩倩信阳师范大学商学院河南信阳464000 江苏大学财经学院江苏镇江212013

黄河流域是我国经济发展的重要区域,增强城市经济韧性是推动其经济高质量发展的关键举措。基于2005—2020年黄河流域78个城市面板数据,从3个维度构建黄河流域城市经济韧性评价体系,采用熵值法度量,在测算结果基础上对黄河流域城市经济... 详细信息

黄河流域是我国经济发展的重要区域,增强城市经济韧性是推动其经济高质量发展的关键举措。基于2005—2020年黄河流域78个城市面板数据,从3个维度构建黄河流域城市经济韧性评价体系,采用熵值法度量,在测算结果基础上对黄河流域城市经济韧性的时空演变趋势进行分析,以明晰其时空分异性,并探究时空分异的驱动因素。结果发现:(1)时间演变趋势上,黄河流域多数城市经济韧性呈上升趋势,下游地区城市经济韧性最强且增速最快;(2)空间演变趋势上,高经济韧性和较高经济韧性城市主要集中在省会及其周边地区,流域内城市经济韧性具有显著的集聚趋势,且其集聚趋势有所增强;(3)在时空分异驱动因素上,居民风险抵抗能力、政府政策扶持力度、市场规模等差异对黄河流域整体城市经济韧性时空分异驱动作用较大,上中下游地区城市经济韧性时空分异的主导因素各不相同,任意两个驱动因素的交互作用均会增强单一因素对城市经济韧性时空分异的解释力。

关键词：城市经济韧性时空分异驱动因素黄河流域

内蒙古自治区生禽畜肉沙门氏菌、单核细胞增生李斯特菌和弯曲菌的污染监测分析

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包头医学院学报 2024年第4期40卷 67-71,86页

作者：李茜茜乌伊罕曲琳内蒙古科技大学包头医学院公共卫生学院2020级研究生内蒙古包头014040 内蒙古自治区综合疾病预防控制中心

目的:了解内蒙古自治区生禽畜肉中沙门氏菌、单核细胞增生李斯特菌和弯曲菌污染状况,为防治食源性疾病提供基础资料,为相关监督部门提供指导意见。方法:2016~2020年,从内蒙古自治区12个盟市采集生禽肉和牲畜肉共3171份样品。依据《食品... 详细信息

目的:了解内蒙古自治区生禽畜肉中沙门氏菌、单核细胞增生李斯特菌和弯曲菌污染状况,为防治食源性疾病提供基础资料,为相关监督部门提供指导意见。方法:2016~2020年,从内蒙古自治区12个盟市采集生禽肉和牲畜肉共3171份样品。依据《食品安全国家标准》(GB 4789-2016、GB 4789-2014)和食源性疾病监测工作手册要求进行致病菌的监测。结果:2016~2020年,在3171份样品中共检出阳性致病菌346株,总检出率为10.91%(346/3171),其中沙门氏菌、单核细胞增生李斯特菌和弯曲菌的总检出率依次为8.56%(85/993)、5.62%(50/889)和16.37%(211/1289);散装样品致病菌污染率高于预包装;冷冻肉中单核细胞增生李斯特菌的检出率最高,为17.53%(27/154);沙门氏菌在网店和便利店/零售店的检出率较高,分别为22.22%(4/18)和14.57%(22/151);弯曲菌在养殖环节的检出率最高,为40.55%(103/254),屠宰环节中样品均未检出。结论:2016~2020年内蒙古自治区生禽畜肉中弯曲菌污染最高,单核细胞增生李斯特氏菌污染率较低。为减少食源性疾病的发生率,应加强我区生禽畜肉在不同环节的监督管理,保障国民的食品安全与健康。

关键词：生禽畜肉沙门氏菌单核细胞增生李斯特菌弯曲菌