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Engineering 2024年第6期37卷 96-104页

作者： Yinglu Liu Dan Wang Changlin Liu qianqian hao Jian Li Jie-Xin Wang Xiuyun Chen Peng Zhong Xibin Shao Jian-Feng Chen State Key Laboratory of Organic–Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China BOE Technology Group Co. Ltd.Beijing 100176China

Transparent photoresists with a high refractive index(RI)and high transmittance in visible wavelengths have promising functionalities in optical *** work reports a kind of tunable optical material composed of titanium dioxide nanoparticles embedded in acrylic resin with a high RI for ultraviolet(UV)-imprint *** hybrid film exhibits a tunable RI of up to 1.67(589 nm)after being cured by UV light,while maintaining both a high transparency of over 98%in the visible light range and a low haze of less than 0.05%.The precision machining of optical microstructures can be imprinted easily and efficiently using the hybrid resin,which acts as a light guide plate(LGP)to guide the light from the side to the top in order to conserve the energy of the display *** preliminary studies based on both laboratory and commercial experiments pave the way for exploiting the unparalleled optical properties of nanocomposite resins and promoting their industrial application.

关键词： Photoresist Tunable refractive index Hanson solubility Ultraviolet imprint Organic-inorganic composites

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不同运动强度与骨关节炎发病风险的效应分析

中国组织工程研究 2025年第6期29卷 1305-1311页

作者：马浩宇乔鸿超郝茜茜史冬博太原理工大学体育学院山西省晋中市030600

背景:越来越多的证据表明不同运动强度与骨关节炎风险之间存在关联,但这可能受到混杂和反向因果关系的影响,结论尚未统一。目的:应用孟德尔随机化探索不同运动强度与骨关节炎的因果关联。方法:选取与不同运动强度相关联的全基因组关联... 详细信息

背景:越来越多的证据表明不同运动强度与骨关节炎风险之间存在关联,但这可能受到混杂和反向因果关系的影响,结论尚未统一。目的:应用孟德尔随机化探索不同运动强度与骨关节炎的因果关联。方法:选取与不同运动强度相关联的全基因组关联研究数据,以阈值P<5×10-8筛选工具变量,采用孟德尔随机化5种分析方法评估暴露与结局风险的因果关系,以逆方差加权法作为主要分析方法。使用选定的工具变量来评估不同运动强度与骨关节炎的因果关联,并进行敏感性分析与反向孟德尔随机化分析。结果与结论:①逆方差加权法分析结果显示,低强度运动对膝骨关节炎的保护效应显著(OR=0.14,95%CI:0.06-0.32,P<0.001),久坐行为(例如电视观看)是膝骨关节炎和髋骨关节炎的危险因素(OR=2.24,95%CI:1.74-2.88,P<0.001;OR=1.34,95%CI:1.01-1.78,P=0.04)。对于骨关节炎与不同运动强度的反向孟德尔随机化分析发现,骨关节炎与低强度运动呈负相关性,与电视观看呈正相关。②分析结果显示,不同运动强度与骨关节炎风险存在双向因果关系。

关键词：运动强度骨关节炎孟德尔随机化因果关联膝骨关节炎髋骨关节炎

Optimization of phenol degradation by Candida tropicalis Z-04 using Plackett-Burman design and response surface methodology

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Journal of Environmental Sciences 2011年第1期23卷 22-30页

作者： Jiangya Zhou Xiaojuan Yu Cong Ding Zhiping Wang qianqian Zhou hao Pao Weimin Ca School of Environmental Science and Engineering Shanghai Jiaotong University Dongchuan Road 800 Shanghai 200240 China.

Statistical experimental designs were used to optimize the process of phenol degradation by Candida tropicalis Z-04, isolated from phenol-degrading aerobic granules. The most important factors influencing phenol degradation （p 〈 0.05）, as identified by a two-level Plackett-Burman design with 11 variables, were yeast extract, phenol, inoculum size, and temperature. Steepest ascent method was undertaken to determine the optimal regions of these four significant factors. Central composite design （CCD） and response surface analysis were adopted to further investigate the mutual interactions between these variables and to identify their optimal values that would generate maximum phenol degradation. The analysis results indicated that interactions between yeast extract and temperature, phenol and temperature, inocuhim size and temperature affected the response variable （phenol degradation） significantly. The predicted results showed that the maximum removal efficiency of phenol （99.10%） could be obtained under the optimum conditions of yeast extract 0.41 g/L, phenol 1.03 g/L, inoculum size 1.43% （V/V） and temperature 30.04℃. These predicted values were further verified by validation experiments. The excellent correlation between predicted and experimental values confirmed the validity and practicability of this statistical optimum strategy. This study indicated the excellent ability of C. tropicalis Z-04 in degrading high-strength phenol. Optimal conditions obtained in this experiment laid a solid foundation for further use of this microorganism in the treatment of highstrength phenol effluents.

关键词： phenol degradation Candida tropicalis Z-04 optimization Plackett-Burman design response surface methodology

博物致知:博物馆形塑公众对世界的认知——“《北辰对话》国际博物馆日学术交流活动”侧记

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自然科学博物馆研究 2024年第3期9卷 79-85页

作者：李竞萌耿娴李敏廖红郝倩倩中国科学技术馆北京市100012 中国科学技术馆科普影视中心

2024年5月,《北辰对话》国际博物馆日学术活动在中国科技馆举行。活动聚焦博物馆在现代社会的教育作用和文化传承价值,探讨了其起源于学者研究及收藏家收藏的历史背景,并强调了博物馆在提升民族文明程度中的关键作用。随着公众科学文化... 详细信息

2024年5月,《北辰对话》国际博物馆日学术活动在中国科技馆举行。活动聚焦博物馆在现代社会的教育作用和文化传承价值,探讨了其起源于学者研究及收藏家收藏的历史背景,并强调了博物馆在提升民族文明程度中的关键作用。随着公众科学文化需求的增长,“博物馆热”现象凸显,智能时代下的博物馆需结合传统与现代,形成特色教育体系。未来,博物馆将继续促进科学文化交流,为公众提供多元化、高质量的文化产品。

关键词：博物馆教育博物馆研究博物学

Highly efficient dual-wavelength acousto-optically Q-switched Tm,La:CaF_(2)laser

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Chinese Optics Letters 2022年第11期20卷 38-42页

作者： qianqian hao Wenxin Liu Yuqian Zu Yangxiao Wang Jie Liu Liangbi Su Shandong Provincial Engineering and Technical Center of Light Manipulations and Shandong Provincial Key Laboratory of Optics and Photonic Device School of Physics and ElectronicsShandong Normal UniversityJinan 250358China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

A highly efficient milli-joule-level Q-switched Tm,La:CaF_(2)laser is experimentally *** employing an acousto-optic modulator,the diode-pumped pulsed lasers are stably operated at repetition rates ranging from 500 Hz to 10 ***-wavelength operation of 1881.7 nm and 1888.5 nm is achieved with slope efficiency of 64.7%.Up to 1.89 mJ of pulse energy is obtained at a pulse width of 100 ns,corresponding to a peak power of 18.88 *** results verified that the Tm,La:CaF_(2)crystal could be a promising candidate for achieving highly efficient and high-energy pulsed lasers.

关键词： 2μm thulium laser acousto-optical Q-switching Tm,La:CaF_(2)crystal dual-wavelength high energy high efficiency.

Recent progress in Prussian blue electrode for electrochromic devices

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Frontiers in Energy 2024年第2期18卷 160-186页

作者： Yongting ZHANG Wanzhong LI Hui GONG qianqian ZHANG Liang YAN hao WANG Key Laboratory for New Functional Materials of the Ministry of Education Faculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China School of Instrument Science and Engineering Southeast UniversityNanjing 210096China Beijing Aerospace Times Laser Inertial Technology Company Beijing 100094China

Great progress has been made in the electrochromic(EC)technology with potential applications in various *** one of the most promising EC materials,Prussian blue(PB)has attracted great attention due to its excellent EC performance,such as low cost,easy synthesis,rich color states,chemical stability,suitable redox potential,and fast color-switching *** review summarizes the recent progress in PB electrodes and devices,including several typical preparation techniques of PB electrodes,as well as the recent key strategies for enhancing EC performance of PB ***,PB-based electrochromic devices(ECDs)have been widely used in various fields,such as smart windows,electrochromic energy storage devices(EESDs),wearable electronics,smart displays,military camouflage,and other *** opportunities and obstacles are suggested for advancing the development of PB-based *** comprehensive review is expected to offer valuable insights for the design and fabrication of sophisticated PBbased ECDs,enabling their practical integration into realworld applications.

关键词： Prussian blue electrochromism energy storage smart windows

High single-pulse energy passively Q-switched laser based on Y b,Gd:SrF2 crystal

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Chinese Optics Letters 2020年第10期18卷 33-37页

作者： Mengfei Zhao Cong Wang qianqian hao Zhengting Zou Jie Liu Xiuwei Fan Liangbi Su Shandong Provincial Engineering and Technical Center of Light Manipulations&Shandong Provincial Key Laboratory of Optics and Photonic Device School of Physics and ElectronicsShandong Normal UniversityJinan 250358China CAS Key Laboratory of Transparent and Opto-functional Inorganic Materials Synthetic Single Crystal Research CenterShanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China State Ley Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China

We report on laser diode(LD) pumped passively Q-switched Yb,Gd:SrF2 lasers with high single-pulse energy for the first time, to the best of our knowledge. In addition, a stable Q-switched laser based on a Cr4+:Y3Al5O12 saturable absorber was demonstrated. The maximum output power of the Q-switched laser obtained was 495 m W, with a pulse width and a pulse repetition rate of 233 ns and 1.238 kHz, respectively. The corresponding single-pulse energy and the peak power were as high as 400 μJ and 1.714 k W. The laser was operated under a transverse electromagnetic mode, and the beam quality was near-diffraction-limited.

关键词： diode pumping solid-state lasers passive Q-switching

男性护理硕士研究生在读期间负性体验的质性研究

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中华现代护理杂志 2024年第8期30卷 1035-1040页

作者：王泽州王小一刘琰郝茜茜薛祉涵方奎董雪中国医科大学附属第一医院神经外科沈阳110001

目的了解男性护理硕士研究生在读期间的负性体验。方法本研究为质性研究。采用目的抽样法,于2023年3月选取11名中国医科大学和武汉大学在读的男性护理硕士研究生为研究对象对其进行半结构式访谈,并用KJ法分析资料。结果提炼出4个主题:... 详细信息

目的了解男性护理硕士研究生在读期间的负性体验。方法本研究为质性研究。采用目的抽样法,于2023年3月选取11名中国医科大学和武汉大学在读的男性护理硕士研究生为研究对象对其进行半结构式访谈,并用KJ法分析资料。结果提炼出4个主题:科研压力、时间与经济的压力、未来与发展的迷惘、对护理专业不认同。结论男性护理硕士研究生在读期间存在着负性情绪体验,护理教育者和管理者应重视男性护理硕士研究生的情绪管理,逐步完善护理研究生的培养方式。

关键词：学生护理男性护理硕士研究生负性体验质性研究

Targeting Haemaphysalis longicornis serpin to prevent tick feeding and pathogen transmission

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Insect Science 2024年第3期31卷 694-706页

作者： Tingting Feng hao Tong qianqian Zhang Zhihao Ming Zhenyu Song Xia Zhou Jianfeng Dai Institute of Biology and Medical Sciences Jiangsu Key Laboratory of Infection and ImmunitySoochow UniversitySuzhouJiangsu ProvinceChina School of Biology and Basic Medical Science Suzhou Medical College of Soochow UniversitySuzhouJiangsu ProvinceChina

Serine proteinase inhibitors(serpins),identified from the hard tick Haemaphysalis longicornis of China,play significant roles in various animal physiological *** this study,we showed that *** serpins(Hlserpin-a and Hlserpin-b)were induced during blood-feeding in nymph ticks and exhibited anticoagulation activity in *** Hlserpins through RNA interference(RNAi)significantly impaired tick *** of mice with recombinant Hlserpins or passive transfer of Hlserpin antiserum significantly curtails the efficacy of tick ***,the transmission of the Langat virus(LGTV)from ticks to mice witnessed a substantial decrease when Hlserpins were *** findings suggest that inhibiting Hlserpins can hamper tick engorgement and pathogen transmission,indicating the potential of Hlserpins as a vaccine to countertick-borne diseases.

关键词： feeding LGTV serpin TBEV tick

New perspective on the treatment of rheumatic arthritis based on“strengthening body resistance(FúZhèng)”in the theory of co-inhibitory receptor-regulated T-cell immunity

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Acupuncture and Herbal Medicine 2024年第3期4卷 290-294页

作者： Yifei Xu Linda Zhong qianqian Liang hao Xu Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Biomedical Sciences and Chinese Medicine School of Biological ScienceNanyang Technological UniversitySingaporeSingapore Spine Institute Shanghai University of Traditional Chinese MedicineShanghaiChina Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education(Shanghai University of Traditional Chinese Medicine)ShanghaiChina

Co-inhibitory receptors serve as crucial regulators of T-cell function,playing a pivotal role in modulating the delicate balance between immune tolerance and *** identified in autoimmune disease models,co-inhibitory receptors,including CTLA-4,PD-1,TIM-3,and TIGIT,were found to be integral to immune *** blockade or absence in these models resulted in the induction or exacerbation of autoimmune ***,scholars have observed that co-inhibitory receptors on lymphocytes hold the potential to influence the prognosis in the context of chronic ***,the blocking of co-suppressor receptors has emerged as a novel therapeutic approach for inhibiting refractory inflammatory diseases,particularly rheumatoid *** the standpoint of traditional Chinese medicine(TCM),the treatment of rheumatoid arthritis based on the“strengthening body resistance(FúZhèng)”theory can be construed as the regulation of co-suppressor receptors to modulate the body’s immune function in combating chronic *** article provides a succinct overview of the role of co-suppressor receptors in anti-inflammatory processes and explores the research prospects of co-suppressor receptor intervention in the treatment of rheumatoid *** exploration integrates the“strengthening body resistance(FúZhèng)”theory with relevant Chinese medicine formulations.

关键词： Combination of Chinese and Western Medicine Co-inhibitory receptors Rheumatic arthritis T-cell exhaustion