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Evaluation of Cell Type Annotation R Packages on Single-cell RNA-seq

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Genomics, Proteomics & Bioinformatics 2021年第2期19卷 267-281页

作者： qianhui huang Yu Liu Yuheng Du Lana X.Garmire Department of Biostatistics University of MichiganAnn ArborMI 48109USA Department of Computational Medicine and Bioinformatics University of MichiganAnn ArborMI 48105USA

Annotating cell types is a critical step in single-cell RNA sequencing(scRNA-seq)data *** supervised or semi-supervised classification methods have recently emerged to enable automated cell type ***,comprehensive evaluations of these methods are ***,it is not clear whether some classification methods originally designed for analyzing other bulk omics data are adaptable to scRNA-seq *** this study,we evaluated ten cell type annotation methods publicly available as R *** of them are popular methods developed specifically for single-cell research,including Seurat,scmap,SingleR,CHETAH,SingleCellNet,scID,Garnett,and *** other two methods were repurposed from deconvoluting DNA methylation data,i.e.,linear constrained projection(CP)and robust partial correlations(RPC).We conducted systematic comparisons on a wide variety of public scRNA-seq datasets as well as simulation *** assessed the accuracy through intra-dataset and inter-dataset predictions;the robustness over practical challenges such as gene filtering,high similarity among cell types,and increased cell type classes;as well as the detection of rare and unknown cell ***,methods such as Seurat,SingleR,CP,RPC,and SingleCellNet performed well,with Seurat being the best at annotating major cell ***,Seurat,SingleR,CP,and RPC were more robust against ***,Seurat did have a major drawback at predicting rare cell populations,and it was suboptimal at differentiating cell types highly similar to each other,compared to SingleR and *** the code and data are available from https://***/qianhuiSenn/scRNA_cell_deconv_benchmark.

关键词： scRNA-seq Cell type Annotation Classification Benchmark

GranatumX:A Community-engaging, Modularized, and Flexible Webtool for Single-cell Data Analysis

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Genomics, Proteomics & Bioinformatics 2021年第3期19卷 452-460页

作者： David G.Garmire Xun Zhu Aravind Mantravadi qianhui huang Breck Yunits Yu Liu Thomas Wolfgruber Olivier Poirion Tianying Zhao Cédric Arisdakessian Stefan Stanojevic Lana X.Garmire Department of Electrical Engineering&Computer Science University of MichiganAnn ArborMI 48109USA Epidemiology Program University of Hawaii Cancer CenterHonoluluHI 96813USA Department of Biostatistics University of MichiganAnn ArborMI 48109USA Department of Computational Medicine and Bioinformatics University of MichiganAnn ArborMI 48105USA Molecular Biosciences and Bioengineering Graduate Program University of Hawaii at ManoaHonoluluHI 96822USA

We present GranatumX,a next-generation software environment for single-cell RNA sequencing(scRNA-seq)data *** is inspired by the interactive webtool *** enables biologists to access the latest scRNA-seq bioinformatics methods in a web-based graphical *** also offers software developers the opportunity to rapidly promote their own tools with others in customizable *** architecture of GranatumX allows for easy inclusion of plugin modules,named Gboxes,which wrap around bioinformatics tools written in various programming languages and on various *** can be run on the cloud or private servers and generate reproducible *** is a community-engaging,flexible,and evolving software ecosystem for scRNA-seq analysis,connecting developers with bench *** is freely accessible at http://***/granatumx/app.

关键词： Single-cell RNA sequencing Analysis Pipeline Webtool Module

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锂离子电池快充石墨负极研究与应用

物理化学学报 2022年第11期38卷 89-104页

作者：丁晓博黄倩晖熊训辉华南理工大学环境与能源学院广州510006

相较于传统燃油汽车,电动汽车缓慢的充电速度始终制约了其进一步推广。为电动汽车实现“加油式”快速充电能够缓解充电桩的使用压力,增加电动汽车的应用场景和市场占有率。因此,亟需开发出具有快速充放电能力的高性能锂离子电池。石墨... 详细信息

相较于传统燃油汽车,电动汽车缓慢的充电速度始终制约了其进一步推广。为电动汽车实现“加油式”快速充电能够缓解充电桩的使用压力,增加电动汽车的应用场景和市场占有率。因此,亟需开发出具有快速充放电能力的高性能锂离子电池。石墨因其低廉的价格和优异的电化学性能已经在锂离子电池负极领域得到了广泛的商业化应用,然而其较低的嵌锂电位导致在快充过程中出现析锂,损害电化学性能的同时会带来安全隐患。因此,必须对石墨进行改良处理,以适应快充技术的需要。本文系统介绍了近年来石墨负极快充化改良领域的研究进展,从成分设计,形貌调控,结构优化,电解液适配等方面进行了评述,并总结了快充石墨面临的挑战,展望了其发展前景,为推动快充技术的商业化应用提供了借鉴。

关键词：石墨负极快充锂离子电池

An online physical simulation method for enhanced oil recovery by air injection in shale oil

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Petroleum Exploration and Development 2023年第4期50卷 909-923页

作者： DU Meng LYU Weifeng YANG Zhengming JIA Ninghong ZHANG Jigang NIU Zhongkun LI Wen CHEN Xinliang YAO Lanlan CHANG Yilin JIANG Sirui huang qianhui University of Chinese Academy of Sciences Beijing 100049China Institute of Porous Flow&Fluid Mechanics Chinese Academy of SciencesLangfang 065007China Research Institute of Petroleum Exploration&Development PetroChinaBeijing 100083China State Key Laboratory of Enhanced Oil Recovery Beijing 100083China

In order to understand the mechanism of air flooding shale oil, an online physical simulation method for enhanced shale oil recovery by air injection was established by integrating CT scanning and nuclear magnetic resonance(NMR). The development effect of shale oil by air flooding under different depletion pressures, the micro-production characteristics of pore throats with different sizes and the mechanism of shale oil recovery by air flooding were analyzed. The effects of air oxygen content, permeability, gas injection pressure, and fractures on the air flooding effect in shale and crude oil production in pores with different sizes were analyzed. The recovery of shale oil can be greatly improved by injecting air into the depleted shale reservoir, but the oil displacement efficiency and the production degree of different levels of pore throats vary with the injection timing. The higher the air oxygen content and the stronger the low-temperature oxidation, the higher the production degree of pores with different sizes and the higher the shale oil recovery. The higher the permeability and the better the pore throat connectivity, the stronger the fluid flow capacity and the higher the shale oil recovery. As the injection pressure increases, the lower limit of the production degree of pore throats decreases, but gas channeling may occur to cause a premature breakthrough;as a result, the recovery increases and then decreases. Fractures can effectively increase the contact area between gas and crude oil, and increase the air sweep coefficient and matrix oil drainage area by supplying oil to fractures through the matrix, which means that a proper fracturing before air injection can help to improve the oil displacement effect under a reasonable production pressure difference.

关键词： shale oil air flooding CT scanning nuclear magnetic resonance EOR physics simulation

助力构建有温度的城市——上海无障碍设施建设的思考

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上海城市发展 2021年第4期42卷 42-45页

作者：黄千惠方芒(上海)商务服务有限公司

在漫长人生中,每一位市民均有使用无障碍设施的可能,再加之无障碍设施建设具有促进就业、消费的作用。因而,无障碍理应成为整个城市的共同追求和全民参与的社会实践。2021年3月12 H,《上海市无障碍环境建设与管理刃、法》公布,2021年6月... 详细信息

在漫长人生中,每一位市民均有使用无障碍设施的可能,再加之无障碍设施建设具有促进就业、消费的作用。因而,无障碍理应成为整个城市的共同追求和全民参与的社会实践。2021年3月12 H,《上海市无障碍环境建设与管理刃、法》公布,2021年6月1日起施行,明确了政府部门在无障碍建设方面的职责;鼓励企事业单位、社会组织及个人支持无障碍设施建设,研发、推广和应用无障碍通用设计技术、产品;邀请残疾人、老年人等参与无障碍设施试用体验。该法令的公布强调了这场重要、紧迫而有序的社会实践的全民性,其下应当有真正落地的人本精神作为根基。

关键词：无障碍环境建设无障碍设施通用设计全民参与企事业单位人本精神全民性无障碍建设

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粮食平房仓电气设计探讨

建筑电气 2011年第5期30卷 57-60页

作者：黄倩卉黄瑞虎广西大学设计研究院南宁市530004

通过工程实例,结合GB50320-2001《粮食平房仓设计规范》的相关规定,对粮食平房仓的主要电气设计特性进行探讨。

关键词：粮食平房仓机械通风熏蒸粮温测控系统

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木粉热处理对木塑复合材料性能的影响

森林与环境学报 2016年第4期36卷 488-493页

作者：邓邵平林姿黄前辉王春灿福建农林大学材料工程学院福建福州350002

为研究热处理木粉对木塑复合材料吸水性能和力学性能的影响,分别将180、200和220℃热处理0、1、2和3 h后的杉木木粉与高密度聚乙烯(HDPE)复合制备木塑复合材料(WPC),并对其吸水性能和力学性能进行测定,通过环境扫描电镜(ESEM)观察材料... 详细信息

为研究热处理木粉对木塑复合材料吸水性能和力学性能的影响,分别将180、200和220℃热处理0、1、2和3 h后的杉木木粉与高密度聚乙烯(HDPE)复合制备木塑复合材料(WPC),并对其吸水性能和力学性能进行测定,通过环境扫描电镜(ESEM)观察材料拉伸断面的形貌。结果表明,随着处理温度的升高和时间的延长,木粉的吸湿性减小,WPC的吸水性明显降低,而WPC的力学性能除冲击强度逐渐降低外,拉伸强度、弯曲强度和弯曲模量总体呈先增大后降低的趋势。与对照相比,180℃热处理1-3 h的木粉基本上使WPC的弯曲性能和拉伸强度有不同程度的增加,200℃热处理木粉,随时间延长,WPC除弯曲性能仍增加外,拉伸强度和冲击强度逐渐降低,进一步提高木粉的处理温度会使WPC的力学性能降低明显,220℃处理3 h的木粉使WPC降低最多,分别较对照降低34.85%、12.85%、8.31%和4.24%,WPC拉伸断面的ESEM图中两相界面结合情况的变化基本反映了各力学性能的变化。

关键词：热处理木粉木塑复合材料吸水性能力学性能

木粉热处理对WPC耐腐性能及力学性能的影响

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森林与环境学报 2017年第3期37卷 266-271页

作者：邓邵平林姿黄前辉王春灿福建农林大学材料工程学院福建福州350002

采用180、200和220℃分别热处理0、1、2和3 h后的马尾松木粉与高密度聚乙烯(HDPE)复合制备木塑复合材料(WPC),并研究热处理木粉对复合材料的耐白腐、褐腐能力及其弯曲性能的影响,通过环境扫描电镜(ESEM)观察分析WPC试样腐朽前后的表面... 详细信息

采用180、200和220℃分别热处理0、1、2和3 h后的马尾松木粉与高密度聚乙烯(HDPE)复合制备木塑复合材料(WPC),并研究热处理木粉对复合材料的耐白腐、褐腐能力及其弯曲性能的影响,通过环境扫描电镜(ESEM)观察分析WPC试样腐朽前后的表面微观形貌。结果表明,处理温度和时间对质量损失率的影响均显著,菌种的影响不显著;木粉热处理后WPC的质量损失率均有不同程度的降低,且随处理温度的升高、时间的延长,降低幅度明显增大,200℃、3 h处理后的木粉使WPC的质量损失率降低最多,经白腐菌和褐腐菌侵蚀后,分别较对照降低了53.52%和57.83%。腐朽前后WPC试样表面菌丝侵蚀情况的ESEM观察结果也进一步说明木粉热处理具有提高WPC耐腐性能的作用。而木粉热处理使WPC的弯曲强度均有所降低,与对照相比最多降低了4.57%,但弯曲模量总体呈先增后减的趋势,温度和时间对WPC弯曲强度和弯曲模量的影响均不显著。

关键词：热处理木粉木塑复合材料耐腐性能质量损失率弯曲强度弯曲模量

义马市张家南坡南侧废弃矿渣堆环境治理恢复研究

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中国资源综合利用 2021年第11期39卷 148-150页

作者：黄迁辉赵彦新河南省地质矿产勘查开发局第一地质环境调查院郑州450000

义马市张家南坡南侧废弃矿渣堆长期无序堆放,负面影响较大,当前急需治理。废弃矿渣不合理堆放造成陡边坡、滑坡、地裂缝和泥石流等灾害发生,严重威胁附近居民和过往车辆、行人的生命财产安全。本文提出"消坡减载+边坡治理+挂网喷播复绿... 详细信息

义马市张家南坡南侧废弃矿渣堆长期无序堆放,负面影响较大,当前急需治理。废弃矿渣不合理堆放造成陡边坡、滑坡、地裂缝和泥石流等灾害发生,严重威胁附近居民和过往车辆、行人的生命财产安全。本文提出"消坡减载+边坡治理+挂网喷播复绿+矿渣清理+绿化工程"的综合治理方案。实践表明,该方案适用于该废弃尾矿渣堆的环境治理,在实际治理过程中取得良好的应用效果,同时为同类矿山环境治理提供参考。

关键词：尾矿渣矿山地质环境地质灾害陡边坡