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不同预警模型下的露天矿滑坡时间预测研究

露天采矿技术 2024年第4期39卷 5-10页

作者：李千慧中煤科工集团沈阳研究院有限公司辽宁抚顺113122 煤矿安全技术国家重点实验室辽宁抚顺113122

露天矿山边坡受重力作用影响,其内部应力平衡破坏,受外界因素如降雨、地震和人工采动活动等因素的诱发,从而发生滑坡、片帮和崩塌等形式的地质灾害;由于其突发性、灾害性和难预测性严重制约了人民的生命和财产安全。以蠕动变形三阶段理... 详细信息

露天矿山边坡受重力作用影响,其内部应力平衡破坏,受外界因素如降雨、地震和人工采动活动等因素的诱发,从而发生滑坡、片帮和崩塌等形式的地质灾害;由于其突发性、灾害性和难预测性严重制约了人民的生命和财产安全。以蠕动变形三阶段理论为基础的速度倒数模型(INV模型)、斜率模型(SLO模型)和对数预测模型(Lgt)因其简单、便捷和易操作性而在滑坡时间预测中被广泛应用。分析了3种预测模型的基本原理,分析了蠕变曲线加速阶段加速变形点(onset of acceleration,OOA)的获取方法,结合3个滑坡案例研究了不同预测模型在滑坡时间预测方面的应用情况。结果表明:3种预测模型均能有效的预测滑坡发生时间,且在曲线拟合相关决定系数和预测时间准确性方面,斜率模型和对数函数模型效果更佳。

关键词：预警模型滑坡灾害监测预警时间预测加速变形点

乙醛脱氢酶2基因多态性与对乙酰氨基酚所致肝损伤关系的研究

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中华肝脏病杂志 2024年第2期32卷 133-139页

作者：陈凤黎倩卉吴英杰吕丽媛徐晓敏王菲中山大学附属第七医院消化医学中心深圳518107

目的探讨乙醛脱氢酶2(ALDH2)基因多态性与对乙酰氨基酚(APAP)药物所致肝功能异常的相关性。方法采用CRISPR/Cas9基因编辑技术构建ALDH2基因敲除小鼠模型,将获得的杂合子型小鼠与异性杂合子交配,提取子代小鼠鼠尾基因组DNA,采用聚合酶链... 详细信息

目的探讨乙醛脱氢酶2(ALDH2)基因多态性与对乙酰氨基酚(APAP)药物所致肝功能异常的相关性。方法采用CRISPR/Cas9基因编辑技术构建ALDH2基因敲除小鼠模型,将获得的杂合子型小鼠与异性杂合子交配,提取子代小鼠鼠尾基因组DNA,采用聚合酶链反应(PCR)方法进行ALDH2基因型鉴定;进一步采用APAP在野生型和ALDH2基因敲除小鼠中诱导急性药物性肝损伤模型,采集小鼠血液和肝脏组织行肝功能指标检测及苏木素-伊红染色、F4/80免疫组织化学检测等。组间均数比较采用单因素方差分析、LSD-t检验方法进行两两比较。结果ALDH2基因敲除小鼠成功繁殖,子代小鼠基因型分别为野生型(ALDH2^(+/+))、杂合突变型(ALDH2^(+/-))、纯合突变型(ALDH2^(-/-))。APAP造模后的生化和组织学实验结果表明:空白对照组的丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、总胆红素(TBil)水平无明显升高;与空白对照组相比,APAP实验组的ALT、AST、ALP和TBil水平均显著升高(P值均<0.05),其中突变组的ALT(P=0.004)、AST(P=0.002)、TBil(P=0.012)水平显著高于野生型组,且这些指标在纯合突变型的表达水平也显著高于杂合突变型(P值分别为0.003、0、0.006)。另外,杂合突变组小鼠的ALP水平高于纯合突变组(P=0.085)和野生型组小鼠,但只与野生型小鼠的比较差异具有统计学意义(P=0.002)。HE染色结果显示APAP实验组小鼠出现肝细胞变性、坏死,炎性细胞浸润增多,以突变型小鼠最明显;同时,F4/80免疫组织化学染色结果显示APAP实验组小鼠肝组织内可见棕褐色颗粒,其表达水平较空白对照组明显增高。结论APAP所致肝功能异常与ALDH2基因多态性相关,ALDH2突变型小鼠在APAP造模后的肝损伤症状有所加重,ALDH2基因缺陷可能在一定程度上加重APAP诱导的肝生物化学指标异常。

关键词：肝损伤基因多态性乙醛脱氢酶2 对乙酰氨基酚

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针灸治疗抑郁症相关机制及临床研究

中医药临床杂志 2024年第5期36卷 833-838页

作者：李前辉李燎原刘磊吴子建胡玲河南省驻马店市中心医院河南驻马店463000 安徽省中医药科学院针灸经络研究所安徽合肥230000

近年来,随着社会经济高速发展所导致生活压力逐渐加大,抑郁症患者数量逐年攀升。针灸作为中医特色疗法,对于防治抑郁症起到重要作用。因此开展了大量关于针灸防治抑郁症的相关研究。作者通过对近年针刺治疗抑郁症相关文献进行检索整理,... 详细信息

近年来,随着社会经济高速发展所导致生活压力逐渐加大,抑郁症患者数量逐年攀升。针灸作为中医特色疗法,对于防治抑郁症起到重要作用。因此开展了大量关于针灸防治抑郁症的相关研究。作者通过对近年针刺治疗抑郁症相关文献进行检索整理,从中医对于抑郁症自古以来的重要认识、针灸改善抑郁样行为的临床研究及针灸治疗抑郁症的机制等方面进行评述,并总结当前针对针灸治疗抑郁症开展的一系列研究不足之处,便于之后完善改进,更加科学严谨深入研究针灸对其治疗作用,有助于针灸疗法发挥独特优势。

关键词：针灸抑郁症作用机制临床疗效文献综述

Clinical characteristics and risk factors of hepatitis B virus-related cirrhosis/hepatocellular carcinoma:A single-center retrospective study

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liver Research 2023年第3期7卷 237-243页

作者： Feng Chen qianhui li Xiaomin Xu Fei Wang Division of Gastroenterology The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenGuangdongChina National Clinical Research Center for Infectious Diseases The Third People's Hospital of ShenzhenShenzhenGuangdongChina

Background and aims:Hepatitis B virus(HBV)infection is a major global health problem which progresses to liver cirrhosis(LC)and hepatocellular carcinoma(HCC).Early prediction of disease changes and intervention are essential to slow disease progression and protect liver *** study aimed to analyze the clinical characteristics of patients with HBV-related LC and HCC at different serum alanine aminotransferase(ALT)levels and explore the risk factors of HBV infection progressing to LC/***:A total of 379 patients with HBV infection treated in The Third People's Hospital of Shenzhen between January 2014 and December 2016 without any antiviral drug therapy were *** were divided into the LC/HCC and non-LC/HCC groups based on clinical diagnosis,which was determined through imaging and expressions of pathological and laboratory test markers,and patients with LC/HCC were further divided into three groups according to the serum ALT *** in general information,clinical symptoms,and expression levels of serological indices of the above groups were compared and analyzed,logistic regression was used to analyze the risk factors for LC/HCC development,and the clinical diagnostic efficacy of indicators was judged by the receiver operator characteristic(ROC).Results:LC/HCC mainly occurred in the ALT normal and mildly elevated groups,with 70.83% of patients with HCC having an LC *** the comparison of different ALT level groups,the moderately eseverely elevated group had the highest proportion of patients with skin jaundice,abdominal varices,rebound tenderness,higher white blood cell and neutrophil(NEUT)counts;and higher levels of aspartate aminotransferase,glutamyl transpeptidase,total bilirubin,and direct *** LC/HCC group was older and had significantly higher proportions of male patients,alcohol consumption,and combined hypertension than the non-LC/HCC group(all P<0.05).Logistic regression analysis showed that age,combi

关键词： Alanine aminotransferase(ALT) Hepatitis B virus(HBV) liver cirrhosis(LC) Hepatocellular carcinoma(HCC) Risk factors

黄河流域民间宗祠保护与文化传承机制的探讨及实证

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华中建筑 2024年第4期42卷 162-166页

作者：陈彦祺王葆华李千卉樊欣西安建筑科技大学建筑学院西安交通大学人文学院西安建筑科技大学艺术学院西安市城市规划设计研究院

宗祠文化在中华优秀传统文化中呈现出最独特、鲜明的表征形式。鉴于宗祠建筑损毁及文化价值流失、传承意识淡薄、系统保护措施匮乏等“文化失忆”问题。选取黄河流域民间宗祠为研究对象,以探索民间宗祠文化的传承机制为研究主线,溯源民... 详细信息

宗祠文化在中华优秀传统文化中呈现出最独特、鲜明的表征形式。鉴于宗祠建筑损毁及文化价值流失、传承意识淡薄、系统保护措施匮乏等“文化失忆”问题。选取黄河流域民间宗祠为研究对象,以探索民间宗祠文化的传承机制为研究主线,溯源民间宗祠文化传承与乡村振兴、文化自信的内在联系。基于SPSS分析,采用田野调查法、因子分析法、比较归纳法等定量与定性结合的方法相耦合,厘清黄河流域民间宗祠的现实困境及宗祠文化传承的影响因素。总结出抢救式保护宗祠建筑本体、活态化转译宗祠文化基因、多维度赋能乡村建设的在地性保护传承模式,以期更好地助推文化遗产的保护传承事业与乡村振兴建设的蓬勃发展。

关键词：文化失忆黄河流域民间宗祠文化传承机制记忆重构

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铁基氟化物作为离子电池正极材料的研究进展

河南化工 2024年第5期41卷 30-33,43页

作者：郑丹丹郑燕慧李倩慧薛峰峰多氟多新材料股份有限公司河南焦作454006

随着能源的枯竭,新能源汽车的不断崛起,高性能电极材料的开发成为重中之重。脱/嵌型材料由于结构的影响导致锂离子的饱和嵌入受限,已不能满足日益增长的能量密度要求,而化学转换型材料的兴起能够突破这种反应机制。介绍了铁基氟化物电... 详细信息

随着能源的枯竭,新能源汽车的不断崛起,高性能电极材料的开发成为重中之重。脱/嵌型材料由于结构的影响导致锂离子的饱和嵌入受限,已不能满足日益增长的能量密度要求,而化学转换型材料的兴起能够突破这种反应机制。介绍了铁基氟化物电极材料的发展背景、反应原理及其研究进展。

关键词：铁基氟化物可逆化学转换反应纳米结构离子电池

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硫酸乙烯酯(DTD)稳定性影响因素分析

河南化工 2024年第6期41卷 12-14页

作者：张双杰李倩慧李鹏王晓兵王艳君多氟多新材料股份有限公司河南焦作454006

模拟投料环境,探索温度、时间、氧化剂NaClO、弱碱NaHCO_(3)、弱酸NaHSO_(3)对DTD分解情况的影响。结果表明:温度低于15℃时DTD分解缓慢,高于15℃时DTD分解迅速,且随时间的延长分解加剧。氧化剂NaClO会造成产物的迅速分解,4 h DTD分解剩... 详细信息

模拟投料环境,探索温度、时间、氧化剂NaClO、弱碱NaHCO_(3)、弱酸NaHSO_(3)对DTD分解情况的影响。结果表明:温度低于15℃时DTD分解缓慢,高于15℃时DTD分解迅速,且随时间的延长分解加剧。氧化剂NaClO会造成产物的迅速分解,4 h DTD分解剩余24.53%。NaHCO_(3)、NaHSO_(3)的加入对DTD的分解影响较小。为避免长时间对收率的影响,合成结束后需迅速进行后处理,对后期工业化生产具有重要的指导意义。

关键词： DTD 温度时间氧化剂弱碱弱酸

COATS:Comprehensive observation on the atmospheric boundary layer three-dimensional structure during haze pollution in the North China Plain

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Science China Earth Sciences 2023年第5期66卷 939-958页

作者： qianhui li Hongsheng ZHANG Xiaoye ZHANG Xuhui CAI Xipeng JIN Lu ZHANG Yu SONG ling KANG Fei HU Tong ZHU Tianjin Key Laboratory for Oceanic Meteorology Tianjin Meteorological Service CenterTianjin Meteorological BureauTianjin 300074China Laboratory for Climate and Ocean-Atmosphere Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China State Key Laboratory of Severe Weather and Key Laboratory of Atmospheric Chemistry of CMA Chinese Academy of Meteorological SciencesChina Meteorological Administration(CMA)Beijing 100081China State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

The North China Plain(NCP)is troubled by severe haze pollution and the evolution of haze pollution is closely related to the atmospheric boundary layer(ABL).However,experimental and theoretical studies on the physical-chemical processes of the ABL in the NCP are lacking,with many scientific problems to be *** solve these problems,the Comprehensive Observation on the Atmospheric boundary layer Three-dimensional Structure(COATS)during haze pollution was carried out in the NCP from 2016 to *** COATS experiment adopted a"point-line-surface"spatial layout,obtaining both spatial-temporal profiles of the meteorological and environmental elements in the ABL and the turbulent transport data of fine particulate matter(PM_(2.5))in winter and *** research achievements are as *** spatial-temporal distribution characteristics of the ABL structure and PM_(2.5)concentrations in NCP were *** typical thermal structure of persistent heavy haze events and the pollutant removal mechanism by low-level jets were *** was determined that the spatial structure of the ABL adjusted by the Taihang Mountains is responsible for the heterogeneous distribution of haze pollution in the NCP,and that mountain-induced vertical circulations can promote the formation of elevated pollution *** restraints of the atmospheric internal boundaries on horizontal diffusion of pollutants were *** contribution of the ABL to haze pollution in winter and summer was qualitatively compared and quantitatively *** turbulent transport nature behind the relationship between the atmospheric boundary layer height(ABLH)and surface PM_(2.5)concentrations was *** concept of"aerosol accumulation layer"was defined,and the applicability of the material method in determining ABLH was clarified.A measurement system for obtaining the turbulent flux of PM_(2.5)concentrations was developed,and the turbulence characteristics of PM_(2.5)concentrations w

关键词： COATS experiment Haze pollution ABL three-dimensional structure Aerosol accumulation layer Turbulent flux of PM_(2.5)concentrations North China Plain

Lactobacillus melliventris promotes hive productivity and immune functionality in Bombus terrestris performance in the greenhouse

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Insect Science 2024年第3期31卷 911-926页

作者： qianhui Yu Yan liu Shanshan liu Shaogang li Yifan Zhai Qingchao Zhang li Zheng Hao Zheng Yifan Zhai Xiaofei Wang Insttute of Plant Protection Shandong Academy of Agricultural SciencesJinanChina Key Laboratory of Natural Enemies Insects Ministry of Agriculture and Rural AffairsJinanChina College of Food Science and Nutritional Engineering China Agricultural UniversityBeijingChina BGI-Qingdao BGI-ShenzhenQingdaoShandongChina

Bumblebees are important pollinators in agricultural ecosystems,but their abundance is declining *** is an urgent need to protect bumblebee health and their pollination *** possess specialized gut microbiota with potential to be used as probiotics to help defend at-risk bumblebee ***,evidence for probiotic benefits on bumblebees is ***,we evaluated how supplementation with Lactobacillus melliventris isolated from bumblebee gut affected the colony development of Bombus *** native strain colonized robustly and persisted long-term in bumblebees,leading to a significantly higher quality of ***,the tyrosine pathway was upregulated in the brain and fat body,while the Wnt and mTOR pathways of the gut were ***,the field experiment in the greenhouse revealed the supplementation of *** led to a 2.5-fold increase in the bumblebee survival rate and a more than 10%increase in the number of flowers visited,indicating a better health condition and pollination ability in field *** study represents a first screening for the potential use of the native gut member,***,as probiotic strains in hive supplement for bumblebee breeding,which may be a practical approach to improve immunity and hive health.

关键词： Bombus terrestris gut microbiota immunity Lactobacillus melliventris transcriptome