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Hemispheric asymmetries and network dysfunctions in adolescent depression:A neuroimaging study using resting-state functional magnetic resonance imaging

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World Journal of Psychiatry 2025年第2期15卷 100-108页

作者： Ying Xiong Ren-qiang yu Xing-yu Wang Shun-Si Liang Jie Ran Xiao Li Yi-Zhi Xu Department of Hematology Chongqing General HospitalChongqing UniversityChongqing 401147China Department of Radiology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Currently,adolescent depression is one of the most significant public health concerns,markedly influencing emotional,cognitive,and social *** advancements in distinguish the neurobiological substrates underlying depression,the intricate patterns of disrupted brain network connectivity in adolescents warrant further *** To elucidate the neural correlates of adolescent depression by examining brain network connectivity using resting-state functional magnetic resonance imaging(rs-fMRI).METHODS The study cohort comprised 74 depressed adolescents and 59 healthy controls aged 12 to 17 *** underwent rs-fMRI to evaluate functional connectivity within and across critical brain networks,including the visual,default mode network(DMN),dorsal attention,salience,somatomotor,and frontoparietal control *** Analyses revealed pronounced functional disparities within key neural circuits among adolescents with *** results demonstrated existence of hemispheric asymmetries characterized by enhanced activity in the left visual network,which contrasted the diminished activity in the right *** DMN facilitated increased activity within the left prefrontal cortex and reduced engagement in the right hemisphere,implicating disrupted self-referential and emotional processing ***,an overactive right dorsal attention network and a hypoactive salience network were identified,underscoring significant abnormalities in attentional and emotional regulation in adolescent *** The findings from this study underscore distinct neural connectivity disruptions in adolescent depression,underscoring the critical role of specific neurobiological markers for precise early diagnosis of adolescent *** observed functional asymmetries and network-specific deviations elucidate the complex neurobiological architecture of adolescent depression,supporting the development of targeted the

关键词： Adolescent depression Brain network connectivity Neuroimaging biomarkers Functional magnetic resonance imaging Default mode network Salience network Hemispheric asymmetry

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Mechanism study of the molluscicide candidate PBQ on Pomacea canaliculata using a viscosity-sensitive fluorescent probe

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Chinese Chemical Letters 2025年第1期36卷 447-452页

作者： Lanyun Zhang Weisi Wang yu-qiang Zhao Rui Huang yuxun Lu Ying Chen Liping Duan Ying Zhou yunnan Characteristic Plant Extraction Laboratory College of Chemical Science and TechnologyYunnan UniversityKunming 650091China National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Centre for Tropical DiseasesNational Key Laboratory of Inteligent Tracking and Forecasting for Infectious DiseasesKey Laboratory on Parasite and Vector Biology MinistryofHealthShanghai200025China

PBQ[1-(4-chlorophenyl)-3-(pyridin-3-yl)urea],an enormous potent molluscicide,showed excellent Pomacea canaliculata(***)control activity and low toxicity for other aquatic organisms,but its snail-killing mechanisms are still not fully *** employed an optical method to elucidate PBQ action via a novel fluorescent viscosity probe,*** the viscosity in the test solutions increased,compared with that in pure ethanol,a 54-fold fluorescence intensity enhancement of NCV was observed in 310 cP of 90%***,NCV successfully exhibited a selective fluorescence response towards monensin-induced cellular viscosity changes in HepG2 *** liver,stomach,and foot plantar of the tested snails were frozen and sectioned for fluorescent imaging experiments after the treatment with different PBQ concentrations over various times.A significant fluorescent increase in the snail's liver was observed upon exposure to 0.75 mg/L PBQ for 72 h,which highlighted an increase in *** and eosin(HE)staining further supported PBQ-induced liver damage with a viscosity increase in *** study provides a new rapid optical visualization method to study the killing mechanisms of PBQ and may help discover new chemicals that control snail populations.

关键词： Fluorescence sensor Viscosity Pomacea canaliculata Molluscicide mechanisms Bio-imaging

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Microstructural evolution during tempering process and mechanical properties of Cr-Ni-Mo-V/Nb high strength steel

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Journal of Iron and Steel Research International 2025年第1期32卷 270-281页

作者： Zi-wei Lv Jing Fan Rui Wang Zhi-qiang yu Yan Kang Yong Hu Lei-feng Tuo Jürgen Eckert Zhi-jie Yan School of Materials Science and Engineering North University of ChinaTaiyuan 030051ShanxiChina Shanxi Key Laboratory of Advanced Metal Materials for Special Environments North University of ChinaTaiyuan 030051ShanxiChina School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024ShanxiChina Erich Schmid Institute of Materials Science Austrian Academy of SciencesLeoben 8700Austria Department of Materials Science Chair of Materials PhysicsMontanuniversitat LeobenLeoben 8700Austria

High strength steels exhibit superior mechanical properties due to the unique microstructure,which successfully solves the drawback of the inevitable strength-toughness trade-off that occurs in traditional *** we investigated the effect of matrix and precipitates on mechanical properties of Cr-Ni-Mo-V/Nb steel after water quenching and tempering(150-500℃).The results showed that the microstructure of the present steel is noticeably tuned by changing the tempering *** excellent combination of strength(a yield strength of 1308 MPa with a total elongation of 8.2%)and toughness(Charpy V-notch impact toughness of 40.5 J/cm^(2))is obtained upon tempering at 200℃.This is attributed to the lath martensite containing high dislocation density,the martensite-twin substructure,and the strengthening effects of the precipitated needle-likeε-carbides and spherical VC *** acicularε-carbides are replaced by the rod-shaped Fe_(3)C at the tempering temperature of 350℃,resulting in the remarkable deterioration in strength,hardness,and *** carbides formed at a tempering temperature of 500℃ are beneficial to the enhancement of the elongation and toughness,but the strength decreases due to the matrix softening caused by the recovery of dislocation.

关键词： High strength steel Tempering Microstructure Carbide Mechanical property

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Improving performance of screening MM/PBSA in protein–ligand interactions via machine learning

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Chinese Physics B 2025年第1期34卷 486-496页

作者： yuan-qiang Chen Yao Xu yu-qiang Ma Hong-Ming Ding Center for Soft Condensed Matter Physics and Interdisciplinary Research School of Physical Science and TechnologySoochow UniversitySuzhou 215006China National Laboratory of Solid State Microstructures and Department of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Accurately estimating protein–ligand binding free energy is crucial for drug design and biophysics, yet remains a challenging task. In this study, we applied the screening molecular mechanics/Poisson–Boltzmann surface area(MM/PBSA)method in combination with various machine learning techniques to compute the binding free energies of protein–ligand interactions. Our results demonstrate that machine learning outperforms direct screening MM/PBSA calculations in predicting protein–ligand binding free energies. Notably, the random forest(RF) method exhibited the best predictive performance,with a Pearson correlation coefficient(rp) of 0.702 and a mean absolute error(MAE) of 1.379 kcal/mol. Furthermore, we analyzed feature importance rankings in the gradient boosting(GB), adaptive boosting(Ada Boost), and RF methods, and found that feature selection significantly impacted predictive performance. In particular, molecular weight(MW) and van der Waals(VDW) energies played a decisive role in the prediction. Overall, this study highlights the potential of combining machine learning methods with screening MM/PBSA for accurately predicting binding free energies in biosystems.

关键词： molecular mechanics/Poisson-Boltzmann surface area(MM/PBSA) binding free energy machine learning protein-ligand interaction

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Stretchable All-Small-Molecule Organic Solar Cells Enabled by Polymer Elastomer Confinement

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CHINESE JOURNAL OF POLYMER SCIENCE 2025年第2期43卷 271-277页

作者： Zhang, Chen-Yi Liu, yu-qiang Li, Hong-Xiang Cui, Xin-yue Wei, Zheng-Dong Liu, yue-Heng Li, Ming-Hua Zhang, An-Dong Cheng, Pei Bo, Zhi-Shan Qingdao Univ Coll Text & Clothing State Key Lab Biofibers & Ecotext Qingdao 266071 Peoples R China Sichuan Univ Coll Polymer Sci & Engn State Key Lab Polymer Mat Engn Chengdu 610065 Peoples R China Qingdao Univ Coll Mat Sci & Engn Qingdao 266071 Peoples R China Beijing Normal Univ Coll Chem Beijing Key Lab Energy Convers & Storage Mat Beijing 100875 Peoples R China

Intrinsic stretchability is a promising attribute of polymer organic solar cells (OSCs). However, rigid molecular blocks typically exhibit poor tensile properties, rendering polymers vulnerable to mechanical stress. In this study, we introduce a different approach utilizing all-small-molecule donors and acceptors to fabricate stretchable OSCs. An elastomer, styrene-b-ethylene-butylene-styrene (SEBS), was embedded to modulate film crystallization and stretchability. SEBS effectively confines the growth process of donors and acceptors, leading to enhancement of the crystallization quality, thus contributing to enhanced device efficiencies. Meanwhile, SEBS can absorb and release mechanical stress during stretching, thereby preventing mechanical degradation of donors and acceptors. The mechanical properties of the OSCs were significantly improved by the incorporation of SEBS. Notably, the crack-onset strain increased from 1.03% to 5.99% with SEBS embedding. These findings present a straightforward strategy for achieving stretchable OSCs using all small molecules, offering a different perspective for realizing stretchable devices.

关键词： All-small-molecule Organic solar cells Elastomer Stretchability Flexibility

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Alkali-extracted polysaccharides from mung bean skin possess protective effect on H_(2)O_(2)-induced IEC-6 cells:the role of NF-κB and MAPK signaling pathways

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Food Science and Human Wellness 2025年第1期14卷 101-111页

作者： Shuai Chen Liuming Xie Pingwei Wen qiang yu Yi Chen Hanyu Lu Ting Chen Xin Tao Jianhua Xie State Key Laboratory of Food Science and Resources Nanchang UniversityNanchang 330047China International Institute of Food Innovation Co. Ltd.Nanchang UniversityNanchang 330200China

Intestinal oxidation-reduction balance is essential to protect host *** on the underlying mechanisms of oxidation homeostasis can provide conditions to the treatment or protection of intestinal oxidative ***,the mechanism of polysaccharide(MBP)with alkali-extracted from mung bean skin in alleviating oxidative damage induced by H_(2)O_(2)-induced in intestinal epithelial cells(IEC)-6 cells was *** indicated that MBP effectively mitigated the H_(2)O_(2)-induced decrease in IEC-6 cell viability,restored superoxide dismutase(SOD)activity,lowered malondialdehyde(MDA)content,and decreased reactive oxygen species(ROS)*** blotting showed that MBP may mitigate oxidative damage through NF-κB,MAPK and Nrf2 signaling pathway,and RNA sequencing(RNA-seq)analysis confirmed that MBP can protect cells by regulating MAPK and NF-κB signaling ***,the results of the inhibitor experiment also support the above *** results verified that MBP has the capacity to mitigate oxidative damage induced by H_(2)O_(2)in IEC-6 cells through MAPK and NF-κB signaling *** study showed that MBP can assist preventing intestinal diseases relating to oxidative stress,which could facilitate the development of functional foods.

关键词： Polysaccharide Alkali-extracted Oxidative stress RNA sequencing Molecular mechanism

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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： yu-Qin Li Wen-Tao Kuai Lin Chen Ming-Hui Zeng Xue-Mei Tao Jia-Xin Han yue-Kui Wang Lian-Xin Xu Li-Ying Ge Yong-Gang Liu Shuang Li Liang Xu yu-qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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黄庭坚文艺观念的经学渊源

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深圳大学学报(人文社会科学版) 2025年第1期42卷 152-160页

作者：陈玉强王炜河北大学文学院河北保定071002 河北大学艺术学院河北保定071002

黄庭坚的经学思想对其文艺观念的生成有根本性影响,原因在于他以经学为本根、文艺为枝叶,二者在思维模式、理论体系上形成同源同构关系。黄庭坚在论述“更须治经,探其渊源”之后,提出文学上的“点铁成金”命题,契合他尊经变古的经学主... 详细信息

黄庭坚的经学思想对其文艺观念的生成有根本性影响,原因在于他以经学为本根、文艺为枝叶,二者在思维模式、理论体系上形成同源同构关系。黄庭坚在论述“更须治经,探其渊源”之后,提出文学上的“点铁成金”命题,契合他尊经变古的经学主张。黄庭坚的经学思想涉及物理之学、义理之学、性命之学,分别与其文艺观物创作论、观韵鉴赏论、主体修养论存在关联。学界关注较多的黄庭坚诗学情性本质论、兴寄功能论,也受到他的性命之学的深刻影响。探讨黄庭坚文艺观念的经学渊源,有助于我们认识其文艺观念的深层结构及潜在体系。黄庭坚在物理之学视野下形成的文艺观物创作论强调实践来源,这是他强调知识来源的“词意高胜,要从学问中来”“点铁成金”等命题的有力补充。黄庭坚的文艺观念之所以具有理论吸引力,其直契北宋经学思潮及体系的经学渊源当是重要原因。对黄庭坚的个案考察,印证了归于集部之学的文艺观念与作为中国传统学术根基的经学之间实有难以割断的血脉联系。

关键词：黄庭坚文艺观念经学物理之学义理之学性命之学

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基于国家数字复合出版系统工程的数字化转型实践探索——以华中科技大学出版社为例

中国数字出版

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中国数字出版 2025年第1期3卷 121-128页

作者：余强华中科技大学出版社武汉430223

通过回顾华中科技大学出版社参加国家数字复合出版系统工程试点、示范、示范中心项目近10年历程,全面梳理华科社依托复合出版工程成果,构建技术系统、推进技术应用、探索转型升级之路。华科社在实践探索中明确了管理信息化-出版数字化-... 详细信息

通过回顾华中科技大学出版社参加国家数字复合出版系统工程试点、示范、示范中心项目近10年历程,全面梳理华科社依托复合出版工程成果,构建技术系统、推进技术应用、探索转型升级之路。华科社在实践探索中明确了管理信息化-出版数字化-融合出版-数字产品化转型路径,结合自身实际,依托复合出版工程构建出版数字化技术支撑体系、完善数字化转型机制建设,推动全员参与,实现数字化转型可持续发展。包括:遵循出版规律,做好顶层设计;依托复合工程,构建技术支撑;强化政策扶持、做好机制保障;加强服务支持,推动技术应用;加强业内交流、实现协同发展。

关键词：复合出版工程数字化转型华中科技大学出版社

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Enhancing adhesive performance of polyvinyl alcohol with sub nanoscale polyoxotungstate clusters under extreme conditions

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Nano Research 2025年第2期18卷 432-441页

作者： Pengcheng Cui qiang yu Jiadong Chen Kun Chen Panchao Yin South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou 510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing South China University of TechnologyGuangzhou 510641China

Innovative advancements in the development of high-performance,eco-friendly adhesives are critical for meeting the demands of diverse applications in various *** study reports a significant leap in adhesive technology by enhancing the interfacial toughness and versatility of polyvinyl alcohol(PVA)through complexation with 1-nm Keggin-type polyoxotungstate clusters(POTs)carrying specific negative *** POT-PVA nanocomposites exhibit superior adhesion to hydrophilic surfaces,attributed to their high crosslinking densities and exceptional fracture energies surpassing 6.23 kJ·m^(-2).These adhesives,endowed with high flexibility and a wealth of surface hydroxyl groups,are uniquely suited for application on a wide array of substrates including glass,steel,aluminum,and beyond,demonstrating their broad ***,the reduction in PVA crystallinity due to the chaotropic effect of POTs,which significantly enhances polymer chain *** enhancement confers robust adhesive properties at extreme temperatures,from the cryogenic−196℃ to the high-temperature threshold of 100℃.By capitalizing on the chaotropic effects of charged POTs,the study achieves a notable enhancement in the adhesive capabilities of the POT-PVA nanocomposites,paving the way for the development of for eco-friendly and cost effective adhesives engineered to withstand extreme conditions.

关键词： water-based adhesives polyoxotungstates nanocomposites interfacial toughness chaotropic effect

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