检索结果-南通市图书馆

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin Zhou ling-qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel gain design method to improve the consensus performance of output-feedback multi-agent systems

引用

Control Theory and Technology 2016年第4期14卷 335-346页

作者： Wei ZHENG qiang ling Hai LIN Department of Automation University of Science and Technology of China Hefei Anhui 230027 China Department of Electrical Engineering University of Notre Dame Notre Dame IN 46556 U.S.A.

This paper considers the consensus problem of a group of homogeneous agents. These agents are governed by a general linear system and can only directly measure the output, instead of the state. In order to achieve the consensus goal, each agent estimates its state through a Luenberger observer, exchanges its estimated state with neighbors, and constructs the control input with the estimated states of its own and neighbors. Due to the existence of observation and process noises, only practical consensus, instead of asymptotical consensus, can be achieved in such multi-agent systems. The performance of the achieved practical consensus can be measured by the ultimate mean square deviation of the states of agents. That performance is closely related to the observation gains of the state observers and the control gains of agents. This paper proposes a method to optimize such performance with respect to the concerned observation and control gains. That method starts with a set of feasible observation and control gains and formulates a group of linear matrix inequalities （LMIs）. Solving these LMIs gives some intermediate matrix variables. By perturbing observation and control gains, and the intermediate matrix variables, the original LMIs yield another group of LMIs, which can be solved to provide a descent direction of observation and control gains. Moving along that descent direction, observation and control gains can be improved to yield better performance and work as the starting point of the next iteration. By iteratively repeating this procedure, we can hopefully improve the consensus performance of the concerned multi-agent system. Simulations are done to demonstrate the effectiveness of the proposed method.

关键词： Consensus output-feedback multi-agent systems least mean square deviation perturbation method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A review on co-pyrolysis of coal and oil shale to produce coke

引用

Frontiers of Chemical Science and Engineering 2020年第4期14卷 504-512页

作者： Xiangchun Liu Ping Cui qiang ling Zhigang Zhao Ruilun Xie Anhui Key Laboratory of Coal Clean Conversion and Utilization School of Chemistry and Chemical EngineeringAnhui University of TechnologyMa'anshanAnhui 243002China

It has become the top priority for coking industry to rationally use and enlarge coking coal resources because of the shortage of the *** review focuses on the potential utilization of oil shale(OS)as a feedstock for coal-blending coking,in which the initial and basic step is ***,OS has a high ash *** such OS is directly used for coal-blending coking,the coke product will not meet market ***,this review firstly summarizes separation and beneficiation techniques for organic matter in OS,and provides an overview on coal and OS pyrolysis through several viewpoints(e.g.,pyrolysis process,phenomena,and products).Then the exploratory studies on co-pyrolysis of coal with OS,including co-pyrolysis phenom-ena and process mechanism,are ***,co-pyrolysis of different ranks of coals with OS in terms of coal-blending coking,where further research deserves to be performed,is suggested.

关键词： coal oil shale co-pyrolysis coal blending coking coke

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A comparison study of existence forms of Fe species in coke for solution loss reaction of carbon

引用

Journal of Iron and Steel Research International 2018年第7期25卷 692-699页

作者： qiang ling Hui-juan Zhao ling-yu Chen Rui-lun Xie Zhao Lei Zhi-gang Zhao Anhui Key Laboratory of Coal Clean Conversion and Utilization School of Chemistry and Chemical Engineering Anhui University of Technology Ma'anshan 243002 Anhui China

Fe species were loaded by two different loading ways （absorption method and addition method） to investigate their effect on thermal properties of coke. The particulate coke reactivity of coke samples indicated that the added sample showed higher catalytic activity than the adsorbed sample at first, owing to the decreased structure and properties of coke and more catalytic active sites caused by the strong interaction between Fe species and coke. The presence of Fe species in the added sample weakened the microstructure of coke, and the Fe species were easier to be reduced than those in the absorbed sample due to its different existence form in coke. With further increased loading of Fe species, the different existence positions of Fe species caused more decrease in surface active sites in the added sample than in the adsorbed sample, leading to lower catalytic activity of added sample when the total iron content exceeded 1%. The catalytic mechanism implied that there may be a catalytic dominant factor change in the reaction between the catalytic effect of iron species and carbon surface active sites in coke; the catalytic effect of iron species is dominant in the reaction at first, but the catalytic effect of carbon surface active sites is dominant in the reaction with the further increased loading amount of Fe species.

关键词： Coke reactivity Catalytic mechanism Coke structure Fe species Existence form

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Systemin/Jasmonate-Mediated Systemic Defense Signaling in Tomato

引用

Molecular Plant 2011年第4期4卷 607-615页

作者： Jia-qiang Sun Hong-ling Jiang Chuan-You Li State Key Laboratory of Plant Genomics National Centre for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy ofSciences Datun Road Beijing 100101 China

Wound-inducible proteinase inhibitors （PIs） in tomato plants provide a useful model system to elucidate the signal transduction pathways that regulate systemic defense response. Among the proposed intercellular signals for wound-induced PIs expression are the peptide systemin and the oxylipin-derived phytohormone jasmonic acid （JA）. An increasing body of evidence indicates that systemin and JA work in the same signaling pathway to activate the ex- pression of PIs and other defense-related genes. However, relatively less is known about how these signals interact to promote cell-to-cell communication over long distances. Genetic analysis of the systemin/JA signaling pathway in tomato plants provides a unique opportunity to study, in a single experimental system, the mechanism by which peptide and oxylipin signals interact to coordinate systemic expression of defense-related genes. Previously, it has been proposed that systemin is the long-distance mobile signal for defense gene expression. Recently, grafting experiments with tomato mutants defective in JA biosynthesis and signaling provide new evidence that JA, rather than systemin, functions as the systemic wound signal, and that the biosynthesis of JA is regulated by the peptide systemin. Further understanding of the systemin/JA signaling pathway promises to provide new insights into the basic mechanisms governing plant defense to biotic stress.

关键词： Systemic defense response systemin jasmonic acid tomato Arabidopsis.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NONLINEAR DYNAMICAL ANALYSIS OF BIFURCATION AND CONFLUENCE OF THE PACIFIC WESTERN BOUNDARY CURRENTS

引用

Journal of Hydrodynamics 2012年第3期24卷 383-390页

作者： NI Guo-xi JIANG Song JU qiang-chang KONG ling-hai LCP Institute of Applied Physics and Computational Mathematics Beijing 100088 China

In this paper, we analyze the bifurcation and the confluence of the Pacific western boundary currents by an analytical approach. Applying the conservation law, the geostrophic balance relation and the Bernoulli integral to a reduced gravity model, we get a quantitative relation for the outflow and the inflow, and establish the related formulae for the width and the veering angle of offshore currents under the inflow condition. Furthermore, a comparison between the volume transport based on the observation data and the analytical value for the Pacific western boundary currents is presented, which validates the theoretical analysis.

关键词： Pacific western boundary currents bifurcation confluence volume transport reduced gravity model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

引用

第36届中国控制会议

作者： Youkang Shi qiang ling University of Science and Technology of China China Academy of Information and Communications Technology(CAICT) Key Laboratory of Internet and Industrial Integration InnovationMinistry of Industry and Information Technology of the People's Republic of China

ISBN: (纸本)9781538629185

The users’ requests for online objects in mobile networks are characterized by fast varying dynamics caused by user mobility and diversity of users who produce *** popularity methods cannot efficiently handle such strong dynamic requests of users,because they pay little attention to the time-varying user behavior which contributes to the growth and fading of online media *** handle this issues,this paper proposes two schemes,including sensing the popularity variation speed of the hot contents and adaptively adjusting the popularity tracking speed of the cache *** the first one,we make use of the pseudo popularity acceleration in a time window to calculate the shifting speed of hot *** the obtained shifting speed can we adaptively adjust the popularity tracking speed of our previous EWMA *** that our adaptive EWMA method can achieve nearly the best performance without prior knowledge regarding the shifting speed of hot objects requested by *** confirm that our adaptive EWMA method significantly outperforms conventional popularity tracking methods.

关键词： mobile network time-varying popularity adaptive popularity tracking

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Investigating effect of coke porosity on blast furnace performance based on multi-physical fields

引用

Journal of Iron and Steel Research International 2024年第2期31卷 357-367页

作者： Ji Chen Zhao Lei Zhe Yao Li Wang qiang ling Ping Cui Anhui Province Key Laboratory of Coal Clean Conversion and High Valued Utilization School of Chemistry and Chemical EngineeringAnhui University of TechnologyMa’anshan243002AnhuiChina Shanxi Academy of Printing Technology Research Institute Co. Ltd.Xi’an710077ShaanxiChina

Reducing coke use is an effective measure to reduce carbon emission and energy consumption in the blast furnace(BF)***,BF is a high-temperature moving bed reactor,where complex physical transformations coupled with complicated reactions *** makes it challenging to investigate the factors determining BF performance with the conventional method.A multi-physical field coupling mathematical model of BF was thus developed to describe its mass and heat transfer as well as its intrinsic ***,the proposed model was validated with the production *** coupling conditions,influences of dominating reactions on BF performance(temperature distribution,gas distribution,iron formation reaction,and direct reduction degree)were *** results indicated that coke combustion,indirect reduction,and direct reduction of iron ore mainly took place nearby the shaft tuyere,cohesive zone,and dripping zone,***,the rate of coke solution loss reaction was increased with the rising coke porosity in the cohesive *** the effect of coke porosity on the efficiency and stability of BF,the coke porosity of 0.42 was regarded as a reasonable value.

关键词： Blast furnace Mathematical model Multi-physical field Simulation Coke porosity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asymptotic stabilization of dynamically quantized nonlinear systems in feedforward form

引用

控制理论与应用（英文版） 2010年第1期8卷 27-33页

作者： qiang ling Michael D. LEMMON Hai LIN Department of Automation University of Science and Technology of China Hefei Anhui 230027 China Department of Electrical Engineering University of Notre Dame Notre Dame IN 46556 USA Department of Electrical and Computer Engineering National University of Singapore Singapore 117576

This paper studies the stabilizability of an n-dimensional quantized feedforward nonlinear system. The state of that system is first quantized into a finite number of bits, and then sent through a digital network to the controller. We want to minimize the number of transmitted bits subject to maintaining asymptotic stability. In the prior literature, n bits are used to stabilize the n-dimensional system by assigning one bit to each state variable （dimension）. Under the stronger assumption of global Lipschitz continuity, this paper extends that result by stabilizing the system with a single bit. Its key contribution is a dynamic quantization policy which dynamically assigns the single bit to the most ＂important＂ state variable. Under this policy, the quantization error exponentially converges to 0 and the stability of the system can, therefore, be guaranteed. Because i is the minimum number of quantization bits （per sampling step）, the proposed dynamic quantization policy achieves the minimum stabilizable bit number for that n-dimensional feedforward nonlinear system.

关键词： Quantization Stability Nonlinear Feedforward

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Non-linear Torsional Vibration Characteristics of an Internal Combustion Engine Crankshaft Assembly

引用

Chinese Journal of Mechanical Engineering 2012年第4期25卷 797-808页

作者： HUANG Ying YANG Shouping ZHANG Fujun ZHAO Changlu ling qiang WANG Haiyan School of Mechanical and Vehicular Engineering Beijing Institute of Technology Beijing 100081 China

Crankshaft assembly failure is one of the main factors that affects the reliability and service life of *** linear lumped mass method,which has been universally applied to the dynamic modeling of engine crankshaft assembly,reveals obvious simulation *** nonlinear dynamic characteristics of a crankshaft assembly are instructionally significant to the improvement of modeling *** this paper,a general expression for the non-constant inertia of a crankshaft assembly is derived based on the instantaneous kinetic energy equivalence *** nonlinear dynamic equations of a multi-cylinder crankshaft assembly are established using the Lagrange rule considering nonlinear factors such as the non-constant inertia of reciprocating components and the structural damping of shaft *** natural frequency and mode shapes of a crankshaft assembly are investigated employing the eigenvector *** forced vibration response of a diesel engine crankshaft assembly taking into account the non-constant inertia is studied using the numerical integral *** simulation results are compared with a lumped mass model and a detailed model using the system matrix *** of non-linear torsional vibration analysis indicate that the additional excitation torque created by non-constant inertia activates the 2nd order rolling vibration,and the additional damping torque resulting from the non-constant inertia is the main nonlinear *** increased torsional angular displacement evoked by the high order excitation torque relates to the non-constant *** research project is aimed at improving nonlinear dynamics theory,and the confirmed nonlinear parameters can be used for the structure design of a crankshaft assembly.

关键词： internal combustion engine,crankshaft assembly,non-constant inertia,nonlinear vibration torsional vibration characteristics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：