检索结果-南通市图书馆

Functionalized graphene oxide nanosheets with unique three-inone properties for efficient and tunable antibacterial applications

在线全文

学校读者我要写书评

暂无评论

Nano Research 2021年第1期14卷 185-190页

作者： Bo-Yao Lu Guan-yin Zhu chen-Hao Yu Ge-Yun chen Chao-Liang Zhang Xin Zeng qian-Ming chen qiang Peng State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UntiversityChengdu 610041China

Developing antibiotics-independent antibacterial agents is of great importance since antibiotic therapy faces great challenges from drug *** oxide(GO)is a promising agent due to its natural antibacterial mechanisms,such as sharp edgemediated cutting ***,the antibacterial activity of GO is limited by its negative charge and low photothermal ***,the amino-functionalized GO nanosheets(AGO)with unique three-in-one properties were *** essential properties(positive charge,strong photothermal effect,and natural cutting effect)were integrated into *** positive charge(30 mV)rendered AGO a strong interaction force with model pathogen Streptococcus mutans(330 nN).The natural cutting effect of 100 ng·mL^(-1)AGO caused 27%loss of bacterial viability after incubation for 30 *** importantly,upon the near-infrared irradiation for just 5 min,the three-in-one properties of AGO caused 98%viability *** conclusion,the short irradiation period and the tunable antibacterial activity confer the three-in-one AGO a great potential for clinical use.

关键词： nanoparticles nanomaterials carbon nano-bio interaction dental caries antimicrobial

Molecular mechanism of fly ash affecting the performance of cemented backfill material

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2023年第8期30卷 1560-1572页

作者： Shuo Yang Jiangyu Wu Hongwen Jing Xinguo Zhang Weiqiang chen Yiming Wang qian yin Dan Ma State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China Shandong Key Laboratory of Mining Disaster Prevention and Control Shandong University of Science and TechnologyQingdao 266590China State Key Laboratory of High Performance Civil Engineering Materials Jiangsu Research Institute of Building Science Co.Ltd.Nanjing 210008China Department of Materials University of OxfordParks RdOxfordOX13PHUnited Kingdom Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringThe University of ManchesterManchester M139PLUnited Kingdom School of Mines China University of Mining and TechnologyXuzhou 221116China

The great challenge of cemented tailings backfill(CTB)is difficult simultaneously maintaining its excellent mechanical properties and low *** ash(FA)can potentially address this problem and further replace cement in favor of low carbon ***,its mechanism on CTB with low cement dosage and low Ca system remains ***,this study conducted uniaxial compression,Xray diffraction(XRD),and scanning electron microscopy(SEM)-energy dispersive spectrometer(EDS)tests to investigate the effect of FA dosage on the mechanical property and microstructure of CTB.A molecular model of FA-CSH was constructed to reproduce the molecular structure evolution of CTB with FA based on the test *** influences of FA dosage and calcium/silica molar ratio(Ca/Si ratio)on the matrix strength and failure model were analyzed to reveal the mechanism of FA on calcium silicate hydrated(C-S-H).The results show that the strength of CTB increases initially and then decreases with FA dosage,and the FA supplement leads to a decrease in Ca(OH)_(2) diffraction intensity and Ca/Si ratio around the FA *** and SEM-EDS findings show that the Ca/Si ratio of C-S-H decreases with the progression of *** FA-CSH model indicates that FA can reinforce the silica chain of C-S-H to increase the matrix ***,this enhancement is weakened by supplementing excessive FA *** addition,the hydrogen bonds among water molecules deteriorate,reducing the matrix strength.A low Ca/Si ratio results in an increase in water molecules and a decrease in the ionic bonds combined with Ca^(2+).The hydrogen bonds among water molecules cannot withstand high stresses,resulting in a reduction in *** water absorption of the FA-CSH model is negatively correlated with the FA dosage and Ca/Si *** use of optimal FA dosage and Ca/Si ratio leads to suitable water absorption,which further affects the failure mode of FA-CSH.

关键词： fly ash cemented tailings backfill calcium/silica ratio microstructure molecular dynamics simulation

A Fast Calculation Method for Long-term Security-constrained Unit Commitment of Large-scale Power Systems with Renewable Energy

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1127-1137页

作者： qian Yang Jianxue Wang Hongrui yin Qingtao Li School of Electrical Engineering Xi'an Jiaotong UniversityXi'anChina

With the increase in the penetration rate of renewable energy, the planning and operation of power systems will face huge challenges. To ensure the sufficient utilization of renewable energy, the reasonable arrangement for the long-term power generation plan has become more crucial. Security-constrained unit commitment(SCUC) is a critical technical means to optimize the long-term power generation plan. However, the plentiful power sources and the complex grid structure in largescale power systems will bring great difficulties to long-term SCUC. In this paper, we propose a fast calculation method for long-term SCUC of large-scale power systems with renewable energy. First, a method for unit status reduction based on temporal decomposition is proposed, which will reduce plenty of binary variables and intertemporal constraints in SCUC. Then,an efficient redundant constraint identification(RCI) method is developed to reduce the number of network constraints. Furthermore, a joint accelerated calculation framework for status reduction and RCI is formed, which can reduce the complexity of long-term SCUC while ensuring a high-precision feasible solution. In case studies, numerical results based on two test systems ROTS2017 and NREL-118 are analyzed, which verify the effectiveness and scalability of the proposed calculation method.

关键词： Accelerated calculation framework long-term security-constrained unit commitment(SCUC) redundant constraints identification renewable energy unit status reduction

Sigmatropic rearrangements of B(MIDA)-propargylic alcohols towards the diverse synthesis of α-functionalized organoborons

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第2期67卷 568-575页

作者： Jiasheng qian Li-Cai Liu Zhi-Hao chen Yuan Liu yin Li Qingjiang Li Honggen Wang Guangdong Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou510006China

α-Functionalized organoborons are useful building blocks and key structural elements in functional *** previous synthesis relied on the famous Matteson reaction or the late-stage borylative modification of alkynes or ***,the synthetic transformation of borylated building blocks offers another useful strategy and is currently actively *** report herein that B(MIDA)-propargylic alcohols(BPAs) are a useful type of borylated building *** two complementary functional group handles(alkyne and hydroxyl) in close proximity,the redox-neutral [3,3] and [2,3] sigmatropic rearrangements of BPAs allow the efficient synthesis of several types of α-functionalized boronates,including α,β-unsaturated acylborons,α-S/P-substituted allenylborons,boryl-substituted thiazoles and a borylated α,β-unsaturated hydrazine,some of which are otherwise challenging targets using other synthetic methods.

关键词： organoboron diverse synthesis sigmatropic rearrangement heteroarene amide

Sword in the woods: How plant hosts defend against vascular pathogens

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2022年第8期64卷 1465-1468页

作者： Xin yin Wei qian State Key Laboratory of Plant Genomics Institution of Microbiology Chinese Academy of Sciences

“We shall fight on the beaches, we shall fight on the landing grounds, we shall fight in the fields and in the streets, we shall fight in the hills”. Winston Churchill’s famous speech inspiring the will to fight is... 详细信息

关键词： pathogens fight beach

Role of interfacial water in adhesion,friction,and wear--A critical review

在线全文

学校读者我要写书评

暂无评论

Friction 2021年第1期9卷 1-28页

作者： Lei chen Linmao qian Tribology Research Institute State Key Laboratory of Traction PowerSouthwest Jiaotong UniversityChengdu 610031China

Surficial water adsorption and interfacial water condensation as natural phenomena that can alter the contact status of the solid interface and tribological performances are crucial in all length scales,i.e.,from earthquakes to skating at the macroscale level and even to micro/nano-electromechanical systems(M/NEMS)at the microscale/nanoscale *** water exhibits diverse structure and properties from bulk water because of its further interaction with solid *** this paper,the evolutions of the molecular configuration of the adsorbed water layer depending on solid surface chemistry(wettability)and structure,environmental conditions(i.e.,relative humidity and temperature),and experimental parameters(i.e.,sliding speed and normal load)and their impacts on tribological performances,such as adhesion,friction,and wear,are systematically *** on these factors,interfacial water can increase or reduce adhesion and friction as well as facilitate or suppress the tribochemical wear depending on the water condensation kinetics at the interface as well as the thickness and structure of the involved interfacial water.

关键词： water adsorption water condensation adhesion friction tribochemical wear

Deformation and failure characteristics of anchorage structure of surrounding rock in deep roadway

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2020年第5期30卷 593-604页

作者： Hongwen Jing Jiangyu Wu qian yin Ke Wang State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and TechnologyXuzhouJiangsu 221116China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhouJiangsu 221116China

This paper investigated the stress evolution,displacement field,local deformation and its overall distribution,and failure characteristics of the anchorage structure of surrounding rock with different rockbolt spacing through the model *** influences of the pre-tightening force and spacing of rockbolt on the support strength of the anchorage structure of surrounding rock were analyzed by the simulation using FLAC3D numerical *** support scheme of the excavated roadway was then designed,and the effectiveness of this support scheme was further verified by the displacement measurement of the *** results showed that the maximum displacement between the roof and floor of the west wing track roadway in Kouzidong coal mine,China is about 42 mm,and the maximum displacement between its both sides is about 72 mm,indicating that the support scheme proposed in this study can ensure the stability and safety of the excavated roadway.

关键词： Deep roadway Anchorage structure Deformation failure Stress evolution Loading capacity

Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第18期9卷 4520-4541页

作者： Teng-Fei yin Dong-Yan Zhao Yuan-chen Zhou qian-qian Wang Shu-Kun Yao Graduate school Peking University China-Japan Friendship School of Clinical MedicineBeijing 100029China Graduate School Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Department of Gastroenterology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The high morbidity and mortality of colorectal cancer(CRC)have posed great threats to human *** RNA(CircRNA)and microRNA(miRNA),acting as competing endogenous RNAs(ceRNAs),have been found to play vital roles in ***,the biological function of ceRNAs in CRC pathogenesis and prognosis remains largely *** To identify the CRC-specific circRNA-miRNA-mRNA regulatory network and uncover the subnetwork associated with its *** CircRNAs,miRNAs and mRNAs differentially expressed(DE)in CRC tissues were selected by expression file analysis in the Gene Expression Omnibus(GEO)database,and the downstream target molecules of circRNAs and miRNAs were ***,the intersection of differentially expressed RNA molecules with the predicted targets was determined to obtain a ceRNA *** ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses were conducted to elucidate the possible mechanism of pathogenesis.A survival analysis using the gene profiles and clinical information in The Cancer Genome Atlas(TCGA)database was performed to identify the mRNAs associated with the clinical outcome of CRC patients and construct a prognostic *** We downloaded three datasets(GSE126095,GSE41655 and GSE41657)of largescale CRC samples from the GEO *** were 55 DEcircRNAs,114 DEmiRNAs and 267 DEmRNAs in CRC tissues compared with normal *** intersecting these molecules with predicted targets,19 circRNAs,13 miRNAs and 28 mRNAs were chosen to develop a circRNA-miRNA-mRNA *** and KEGG functional enrichment analyses indicated that the retinol metabolic process,leukocyte chemotaxis,extracellular matrix remodeling,endoplasmic reticulum stress,alcohol dehydrogenase activity,gastric acid secretion,nitrogen metabolism and NOD-like receptor signaling pathway might participate in the tumorigenesis of *** verifying the identified mRNA effect in the TCGA database,we finally

关键词： CircRNA miRNA Network Colorectal cancer Prognosis Biomarkers

Local parameter identification with neural ordinary differential equations

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2022年第12期43卷 1887-1900页

作者： qiang yin Juntong CAI Xue GONG qian DING Department of Mechanics Tianjin UniversityTianjin 300350China

The data-driven methods extract the feature information from data to build system models, which enable estimation and identification of the systems and can be utilized for prognosis and health management(PHM). However, most data-driven models are still black-box models that cannot be interpreted. In this study, we use the neural ordinary differential equations(ODEs), especially the inherent computational relationships of a system added to the loss function calculation, to approximate the governing equations. In addition, a new strategy for identifying the local parameters of the system is investigated, which can be utilized for system parameter identification and damage detection. The numerical and experimental examples presented in the paper demonstrate that the strategy has high accuracy and good local parameter identification. Moreover, the proposed method has the advantage of being interpretable. It can directly approximate the underlying governing dynamics and be a worthwhile strategy for system identification and PHM.

关键词： neural ordinary differential equation(ODE) parameter identification prognosis and health management(PHM) system damage detection