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Closed-Loop Iterative Learning Control for Discrete Singular Systems with Fixed Initial Shift

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Journal of Systems Science & Complexity 2019年第2期32卷 577-587页

作者： GU Panpan TIAN Senping liu qian School of Automation Science and Engineering South China University of Technology

This paper deals with the problem of iterative learning control for a class of discrete singular systems with fixed initial shift. According to the characteristics of the discrete singular systems, a closed-loop learning algorithm is proposed and the corresponding state limiting trajectory is *** is shown that the algorithm can guarantee that the system state converges uniformly to the state limiting trajectory on the whole time interval. Then the initial rectifying strategy is introduced to the discrete singular systems for eliminating the effect of the fixed initial shift. Under the action of the initial rectifying strategy, the system state can converge to the desired state trajectory within the pre-specified finite time interval no matter what value the fixed initial shift takes. Finally, a numerical example is given to illustrate the effectiveness of the proposed approach.

关键词： Closed-loop learning algorithm discrete singular systems, fixed initial shift iterative learning control

Multi-objective optimization for task offloading based on network calculus in fog environments

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Digital Communications and Networks 2022年第5期8卷 825-833页

作者： qian Ren Kui liu Lianming Zhang College of Information Science and Engineering Hunan Normal UniversityChangsha410081China

With the widespread application of wireless communication technology and continuous improvements to Internet of Things(IoT)technology,fog computing architecture composed of edge,fog,and cloud layers have become a research *** architecture uses Fog Nodes(FNs)close to users to implement certain cloud functions while compensating for cloud ***,because of the limited computing and storage capabilities of a single FN,it is necessary to offload tasks to multiple cooperating FNs for task *** effectively and quickly realize task offloading,we use network calculus theory to establish an overall performance model for task offloading in a fog computing environment and propose a Globally Optimal Multi-objective Optimization algorithm for Task Offloading(GOMOTO)based on the performance *** results show that the proposed model and algorithm can effectively reduce the total delay and total energy consumption of the system and improve the network Quality of Service(QoS).

关键词： Fog computing Task offloading Multi-objective optimization Network calculus

Preclinical and clinical trials of oncolytic vaccinia virus in cancer immunotherapy:a comprehensive review

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Cancer Biology & Medicine 2023年第9期20卷 646-661页

作者： Mengyuan Li Minghuan Zhang qian Ye Yunhua liu Wenbin qian Department of Hematology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Hangzhou Rong-Gu Biotechnology Limited Company Hangzhou 310056China Department of Pathology&Pathophysiology and Department of Surgical Oncology of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310058China

Oncolytic virotherapy has emerged as a promising treatment for human cancers owing to an ability to elicit curative effects via systemic *** cells often create an unfavorable immunosuppressive microenvironment that degrade viral structures and impede viral replication;however,recent studies have established that viruses altered via genetic modifications can serve as effective oncolytic agents to combat hostile tumor ***,oncolytic vaccinia virus(OVV)has gained popularity owing to its safety,potential for systemic delivery,and large gene insertion *** review highlights current research on the use of engineered mutated viruses and gene-armed OVVs to reverse the tumor microenvironment and enhance antitumor activity in vitro and in vivo,and provides an overview of ongoing clinical trials and combination *** addition,we discuss the potential benefits and drawbacks of OVV as a cancer therapy,and explore different perspectives in this field.

关键词： Oncolytic virotherapy oncolytic vaccinia virus engineered virus arming strategy

A rice geranylgeranyl reductase is essential for chloroplast development

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Journal of Integrative Agriculture 2021年第10期20卷 2592-2600页

作者： liu Xi YI Xin YANG Yan-rong HUANG qian-qian Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental Protection/Jiangsu Key Laboratory for Eco-Agricultural Biotechnology Around Hongze Lake Huaiyin Normal UniversityHuai’an 223300P.R.China

Chloroplasts are essential for plant photosynthesis and *** genes have been identified that regulate plant chloroplast ***,it is not known at a molecular level how these genes regulate chloroplast *** this study,we isolated a mutant ygl2(yellow-green leaf2)that exhibited a pigment-defective ***2 encodes a geranylgeranyl reductase,and in mutant ygl2,there was a single base change(T1361G)located in the third exon of YGL2 that resulted in a missense mutation(L454R)in the encoded *** electron microscopy revealed that chloroplast development was impaired in the ygl2 *** expression levels of plastid-encoded genes were significantly altered in the ygl2 ***,in a yeast two-hybrid assay,we found that YGL2 interacted with the RNA editing factor MORF8.

关键词： rice(Oryza sativa L.) chloroplast YGL2 geranylgeranyl reductase

A New Class of Strong Orthogonal Arrays of Strength Three

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Journal of Systems Science & Complexity 2024年第3期37卷 1233-1250页

作者： WANG Chunyan liu Min-qian YANG Jinyu Center for Applied Statistics and School of Statistics Renmin University of ChinaBeijing 100872China School of Statistics and Data Science LPMC&KLMDASRNankai UniversityTianjin 300071China

Strong orthogonal arrays(SOAs) were recently introduced and studied as a class of spacefilling designs for computer experiments. To surely realize better space-filling properties, SOAs of strength three or higher are desirable. In addition, orthogonality is also an important property for designs of computer experiments, because it guarantees that the estimates of the main effects are uncorrelated. This paper first provides a systematic study on the construction of(nearly) orthogonal strength-three SOAs with better space-filling properties. The newly proposed strength-three SOAs enjoy almost the same space-filling properties of strength-four SOAs, and can accommodate much more columns than the latter. Moreover, they are(nearly) orthogonal and flexible in run sizes. The construction methods are straightforward to implement, and their theoretical supports are well established. In addition to the theoretical results, many designs are tabulated for practical needs.

关键词： Computer experiment orthogonality space-filling property strong orthogonal array

Clinicopathological Characters of Triple Negative Breast Cancer

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Chinese Journal of Cancer Research 2010年第1期22卷 17-20页

作者： Xin Zhou qian liu Chongqing Cancer Institute Chongqing 400030 China

Objective： To study the clinicopathological characters Methods： A total of 629 patients with breast cancer of triple negative breast cancer （TNBC）. were reviewed, who were treated from 2003 to 2007 in Chongqing Cancer Institute. The comparison of clinicopathological features including TNM classification, histological type, tumor location, axillary lymphonodes status and neoadjuvant chemotherapy between TNBC and nontriple negative breast cancer （NTNBC） was performed. The overall response was evaluated by whether the patients achieve complete remission （CR） and partial remission （PR） after chemotherapy. Results： There were 69 TNBCs in the 629 patients with breast cancer. The premenopausal patients, which was found in 49/69 of TNBCs, was more than NTNBCs. The average diameter of tumor in TNBC group was 4.1 cm, lager than NTNBC group. TNBC with axillary nodes metastasis occurred in 21 cases, and the axillary nodes metastasis rate was lower than NTNBC. The positive expression rate of p53 in TNBC was 44.9%, and the overall response （CR＋PR） was 72.2%. No statistical differences were found regarding the positive expression rate of p53 and the overall response between TNBC and NTNBC. Conclusion： TNBC were a group of primary breast cancers with triple negative, tending to occur in premenopausal women, with larger tumors, lower axillary nodes metastasis rate. TNBC had worse clinical prognosis and currently lacked effective targeted therapies.

关键词： Breast cancer Triple negative Prognosis

A novel hanging bowl-shaped mask for the fabrication of vertical sidewall structures

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Frontiers of physics 2016年第1期11卷 111-114页

作者： Dongxue Chen qian liu National Center for Nanoscience and Technology Beijing 100190 China University of Chinese Academy of Sciences Beijing 100080 China

Contact exposure is expected to occur in conventional lithography, and can be a source of process deviations （such as shrinking and distortion of templates） during reactive ion etching and inductively coupled plasma etching, as these deviations are induced by ion bombardment. This typically results in undesired sidewall effects, such as lower sidewall angles. Here we report a novel hanging bowlshaped lithography mask that can effectively minimize sidewall effects in lithography applications. As a test case, standard silicon carbide pillars with vertical sidewalls are fabricated using this mask. The mask could be used for fabrication of high-aspect-ratio structures with ultra-violet lithography.

关键词： UV lithography hanging bowl-shaped mask sidewall effects ICP SiC

Flow Stealer: lightweight load balancing by stealing flows in distributed SDN controllers

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Science China(Information Sciences) 2017年第3期60卷 123-138页

作者： Ping SONG Yi liu Tianxiao liu Depei qian Sino-German Joint Software Institute Beihang University Beijing Key Laboratory of Network Technology

Software-defined networking(SDN) introduces centralized controllers to increase network programmability drastically. Distributed control planes, in which multiple SDN controllers work together to manage a network, have been proposed to satisfy the requirements of large-scale networks, and different kinds of load-balancing approaches have been proposed to balance the workloads among these controllers. Current load-balancing approaches generally use switch migration, which adjusts the mapping between switches and controllers dynamically according to controller workloads. These switch migration-based approaches face challenges under burst traffic as a result of their overhead and longer detection periods. This paper proposes Flow Stealer,a lightweight load-balancing method for distributed SDN controllers. Flow Stealer uses a low-cost flow-stealing method, in which idle controllers share workloads temporarily with overloaded controllers by stealing flow events from them. The flow-stealing method not only can react to changes of network traffic more quickly, but can also reduce the frequency of switch migration. In addition, Flow Stealer incorporates both flow stealing and switch migration to adapt to burst traffic and long-term traffic changes. Experimental results show that Flow Stealer can balance the workloads among controllers more efficiently, especially under burst traffic.

关键词： software defined networking load balancing flow stealing distributed controller switch migration

Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex promotes intestinal development as a new iron supplement

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Science China Life Sciences 2025年第1期 219-231页

作者： Yingying Feng Yuying Wu Jialu Wang Zhenglin Dong qian Yu Shuangshuang Xia Chunxue liu Haihua Wang Xin Wu Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of Sciences ANYOU Biotechnology Group Co.Ltd Qingdao Seawin Biotech Group Co. LTD

Iron is a crucial micronutrient, and its deficiency can have detrimental effects on the health of infants. Dietary polysaccharide-iron(Ⅲ) complexes(PICs) are promising for addressing iron deficiency due to their minimal adverse reactions and high iron absorption rate. This study aimed to investigate the effects of dietary Enteromorpha prolifera polysaccharide-Fe(Ⅲ) complex(EP-Fe) on newborns, using 3-day weaned piglets as the iron-deficiency model. Results showed that EP-Fe improved iron levels and promoted intestinal development in piglets. Transcriptome sequencing revealed that EP-Fe increased the survival of intestinal epithelial cells under hypoxia by upregulating the expression of genes that promote the development of the vascular system. Additionally, EP-Fe enhanced the mucosal barrier functions by inhibiting myosin light chain kinase(MLCK)/phosphorylated myosin light chain(p-MLC) signaling pathway to increase the expression of intestinal tight junction proteins. Furthermore, the 16S r RNA gene sequencing of gut microbiota showed that EP-Fe promoted the enrichment of Bacteroides＿fragilis and other gut microbes that can metabolize carbohydrates. In conclusion, EP-Fe is an effective iron supplement for newborns, and it can be developed as a comprehensive nutritional supplement.

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