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Optoelectronics Letters 2005年第2期 34-36页

作者： WANG Yun, FAN Xiu-wei, PENG qian-qian, liu Jie, and HE Jing-liang- College of Physics and Electronics,Shandong Normal University,Ji′nan 250014

We have demonstrated a laser-diode pumped Nd:GdVO4 extra-cavity frequency tripling ultraviolet laser with a LBO crystal in this *** the acousto-optic （A-O） Q-switched operation,we have obtained 355 nm ultraviolet laser,with pulse width of 25 ns and pulse repetition rate of 20 *** using a type Ⅰ non-critical phase-matched LBO crystal,the SHG output power of 822 mW is achieved at the incident pump power of 16 W. The output power of 355nm UV laser is 260mW with a type Ⅱ phase-matched LBO crystal,and the conversion efficiency （1 064 nm-355 nm ） is 5.9 %.The power stability of 355 nm laser is 1.7% in 1 h.

关键词： LBO Laser-diode pumped Nd Nd

Reproductive traits associated with invasiveness in Conyza sumatrensis

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Journal of Systematics and Evolution 2009年第3期47卷 245-254页

作者： 1,2Jian-Hua HAO 1Sheng qianG 1qian-qian liu 1Fei CAO 1(Weed Research Laboratory, Nanjing Agricultural University, Nanjing 210095, China) 2(College of Biology and Food Engineering, Changshu Institute of Technology, Changshu 215500, China) (College of Biology and Food Engineering Changshu Institute of Technology Changshu 215500 China)

Conyza sumatrensis (Retz.) E. Walker, a member of Asteraceae, is a highly invasive species. However, its reproduction biology remains poorly known. To understand the role of reproductive traits in successful invasion of the species, we studied several traits of its reproductive system: the miniature capitulum and gynomonoecious sexual system, the biology and phenology of capitula and florets, pollen/ovule ratio, the mating system (self-compatibility), flower visitors, physical traits and dispersal potential of achenes, germination potential of achenes from manually pollinated capitula, and the association of these traits with invasiveness. Our study showed that the reproductive traits of autonomous seed production, versatile mating system of self- and cross-pollination, and generalized pollination system might contribute to the species’ successful invasive capability. The invasiveness was further enhanced by the high and rapid production of achenes, as well as the high percentage, rapid germination rate and high dispersal capability of achenes. It was concluded that in annual or winter-annual weeds, autonomous seed production contributed significantly to the invasiveness of the species.

关键词： Asteraceae Conyza sumatrensis gynomonoecy invasiveness mating system reproduction.

Exploring the mechanism of Huangjing pill in the treatment of Alzheimer’s disease based on network pharmacology and molecular docking

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TMR Modern Herbal Medicine 2023年第1期6卷 41-47页

作者： Shuang-Hui Shi Meng-Lin Wang Xiao-Tong Wei Si-Yuan Ma Yu-Feng Hu Jing-Qiu Zhang Hui-Nan Wang Meng-Yu Chen qian-qian liu Ying-Zi Wang School of Chinese Materia Medica Beijing University of Chinese Medicine102488BeijingChina

Objective To reveal the mechanism of Huangjing pill in treating Alzheimer’s disease(AD)based on network pharmacology and molecular docking *** We obtained the active ingredients and targets of Huangjing pill through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,and supplemented the effective components by consulting literature and predicted targets through the PharmMapper *** used DrugBank,the GeneCards,the TTD,and the OMIM database to collect targets of *** Venn diagram was drawn and the key targets of Huangjing pill in the treatment of AD were obtained by Venny 2.1 *** Cytoscape 3.8.1 software was used to construct a network diagram of“drugs-active ingredients-key targets-disease”.The protein-protein interaction(PPI)network diagram was constructed through the STRING 11.5 *** database was used for Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment *** Vina1.1.2 software was used for molecular docking of the active components and core targets,and PyMOL 1.***.2.1 software was used for visual *** After screening,we obtained 13 active ingredients and 116 targets of Huangjing Pill,1438 related targets for AD,and 75 common targets.566 items by GO enrichment analysis and 149 items related to KEGG pathway enrichment were *** docking results showed that there is a strong affinity between the key active ingredients and the core *** This study revealed that Huangjing pill could treat AD through multiple components,multiple targets and multiple pathways.

关键词： Huangjing pill Alzheimer’s disease Network pharmacology Molecule docking

Effect of Toosendan Fructus before and after stir-frying process extract on CYP450 enzyme activities in rats in vivo and vitro by cocktail probe drug method

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TMR Modern Herbal Medicine 2023年第2期6卷 1-8页

作者： Yu-Feng Hu Si-Yuan Ma Meng-Lin Wang Shuang-Hui Shi Xiao-Tong Wei Ming-Rui Jiang Hui-Nan Wang Jing-Qiu Zhang qian-qian liu Ying-Zi Wang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China.

Background:The traditional Chinese medicine Toosendan Fructus has certain hepatotoxicity,which is used after being processed by stir-frying to attenuate ***,there are few studies on its attenuating toxicity *** effects of Toosendan Fructus on the activities of CYP450P1A2,CYP2E1 and CYP3A4 were studied in vivo and in vitro and the dose-toxicity mechanism of hepatotoxicity before and after stir-frying was explored to provide the basis for safe,rational use of Toosendan ***:The rat liver microsomes in vitro incubation method and in vivo pharmacokinetics were used to detect the concentrations of phenacetin,chlorzoxazone and dapsone in the liver microsomes in vitro incubation system and the rat plasma to study the effect of stir-frying of Toosendan Fructus on the activity of CYP450P1A2,CYP2E1,***:The results of pharmacokinetics in vivo showed that the AUC of phenacetin and dapsone in different groups was lower,and CL value was higher than those of the normal *** the same dose,the AUC of stir-fried Toosendan Fructus was higher than that of the raw,while CL value was *** the same processed product,AUC value was high-dose>low-dose>middle-dose group,CL value was high-dose

关键词： Toosendan Fructus toxicology pharmacokinetics CYP450

Key genes of deficiency of liver and kidney type chronic pain through bioinformatics analyses

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TMR Modern Herbal Medicine 2022年第2期5卷 1-8页

作者： Zhi-Cheng Wang Ming-Rui Jiang Zhu-Zhu Yue Xiao-Tong Wei Shuang-Hui Shi Meng-Lin Wang Hui-Nan Wang qian-qian liu Jing-Qiu Zhang Meng-Yu Chen Ying-Zi Wang School of Chinese Materia Medica Beijing University of Chinese Medicine102488BeijingChina

Objective To screen the key genes of chronic pain and provide a reference for the treatment of chronic *** We performed comprehensive bioinformatics analysis by screening chronic primary pain-related datasets to obtain differentially expressed genes(DEGs)and then imported DEGs into the DAVID database for Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment *** Set Enrichment Analysis(GESA)analysis was done by GSEA_4.1.0 *** the same time,we imported the intersecting genes into the STRING database and processed them by Cytoscape_3.8.1 software to obtain the protein-protein interaction(PPI)network and the central *** As a result,a total of 54 DEGs were screened,including 47 up-regulated genes,1 down-regulated gene,and 6 genes that were expressed differently in different datasets.23 GO terms and 8 KEGG pathways were enriched by *** network analysis found that SPI1,STAT3,TNFRSF1B,PTGS2,and CXCL1 genes interacted more strongly with other genes,and were predicted to be key genes in chronic primary *** Our results suggested that 5 DEGs,STAT3,SPI1,TNFRSF1B,PTGS2,and CXCL1,have the potential to be used as prognostic and predictive markers for the clinical management of patients with this disease.

关键词： Chronic pain Differentially expressed genes Functional enrichment analysis Protein-protein interaction network

Prevalence and influencing factors of poly-victimization in Chinese children

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Prevalence and influencing factors of poly-victimization in ...

Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

第十九届世界儿童及青少年精神卫生与相关学科学术会议

作者： CAO Feng-lin KONG Zhen DONG Fang-hong LI Yu-li CHENG Pei-xia CHEN qian-qian and liu Jia-jia Nursing school of Shandong University China

＜正＞Background To explore the prevalence of Poly-Victimization and influencing factors in children. Methods Six hundred and twenty-four primary school students were administered the self-rating version of Juvenile Victimization Questionnaire（JVQ）.We analyzed the influencing factors of poly-victimization via logistic regression. Results 72.28%of students had experienced at least one form of the 33 *** top four victimizations were vandalism

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang Lulu Jin Jinke Wang Rongqiao Wang Xiuchun liu Kai Gao Jingli Sun Yong Yuan Lingwei Ma Hongchang qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

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可瓷化硅橡胶材料的研究

高分子通报 2017年第9期 45-53页

作者：郑典模陈昕兰倩倩刘洋陈秋霞刘巍巍南昌大学资源环境与化工学院南昌330031

研究了一种可瓷化硅橡胶,其特点是在火灾发生时可在金属线外形成瓷化绝缘保护层,600℃的成瓷温度大幅度低于目前文献报道的成瓷温度。实验得到的优化瓷化填料配方为:相对于100份混炼胶,氧化铝10份、硅灰石15份、结构控制剂9份、碳酸锂3... 详细信息

研究了一种可瓷化硅橡胶,其特点是在火灾发生时可在金属线外形成瓷化绝缘保护层,600℃的成瓷温度大幅度低于目前文献报道的成瓷温度。实验得到的优化瓷化填料配方为:相对于100份混炼胶,氧化铝10份、硅灰石15份、结构控制剂9份、碳酸锂3份。在此配方条件下,未瓷化硅橡胶的断裂伸长率316%、拉伸强度10.79MPa、体积电阻率134×10^(12)Ω·cm,其在600℃、800℃瓷化后的抗压强度分别为3.47MPa、10.13MPa、体积电阻率≥28×10^(12)Ω·cm,满足电缆用硅橡胶的力学和绝缘要求。经热重分析及SEM分析可知加入瓷化填料后,试样烧蚀重量减少了39.4%,烧蚀残留率大大提高,且成瓷试样结构致密。

关键词：瓷化硅橡胶氧化铝硅灰石结构控制剂

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Mimic synthesis and production of the natural chiral compounds

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Mimic synthesis and production of the natural chiral compoun...