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物理学报 2001年第5期50卷 926-932页

作者：王谦何赛灵浙江大学光电系现代光学仪器国家重点实验室光与电磁波研究中心杭州310027

用差分迭代法计算了扭曲、超扭曲以及混合排列丝状液晶在电场中指向矢的空间分布 ,与牛顿法和张弛法的计算作了比较 ;

关键词：液晶指向矢差分迭代牛顿法张弛法扭曲丝状液晶盒超扭曲丝状液晶盒混合排列丝状液晶盒电光特性模拟计算

On the Nonlinear Growth of Multiphase Richtmyer-Meshkov Instability in Dilute Gas-Particles Flow

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Chinese Physics Letters 2020年第1期37卷 24-28页

作者： Huan Zheng qian Chen Baoqing Meng Junsheng Zeng Baolin Tian Institute of Applied Physics and Computational Mathematics Beijing 100094 College of Engineering Peking UniversityBeijing 100871

We discuss evolutions of nonlinear features in Richtmyer-Meshkov instability(RMI)f which are known as spikes and *** single-phase RMI,the nonlinear growth has been extensively studied but the relevant investigation in multiphase RMI is ***,we illustrate the dynamic coupling behaviors between gas phase and particle phase and then analyze the growth of the nonlinear features theoretically.A universal model is proposed to describe the nonlinear finger(spike and bubble)growth velocity qualitatively in multiphase *** the effects of gas and particles have been taken into consideration in this ***,we derive the analytical expressions of the nonlinear growth model in limit cases(equilibrium How and frozen How).A novel compressible multiphase particle-in-cell(CMP-PIC)method is used to validate the applicability of this *** finger growth velocity matches well with our *** present study reveals that particle volume fraction,particle density and Stokes number are the three key factors,which dominate the interphase momentum exchange and further induce the unique property of multiphase RMI.

关键词： multiphase nonlinear Nonlinear

A Derivation of the Entropy-Based Relativistic Smoothed Particle Hydrodynamics by Variational Principle

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Communications in Theoretical Physics 2017年第9期67卷 382-386页

作者： Philipe Mota Wei-Xian Chen Wei-Liang qian Centro Brasileiro de Pesquisas Fisicas R J Brazil Escola de Engenharia de Lorena Universidade de Sgo Paulo SP Brazil Instituto de Ffsica e Qufmica Universidade Estadual Paulista Jdlio de Mesquita Filho SP Brazil

In this work, a second order smoothed particle hydrodynamics is derived for the study of relativistic heavy ion collisions. The hydrodynamical equation of motion is formulated in terms of the variational principle. In order to describe the fluid of high energy density but of low baryon density, the entropy is taken as the base quantity for the interpolation. The smoothed particle hydrodynamics algorithm employed in this study is of the second order, which guarantees better particle consistency. Furthermore, it is shown that the variational principle preserves the translational invariance of the system, and therefore improves the accuracy of the method. A brief discussion on the potential implications of the model in heavy ion physics as well as in general relativity are also presented.

关键词： hydrodynamics SPH method variational principle

Observation of atomic steps on CaCO_3 crystal surface

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Nuclear Science and Techniques 1998年第2期9卷 90-91页

作者： Sun Jie-Lin Hu Jun Zhang Yi Chen Sheng-Fu Ouyang Zhen-qian and Li Min-qian (Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800 ) Shangfiai Institute of Nuclear Research Chinese Academy of Sciences Slianghai 201800 China

By using scanning polarization force microscopy,the deliquescence process and the atomic steps on the cleavage surface of CaCO3 in air were studied in *** an exposure to medium umidity(-57%),the sloiw step movement ha... 详细信息

关键词： CaCO3晶体表面原子阶跃观测

Methological Quality of Systematic Reviews and Meta-Analyses on Acupuncture for Stroke: A Review of Review

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Chinese Journal of Integrative Medicine 2017年第11期23卷 871-877页

作者： CheN Xin-lin MO Chuan-wei LU Li-ya GAO Ri-yang XU qian WU Min-feng ZHOU qian-yi HU Yue ZHOU Xuan LI Xian-tao College of Basic Medical Science Guangzhou University of Chinese Medicine Public health Institute of Health and Wellbeing University of Glasgow First Clinical College Guangzhou University of Chinese Medicine

Objective： To assess the methodological quality of systematic reviews and meta-analyses regarding acupuncture intervention for stroke and the primary studies within them. Methods： Two researchers searched Pub Med, Cumulative index to Nursing and Allied health Literature, Embase, ISI Web of Knowledge, Cochrane, Allied and Complementary Medicine, Ovid Medline, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang and Traditional Chinese Medical Database to identify systematic reviews and meta-analyses about acupuncture for stroke published from the inception to December 2016. Review characteristics and the criteria for assessing the primary studies within reviews were extracted. The methodological quality of the reviews was assessed using adapted Oxman and Guyatt Scale. The methodological quality of primary studies was also assessed. Results： Thirty-two eligible reviews were identified, 15 in English and 17 in Chinese. The English reviews were scored higher than the Chinese reviews（P=0.025）, especially in criteria for avoiding bias and the scope of search. All reviews used the quality criteria to evaluate the methodological quality of primary studies, but some criteria were not comprehensive. The primary studies, in particular the Chinese reviews, had problems with randomization, allocation concealment, blinding, dropouts and withdrawals, intent-to-treat analysis and adverse events. Conclusions： Important methodological flaws were found in Chinese systematic reviews and primary studies. It was necessary to improve the methodological quality and reporting quality of both the systematic reviews published in China and primary studies on acupuncture for stroke.

关键词： systematic review meta-analyses stroke acupuncture review of review methodological quality

Homocysteine-Induced Disturbances in DNA Methylation Contribute to Development of Stress-Associated Cognitive Decline in Rats

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Neuroscience Bulletin 2022年第8期38卷 887-900页

作者： Shi-Da Wang Xue Wang Yun Zhao Bing-Hua Xue Xiao-Tian Wang Yu-Xin Chen Zi-qian Zhang Ying-Rui Tian Fang Xie Ling-Jia qian Institute of Military Cognitive and Brain Sciences Academy of Military Medical SciencesBeijing100850China 8th People’s Hospital of Qingdao Qingdao266041China School of Public health Lanzhou UniversityLanzhou730000China

Chronic stress is generally accepted as the main risk factor in the development of cognitive decline;however,the underlying mechanisms remain *** data have demonstrated that the levels of homocysteine(Hcy)are significantly elevated in the plasma of stressed animals,which suggests that Hcy is associated with stress and cognitive *** test this hypothesis,we analyzed the cognitive function,plasma concentrations of Hcy,and brain-derived neurotropic factor(BDNF)levels in rats undergoing chronic unpredicted mild stress(CUMS).The results showed that decreased cognitive behavioral performance and decreased BDNF transcription and protein expression were correlated with hyperhomocysteinemia(HHcy)levels in stressed ***-induced HHcy mimicked the cognitive decline and BDNF downregulation in the same manner as CUMS,while Hcy reduction(by means of vitamin B complex supplements)alleviated the cognitive deficits and BDNF reduction in CUMS ***,we also found that both stress and HHcy disturbed the DNA methylation process in the brain and induced DNA hypermethylation in the BDNF *** contrast,control of Hcy blocked BDNF promoter methylation and upregulated BDNF levels in the *** results imply the possibility of a causal role of Hcy in stress-induced cognitive *** also used ten-eleven translocation(TET1),an enzyme that induces DNA demethylation,to verify the involvement of Hcy and DNA methylation in the regulation of BDNF expression and the development of stress-related cognitive *** data showed that TET1-expressing viral injection into the hippocampus inhibited BDNF promoter methylation and significantly mitigated the cognitive decline in HHcy *** together,novel evidence from the present study suggests that Hcy is likely involved in chronic stress-induced BDNF reduction and related cognitive *** addition,the negative side-effects of HHcy may be associated with Hcy-induced DNA hypermethylation in the BDN

关键词： Stress-associated cognitive decline Homocysteine DNA methylation BDNF

helicobacter pylori infection alters gastric microbiota structure and biological functions in patients with gastric ulcer or duodenal ulcer

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World Journal of Gastroenterology 2024年第24期30卷 3076-3085页

作者： Ling-Xiao Jin Yu-Peng Fang Chen-Mei Xia Teng-Wei Cai qian-qian Li Yu-Yin Wang Hai-Fan Yan Xia Chen Department of Gastroenterology Wenling Hospital of Wenzhou Medical University(The First People’s Hospital of Wenling)Wenling 317500Zhejiang ProvinceChina

BACKGROUND helicobacter pylori(***)infection is closely associated with gastrointestinal *** preliminary studies have indicated that *** infection had a significant impact on the mucosal microbiome structure in patients with gastric ulcer(GU)or duodenal ulcer(DU).AIM To investigate the contributions of *** infection and the mucosal microbiome to the pathogenesis and progression of ulcerative *** Patients with *** infection and either GU or DU,and healthy individuals without *** infection were *** or duodenal mucosal samples was obtained and subjected to metagenomic *** compositions of the microbial communities and their metabolic functions in the mucosal tissues were *** Compared with that in the healthy individuals,the gastric mucosal microbiota in the ***-positive patients with GU was dominated by ***,with signi-ficantly reduced *** intergroup differential functions,which were enriched in the ***-positive GU patients,were all derived from ***,particularly those concerning transfer RNA queuosine-modification and the synthesis of demethylmenaquinones or menaquinones.A significant enrichment of the uibE gene was detected in the synthesis *** was no significant difference in microbial diversity between the ***-positive DU patients and healthy *** *** infection significantly alters the gastric microbiota structure,diversity,and biological functions,which may be important contributing factors for GU.

关键词： helicobacter pylori Gastric ulcer Duodenal ulcer Metagenomic sequencing Transfer RNA queuosine-modification Menaquinones

Pneumocystis jirovecii diagnosed by next-generation sequencing of bronchoscopic alveolar lavage fluid: A case report and review of literature

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World Journal of Clinical Cases 2023年第4期11卷 866-873页

作者： Qing-Wei Cheng Hong-Li Shen Zhi-Hui Dong qian-qian Zhang Ya-Fen Wang Jin Yan Yu-Sheng Wang Ning-Gang Zhang Department of Oncology The Sixth Division HospitalXinjiang Production and Construction CorpsWujiaqu 831300Xinjiang Uygur Autonomous RegionsChina Department of Gastrointestinal Oncology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013Shanxi ProvinceChina

BACKGROUND The advent of molecular targeted agents and immune checkpoint inhibitors has greatly improved the treatment of advanced renal cell carcinoma(RCC), thus significantly improving patient survival. The incidence of rare drug-related adverse events has gained increased *** SUMMARY We report a patient with advanced RCC treated with multiple lines of molecular targeted agents and immune checkpoint inhibitors, who developed a pulmonary infection after treatment with everolimus in combination with lenvatinib. Determining the pathogenic organism was difficult, but it was eventually identified as Pneumocystis jirovecii by next-generation sequencing(NGS) of bronchoscopic alveolar lavage fluid(BALF) and successfully treated with *** Rare pulmonary infections caused by molecular targeted agents are not uncommon in clinical practice, but their diagnosis is difficult. Evaluating BALF with NGS is a good method for rapid diagnosis of such infections.

关键词： Renal cell carcinoma Everolimus Pneumocystis jirovecii pneumonia Next-generation sequencing Bronchoscopic alveolar lavage fluid Case report

Microscopic study of higher-order deformation effects on the ground states of superheavy nuclei around^(270)Hs

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Chinese Physics C 2022年第2期46卷 140-148页

作者： Xiao-qian Wang Xiang-Xiang Sun Shan-Gui Zhou CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of ScienceBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

We investigate the effects of higher-order deformations β_(λ)(λ=4,6,8,and 10)on the ground state prop-erties of superheavy nuclei(SHN)near the doubly magic deformed nucleus ^(270)Hs using the multidimensionally-con-strained relativistic mean-field(MDC-RMF)model with five effective interactions:PC-PK1,PK1,NL3^(+),DD-ME2,and *** doubly magic properties of ^(270)Hs include large energy gaps at N=162 and Z=108 in the single-particle *** investigating the binding energies and single-particle levels of ^(270)Hs in the multidimensional de-formation space,we find that,among these higher-order deformations,the deformationβ6 has the greatest impact onthe binding energy and influences the shell gaps *** conclusions hold for other SHN near ^(270)*** calculations demonstrate that the deformation β_(6) must be considered when studying SHN using MDC-RMF.

关键词： density functional theory superheavy nuclei deformation effects

Globus hystericus co-treated with acupuncture and five-element music therapy

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World Journal of Acupuncture-Moxibustion 2019年第1期29卷 80-82页

作者： Lin-xia qian Fa-cai LIN Second Clinical Medical School Nanjing University of Chinese MedicineNanjing 210023China

In order to mutually regulate mental and physical conditions, the authors adopted acupuncture in combination with five-element music therapy of traditional Chinese medicine(TCM) for 1 case of globus hystericus. Bǎihui(百会 GV 20),Hégǔ(合谷 LI 4)、Zhōngwǎn(中脘 CV 12).Qìhǎi(气海 CV 6) et al. were needled once every other day and music of Zhi tone was played for the patient. A further study is needed for the application of this therapeutic method.

关键词： Acupuncture Five-element music Music therapy Emotion Globus hystericus