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Recombinant adeno-associated virus carrying thymosin β4 suppresses experimental colitis in mice

World Journal of Gastroenterology 2017年第2期23卷 242-255页

作者： Xiao-Yan Zheng Yi-Fei Lv Shuang Li qian Li qian-nan zhang Xue-Ting zhang Zhi-Ming Hao Department of Rheumatology The First Affiliated Hospital of Xi’an Jiaotong University Department of Gastroenterology Shaanxi Provincial People’s Hospital Department of Gastroenterology The First Affiliated Hospital of Xi’an Jiaotong University

AIMTo investigate the protective effect of a recombinant adeno-associated virus carrying thymosin β4 (AAV-Tβ4) on murine colitis via intracolonic ***-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons. Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn’s disease. The disease severity and colon injuries were observed and graded to reveal the effects of AAV-Tβ4 on colitis. The activities of myeloperoxidase (MPO) and superoxide dismutase (SOD) and the content of malondialdehyde (MDA) were determined using biochemical assays. Colonic levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-10 were measured using ELISA, and mucosal epithelial cell apoptosis and proliferation were detected by TUNEL assay and immunochemistry, *** AAVs efficiently delivered LacZ and Tβ4 into the colonic tissues of the mice, and AAV-Tβ4 led to a strong expression of Tβ4 in mouse colons. In both the DSS and TNBS colitis models, AAV-Tβ4-treated mice displayed distinctly attenuated colon injuries and reduced apoptosis rate of colonic mucosal epithelia. AAV-Tβ4 significantly reduced inflammatory cell infiltrations and relieved oxidative stress in the inflamed colons of the mice, as evidenced by decreases in MPO activity and MDA content and increases in SOD activity. AAV-Tβ4 also modulated colonic TNF-α, IL-1β and IL-10 levels and suppressed the compensatory proliferation of colonic epithelial cells in DSS- and TNBS-treated ***β4 exerts a protective effect on murin

关键词： Thymosin β 4 Mice Colitis Dextran sulfate sodium 2 4 6-trinitrobenzene sulfonic acid

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Nebulized Mycobacterium vaccae protects against asthma by attenuating the imbalance of IRF4/IRF8 expression in dendritic cells

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Asian Pacific Journal of Tropical Biomedicine 2022年第12期12卷 520-529页

作者： Qi-Xiang Sun Si-Yue Xu Lao-Dong Li Huan Xiao qian-nan zhang Chao-qian Li Department of Respiratory Medicine The First Affiliated Hospital of Guangxi Medical UniversityNanningChina

Objective:To assess the effects of nebulized inhaled Mycobacterium vaccae on allergic airway inflammation,airway hyperresponsiveness,and Th1/Th2 cell imbalance in mice with ovalbumin(OVA)-induced ***:Mice received OVA sensitization and challenge for establishment of the asthmatic *** intervention,mice received Mycobacterium vaccae nebulization once every other day from the first day of sensitization to the day before *** challenge,pulmonary histological analysis and airway responsiveness measurement were *** addition,Th1/Th2 cytokines and OVA-specific IgE levels in bronchoalveolar lavage fluid were measured by ***1/Th2 subset ratios and the expression of interferon-regulatory factor 4(IRF4),IRF8 and Toll-like receptor 4(TLR4)in dendritic cells were evaluated by flow ***:Severe inflammatory infiltration and airway hyperresponsiveness were observed in OVA-induced asthmatic *** mice showed higher Th2 cytokine concentration and increased percentage of Th2 cells,along with lower Th1 cytokine concentration and reduced percentage of Th1 cells compared with the normal ***,an imbalance of IRF4^(+)and IRF8^(+)in dendritic cells was found in asthmatic *** inhaled Mycobacterium vaccae reduced airway hyperresponsiveness and inflammation in OVA-induced asthmatic *** addition,nebulized inhaled Mycobacterium vaccae enhanced TLR4 and IRF8 expression,and alleviated the imbalance of Th1/Th2 as well as IRF4^(+)and IRF8^(+)in dendritic ***:Nebulized inhaled Mycobacterium vaccae protects against asthma by alleviating the imbalance of Th1/Th2 and IRF4/IRF8 in OVA-induced asthmatic mice.

关键词： Mycobacterium vaccae Asthma Nebulization IRF4 IRF8 TLR4

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QoS Routing Optimization Based on Deep Reinforcement Learning in SDN

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Computers, Materials & Continua 2024年第5期79卷 3007-3021页

作者： Yu Song Xusheng qian nan zhang Wei Wang Ao Xiong State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing100876China Marketing Service Center State Grid Jiangsu Electric Power Co.Ltd.Nanjing220000China Customer Service Center State Grid Co.Ltd.Nanjing211161China

To enhance the efficiency and expediency of issuing e-licenses within the power sector, we must confront thechallenge of managing the surging demand for data traffic. Within this realm, the network imposes stringentQuality of Service (QoS) requirements, revealing the inadequacies of traditional routing allocation mechanismsin accommodating such extensive data flows. In response to the imperative of handling a substantial influx of datarequests promptly and alleviating the constraints of existing technologies and network congestion, we present anarchitecture forQoS routing optimizationwith in SoftwareDefinedNetwork (SDN), leveraging deep reinforcementlearning. This innovative approach entails the separation of SDN control and transmission functionalities, centralizingcontrol over data forwardingwhile integrating deep reinforcement learning for informed routing decisions. Byfactoring in considerations such as delay, bandwidth, jitter rate, and packet loss rate, we design a reward function toguide theDeepDeterministic PolicyGradient (DDPG) algorithmin learning the optimal routing strategy to furnishsuperior QoS provision. In our empirical investigations, we juxtapose the performance of Deep ReinforcementLearning (DRL) against that of Shortest Path (SP) algorithms in terms of data packet transmission delay. Theexperimental simulation results show that our proposed algorithm has significant efficacy in reducing networkdelay and improving the overall transmission efficiency, which is superior to the traditional methods.

关键词： Deep reinforcement learning SDN route optimization QoS

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Simulation of gas-solids heat transfer in cyclone pyrolyzer using CFD-DEM model

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Particuology 2024年第2期85卷 155-166页

作者： nan zhang Xueer Pan Jingxuan Yang qian Liu Wenhao Lian Xiao Du Zhonglin zhang Xiaogang Hao Guoqing Guan College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan030024China School of Chemistry and Chemical Engineering North University of ChinaTaiyuan030051China Shanxi Jinke Technology Service Company Limited Taiyuan030000China Labraory of Eey onveron Engineerng Institute f Rgional Innvation(RI)Hosaki Univerty3-BunkychoHiroak036-8561Japan

Fast heat transfer in the pyrolyzer can increase the yield of pyrolysis gas and tar,and improve the quality of *** with the downer pyrolyzer,the cyclone pyrolyzer can simultaneously achieve high solids holdup and violent turbulence,and correspondingly faster heat *** this work,the heat transfer behavior in the cyclone pyrolyzer is specifically studied using the computational fluid dynamics-discrete element *** simulation results reveal that the gas-solids heat convection contributes mainly to the heat transfer process,and the heat radiation and conduction are relatively small and almost negligible,*** with the downer pyrolyzer under the same operating conditions,the heating rate is significantly increased in the cyclone *** analyzing the flow characteristics in the cyclone pyrolyzer,it is found that the region of high convective heat transfer rate coincides with that of natural cyclone ***,the final coal temperature increases with the increase of gas velocity and exists a maximum *** results can offer some qualitative understanding of the heat transfer behavior in the cyclone pyrolyzer.

关键词： Cyclone pyrolyzer Rapidly heating Heat convection Natural cyclone length CFD-DEM

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Enhancing alkaline water oxidation with NiFe alloy-encapsulated nitrogen-doped vertical graphene array

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nano Research 2024年第6期17卷 4790-4796页

作者： Jue nan Beirong Ye Xun He Chen Li Wanli zhang qian Liu Luming Li Wei Chu Xuping Sun Yongqi zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengdu 611731China Institute for Advanced Study Chengdu UniversityChengdu 610106China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China

Advancing efficient and affordable electrocatalysts to boost the oxygen evolution reaction(OER)is pivotal for sustainable green hydrogen ***,we propose the fabrication of nickel-iron alloy nanoparticles-encapsulated on N-doped vertically aligned graphene array on carbon cloth(NiFe@NVG/CC)as a highly active three-dimensional(3D)catalyst electrode for *** 1 M KOH,such NiFe@NVG/CC demonstrates outstanding catalytic performance,necessitating merely overpotential of 245 mV for achieving a current density of 10 mA·cm^(−2),a remarkably low Tafel slope of 36.2 mV·dec^(−1).Furthermore,density functional theory calculations validate that the incorporate of N species into graphene can reinforce the electrocatalytic activity though reducing the reaction energy barrier during the conversion of*O to*OOH *** outstanding performance and structural benefits of NiFe@NVG/CC offer valuable insights for the development of innovative and efficient electrocatalysts for water oxidation.

关键词： NiFe alloy N-doped vertical graphene array electrocatalyst oxygen evolution reaction density functional theory

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Enhanced quality of Al2O3/SiC gate stack via microwave plasma annealing

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Rare Metals 2024年第10期43卷 5362-5371页

作者： nan-nan You Xin-Yu Liu qian zhang Zhen Wang Jia-Yi Wang Yang Xu Xiu-Yan Li Yu-Zheng Guo Sheng-Kai Wang High-Frequency High-Voltage Device and Integrated Circuits R&D Center Institute of Microelectronics of the Chinese Academy of Sciences School of Integrated Circuits University of Chinese Academy of Sciences School of Electrical Engineering and Automation Wuhan University Department of Micro/nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong University

The high-quality gate dielectric on silicon carbide （SiC） surface is critical to fabricate high-performance SiC metal-oxide-semiconductor field-effect transistors（MOSFETs）.This research employs microwave plasma annealing （MPA） to obtain high-quality Al2O3/SiC gate *** designing MPA atmosphere and optimizing the plasma power,the SiC MOS capacitor with a Al2O3dielectric film shows the enhanced *** interface state density is reduced by 1 order of magnitude to 6×1011cm-2·eV-1,the breakdown electric field is increased,and the voltage shift is effectively suppressed Besides,the mechanism of MPA process is discussed in terms of the thermal effect and reactant species.X-ray photoelectron spectroscopy （XPS） results unveil oxygen plasma plays the main *** plasma power during the MPA process results in defect repairs of the firstneighbor Al-O bonding and partial removal of Al-O-H bond from the interface *** study demonstrates that MPA process is an effective option to realize highquality dielectric and interface on SiC.

关键词： Al2O3 Defect repairs Metal–oxide–semiconductor Microwave plasma annealing Silicon carbide X-ray photoelectron spectroscopy

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High-performance localized high-concentration electrolytes by diluent design for long-cycling lithium metal batteries

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Chinese Chemical Letters 2024年第4期35卷 244-247页

作者： Zhe Wang Li-Peng Hou qian-Kui zhang nan Yao Aibing Chen Jia-Qi Huang Xue-qiang zhang College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018China Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China

Electrolyte design is essential for stabilizing lithium metal anodes and localized high-concentration electrolyte(LHCE) is a promising one. However, the state-of-the-art LHCE remains insufficient to ensure long-cycling lithium metal anodes. Herein, regulating the solvation structure of lithium ions in LHCE by weakening the solvating power of diluents is proposed for improving LHCE performance. A diluent,1,1,2,2,3,3,4,4-octafluoro-5-(1,1,2,2-tetrafluoroethoxy) pentane(OFE), with weaker solvating power is introduced to increase the proportion of aggregates(an anion interacts with more than two lithium ions,AGG-n) in electrolyte compared with the commonly used 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether(TTE). The decomposition of AGG-n in OFE-based LHCE intensifies the formation of anion-derived solid electrolyte interphase and improves the uniformity of lithium deposition. Lithium metal batteries with OFE-based LHCE deliver a superior lifespan of 190 cycles compared with 90 cycles of TTE-based LHCE under demanding conditions. Furthermore, a pouch cell with OFE-based LHCE delivers a specific energy of 417 Wh/kg and undergoes 49 cycles. This work provides guidance for designing high-performance electrolytes for lithium metal batteries.

关键词： Lithium metal anodes Electrolyte Diluents Solid electrolyte interphase Pouch cells

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Interfacial Oxygen Octahedral Coupling-Driven Robust Ferroelectricity in Epitaxial Na_(0.5)Bi_(0.5)TiO_(3)Thin Films

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Research 2024年第2期2023卷 149-157页

作者： Haojie Han Qinghua zhang Wei Li Yiqun Liu Jiasheng Guo Yue Wang qian Li Lin Gu Ce-Wen nan Jing Ma State Key Laboratory of New Ceramics and Fine Processing Schoolof Materials Science and EngineeringTsinghua UniversityBeijing 100084China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

The oxygen octahedral rotation(OOR)forms fundamental atomic distortions and symmetries in perovskite oxides and definitely determines their properties and ***,epitaxial strain and interfacial structural coupling engineering have been developed to modulate the OOR patterns and explore novel properties,but it is difficult to distinguish the 2 ***,different symmetries are induced in Na_(0.5)Bi_(0.5)TiO_(3)(NBT)epitaxial films by interfacial oxygen octahedral coupling rather than epitaxial *** NBT film grown on the Nb:SrTiO_(3)substrate exhibits a paraelectric tetragonal phase,while with La_(0.5)Sr_(0.5)MnO_(3)as a buffer layer,a monoclinic phase and robust ferroelectricity are obtained,with a remanent polarization of 42μC cm^(-2)and a breakdown strength of 7.89 MV cm^(-1),which are the highest record among NBT-based ***,the interfacial oxygen octahedral coupling effect is demonstrated to propagate to the entire thickness of the film,suggesting an intriguing long-range *** work provides a deep insight into understanding the structure modulation in perovskite heterostructures and an important avenue for achieving unique functionalities.

关键词： effect. interfacial coupling

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Intelligent secure near-field communication

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Science China(Information Sciences) 2024年第9期67卷 340-341页

作者： nan zhang Jifa zhang Chengwen XING Na DENG nan ZHAO School of Information and Communication Engineering Dalian University of Technology School of Information and Electronics Beijing Institute of Technology

The research and development efforts for the sixth generation(6G) wireless communication are underway to fulfill the growing demands for wireless communications. 6G is expected to become the key enabler for diverse new applications and services [1]. To achieve the excellent performance, 6G will implement extremely large-scale antenna arrays(ELAAs), terahertz [2], and new types of antennas with metamaterials, leading to a paradigm shift for the electromagnetic characteristics.

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BLS-identification:A device fingerprint classification mechanism based on broad learning for Internet of Things

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Digital Communications and Networks 2024年第3期10卷 728-739页

作者： Yu zhang Bei Gong qian Wang Faculty of Information Technology Beijing University of TechnologyBeijing100124China School of Information Science and Technology Zhengzhou Normal UniversityHenan450044China

The popularity of the Internet of Things(IoT)has enabled a large number of vulnerable devices to connect to the Internet,bringing huge security *** a network-level security authentication method,device fingerprint based on machine learning has attracted considerable attention because it can detect vulnerable devices in complex and heterogeneous access ***,flexible and diversified IoT devices with limited resources increase dif-ficulty of the device fingerprint authentication method executed in IoT,because it needs to retrain the model network to deal with incremental features or *** address this problem,a device fingerprinting mechanism based on a Broad Learning System(BLS)is proposed in this *** mechanism firstly characterizes IoT devices by traffic analysis based on the identifiable differences of the traffic data of IoT devices,and extracts feature parameters of the traffic packets.A hierarchical hybrid sampling method is designed at the preprocessing phase to improve the imbalanced data distribution and reconstruct the fingerprint *** complexity of the dataset is reduced using Principal Component Analysis(PCA)and the device type is identified by training weights using *** experimental results show that the proposed method can achieve state-of-the-art accuracy and spend less training time than other existing methods.

关键词： Device fingerprint Traffic analysis Class imbalance Broad learning system Access authentication

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