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International Journal of Dermatology and Venereology 2024年第2期7卷 99-107页

作者： Li-Qing Shi Shi-Hang Zhou Ping-Lang Ruan Bo Zhang Yue Xin Cheng Zhao Xu Yao jing-Ru Tian qian-jin lu Hospital for Skin Diseases(Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases Chinese Academy of Medical SciencesNanjingJiangsu 210042China Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs NanjingJiangsu 210042China Department of Dermatology Hunan Key Laboratory of Medical Epigenomicsthe Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China

Objective:Heterogeneity of participants in clinical trials distorts intervention ***,factors associated with participant heterogeneity in randomized clinical trials(RCTs)focusing on systemic sclerosis(SSc)are not *** conducted this systematic review to establish normative standards for future research and help develop management ***:Three databases and 4 registries were searched to identify characteristics of SSc RCTs across different *** of bias was assessed by the Cochrane Collaboration’s tool and logistic regression was performed to calculate crude and adjusted odds ***:In total,261 trials met our inclusion *** quality of SSc RCTs worldwide was relatively poor,with no trend of improvement in recent years,and only 12.2%were ranked as having a low risk of *** with a low risk of bias as well as single-center,single-country,or open-label trials tended to have better participant adherence than trials with a high risk of bias and multiple-center,multiple-country,or double-blind ***,trial registration and primary outcome definition contributed to high *** income was also relevant;participant adherence in high-income countries,but not in upper-and lower-middle-income countries,was significantly altered by different ***:Overall,the risk of bias,national income,and trial design may lead to participant heterogeneity of SSc RCTs and ultimately confound the general clinical utility of the *** with a rigorous design and transparent conduction protocol are crucial for obtaining unbiased data that can serve as a reference and for maintaining the fundamental repeatability of SSc RCTs.

关键词： systemic sclerosis randomized clinical trials heterogeneity participant adherence national income risk of bias

Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis

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Chinese Medical Journal 2016年第7期129卷 757-762页

作者： Ping Liu Yan Zhao Zhang-Lei Mu qian-jin lu qian-jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang Department of Dermatology Peking University People's Hospital Beijing 100044 China Department of Dermatology The Second Xiangya Hospital of Central South University Changsha Hunan 410011 China Department of Dermatology The First Hospital of China Medical University Shenyang Liaoning 110001 China Department of Dermatology Institute of Dermatology Chinese Academy of Medical Sciences Nanjing Jiangsu 210042 China Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Dermatology Tianjin Changzheng Hospital Tianjin 300120 China Department of Dermatology The Affiliated Hospital of Inner Mongolia Medical University Hohhot Inner Mongolia 010050 China Department of Dermatology Yantai Yuhuangding Hospital Yantai Shandong 264000 China Department of Dermatology The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China Department of Dermatology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Dermatology The Second Hospital of Dalian Medical University Dalian Liaoning 116023 China Department of Dermatology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Department of Dermatology Shanghai Huashan Hospital Shanghai 200040 China Department of Dermatology Xijing Hospital Xi'an Shaanxi 710032 China Department of Dermatology The Third Affiliated Hospital Of Sun Yat-sen University Guangzhou Guangdong 510630 China Department of Dermatology The Second Hospital of Heilongjiang Province Harbin Heilongjiang 150010 China Department of Dermatology Xiangya Hospital of Central South University Changsha Hunan 410008 China Department of Dermatology.Shengjing Hospital of China Medical University Shenyang Liaoning 110004 China Department of Dermatology Peking University Third Hospital Beijing 100191 China Department of Dermatology The First Affili

Background： Atopic dermatitis （AD） is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria have been proposed for the diagnosis of AD. Although the clinical features of childhood AD have been widely studied, there has been less large-scale study on adult/adolescent AD. The aim of this study was to investigate the clinical features of adult/adolescent patients with chronic symmetrical eczemaJAD and to propose Chinese diagnostic criteria for adult/adolescent AD. Methods： A hospital-based study was performed. Forty-two dermatological centers participated in this study. Adult and adolescent patients （12 years and over） with chronic symmetrical eczema or AD were included in this study. Questionnaires were completed by both patients and-investigators. The valid questionnaires were analyzed using EpiData 3.1 and SPSS 17.0 software. Results： A total of 2662 valid questionnaires were collected （1369 male and 1293 female）. Of all 2662 patients, 2062 （77.5%） patients had the disease after 12 years old, while only 600 （22.5%） patients had the disease before 12 years old, suggesting late-onset eczema/AD is common. Two thousand one hundred and thirty-nine （80.4%） patients had the disease for more than 6 months. One thousand one hundred and forty-four （43.0%） patients had a personal and/or family history of atopic diseases. One thousand five hundred and forty-eight （58.2%） patients had an elevated total serum IgE and/or eosinophilia and/or positive allergen-specific IgE. Based on these clinical and laboratory features, we proposed Chinese criteria for adult/adolescent AD. Of all 2662 patients, 60.3% were satisfied with our criteria, while only 48.2% satisfied with Hanifin Rajka criteria and 32.7% satisfied with Williams criteria, suggesting a good sensitivity of our criteria in adult/adolescent AD patients. Conclusion： Late-onset of eczema or AD is co

关键词： Adolescents and Adults Atopic Dermatitis Clinical Features Diagnostic Criteria Eczema

Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults

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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan Fang Li-Hui Li Ming-qian He Yue Ji Dong-Yan lu Li-Bing Zhang jin-Lan Yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the lubben Social Network Scale-6,12-item Short-Form Health Literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,P<0.001),social isolation impact on psycho-logical distress pre-frail older adults(β=-0.415,P<0.001);health literacy was identified effect on psychological distress among pre-frail older persons(β=-0.307,P<0.001).Health literacy partially mediated the relationship between social isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy Social isolation

A double-blind,randomized,placebo-and positive-controlled phase III trial of 1% benvitimod cream in mild-to-moderate plaque psoriasis

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Chinese Medical Journal 2020年第24期133卷 2905-2909页

作者： Lin Cai Gen-Hui Chen qian-jin lu Min Zheng Yu-Zhen Li jin Chen Jie Zheng Fu-Ren Zhang Jian-Bin Yu Sen Yang Fu-Qiu Li Sheng-Xiang Xiao Qiu-Ning Sun jin-Hua Xu Xing-Hua Gao Hong Fang Tian-Wen Gao Fei Hao Quan-Zhong Liu Ya-Ting Tu Ruo-Yu Li Bao-Xi Wang Dan-Qi Deng Qing-Shan Zheng Hong-Xia Liu Jian-Zhong Zhang Department of Dermatology Peking University People’s HospitalBeijing 100044China Beijing Wenfeng Tianji Pharma Ltd. Beijing 100044China Department of Dermatology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China Department of Dermatology Harbin Medical University Second HospitalHarbinHeilongjiang 150001China Department of Dermatology Sichuan Provincial People’s HospitalChengduSichuan 610072China Department of Dermatology Shanghai JiaoTong University School of Medicine Ruijin HospitalShanghai 213002China Shandong Provinical Institute of Dermatology and Venereology JinanShandong 250022China Department of Dermatology The First Affiliated HospitalZhengzhou UniversityZhengzhouHenan 450052China Department of Dermatology The First Affiliated HospitalAnhui Medical UniversityHefeiAnhui 230022China Department of Dermatology The Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Dermatology The Second Affiliated HospitalXi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Dermatology Peking Union Medical College HospitalBeijing 100730China Department of Dermatology Fudan University Huashan HospitalShanghai 200041China Department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Dermatology The First Affiliated HospitalZhejiang UniversityHangzhouZhejiang 310006China Department of Dermatology Xijing HospitalAir Force Medical University of People’s Liberation ArmyXi’anShaanxi 710032China Department of Dermatology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Dermatology Tianjin Medical University General HospitalTianjin 300052China Department of Dermatology Wuhan Union HospitalWuhanHubei 430022China Department of Dermatology Peking University First HospitalBeijing

Background:Benvitimod cream,a novel synthetic small molecule,was effective in treating mild-to-moderate plaque *** conducted a phase III clinical trial to assess the efficacy and safety of benvitimod cream in patients with mild-to-moderate plaque ***:We randomly assigned 686 patients(2:1:1)to receive 1%benvitimod cream,0.005%calcipotriol ointment or placebo twice a day for 12 *** primary efficacy end points were the percentage of patients with a 75%or greater reduction from baseline in the psoriasis area and severity index(PASI 75)score and with a score of 0 or 1 in static physician’s global assessment(sPGA)at week ***:The results showed that 50.4%of patients in the benvitimod group achieved PASI 75,which was significantly higher than that in the calcipotriol(38.5%,Pluded application site irritation,follicular papules,and contact *** systemic adverse reactions were ***:During this 12-week study,benvitimod cream was demonstrated with high effectiveness and safety in patients with mild-to-moderate plaque psoriasis.

关键词： Psoriasis Benvitimod Immune modulator Drug discovery 3,5-dihydroxy-4-isopropylstilbene

Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang lulu jin jinke Wang Rongqiao Wang Xiuchun Liu Kai Gao jingli Sun Yong Yuan Lingwei Ma Hongchang qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

Chinese Expert Consensus on the Diagnosis and Treatment of Adult Dermatomyositis (2022)

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International Journal of Dermatology and Venereology 2024年第3期7卷 163-173页

作者： Hua Cao Ai-Jun Chen Yong Cui Dan-Qi Deng Xing-Hua Gao Yan-Ling He Xiao-jing Kang Hong-Zhong jin Cheng-Xin Li Feng Li Heng-jin Li Wen-Jun Liao Xiao-Ming Liu qian-jin lu Yan lu Meng Pan Wei-Hua Pan Xiao-Ming Shu Qing Sun Ke-Yun Tang Juan Tao Yu Wang Ting Xiao Fu-Ren Zhang Han-Lin Zhang Dermatology Branch of the China International Exchange and Promotion Association for Medical and Health Care National Clinical Research Center for Dermatologic and Immunologic Diseases Department of Dermatology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Dermatology First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China Department of Dermatology the Second Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650101China Department of Dermatology the First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Dermatology Beijing Chaoyang Hospital Affiliated to Capital Medical UniversityBeijing 100020China Department of Dermatology and Venereology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uygur Autonomous Region 830001China Department of Dermatology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of Dermatology First Medical CenterPLA General HospitalBeijing 100853China Department of Dermatology Hainan Hospital of PLA General HospitalSanyaHainan 572013China Department of Dermatology Xijing HospitalAir Force Medical UniversityXi’anShaanxi 710032China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenGuangdong 518052China Hospital for Skin Diseases(Institute of Dermatology) Chinese Academy of Medical Sciences and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Dermatology Jiangsu Province Hospitalthe First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Dermatology Shanghai Changzheng HospitalSecond Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Rheumatology China-Japan Friendship HospitalBeijing 100029China Department of Dermatology Qilu Hospital of Shandong UniversityJinanShandong 250012China Department of Dermatology Union Hospital

Dermatomyositis,an idiopathic inflammatory myopathy,is characterized by distinctive skin manifestations,proximal muscle weakness,and multiple organ involvement and can be accompanied by *** provide a reference for dermatologists and clinicians in other relevant fields of clinical practice,experts from the Dermatology Branch of the China International Exchange and Promotion Association for Medical and Health Care and the National Clinical Research Center for Dermatologic and Immunologic Diseases developed this consensus on the diagnosis and treatment of adult dermatomyositis using Chinese and international literature and expert advice.

关键词： dermatomyositis adult diagnosis treatment clinical protocols expert consensus

An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun Wu Songfeng E qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng Ding Yue Hu jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

Tubular apocrine adenoma of the upper eyelid:a case report and literature review

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International Journal of Dermatology and Venereology 2018年第2期1卷 117-119页

作者： Si-Qi Fu Hai-jing Wu Edward I.Herman jing Zhang Gui-Ying Zhang Ying Zhou qian-jin lu Yan-Nan Wang Department of Dermatology the Second Xiangya Hospital Central South University Changsha Hunan 410011 China St.Vincent' s Medical Center Bridgeport CT 06606 USA Xiangya School of Medicine Central South University Changsha Hunan 410013 China

Introduction Tubular Apocrine Adenoma (TAA) is a rare benign adnexal neoplasm with apocrine differentiation,which is now considered as a part of the spectrum of tubular *** with TAA usually presents as a asymptomatic,solitary,slow-growing cutaneous nodule or a pedunculated *** has a predilection for the scalp,occasionally on the face,axilla,and anogenital ***,we reported a case of TAA appearing on the left upper eyelid of a 23-year-old Chinese man,and further analyzed retrospectively the features of facial TAA cases proviously reported in the world.

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Preface to the"Soft Matter Mechanics"Special Issue of Acta Mechanica Solida Sinica

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Acta Mechanica Solida Sinica 2019年第5期32卷 533-534页

作者： jin qian Tongqing lu Shaoxing Qu Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China State Key Lab for Strength and Vibration of Mechanical Structures Department of Engineering MechanicsXi'an Jiaotong UniversityXi'an 710049China

Different from ordinary solids,liquids and gases,soft matter is a subfield of condensed matter comprising a complexity of physical states and softness that are easily modulated by external stimuli and/or thermal flue tu at ions,with the featured sensitivity to tiny perturbations from the *** soft matter research is considered to be“the science of the 21st century,”which is rapidly evolving and growing at the interfaces of mechanics,physics,biology,material science,chemistry,etc.

关键词： environment. solids gases