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Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging

Chinese Chemical Letters 2024年第6期35卷 433-438页

作者： Boran Cheng Lei Cao Chen Li fang-Yi Huo qian-fang meng Ganglin Tong Xuan Wu Lin-Lin Bu Lang Rao Shubin Wang Department of Oncology Shenzhen Key Laboratory of Gastrointestinal Cancer Translational ResearchCancer InstitutePeking University Shenzhen HospitalShenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518132China The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhan 430079China

As a type of new carbon-based nanomaterials,carbon dots(CDs)possess exceptional optical properties,making them highly desirable for use in fluorescent ***,the CDs with deep-red(DR)or near-infrared(NIR)emission have rarely been *** this work,we prepared deep-red emissive fluorine-doped carbon quantum dots(F-CDs)by introducing a precursor simultaneously containing fluorine and *** synergistic effect of nitrogen doping and D-π-A pattern production contributed to the maximum emission of F-CDs at 636 nm with an absolute quantum yield of 36.00%±0.68%.Moreover,we designed an F-CDs-based fluorescence assay to determine the content of hypochlorite(ClO^(-)),with a limit of detection(LOD)as low as 15.4 nmol/L,indicating the high sensitivity of F-CDs to ClO^(-).In real samples,the F-CDs-based fluorescent sensor exhibited excellent sensitivity and selectivity in the detection of ClO^(-),with an error below 2%,suggesting their great potential in daily *** cancer cell imaging,the F-CDs not only demonstrated high sensitivity to ClO^(-)but also exhibited excellent mitochondria targeting,as evidenced by the high Pearson's correlation coefficient(PCC)of 0.93 in colocalization *** work presented here suggests the great potential of replacing commercial dyes with F-CDs for highly specific mitochondria labeling and cell imaging.

关键词： Carbon dots Near-infrared Cell imaging Mitochondria labeling Hypochlorite determination

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Supramolecular engineering of cell membrane vesicles for cancer immunotherapy

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Science Bulletin 2022年第18期67卷 1898-1909,M0004页

作者： Shaolong Qi Haiyan Zhang Xueyan Zhang Xinyang Yu Yajun Wang qian-fang meng Kai Yang Bing Bai Rui Tian Shoujun Zhu Lang Rao Feihe Huang Guocan Yu Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518132China State Key Laboratory of Chemical Engineering Stoddart Institute of Molecular ScienceDepartment of ChemistryZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China

The clinical translation of nanomedicines has been strongly hampered by the limitations of delivery vehicles,promoting scientists to search for novel *** cell membrane-based delivery systems have attracted extensive attention,further functionalizations are urgently desired to augment their theranostic *** propose a cell-friendly supramolecular strategy to engineer cell membranes utilizing cyclodextrin-based host–guest molecular recognitions to fix the defects arising from chemical and genetic *** this study,the supramolecular cell membrane vesicles(SCMVs)specifcally accumulate in tumors,benefting from tumor-homing capability and the enhanced permeability and retention *** co-delivering indocyanine green and an indoleamine 2,3-dioxygenase inhibitor effectively ablate tumors combining photodynamic therapy and *** by host–guest inclusion complexation,SCMVs successfully encapsulate resiquimod to repolarize tumor-associated macrophages into M1 phenotype,synergizing with immune checkpoint blockade *** supramolecular engineering methodology based on noncovalent interactions presents a generalizable and cell-friendly tactic to develop living cell–originated nanomaterials for precise cancer therapy.

关键词： Cancer theranostics Host–guest systems Immunotherapy Nanomedicine Supramolecular chemistry

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化石燃料环境友好工业路线开发

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山东大学学报（理学版） 2017年第5期52卷 25-30页

作者：朱维群齐情情王倩房亚杰孟丽柴树山东大学化学与化工学院山东济南250100 山东大学国家胶体材料工程技术研究中心山东济南250100

提出了化石燃料环境友好的工业开发路线。将化石燃料碳氢化合物在一定工艺过程条件转化为H2和CO_2,将CO_2转化为CO_2含量最高的稳定固体产品三嗪醇C_3H_3N_3O_3,部分H_2再进行发电,这是一条化石燃料环境友好的能源工业路线;将二氧化碳... 详细信息

提出了化石燃料环境友好的工业开发路线。将化石燃料碳氢化合物在一定工艺过程条件转化为H2和CO_2,将CO_2转化为CO_2含量最高的稳定固体产品三嗪醇C_3H_3N_3O_3,部分H_2再进行发电,这是一条化石燃料环境友好的能源工业路线;将二氧化碳封存产品三嗪醇继续合成低碳排放的三嗪类高分子材料是一条化石燃料环境友好的材料工业路线。阐述了化石燃料环境友好工业路线的关键工艺过程,并从能耗及产品应用等方面分析了该路线的优点,该路线从源头上控制了二氧化碳排放,是一条化石燃料环境友好的工业路线。

关键词：化石燃料环境友好 CO2封存三嗪醇

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Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults

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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan fang Li-Hui Li Ming-qian He Yue Ji Dong-Yan Lu Li-Bing Zhang Jin-Lan Yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the Lubben Social Network Scale-6,12-item Short-Form Health Literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,P<0.001),social isolation impact on psycho-logical distress pre-frail older adults(β=-0.415,P<0.001);health literacy was identified effect on psychological distress among pre-frail older persons(β=-0.307,P<0.001).Health literacy partially mediated the relationship between social isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy Social isolation

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming qian Jiashu Lian Xin Hua Jianhong Dong Zheyu fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Secondary battery inspired ɑ-nickel hydroxide as an efficient Ni-based heterogeneous catalyst for sulfate radical activation

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Science Bulletin 2018年第5期63卷 278-281页

作者： Dongting Yue Xufang qian meng Ren mengyuan fang Jinping Jia Yixin Zhao School of Environmental Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China

Highly reactive radical species play an important role in syn-thetic chemistry, industrial processes, and environmental remedi-ation applications [1,2]. The radicals can be formed by eitherthermal decomposition of highly active oxidants or by catalyticactivation of stable oxidants under mild conditions [2]. Recently,the sulfate radical （.504） with its advantages of strong oxidizingpower, selective reactivity, and stability over a broad range of pHhas emerged as an excellent and versatile oxidant for a variety ofapplication [5].

关键词：中国科学通报英文版

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Structure and Morphology of Poly(ε-caprolactone)Heterogeneous Shish-Kebab Structure Induced by Poly(lactic acid)Nanofibers

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Chinese Journal of Polymer Science 2022年第10期40卷 1223-1232,I0009页

作者： Zhong-Hua Chang Dong-fang Wang Yi-Yang Xu meng-Yuan Zhang qian Li School of Mechanics and Safety Engineering Zhengzhou UniversityZhengzhou 450001China National Center for International Research of Micro-Nano Molding Technology Zhengzhou UniversityZhengzhou 450001China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China

In recent years,the hybrid shish-kebab structure with excellent physical properties and functionalities has attracted much attention because it provides a way of blending nanofibers with different properties into polymer matrix in a regular *** is often not easy to induce the formation of the hierarchically ordered structure for the semi-crystalline polymer in heterogeneous shish-kebab structure.A poly(lactic acid)(PLA)/poly(ε-caprolactone)(PCL)heterogeneous shish-kebab structure,i.e.,the PCL crystals periodically crystallized onto PLA nanofibers,was successfully created and the interfacial crystal morphology of the PLA/PCL heterogeneous shish-kebab structure was observed using scanning electron microscopy and atomic force *** aqueous solution was applied to modify the surface of the PLA nanofibers to produce adsorption sites and carboxyl *** total reflectance Fourier transform infrared spectroscopy(ATR-FTIR)and X-ray diffraction(XRD)results demonstrated that the formation of the heterogeneous shish-kebab structure was mainly due to the hydrogen bonding interaction between the kebab and shish interface,and the growth process of the kebab crystals also promoted the crystallization of the shish *** heterogeneous nanostructure of biodegradable polymers will have great applications in tissue engineering and regenerative medicine.

关键词： Shish-kebab structure PCL PLA Crystallization Surface modification

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Characterization of the chemical constituents of Jie-Geng-Tang and the metabolites in the serums and lungs of mice after oral administration by LC-Q-TOF-MS

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Chinese Journal of Natural Medicines 2021年第4期19卷 284-294页

作者： LIU Yin-Ning HU meng-Ting qian Jing WANG Yi WANG Shu-fang College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Zhoushan Hospital of Zhejiang Province Zhoushan 316100China

Jie-Geng-Tang(JGT),a traditional formula,is employed in the treatment of sore throat and cough and comprises Platycodonis Radix and Glycyrrhizae Radix et Rhizoma in the ratio 1:*** previous study demonstrated that JGT protected mice from ***-induced acute lung injury(ALI).Five constituents of JGT showed antibacterial activities against *** in ***,the potential effective constituents of JGT in vivo were still *** this study,the chemical constituents of JGT were identified by liquid chromatography with quadrupole time-of-flight spectrometry(LC-Q-TOF-MS).A total of 96 constituents were identified or assumed,including seven organic acids,45 flavonoids,36 triterpene saponins,and eight compounds of other *** structures of 31 of the constituents were confirmed by comparing them with corresponding authentic ***,15 prototypes and 49 metabolites were deduced in the serums of mice,24 prototypes and 47 metabolites were deduced in the lungs of mice after the oral administration of *** types of constituents,namely organic acids,flavonoids,and triterpene saponins,could be absorbed into the ***,flavonoids and triterpene saponins were more likely distributed in the lung than in the *** the best of our knowledge,this is the first report on the systematic metabolites profile of JGT in *** results reported were beneficial to the elucidation of the effective material basis of JGT.

关键词： Jie-Geng-Tang LC-Q-TOF-MS Constituents Metabolite Serum Lung

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EAT-NAS: elastic architecture transfer for accelerating large-scale neural architecture search

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Science China(Information Sciences) 2021年第9期64卷 103-115页

作者： Jiemin fang Yukang CHEN Xinbang ZHANG qian ZHANG Chang HUANG Gaofeng meng Wenyu LIU Xinggang WANG Institute of Artificial Intelligence Huazhong University of Science and Technology School of Electronic Information and Communications Huazhong University of Science and Technology National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences

Neural architecture search(NAS) methods have been proposed to relieve human experts from tedious architecture engineering. However, most current methods are constrained in small-scale search owing to the issue of huge computational resource consumption. Meanwhile, the direct application of architectures searched on small datasets to large datasets often bears no performance guarantee due to the discrepancy between different datasets. This limitation impedes the wide use of NAS on large-scale tasks. To overcome this obstacle, we propose an elastic architecture transfer mechanism for accelerating large-scale NAS(EATNAS).In our implementations, the architectures are first searched on a small dataset, e.g., CIFAR-10. The best one is chosen as the basic architecture. The search process on a large dataset, e.g., ImageNet, is initialized with the basic architecture as the seed. The large-scale search process is accelerated with the help of the basic architecture. We propose not only a NAS method but also a mechanism for architecture-level transfer learning. In our experiments, we obtain two final models EATNet-A and EATNet-B, which achieve competitive accuracies of 75.5% and 75.6%, respectively, on ImageNet. Both the models also surpass the models searched from scratch on ImageNet under the same settings. For the computational cost, EAT-NAS takes only fewer than 5 days using 8 TITAN X GPUs, which is significantly less than the computational consumption of the state-of-the-art large-scale NAS methods.

关键词： architecture transfer neural architecture search evolutionary algorithm large-scale dataset

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Microstructure evolution and performance improvement of powder metallurgy stainless steel with P addition

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Journal of Iron and Steel Research International 2023年第10期30卷 2055-2066页

作者： qian Qin Dao-qing Zhang fang Yang Cun-guang Chen Jun-jie Hao Zhi-meng Guo Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Shunde Innovation School University of Science and Technology BeijingGuangzhou 528399GuangdongChina

P-containing 316L stainless steel was prepared by powder metallurgy technology using gas atomized alloy powder and phosphorus-iron alloy powder as raw materials.P addition was beneficial to sintering *** 0.6 wt.%P addition,the density increased from 7.60 to 7.82 g/cm^(3).In such case,the samples with 0.6 wt.%P addition should be sintered at a lower temperature of 1200℃.Otherwise,there were coarse grain boundary precipitates,which would seriously deteriorate the performance of stainless *** the case of suppressing the formation of coarse precipitates,appropriate P content had a beneficial effect on apparent morphology,hardness and strength of stainless *** 316L-0.6 wt.%P sample was sintered at 1200℃,the hardness and tensile strength were increased to 86.3 HRB and 672.8 MPa,respectively,and the elongation still reached 38.1%.Besides,it also had good corrosion resistance.

关键词： Phosphorus Stainless steel Powder metallurgy Precipitate phase Performance

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