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Efflcient machining of a complex blisk channel using a disc cutter

Chinese Journal of Aeronautics 2024年第1期37卷 414-437页

作者： Xiangyu LI Zhaoyu LI Dong HE Junxue REN qian feng Kai TANG Department of Mechanical and Aerospace Engineering Hong Kong University of Science and TechnologyHong Kong 999077China Key Laboratory of High Performance Manufacturing for Aero Engine(Northwestern Polytechnical University) Ministry of Industry and Information TechnologyXi’an 710072China Xi’an Sanhang Power Technology Co. LtdXi’an 710000China HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute FutianShenzhen 518057China HKUST Shenzhen Research Institute Shenzhen 518057China

For rough machining of a complex narrow cavity,e.g.,a complex blisk channel on an aero-engine,the typically used cutting tools are the slender cylindrical cutter and conical cutter.Nevertheless,as neither of the two is particularly suited for rough machining,wherein the main purpose is to remove a large volume as quickly as possible,the machining efficiency is low,especially when the part materials are of hard-to-cut types(e.g.,Titanium-alloy)for which it often takes days to rough machine a blisk.Fortunately,disc machining provides a new and efficient roughing solution,since a disc cutter with a large radius enables a much larger cutting speed and thus a larger material removal rate.However,due to the large radius of the disc cutter,its potential collision with narrow and twisted channels becomes a serious concern.In this paper,we propose a novel twophase approach for efficiently machining a complex narrow cavity workpiece using a disc-shaped cutter,i.e.,3+2-axis disc-slotting of the channel by multiple layers(rough machining)+five-axis disc-milling of the freeform channel side surfaces(semi-finish machining).Both simulation and physical cutting experiments are conducted to assess the effectiveness and advantages of the proposed method.The experimental results show that,with respect to a same cusp-height threshold on the channel side surfaces,the total machining time of the tested part by the proposed method is about only 36%of that by the conventional approach of plunging-milling(for roughing)plus milling by a slender cylindrical cutter(for semi-finishing).

关键词： Blisk channel CNC machining Disc cutter Roughing efficiency Tool path planning

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Regulating Signal Pathway Triggers Circular Reactive Oxygen Species Production to Augment Oxidative Stress with Enzyme-Activated Nanoparticles

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CCS Chemistry 2024年第3期6卷 693-708页

作者： Benkai Bao Qiong Yuan qian feng Ling Li Meiqi Li Yanli Tang Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid ChemistryMinistry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi’anShaanxi Province 710119

Regulating antioxidative stress pathways to augment oxidative stress and enhance antitumor therapy is highly desirable but very challenging.Herein,we initiated a multifunctional nanoparticle to regulate the Keap1-Nrf2 antioxidative stress pathway to promote cancer cell apoptosis.The OPFV-SnMP@GE11 nanoparticles were assembled by enzyme-activated OPFV-TLQ,tin mesoporphyrin(SnMP),and DSPEPEG-GE11.OPFV-SnMP@GE11 accumulated at tumor sites through specific targeting with GE11.OPFV-TLQ was specifically reduced to a photosensitizer OPFVNH2 by endocellular NAD(P)H:quinone oxidoreductase 1(NQO1).Under irradiation,OPFV-NH2 greatly produced reactive oxygen species(ROS)through a type I mechanism,which activated the Keap1-Nrf2 signal pathway and enhanced the transcription of NQO1,resulting in a continuous and explosive generation of ROS.Additionally,SnMP inhibited the activity of heme oxygenase-1(HO-1),further depressing antioxidative stress.This strategy provides insight into the regulation of the signal pathway to amplify oxidative stress,paving the way to studying the molecular mechanisms of cellular activities to enhance cancer therapy.

关键词： Keap1-Nrf2 pathway enzyme-activated probe reactive oxygen species oxidative stress antitumor therapy

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Triazine-based multicomponent metallacages with tunable structures for SO_(2) selective capture and conversion

Aggregate

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Aggregate 2024年第1期5卷 270-279页

作者： Ruoqian Zhang Dingyue Hu Yu Fu qian feng Chaoqun Mu Kai Gao Heping Ma Ming Liu Mingming Zhang State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’anP.R.China Department of Chemistry Hangzhou Global Scientific and Technological Innovation Center(HIC)Zhejiang UniversityHangzhouP.R.China School of Chemical Engineering and Technology Xi’an Jiaotong UniversityXi’anP.R.China

The design of novel materials for sulfur dioxide(SO_(2))capture and conversion with considerable efficiency under mild conditions is of great significance for human health and environmental protection yet highly challenging.Herein,we report a series of triazine-based multicomponent metallacages via coordination-driven self-assembly of 2,4,6-tri(4-pyridyl)-1,3,5-triazine,cis-Pt(PEt3)2(OTf)2 and different tetracarboxylic ligands.As the increase of the length of the tetracarboxylates,the structures of the metallacages change from pyramids to extended octahedrons.Owing to their N-rich structure,these metallacages are further used for selective SO_(2)capture,showing good adsorption capacity and remarkable SO_(2)/CO_(2)selectivity in ambient conditions,suggesting their potential applications toward real flue gas desulfurization.The metallacages are further employed for the conversion of SO_(2)into value-added compounds,showing exceptional efficiency even dilute SO_(2)is used as the reactant.This study represents a type of structure-tunable triazinebased metallacages for SO_(2)capture and conversion,which will pave the way on the applications of metal-organic complexes for gas adsorption.

关键词： multicomponent metallacages self-assembly SO_(2) adsorption SO_(2) conversion tunable structures

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Curation,nomenclature,and topological classification of receptor-like kinases from 528 plant species for novel domain discovery and functional inference

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Molecular Plant 2024年第4期17卷 658-671页

作者： qian Liu Qiong Fu Yujie Yan qian Jiang Longfei Mao Long Wang feng Yu Heping Zheng State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University College of BiologyChangshaHunan 410082China Bioinformatics Center Hunan University College of BiologyChangshaHunan 410082China

Receptor-like kinases(RLKs)are the most numerous signal transduction components in plants and play important roles in determining how different plants adapt to their ecological environments.Research on RLKs has focused mainly on a small number of typical RLK members in a few model plants.There is an urgent need to study the composition,distribution,and evolution of RLKs at the holistic level to increase our understanding of how RLKs assist in the ecological adaptations of different plant species.In this study,we collected the genome assemblies of 528 plant species and constructed an RLK dataset.Using this dataset,we identified and characterized 524948 RLK family members.Each member underwent systematic topological classification and was assigned a gene ID based on a unified nomenclature system.Furthermore,we identified two novel extracellular domains in some RLKs,designated Xiao and Xiang.Evolutionary analysis of the RLK family revealed that the RLCK-XVII and RLCK-XII-2 classes were present exclusively in dicots,suggesting that diversification of RLKs between monocots and dicots may have led to differences in downstream cytoplasmic responses.We also used an interaction proteome to help empower data mining for inference of new RLK functions from a global perspective,with the ultimate goal of understanding how RLKs shape the adaptation of different plants to the environments/ecosystems.The assembled RLK dataset,together with annotations and analytical tools,forms an integrated foundation of multiomics data that is publicly accessible via the metaRLK web portal(http://metaRLK.biocloud.top).

关键词： RLK RLCK domain signaling pathway receptor-protein interactions

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Ferritinophagy: A new idea for liver diseases regulated by ferroptosis

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 160-170页

作者： Zi-Bing qian Jun-feng Li Wan-Yuan Xiong Xiao-Rong Mao The First Clinical Medical College of Lanzhou University Lanzhou 730000China Institute of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000China Department of Infectious Disease The First Hospital of Lanzhou UniversityLanzhou 730000China

Background:The discovery of regulatory cell death has led to a breakthrough in the therapeutic field.Various forms of cell death,such as necrosis,apoptosis,pyroptosis,autophagy,and ferroptosis,play an important role in the development of liver diseases.In general,more than one form of cell death pathways is responsible for the disease state.Therefore,it is particularly important to study the regulation and interaction of various cell death forms in liver diseases.Data sources:We performed a PubMed search up to November 2022 with the following keywords:ferritinophagy,ferroptosis,and liver disease.We also used terms such as signal path,inducer,and inhibitor to supplement the query results.Results:This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver diseases.Conclusions:Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.

关键词： Ferritinophagy Ferroptosis Liver disease

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Regeneration of the heart:f rom molecular mechanisms to clinical therapeutics

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Military Medical Research 2024年第1期11卷 80-97页

作者： qian-Yun Guo Jia-Qi Yang Xun-Xun feng Yu-Jie Zhou Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease Beijing Institute of Heart Lung and Blood Vessel DiseaseClinical Center for Coronary Heart DiseaseDepartment of CardiologyBeijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health burden.Military personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military medicine.So far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart regeneration.In the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury.Insights have emerged from studies in animal models and early clinical trials.Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease.In this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.

关键词： Heart regeneration Cardiac disease Therapeutics Signaling mechanisms

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Biomimetic chitin hydrogel via chemical transformation

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Nano Research 2024年第2期17卷 771-777页

作者： Rui-Rui Liu qian-qian Shi Yu-feng Meng Yong Zhou Li-Bo Mao Shu-Hong Yu Division of Nanomaterials&Chemistry Hefei National Research Center for Physical Sciences at the MicroscaleDepartment of ChemistryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsUniversity of Science and Technology of ChinaHefei 230026China College&Hospital of Stomatology Key Laboratory of Oral Diseases Research of Anhui ProvinceAnhui Medical UniversityHefei 230032China Department of Dental Implantology College&Hospital of StomatologyAnhui Medical UniversityHefei 230032China

Chitin hydrogel has been recognized as a promising material for various biomedical applications because of its biocompatibility and biodegradability.However,the fabrication of strong chitin hydrogel remains a big challenge because of the insolubility of chitin in many solvents and the reduced chain length of chitin regenerated from solutions.We herein introduce the fabrication of chitin hydrogel with biomimetic structure through the chemical transformation of chitosan,which is a water-soluble deacetylated derivative of chitin.The reacetylation of the amino group in chitosan endows the obtained chitin hydrogel with outstanding resistance to swelling,degradation,extreme temperature and pH conditions,and organic solvents.The chitin hydrogel has excellent mechanical properties while retaining a high water content(more than 95 wt.%).It also shows excellent antifouling performance that it resists the adhesion of proteins,bacteria,blood,and cells.Moreover,as the initial chitosan solution can be feasibly frozen and templated by ice crystals,the chitin hydrogel structure can be either nacre-like or wood-like depending on the freezing method of the precursory chitosan solution.Owing to these anisotropic structures,such chitin hydrogel can exhibit anisotropic mechanics and mass transfer capabilities.The current work provides a rational strategy to fabricate chitin hydrogels and paves the way for its practical applications as a superior biomedical material.

关键词： chitin hydrogel biomimetic structure chemical stability mechanical strength antifouling

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Remote copper-catalyzed enantioselective substitution of yne-thiophene carbonates

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Science China Chemistry 2024年第4期67卷 1175-1180页

作者： Hao-Dong qian Xiang Li Tingrui Yin Wei-feng qian Chunhui Zhao Cuiju Zhu Hao Xu CCNU-uOttawa Joint Research Centre Key Laboratory of Pesticides&Chemical Biology of Ministry of EducationInternational Joint Research Center for Intelligent Biosensing Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

Here,we describe a strategy for the copper-catalyzed asymmetric heteroarylation of yne-thiophene carbonates with indoles via remote substitution.The key to the success of this strategy lies in the design of the alkynyl group at the ortho-position of the heterocycle thiophene,enabling the formation of a triarylmethane moiety via very remote substitution.Thus,the concept of remote copper-catalyzed asymmetric transformation extends not only to yne-allylic esters but also to yne-aryl esters.The reaction readily provides a diverse array of chiral triarylmethanes with high efficiency,enantioselectivity,and excellent functional group compatibility.Moreover,facile follow-up transformations underscore their potential utility in the synthesis of various enantioenriched building blocks.Preliminary mechanistic studies support the plausibility of the remote substitution pathway.

关键词： remote substitution copper catalyst asymmetric catalysis triaryl methanes

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Advances in mesenchymal stem cells therapy for tendinopathies

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Chinese Journal of Traumatology 2024年第1期27卷 11-17页

作者： Xu-feng Mao Xi-qian Zhang Zhe-Yu Yao Hai-Jiao Mao Department of Orthopaedic Surgery The First Affiliated Hospital of Ningbo UniversityNingbo315010Zhejiang provinceChina

Tendinopathies are chronic diseases of an unknown etiology and associated with inflammation.Mesenchymal stem cells(MSCs)have emerged as a viable therapeutic option to combat the pathological progression of tendinopathies,not only because of their potential for multidirectional differentiation and self-renewal,but also their excellent immunomodulatory properties.The immunomodulatory effects of MSCs are increasingly being recognized as playing a crucial role in the treatment of tendinopathies,with MSCs being pivotal in regulating the inflammatory microenvironment by modulating the immune response,ultimately contributing to improved tissue repair.This review will discuss the current knowledge regarding the application of MSCs in tendinopathy treatments through the modulation of the immune response.

关键词： Mesenchymal stem cells Tendinopathy Immunomodulation Treatment Review

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Development and Application of a Power Law Constitutive Model for Eddy Current Dampers

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2403-2419页

作者： Longteng Liang Zhouquan feng Hongyi Zhang Zhengqing Chen Changzhao qian School of Civil Engineering and Architecture Xiamen University of TechnologyXiamen361024China Hunan Provincial Key Laboratory ofWind and Bridge Engineering Hunan UniversityChangsha410082China Fujian Provincial Key Laboratory ofWind Disaster and Engineering Xiamen University of TechnologyXiamen361024China State Key Laboratory of Bridge Engineering Safety and Resilience Hunan UniversityChangsha410082China

Eddy current dampers (ECDs) have emerged as highly desirable solutions for vibration control due to theirexceptional damping performance and durability. However, the existing constitutive models present challenges tothe widespread implementation of ECD technology, and there is limited availability of finite element analysis (FEA)software capable of accurately modeling the behavior of ECDs. This study addresses these issues by developing anewconstitutivemodel that is both easily understandable and user-friendly for FEAsoftware. By utilizing numericalresults obtained from electromagnetic FEA, a novel power law constitutive model is proposed to capture thenonlinear behavior of ECDs. The effectiveness of the power law constitutive model is validated throughmechanicalproperty tests and numerical seismic analysis. Furthermore, a detailed description of the application process ofthe power law constitutive model in ANSYS FEA software is provided. To facilitate the preliminary design ofECDs, an analytical derivation of energy dissipation and parameter optimization for ECDs under harmonicmotionis performed. The results demonstrate that the power law constitutive model serves as a viable alternative forconducting dynamic analysis using FEA and optimizing parameters for ECDs.

关键词： Eddy current damper constitutive model finite element analysis vibration control power law constitutive model

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