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QoS Routing Optimization Based on Deep Reinforcement Learning in SDN

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Computers, Materials & Continua 2024年第5期79卷 3007-3021页

作者： yu Song Xusheng qian Nan Zhang Wei Wang Ao Xiong State Key Laboratory of Networking and Switching Technology Beijing University of Posts and TelecommunicationsBeijing100876China Marketing Service Center State Grid Jiangsu Electric Power Co.Ltd.Nanjing220000China Customer Service Center State Grid Co.Ltd.Nanjing211161China

To enhance the efficiency and expediency of issuing e-licenses within the power sector, we must confront thechallenge of managing the surging demand for data traffic. Within this realm, the network imposes stringentQuality of Service (QoS) requirements, revealing the inadequacies of traditional routing allocation mechanismsin accommodating such extensive data flows. In response to the imperative of handling a substantial influx of datarequests promptly and alleviating the constraints of existing technologies and network congestion, we present anarchitecture forQoS routing optimizationwith in SoftwareDefinedNetwork (SDN), leveraging deep reinforcementlearning. This innovative approach entails the separation of SDN control and transmission functionalities, centralizingcontrol over data forwardingwhile integrating deep reinforcement learning for informed routing decisions. Byfactoring in considerations such as delay, bandwidth, jitter rate, and packet loss rate, we design a reward function toguide theDeepDeterministic PolicyGradient (DDPG) algorithmin learning the optimal routing strategy to furnishsuperior QoS provision. In our empirical investigations, we juxtapose the performance of Deep ReinforcementLearning (DRL) against that of Shortest Path (SP) algorithms in terms of data packet transmission delay. Theexperimental simulation results show that our proposed algorithm has significant efficacy in reducing networkdelay and improving the overall transmission efficiency, which is superior to the traditional methods.

关键词： Deep reinforcement learning SDN route optimization QoS

Simulation model optimization for bonnet polishing considering consistent contact area response

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Frontiers of Mechanical Engineering 2024年第4期19卷 87-105页

作者： Yanjun HAN Haiyang ZHANG Menghuan yu Jinzhou YANG Linmao qian School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031China Institute of Data Science Maastricht UniversityMaastricht 6229ENthe Netherlands

Simulation model optimization plays a crucial role in the accurate prediction of material removal function in bonnet polishing processes,but model complexity often poses challenges to the practical implementation and efficiency of these *** paper presents an innovative method for optimizing simulation model parameters,focusing on achieving consistent contact area and the accurate prediction of the material removal function while preventing increase in model ***,controllable and uncontrollable factors in bonnet simulations are analyzed,and then a simplified contact model is developed and applied under constant force *** characterize the bonnet's contact performance,a contact area response curve is introduced,which can be obtained through a series of single spot contact ***,a rubber hyperelastic parameter optimization model based on a neural network is proposed to achieve optimal matching of the contact area between simulation and *** average deviation of the contact area under different conditions was reduced from 22.78%before optimization to 3.43%after optimization,preliminarily proving the effectiveness of the proposed simulation optimization ***,orthogonal experiments are further conducted to validate the proposed *** comparison between the experimental and predicted material removal functions reveals a high consistency,validating the accuracy and effectiveness of the proposed optimization method based on consistent contact *** research provides valuable insights into enhancing the reliability and effectiveness of bonnet polishing simulations with a simple and practical approach while mitigating the complexity of the model.

关键词： bonnet polishing simulation contact area tool influence function optimization

Quantum support vector machine for multi classification

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Communications in Theoretical Physics 2024年第7期76卷 57-62页

作者： Li Xu Xiao-yu Zhang Ming Li Shu-qian Shen College of Science China University of PetroleumQingdao 266580China

Classical machine learning algorithms seem to be totally incapable of processing tremendous data,while quantum machine learning algorithms could deal with big data unhurriedly and provide exponential acceleration over classical *** this paper,we propose two quantum support vector machine algorithms for multi *** is the quantum version of the directed acyclic graph support vector *** other one is to use the Grover search algorithm before measurement,which amplifies the amplitude of the phase storing of the classification *** k classification,the former provides quadratic reduction in computational complexity when *** latter accelerates the training speed significantly and more importantly,the classification result can be read out with a probability of at least 50%using only one *** conduct numerical simulations on two algorithms,and their classification success rates are 96%and 88.7%,respectively.

关键词： quantum support vector machine quantum feature mapping Grover search algorithm

Berberine alleviates ovarian tissue damage in mice with hepatolenticular degeneration by suppressing ferroptosis and endoplasmic reticulum stress

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Journal of Integrative Medicine 2024年第4期22卷 493-502页

作者： qian-zhuo Liu Hui Han Xin-ru Fang Lu-yao Wang Dan Zhao Miao-zhu Yin Nian Zhang Peng-yu Jiang zhi-hui Ji Li-min Wu Department of Neurology the First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Center for Reproduction and Genetics the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230031Anhui ProvinceChina

Objective:Hepatolenticular degeneration (HLD) is an autosomal recessive disorder that manifests as multiorgan damage due to impaired copper (Cu) metabolism. Female patients with HLD often experience reproductive impairments. This study investigated the protective effect of berberine against ovarian damage in toxic-milk (TX) mice, a murine model for ***:Mice were categorized into control group, HLD TX group (HLD group), penicillamine (Cu chelator)-treated TX group and berberine-treated TX group. Body weight, ovary weight and the number of ovulated eggs were recorded. Follicular morphology and cellular ultrastructure were examined. Total iron, ferrous iron (Fe2+) and trivalent iron (Fe3+) levels, as well as malondialdehyde (MDA), glutathione(GSH) and oxidized glutathione (GSSG), were measured in the ovaries. Western blot analysis was used to analyze the expression of proteins related to ferroptosis and endoplasmic reticulum (ER) ***:Ovarian tissue damage was evident in the HLD group, with a significant increase in ferroptosis and ER stress compared to the control group. This damage was inhibited by treatment with penicillamine,a Cu chelator. Compared with the HLD group, berberine increased the number of ovulations, and improved ovarian morphology and ultrastructure. Further, we found that berberine reduced total iron,Fe2+, MDA and GSSG levels, elevated GSH levels, decreased the expression of the ferroptosis marker protein prostaglandin-endoperoxide synthase 2 (PTGS2), and increased glutathione peroxidase 4 (GPX4)expression. Furthermore, berberine inhibited the expression of ER stress-associated proteins mediated by the protein kinase RNA-like ER kinase (PERK) ***:Ferroptosis and ER stress are involved in Cu-induced ovarian damage in TX mice. Berberine ameliorates ovarian damage in HLD TX mice by inhibiting ferroptosis and ER stress.

关键词： Berberine Hepatolenticular degeneration Copper deposition Ferroptosis Endoplasmic reticulum stress

Promoting Environmental Risk Assessment and Control of Emerging Contaminants in China

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Engineering 2024年第6期37卷 13-17页

作者： Bin Wang qian Sui Huijuan Liu Gang yu Jiuhui Qu School of Environment Tsinghua UniversityBeijing 100084China School of Resources and Environmental Engineering East China University of Science and TechnologyShanghai 200237China Advanced Interdisciplinary Institute of Environmental and Ecology Beijing Normal UniversityZhuhai 519000China

*** In recent years,China has carried out an extensive preventative battle against air,water,and soil pollution,and the nation’s environmental quality-as reflected by conventional pollutant indicators—has significantly *** the same time,the issue of emerging contaminants(ECs)is beginning to receive increasing *** generally refer to newly discovered or noticeable pollutants that pose risks to the ecological environment or human *** they have not been included in environmental management,or existing management measures are insufficient to effectively prevent and control their *** ECs of greatest concern generally include persistent organic pollutants(POPs),endocrine-disrupting chemicals(EDCs),pharmaceuticals and personal care products(PPCPs),and *** four categories of ECs are not entirely separate,as they interrelate with each other(Fig.1).Chemical production and product usage are the main sources of *** is the world’s largest producer and consumer of bulk chemicals,and the production value of China’s chemical industry is predicted to reach 50%of the global total by 2030[1].Scientific control of ECs based on their environmental risk assessment is a necessary way to support the prevention and legal governance of ECs.

关键词： legal entirely prevention

Predictive Ability of Hypertriglyceridemic Waist,Hypertriglyceridemic Waist-to-Height Ratio,and Waist-to-Hip Ratio for Cardiometabolic Risk Factors Clustering Screening among Chinese Children and Adolescents

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Biomedical and Environmental Sciences 2024年第3期37卷 233-241页

作者： XIAO Tian Li yuAN Shu qian GAO Jing yu Julien SBaker YANG Yi De WANG Xi Jie ZHENG Chan Juan DONG Yan Hui ZOU zhi Yong Key Laboratory of Molecular Epidemiology of Hunan Province School of MedicineHunan Normal UniversityChangsha 410081HunanChina The Institute of Interdisciplinary Studies Hunan Normal UniversityChangsha 410013HunanChina Chenzhou First People's Hospital Chenzhou 423000HunanChina Centre for Health and Exercise Science Research Hong Kong Baptist UniversityKowloon TongHong Kong 999077China Department of Sport Physical Education and HealthHong Kong Baptist UniversityKowloon TongHong Kong 999077China Vanke School of Public Health Tsinghua UniversityBeijing 100084China Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterBeijing 100191China

Objective Hypertriglyceridemic waist(HW),hypertriglyceridemic waist-to-height ratio(HWHtR),and waist-to-hip ratio(WHR)have been shown to be indicators of cardiometabolic risk ***,it is not clear which indicator is more suitable for children and *** aimed to investigate the relationship between HW,HWHtR,WHR,and cardiovascular risk factors clustering to determine the best screening tools for cardiometabolic risk in children and *** This was a national cross-sectional *** and biochemical variables were assessed in approximately 70,000 participants aged 6–18 years from seven provinces in ***,physical activity,dietary intake,and family history of chronic diseases were obtained through ***,χ2 and logistic regression analysis was *** A significant sex difference was observed for HWHtR and WHR,but not for HW *** risk of cardiometabolic health risk factor clustering with HW phenotype or the HWHtR phenotype was significantly higher than that with the non-HW or non-HWHtR phenotypes among children and adolescents(HW:OR=12.22,95%CI:9.54-15.67;HWHtR:OR=9.70,95%CI:6.93-13.58).Compared with the HW and HWHtR phenotypes,the association between risk of cardiometabolic health risk factors(CHRF)clustering and high WHR was much weaker and not significant(WHR:OR=1.14,95%CI:0.97-1.34).Conclusion Compared with HWHtR and WHR,the HW phenotype is a more convenient indicator with higher applicability to screen children and adolescents for cardiovascular risk factors.

关键词： Hypertriglyceridemic waist Waist-to-hip ratio Children and adolescents China Hypertriglyceridemic waist-to-height ratio Cardiovascular risk factors

西红花酸对大鼠心肌缺血再灌注损伤的保护作用

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中草药 2008年第7期39卷 1049-1053页

作者：寇鑫晖钱之玉中国药科大学药理教研室江苏南京210009

目的研究西红花酸对大鼠心肌缺血再灌注损伤的保护作用及可能的机制。方法梗死模型,结扎大鼠左前降支冠状动脉45min,再灌注180min测定心肌梗死率,并于缺血前和再灌注5、60、180min测定血清中的肌酸激酶(CK)和乳酸脱氢酶(LDH)活性。顿抑... 详细信息

目的研究西红花酸对大鼠心肌缺血再灌注损伤的保护作用及可能的机制。方法梗死模型,结扎大鼠左前降支冠状动脉45min,再灌注180min测定心肌梗死率,并于缺血前和再灌注5、60、180min测定血清中的肌酸激酶(CK)和乳酸脱氢酶(LDH)活性。顿抑模型,结扎大鼠左前降支冠状动脉15min,再灌注180min测定缺血和非缺血心肌组织中Na+,K+-ATP酶、Ca2+,Mg2+-ATP酶活性、总腺苷酸(TAC)的量、能荷(EC)和血清中丙二醛(MDA)的量。并于缺血前、缺血末,再灌注5、30、90、180min时测定心率、左心室内收缩压、舒张压、射血分数、最大和最小左心室内压变化速率(±dp/dt)、最大和最小左心室容积变化速率(±dV/dt)以及每搏功。结果缺血前或者再灌注前给予西红花酸能够显著降低心肌梗死率,呈剂量依赖关系;并且降低血清中CK和LDH的活性。50mg/kg西红花酸可以改善心脏功能,减轻心肌顿抑的程度,升高心肌组织ATP的量及EC。结论西红花酸可以有效抑制因心肌缺血和再灌注引发的心肌梗死,缓解心肌顿抑,西红花酸可能是通过改善心肌能量代谢发挥其抗心肌缺血再灌注损伤作用的。

关键词：西红花酸心肌梗死心肌顿抑血流动力学

Correction:A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimerlike pathology

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3537-3540页

作者： Xin Wang qian Liu Hai-tao yu Jia-zhao Xie Jun-ning Zhao zhi-ting Fang Min Qu Yao Zhang Ying Yang Jian-zhi Wang Department of Pathophysiology School of Basic Medicine Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Fundamental Medicine Wuxi School of Medicine Jiangnan University Wuxi Jiangsu 214122 China Co-innovation Center of Neuroregeneration Nantong University Nantong 226000 China Hubei Provincial Key Laboratory for Applied Toxicology Hubei Provincial Center for Disease Control and Prevention Hubei Provincial Academy of Preventive Medicine Wuhan 430000 China Endocrine Department of Liyuan Hospital Key Laboratory of Ministry of Education of China for Neurological Disorders Tongji Medical College Huazhong University of Science and Technology Wuhan 430077 China

After online publication of the article',the authors noticed that,owing to authors'oversight in layer placement within the illustration,Golgi staining images representing both the 5xFAD group and,the 5xFAD+IDH3β_grou... 详细信息

关键词： illustration representing noticed

Robust tantalum tuned perovskite oxygen electrode for reversible protonic ceramic electrochemical cells

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Rare Metals 2024年第7期43卷 3055-3065页

作者： yu-Shi Feng yu Shen Fang Wang Chuan Tian Qin-Yi Hu qian Duan Jing-Wei Li Di Bao School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China Zhongshan Institute of Changchun University of Science and Technology Zhongshan528437China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China Key Laboratory of Preparation and Applications of Environmental Friendly Materials Ministry of EducationJilin Normal UniversityChangchun 130103China

Perovskite oxides with diverse composition and structure have exhibited grand advances in boosting the oxygen reduction and evolution reaction(ORR/OER),which are essential for the reversible protonic ceramic electrochemical cell(R-PCEC)toward the sustainable hydrogen production and ***,enhancement of their activity and stability remains ***,we develop the Ta-regulated BaCo_(0.7)Fe_(0.3)O_(3-δ)perovskite oxygen electrode(Ba(Co_(0.7)Fe_(0.3))_(1-x)Ta_xO_(3-δ))with abundant oxygen defects and achieve the simultaneous enhancement in the electrocatalytic activity and stability toward ORR and ***-fabricated R-PCEC with(Ba(Co_(0.7)Fe_(0.3))_(0.9)Ta_(0.1)O_(3-δ))(BCFT10)oxygen electrode performs high power density of 1.47 W·cm^(-2)at 650℃in fuel cell mode,and the current density is up to-2.11 A·cm^(-2)at 1.4 V at 650℃in electrolysis mode,as well as the good stability in both the fuel cell and electrolysis ***,the cell also demonstrates a stable cycling operation between fuel cell and electrolysis mode,suggesting a great potential of BCFT10 as oxygen electrode material for R-PCECs.

关键词： Reversible protonic ceramic electrochemical cells Perovskite oxide Oxygen electrode Ta element doping Oxygen defects