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Effectiveness of co-treatment with traditional Chinese medicine and letrozole for polycystic ovary syndrome:a meta-analysis

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Journal of Integrative Medicine 2017年第2期15卷 95-101页

作者： qian-wen Ma Yong Tan The First Clinical Medical College Nanjing University of Chinese Medicine Department of Gynecology Zhenjiang Hospital of Traditional Chinese Medicine

BACKGROUND： Polycystic ovary syndrome （PCOS） is an endocrine disease that affects gynecologica health. Treatment of PCOS remains a big challenge for clinicians. OBJECTIVE： This meta-analysis was developed to compare the efficacy of co-treatment with traditiona Chinese medicine （TCM） and letrozole against letrozole monotherapy in the treatment of PCOS. SEARCH STRATEGY： Randomized controlled trials （RCTs） were electronically retrieved from PubMed, Cochrane Library, China Biomedical Literature Database, China National Knowledge Infrastructure and Wanfang Data; related papers that were not available electronically were manually checked. All papers were assessed according to the Cochrane Handbook for Systematic Reviews of Interventions and the valid data were analyzed using Revman software （The Cochrane Collaboration, Copenhagen, Denmark） INCLUSION CRITERIA： We included RCTs that compared co-treatment with TCM and letrozole against letrozole monotherapy in women with PCOS, which was defined by anovulation, biochemical or clinical hyperandrogenemia and polycystic ovaries. We included trials from all sources. DATA EXTRACTION AND ANALYSIS： Two independent reviewers extracted data, and evaluated study quality according to the Cochrane Handbook for Systematic Reviews of Interventions criteria for RCT, including issues of patient randomization, blinding and bias. RESULTS： Eight RCTs, involving a total of 537 patients, were included in the present study. The meta-analysis showed that the cycle ovulation rate, the pregnancy rate and the total effective rate of symptom treatment were higher in treatments combining TCM with letrozole, compared with letrozole monotherapy. Although the rate of luteinizing hormone （LH）/follicle-stimulating hormone （FSH） and the body mass index of the group receiving combined therapy were lower than in letrozole monotherapy, no statistical difference was found in the LH and FSH level between the two groups. CONCLUSION： Available evidence showed that c

关键词： medicine, Chinese traditional letrozole polycystic ovary syndrome meta-analysis

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Recent advances of long noncoding RNAs involved in the development of multiple sclerosis

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Chinese Journal of Natural Medicines 2020年第1期18卷 36-46页

作者： LI qian-wen LEI wen CHEN Cong GUO Wei School of Life Science and Technology China Pharmaceutical UniversityJiangsu Key Laboratory of Druggability of BiopharmaceuticalsNanjing 210009China Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China

Given the rapid increase of patients with autoimmune diseases and the lack of satisfactory therapies,the discovery of novel and effective therapeutic targets have been in an urgent *** studies have revealed that long noncoding RNAs(lncRNAs)play crucial roles in the development of multiple sclerosis(MS),which provides a new opportunity of uncovering novel mechanism associated with the progression of *** review highlights the dysregulation of lncRNAs in the development of MS in patients and animal ***,the potential clinical relevance of lncRNAs severed as therapeutic targets and diagnostic markers are discussed.

关键词： Multiple sclerosis Long noncoding RNA Experimental autoimmune encephalomyelitis Clinical relevance Dysregulation

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Effects of Dietary Lysine on Growth Performance, Serum Concentrations of Insulin-Like Growth Factor-I (IGF-I) and IGF-I mRNA Expression in Growing Rabbits

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Agricultural Sciences in China 2010年第6期9卷 887-895页

作者： JING wen-qian LI Fu-chang College of Animal Science and Technology Shandong Agricultural University Tai＇an 271018 P.R.China College of Life Science Linyi Normal University Linyi 276005 P.R.China

The effects of dietary lysine on production performance,serum concentrations of metabolites,growth hormone （GH）,insulin-like growth factor-I （IGF-I） and IGF-I mRNA expression in growing rabbits were *** hundred weaned New Zealand rabbits were allocated to individual cages and randomly offered a diet containing 5.5 （L1）,6.5 （L2）,7.5 （L3）,8.5 （L4）,or 9.5 g （L5） lysine per kg *** results showed that the average daily gain （ADG） of the rabbits from L3,L4 or L5 was higher than those from L1 or L2 （P 〈 0.05）.The feed gain ratio （F/G） in the rabbits from L4 or L5 was lower than those from L1 or L2 （P 〈 0.05）.Dietary lysine did not affect serum concentrations of total protein （TP）,glucose,insulin （INS）,and growth hormone （GH）（P 〉 0.05）.The quadratic effects of lysine on the serum urea nitrogen （SUN） concentration was detected （P = 0.035）.Serum IGF-I concentrations had a trend to increase quadratically with the increasing dietary lysine （P = 0.07）.A significant correlation was found between serum IGF-I concentrations （x,ng mL-1） and ADG （y,g kg-1）： y = -0.017x2 ＋ 1.984x ＋ 20.87 （R2 = 0.8982,P = 0.003）.The relative abundance of hepatic and muscular IGF-I mRNA tended to increase with increasing dietary lysine levels （P = 0.053 and 0.082,respectively）.Providing the diets mainly consisted of corn,wheat bran and peanut vine,the most appropriate dietary lysine level for growing meat rabbits from weaning to 70 d old was found to be 8.5 g kg-1,and IGF-I may be an important factor controlling growth of weaned rabbits.

关键词： New Zealand rabbit lysine growth performance IGF-I mRNA expression

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Modeling the effects of urbanization on grain production and consumption in China

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Journal of Integrative Agriculture 2017年第6期16卷 1393-1405页

作者： LU wen-cong Chen Ning-lu qian wen-xin China Academy for Rural Development Zhejiang University Hangzhou 310058 P.R. China School of Management Zhejiang University Hangzhou 310058 P.R. China

The impact of rapid urbanization on food security of China has received considerable *** is not clear whether China can strike a balance between urbanization and food security,especially grain *** have been numerous studies examining the effects of urbanization on grain production or consumption,but few studies have yet analyzed grain *** on the Chinese World Agricultural Regional Market Equilibrium Model（CWARMEM）,this paper explores the impacts of urbanization on national and regional grain balances through different *** CWARMEM is a global partial equilibrium multimarket model which captures the differences between urban and rural residents as well as the effects of *** results show that urbanization has a small negative effect on maintaining grain *** of that,China is able to achieve the objective of grain security set by its ***,urbanization changes regional grain balances across China：The position of Northeast China and North China,as two dominant grain suppliers of China,will be weaken;Central China and East China will increase dependence on other grain suppliers;the grain surplus of Northwest China will increase ***,in terms of grain category,urbanization helps China achieve self-sufficiency in food grain（rice and wheat）,while expands deficit of feed grain（maize）.

关键词： urbanization grain self-sufficiency grain security

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PREPARATION AND APPLICATION OF PHOTOSENSITIVE COPOLYMERS FOR PDP BARRIER RIBS FORMED BY PHOTOLITHOGRAPHY

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Chinese Journal of Polymer Science 2013年第3期31卷 444-451页

作者： Tao Zhang qian-wen Dong Wei Zhang 魏杰 College of Materials Science and Engineering Beijing University of Chemical Technology

In this work, the photosensitive paste was prepared. It was comprised of inorganic particles and a photosensitive organic component. The inorganic panicles included glass, ceramics, and metals. The organic component should contain at least the following photosensitive materials： photosensitive monomers, photoreactive copolymer and photopolymerization initiators. The photoreactive copolymer played a role of an adhesive in the photosensitive paste. Meanwhile in the development stage, the carboxyl groups of the copolymer reacted with the alkalescent developer. Following this, the unexposed part must be removed and an excellent pattern can be formed. A series of three-component acrylic copolymers （MAA/St/MMA） were designed, and then synthesized via free radical polymerization. Subsequently glycidyl methacrylate （GMA） was employed to modify the prepared copolymers through ring-opening reactions between the carboxyl groups and the epoxide groups. Eventually the photosensitive copolymers were obtained and used to form the barrier ribs of PDPs. The chemical structure, glass transition temperature, acid value and molecular weight of photosensitive copolymers had different effects on the structure and pattern of PDP barrier ribs. Through analyzing effects of different polymer performance parameters on the patterns of barrier ribs, the optimal photosensitive copolymer was acquired.

关键词： Plasma display panel Barrier rib Photosensitive copolymer Photosensitive paste.

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Research of 6-DOF Serial-Parallel Mechanism Platform for Stability Training of Legged-Walking Robot

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Journal of Harbin Institute of Technology(New Series) 2014年第2期21卷 75-82页

作者： Wei-Guo Wu wen-qian Du Humanoid and Gorilla Robot & Its Intelligent Motion Control Lab Harbin Institute of Technology

The concept of legged-robot stability training with a training platform is proposed and a serial-parallel mechanism platform with 6 degrees of freedom is designed for this target. The designed platform is composed of 4-DOF parallel mechanism with spherical joints and prismatic pairs,and 2-DOF serial mechanism with prismatic pairs. With this design,the platform has advantages of low platform countertop,big workspace,high carrying capacity and high stiffness. On the basis of DOF analysis and computation of space mechanism,weight supporting auxiliary mechanism and raceways-balls supporting mechanism are designed,so as to improve the stiffness of designed large platform and payload capacity of servo motors. And then the whole structure design work of the platform is done. Meanwhile,this paper derives the analytical solutions of forward kinematics, inverse kinematics and inverse dynamics. The error analysis model of position and orientation is established. And then the simulation is done in ADAMS to ensure the correctness and feasibility of this design.

关键词： 6-DOF serial-parallel mechanism forward kinematics stability training legged-walking robot

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Eosinopenia is a predictive factor for the severity of acute ischemic stroke

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Neural Regeneration Research 2019年第10期14卷 1772-1779页

作者： Hui-Min Zhao wen-qian Qin Pei-Ji Wang Zhong-Min wen Department of Neurology the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Orthopedics the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina

Previous data have revealed an association between eosinopenia and mortality of acute ischemic ***,the relationship of eosinopenia with infarct volume,infection rate,and poor outcome of acute ischemic stroke is still *** retrospective study included 421 patients(273 males,65%;mean age,68.0± 13.0 years)with first acute ischemic stroke who were hospitalized in the Second Affiliated Hospital of Soochow University,China,from January 2017 to February *** data,neuroimaging results,and modified Rankin Scale scores were *** were divided into four groups according to their eosinophil percentage level(3)after adjusting for potential confounding factors(P-trend<0.001).These findings suggest that eosinopenia has the potential to predict the severity of acute ischemic *** study was approved by the Ethics Committee of the Second Affiliated Hospital of Soochow University,China(approval number:K10)on November 10,2015.

关键词： nerve regeneration eosinopenia eosinophil ischemia stroke infarct volume infection clinical outcome neutrophilia risk factors predictive factor neural regeneration

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Expression, Purification, and Refolding of Recombinant Fusion Protein hIL-2/mGM-CSF

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Biomedical and Environmental Sciences 2008年第6期21卷 509-513页

作者： qian wen LI MA WEI LUO MING-qian ZHOU XIAO-NING WANG Institute of Molecular Immunology Southern Medical University Guangzhou 510515 Guangdong China School of Biosciences and Bioengineering South China University of Technology Guangzhou 510641 Guangdong China

Objective To study the activities of interleukin （IL）-2 and granulocyte-macrophage colony-stimulating factor （GM-CSF）（hlL-2/mGM-CSF）. Methods SOE PCR was used to change the linker of the fusion protein for higher activities. The fusion protein was expressed in Escherichia coli （E. coil） BL21 （DE3） in inclusion body （IB） form. After IB was extracted and clarified, it was denatured and purified by affinity chromatography. The protein was refolded by dilution in a L-arginine refolding buffer and refined by anion chromatography. The protein activity was detected by cytokine-dependent cell proliferation assay. Results The expression of hIL-2/mGM-CSF in E. coli yielded approximately 20 mg protein/L culture and the purity was about 90%. The specific activities of IL-2 and GM-CSF were 5.4×10^6 IU/mg and 7.1×10^6 IU/mg, respectively. Conclusion This research provides important information about the anti-tumor activity of hIL-2/mGM-CSF in vivo, thus facilitating future clinical research on hlL-2/mGM-CSF used in immune therapy.

关键词： HIL-2/mGM-CSF Fusion protein Purification Refolding

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Unthermal Hawking Radiation from a General Stationary Black Hole

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Communications in Theoretical Physics 2008年第2期49卷 379-381页

作者： ZHANG Yong-Ping DAI qian LIU wen-Biao Department of Physics Institute of Theoretical Physics Beijing Normal University Beijing 100875 China

Using Damour-Ruflini＇s method, Hawking radiation from a general stationary black hole is investigated again deeply. Considering the back reaction of the particle to the space-time and energy conservation, we find that the radiation is not exactly thermal and can take out information from the black hole. This can be used to explain the information loss paradox, and the result is consistent with the works finished before.

关键词： Hawking radiation stationary black hole back-reaction information loss paradox unitary theory

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Fractal characteristics of filamentous bacteria in activated sludge and its significance

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Journal of Environmental Sciences 2000年第2期12卷 59-63页

作者： Yi, Shun-Min Zhao, wen-qian Li, Ran State Key Hydraulic Laboratory of High Speed Flows Sichuan Union University Chengdu 610065 China

On the basis of fractal theory, the fractal characteristics of filamentous bacteria in activated sludge are studied by image dissector system. The results show that the spatial distribution structure of filamentous bacteria in activated sludge has high self similarity in statistics and the filamentous bacteria have clear phenomenon of fractal growth. The critical fractal dimension values of filamentous bacteria bulking such as Eikelboom 021N, Eikelboom 1701, Sphaerotilus natans and Eikelboom 0041 are determined initially. The fractal dimensions can be taken as a parameter to describe filamentous bacteria of activated sludge quantitatively and bring to light the disorder in appearance and the rule in inherence of filamentous bacteria system.

关键词： activated sludge filamentous bacteria fractal fractal growth fractal dimension CLC number: X703 Document code: A

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