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Isotoosendanin exerts inhibition on triple-negative breast cancer through abrogating TGF-β-induced epithelial—mesenchymal transition via directly targeting TGFβR1

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Acta Pharmaceutica Sinica B 2023年第7期13卷 2990-3007页

作者： Jingnan Zhang Ze Zhang Zhenlin Huang Manlin Li Fan Yang Zeqi Wu qian guo Xiyu Mei Bin Lu Changhong Wang Zhengtao Wang Lili Ji The MOE Key Laboratory for Standardization of Chinese Medicines Shanghai Key Laboratory of Compound Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese MedicinesInstitute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China

As the most aggressive breast cancer,triple-negative breast cancer(TNBC) is still incurable and very prone to *** transform growth factor β(TGF-β)-induced epithelial—mesenchymal transition(EMT) is crucially involved in the growth and metastasis of *** study reported that a natural compound isotoosendanin(ITSN) reduced TNBC metastasis by inhibiting TGF-β-induced EMT and the formation of *** can directly interact with TGF-β receptor type-1(TGFβR1) and abrogated the kinase activity of TGFβR1,thereby blocking the TGF-β-initiated downstream signaling ***,the ITSN-provided inhibition on metastasis obviously disappeared in TGFβR1-overexpressed TNBC cells in vitro as well as in mice bearing TNBC cells overexpressed TGFβ***,Lys232 and Asp351 residues in the kinase domain of TGFβR1 were found to be crucial for the interaction of ITSN with TGFβ***,ITSN also improved the inhibitory efficacy of programmed cell death 1 ligand 1(PD-L1) antibody for TNBC in vivo via inhibiting the TGF-β-mediated EMT in the tumor *** findings not only highlight the key role of TGFβR1 in TNBC metastasis,but also provide a leading compound targeting TGFβR1 for the treatment of TNBC ***,this study also points out a potential strategy for TNBC treatment by using the combined application of anti-PD-L1 with a TGFβR1 inhibitor.

关键词： TNBC Isotoosendanin Metastasis TGFβR1 Epithelial-mesenchymal transition Invadopodia PD-L1 Tumor microenvironment

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Group Decision-making Models on Determining the Importance Ratings of Technical Characteristics

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Computer Aided Drafting,Design and Manufacturing 2011年第2期21卷 81-86页

作者： guo qian PU Yun ZHANG Jing School of Economics and Management Southwest Jiaotong University Chengdu 610031 China

Determining the importance ratings of technical characteristics is a typical group decision-making process. The linguistic-based approach can effectively manage the imprecise and multi-granularity information i;n quality function deployment and facilitate decision-making in deriving the importance ratings. Based on the linguistic weighted averaging （LWA） operator and the linguistic hybrid averaging （LHA） operator, a practical approach is proposed to first aggregate the individual judgments into a collective value for each technical characteristic under linguistic environment, and then measure the deviation degree of linguistic variables to obtain the importance ratings of technical characteristics. A case study shows the application of the proposed method.

关键词： quality function deployment technical characteristics group decision-making linguistic variables

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红外热像技术在炉墙烧损检测上的应用研究

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金属热处理 2007年第2期32卷 74-77页

作者：钱惠国东华大学环境科学与工程学院

利用热像仪在实验室对两种不同形状缺陷的试样进行了检测试验。结果表明,孔底角度系数较大的试样A的检测误差<5%,并且随着炉膛温度的提高,其检测精度也随之提高;由于试样B的孔底角度系数太小,造成检测误差较大而产生误判。现场调查发现... 详细信息

利用热像仪在实验室对两种不同形状缺陷的试样进行了检测试验。结果表明,孔底角度系数较大的试样A的检测误差<5%,并且随着炉膛温度的提高,其检测精度也随之提高;由于试样B的孔底角度系数太小,造成检测误差较大而产生误判。现场调查发现,实际上大部分缺陷的形状与A试样类似,在检测中可忽略角度系数的影响,并在实际应用过程中得到了验证。

关键词：红外热像仪热像图曲面图

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Comprehensive evaluation of medullary thyroid carcinoma before surgery

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Chinese Medical Journal 2019年第7期132卷 834-841页

作者： qian-qian guo Shao-Hang Zhang Li-Juan Niu Yu-Kang Zhang Zheng-Jiang Li Qing Chang Department of Ultrasound National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Ultrasound Beijing Haidian HospitalHaidian Section of Peking University Third HospitalBeijing 100080China Department of Ultrasound Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China Department of Head and Neck Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background:Medullary thyroid carcinoma(MTC)is a rare disease,but it exhibits more aggressive *** aim of this study was to improve the diagnostic accuracy of MTC before surgery by analyzing the clinical and ultrasonic data of patients with ***:The study included 71 patients(96 lesions)with histopathologically proven MTC between April 2011 and September 2016 in the Cancer Hospital of Chinese Academy of Medical Sciences and Peking Union Medical *** clinical characteristics and sonographic findings were retrospectively reviewed and compared between the ultrasonic correct diagnosis group and the ultrasonic misdiagnosis group with the t test or Mann-Whitney U test for quantitative parameters and the Х^2 test or Fisher exact test for qualitative ***:Compared with the ultrasonic correct diagnosis group,the proportion of the cystic change in the ultrasonic misdiagnosed group was high(25.0%vs.4.2%),the uncircumscribed margin and irregular shape proportions were low(20.8%,58.3%vs.74.7%,87.3%),calcification was relatively rare(20.8%vs.56.3%),and rich vascularity was relatively rare(25.0%vs.78.9%).Conclusions:In the case of atypical MTC,such as cystic change,circumscribed margin,regular shape,no calcification,no rich vascularity,and normal cervical lymph nodes,MTC is easily misdiagnosed as benign by ***,ultrasound,cytology and serum calcitonin should be comprehensively evaluated for a preoperative diagnosis of MTC.

关键词： Thyroid cancer Medullary Ultrasonography Diagnostic errors

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Mediating effect of mindfulness level on the relationship between marital quality and postpartum depression among primiparas

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World Journal of Clinical Cases 2023年第12期11卷 2729-2739页

作者： Jian Yang Xin-Zhu Lin qian-Wen guo Cheng-Ling Wang Ren-Yan Yang Jun-Wen Zhang Yan Zeng Department of Gastroenterology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Psychology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Obstetrics the Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Obstetrics Chongqing Shizhu Tujia Autonomous County People’s HospitalChongqing 409100China

BACKGROUND Postpartum depression refers to a depressive episode or depressive symptoms up to 12 mo after *** mindfulness has presented a protective factor for postpartum depressive symptoms and proved efficient in improving relationship satisfaction among *** To investigate the correlations among mindfulness,marital quality,anxiety,and depression in a large city in western China during the post-corona virus infectious disease-2019 era and determine whether trait mindfulness mediates the relationship between marital quality and postpartum anxiety and depression among *** A cross-sectional study was *** self-administered questionnaire was submitted online through *** levels of mindfulness,anxiety,depression,and marital quality were respectively investigated by the mindful attention awareness scale(MAAS),the self-rating anxiety scale(SAS),the selfrating depression scale(SDS),and the marriage perception scale(MPS)in these enrolled Han and Tujia *** No statistical significance was observed in the prevalence of postpartum anxiety and depression,nor scores of MAAS and MPS-Total in different regions or ethnicities(P>0.05).However,MPSMarital interaction(P<0.05),MPS-Family relationship(MPS-FR)(P<0.01),and MPS-Marital conflict(MPS-MC)(P<0.01)scores of urban primiparas were higher than those of rural *** MPS-MC score of Han primiparas was higher than that of Tujia primiparas(P<0.05).Negative correlations were observed between MAAS and SAS(r=-0.457,P<0.01),and MAAS and SDS(r=-0.439,P<0.01).SAS has revealed a highly positive correlation with SDS(r=0.720,P<0.01)and a weak negative correlation with MPS(r=-0.200,P<0.05).Besides,a weak negative correlation was observed between MAAS and MPS-MC(r=-0.184,P<0.05),and a weak positive correlation was noticed between SAS and MPS-MC(r=-0.225,P<0.01).Mediation analysis demonstrated a full mediation effect of mindfulness level on the relationship between MPS-FR a

关键词： Mediating effect Mindfulness Marital quality Postpartum depression Postpartum anxiety Primiparas

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Soil Organic Carbon,Carbon Fractions and Nutrients as Affected by Land Use in Semi-Arid Region of Loess Plateau of China

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Pedosphere 2010年第2期20卷 146-152页

作者： LIU Xun,LI Feng-Min,LIU Da-qian and SUN guo-Jun Key Laboratory of Arid and Grassland Ecology of the Ministry of Education,School of Life Sciences,Lanzhou University,Lanzhou 730000 (China) [a] Key Laboratory of Arid and Grassland Ecology of the Ministry of Education School of Life Sciences Lanzhou University Lanzhou 730000 (China)

Cropland (CP),native grassland (NG) and two shrub land treatments which were converted from cropland in 1985:seabuckthorn (Hippophae rhamnoides L.) (ST),and branchytamarisk (Tamarix ramosissima) (BT) were investigated to evaluate effects of land use conversion on soil organic carbon (SOC) and soil nutrients in the semi-arid region of the Loess Plateau of *** organic carbon (TOC),light fraction organic carbon (LFOC),heavy fraction organic carbon (HFOC),total N (TN),nitrate nitrogen (NO 3-N) and nitrite nitrogen (NO 2-N),ammonium nitrogen (NH + 4-N),total P,and available P (AP) were *** results showed that SOC in NG,ST and BT were 12.7%,27.7% and 34.8% higher than that of the cropland,***,light fraction (LF) dry matter,ratio of TOC to TN (C/N) and the ratio of TOC to AP (C/P) were higher in the shrub land or native grassland than in the *** had the highest TN,the sum of NO 3-N and NO 2-N,TP and AP due to the use of chemical *** significantly correlated with LFOC,HFOC and C/*** significantly correlated with dry matter of the LF and C/***,the sum of NO 3-N and NO 2-N and AP were significantly negatively correlated with TOC and ***,land use conversion from cropland to shrub land,or maybe grassland,contributed to SOC sequestration and improved soil nutrients stabilization.

关键词： cropland heavy fraction organic carbon light fraction organic carbon native grassland shrub land

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Renal protective effect of Ganoderma lucidum

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中国药理学与毒理学杂志 2018年第4期32卷 254-255页

作者： Dan-dan ZHONG Zheng-wei XIE Bo-yue HUANG Shuai ZHU guo-qian WANG Hong ZHOU Shu-qian LIN Zhi-bin LIN Bao-xue YANG State Key Laboratory of Natural and Biomimetic Drugs Department of Pharmacology School of Basic Medical Sciences Peking University Beijing China Fuzhou Institute of Green Valley Bio-Pharm Technology Fuzhou China JUNCAO Technology Research

OBJECTIVE Non-alcoholic fatty liver disease(NAFLD) encompasses a series of *** changes ranging from steatosis to steatohepatitis,which may progress to cirrhosis and *** *** purpose of this study was to determine whether Ganoderma lucidum *** peptide(GLPP) has therapeutic effect on *** ob/ob mouse model and ApoC3 transgenic mouse model were used for exploring the effect of GLPP on *** metabolic *** and enzymes were identified by metabolomics combining with KEGG and PIUmet analyses and key enzymes were detected by Western *** models of HepG2 cells and primary hepatocytes were used to further confirm the therapeutic effect of GLPP on *** GLPP administrated for a month alleviated hepatosteatosis,dyslipidemia,liver dysfunction and liver insulin *** of glycerophospholipid metabolism,fatty acid metabolism and primary bile acid biosynthesis were involved in the therapeutic effect of GLPP on *** of key enzymes revealed that GLPP reversed low expression of CYP7 A1,CYP8 B1,FXR,SHP and high expression of FGFR4 in ob/ob mice and ApoC3 ***,GLPP inhibited fatty acid synthesis by reducing the expression of SREBP1 c,FAS and ACC via a FXR-SHP dependent ***,GLPP reduced the accumulation of lipid droplets and the content of TG in HepG2 cells and primary *** induced by oleic acid and palmitic *** GLPP significantly improves NAFLD via regulating bile acid synthesis dependent on FXR-SHP/FGF pathway,which finally inhibits fatty acid synthesis,indicating that GLPP might be developed as a therapeutic drug for NAFLD.

关键词：非酒精性脂肪性肝病脂肪变性治疗方法临床分析

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Different patterns of association between white matter microstructure and plasma unsaturated fatty acids in those with high risk for psychosis and healthy participants

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General Psychiatry 2022年第2期35卷 109-118页

作者： Wenjun Su Zhixing Li Lihua Xu Jiahui Zeng Yingying Tang Xiaochen Tang Yanyan Wei qian guo Tianhong Zhang Jijun Wang Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Heaith Center Shanghai Jiao Tong University School of MedicineShanghaiChina CAS Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of ScienceShanghaiChina Institute of Psychology and Behavioral Science Shanghai Jiao Tong UniversityShanghaiChina

Background Disrupted white matter(WM)microstructure has been commonly identified in youth at clinical high risk(CHR)for *** lines of evidence suggest that fatty acids,especially unsaturated fatty acids(UFAs),might play a crucial role in the WM pathology of early onset ***,evidence linking UFA and WM microstructure in CHR is quite *** We investigated the relationship between the plasma UFA level and WM microstructure in CHR participants and healthy controls(HC).Methods Plasma fatty acids were assessed and diffusion tensor imaging(DTI)data were performed with tract-based spatial statistics(TBSS)analysis for 66 individuals at CHR for psychosis and 70 *** Both the global and regional diffusion measures showed significant between-group differences,with decreased fractional anisotropy(FA)but increased mean diffusivity(MD)and radial diffusivity(RD)found in the CHR group compared with the HC *** top of that,we found that in the HC group,plasma arachidic acid showed obvious trend-level associations with higher global FA,lower global MD and lower global RD,which regionally spread over the corpus callosum,right anterior and superior corona radiata,bilateral anterior and posterior limb of the internal capsule,and bilateral superior longitudinal ***,there were no associations between global WM measures and any UFA in the CHR ***,we even found negative associations between arachidic acid levels and regional FA values in the right superior longitudinal fasciculus and right retrolenticular part of the internal capsule in the CHR *** Compared with the HC group,CHR subjects exhibited a different pattern of association between WM microstructure and plasma UFA,with a neuroprotective effect found in the HC group but not in the CHR *** discrepancy could be due to the excessively upregulated UFAs accumulated in the plasma of the CHR group,highlighting the role of balanced plasma-membrane fatty

关键词： unsaturated diffusion linking

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论行政规划中公民财产权的保障——以英国《2008规划法案》为借鉴

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上海财经大学学报（哲学社会科学版） 2010年第1期12卷 27-34页

作者：郭倩上海财经大学法学院上海200433

我国行政规划中对公民财产权的保障机制严重缺失。英国《2008规划法案》首次规定了IPC、NPS与CIL的配套制度,其对规划方案的决策主体、标准以及规划实施程序的规定是控制权力滥用、保障公民财产权的有力措施。其中,CIL制度中开发建设基... 详细信息

我国行政规划中对公民财产权的保障机制严重缺失。英国《2008规划法案》首次规定了IPC、NPS与CIL的配套制度,其对规划方案的决策主体、标准以及规划实施程序的规定是控制权力滥用、保障公民财产权的有力措施。其中,CIL制度中开发建设基金的设立,使拆迁人与被拆迁人之间的安置、赔偿矛盾得以缓解,对解决拆迁中公民财产权益纠纷具有现实的借鉴意义。

关键词：行政规划公民财产权保障英国《2008规划法案》

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基于云模型的京津冀物流一体化指标权重研究

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云南财经大学学报 2018年第6期34卷 96-104页

作者：郭茜北京物资学院信息学院北京101149

准确评价物流一体化发展现状有利于推动京津冀协同发展,指标权重设置的科学性直接影响评价结果的准确性。权重是从主观层面对客观事物重要程度的认知与评价,赋权过程需要发挥人的主观能动性,在某种意义上导致了自然语言具有明显的模糊... 详细信息

准确评价物流一体化发展现状有利于推动京津冀协同发展,指标权重设置的科学性直接影响评价结果的准确性。权重是从主观层面对客观事物重要程度的认知与评价,赋权过程需要发挥人的主观能动性,在某种意义上导致了自然语言具有明显的模糊性和随机性,即不确定性。文章在梳理国内外权重设置研究的基础上,利用云模型设计定性与定量统一的权重体系,使权重结果贴近人类认知,易于理解和接受。

关键词：云模型权重物流一体化不确定性

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