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高压氧联合阿替普酶静脉溶栓对急性缺血性脑卒中患者脑组织血流灌注状态及血清IMA、NFL、Occludin水平的影响

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现代生物医学进展 2024年第16期24卷 3075-3078页

作者：钱晓林耿文丽马莉莉乔妍李焕济宁医学院附属医院高压氧医学科山东济宁272000

目的:探讨高压氧联合阿替普酶静脉溶栓对急性缺血性脑卒中(AIS)患者脑组织血流灌注状态及血清缺血修饰白蛋白(IMA)、神经丝轻链蛋白(NFL)、闭合蛋白(Occludin)水平的影响。方法:选取我院2022年6月~2023年6月124例AIS患者为研究对象,随... 详细信息

目的:探讨高压氧联合阿替普酶静脉溶栓对急性缺血性脑卒中(AIS)患者脑组织血流灌注状态及血清缺血修饰白蛋白(IMA)、神经丝轻链蛋白(NFL)、闭合蛋白(Occludin)水平的影响。方法:选取我院2022年6月~2023年6月124例AIS患者为研究对象,随机抽签法分为对照组和观察组,各62例,对照组给予阿替普酶静脉溶栓治疗,观察组在对照组基础上给予高压氧治疗。比较两组临床疗效、卒中量表(NHISS)与改良型Rankin(m RS)评分、脑组织血流灌注状态[脑血流量(CBF)、脑血容量(CBV)、平均通过时间(MTT)、达峰反应时间(TMax)]、血清IMA、NFL、Occludin水平及不良反应发生率。结果:相较于对照组,观察组总有效率较高,治疗2周后NHISS、m RS评分降低(P0.05)。结论:高压氧联合阿替普酶静脉溶栓治疗AIS患者,可改善脑组织血流灌注状态,降低血清IMA、Occludin、NFL水平,减轻神经功能损伤,疗效显著,且安全性高。

关键词：高压氧阿替普酶静脉溶栓急性缺血性脑卒中血流灌注状态 IMA NFL Occludin

Characterization of subunits encoded by Sn RK1 and dissection of combinations among these subunits in sorghum(Sorghum bicolor L.)

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Journal of Integrative Agriculture 2023年第2期22卷 642-649页

作者： xiao qian-lin HUANG Tian-hui ZHOU Chang CHEN Wei-xi CHA Jian-kui WEI Xi-mei XING Fang-yu qian Meng-ya MA qian-nan DUAN Hong LIU Zhi-zhai College of Agronomy and Biotechnology Southwest UniversityChongqing 400715P.R.China

Sucrose nonfermenting-related protein kinase 1(SnRK1)is one of the critical serine/threonine protein *** commonly mediates plant growth and development,cross-talks with metabolism processes and physiological responses to biotic or abiotic *** plays a key role in distributing carbohydrates and sugar signal *** the present study,eight SnRK1 coding genes were identified in sorghum(Sorghum bicolor L.)via sequences alignment,with three forαsubunits(SnRK1α1 to SnRK1α3),three forβ(SnRK1β1 to SnRK1β3),and one for bothγ(SnRK1γ)andβγ(SnRK1βγ).These eight corresponding genes located on five chromosomes(Chr)of Chr1–3,Chr7,and Chr9 and presented collinearities to SnRK1s from maize and rice,exhibiting highly conserved domains within the same subunits from the three kinds of *** results via qRT-PCR showed that different coding genes of SnRK1s in sorghum possessed similar expression patterns except for SnRK1α3 with a low expression level in grains and SnRK1β2 with a relatively high expression level in *** of subcellular localization in sorghum leaf protoplast showed that SnRK1α1/α2/α3/γmainly located on organelles,while the rest four of SnRK1β1/β2/β3/βγlocated on both membranes and some ***,three combinations were discovered among eight SnRK1 subunits in sorghum through yeast two hybrid,includingα1-β2-βγ,α2-β3-γ,andα3-β3-γ.These results provide informative references for the following functional dissection of SnRK1 subunits in sorghum.

关键词： sorghum(Sorghum bicolor L.) SnRK1 expression analysis combination pattern

Genome-wide identification,expression and functional analysis of sugar transporters in sorghum(Sorghum bicolor L.)

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Journal of Integrative Agriculture 2022年第10期21卷 2848-2864页

作者： xiao qian-lin LI Zhen WANG Ya-yun HOU Xian-bin WEI Xi-mei ZHAO xiao HUANG Lei GUO Yan-jun LIU Zhi-zhai College of Agronomy and Biotechnology Southwest UniversityChongqing 400715P.R.China State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130P.R.China College of Agriculture and Food Engineering Baise UniversityBaise 533000P.R.China College of Animal Science and Technology Southwest UniversityChongqing 400715P.R.China

Sugar transporters are essential for osmotic process regulation,various signaling pathways and plant growth and ***,few studies are available on the function of sugar transporters in sorghum(Sorghum bicolor L.).In this study,we performed a genome-wide survey of sugar transporters in *** total,98 sorghum sugar transporters(SSTs)were identified via *** SSTs were classified into three families based on the phylogenetic and conserved domain analysis,including six sucrose transporters(SUTs),23 sugars will eventually be exported transporters(SWEETs),and 69 monosaccharide transporters(MSTs).The sorghum MSTs were further divided into seven subfamilies,including 24 STPs,23 PLTs,two VGTs,four INTs,three p Glc T/SBG1 s,five TMTs,and eight *** localization of the SST genes showed that they were randomly distributed on 10 chromosomes,and substantial clustering was evident on the specific ***-seven SST genes from the families of SWEET,ERD,STP,and PLT were found to cluster in eight tandem repeat event *** total,22 SSTs comprising 11 paralogous pairs and accounting for 22.4%of all the genes were located on the duplicated *** different subfamilies of SST proteins possessed the same conserved domain,but there were some differences in features of the motif and transmembrane helices(TMH).The publicly-accessible RNA-sequencing data and real-time PCR revealed that the SST genes exhibited distinctive tissue specific *** studies showed that seven SSTs were mainly located on the cell membrane and membrane organelles,and 14 of the SSTs could transport different types of monosaccharides in *** findings will help us to further elucidate their roles in the sorghum sugar transport and sugar signaling pathways.

关键词： sorghum(Sorghum bicolor L.) sugar transporter SUT SWEET MST phylogenetic analysis

Application of neutrophil-lymphocyte ratio and red blood cell distribution width in diabetes mellitus complicated with heart failure

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World Journal of Diabetes 2024年第6期15卷 1226-1233页

作者： Jie Pang lin-Yan qian Ping Lv xiao-Ru Che Heart Center Department of Cardiovascular MedicineZhejiang Provincial People’s Hospital(The Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular *** To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December *** NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were *** receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of *** correlation between NLR and RDW with the presence or absence of cardiac events was also *** Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of ***,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac *** NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic ***,NLR and RDW values were directly proportional to patient outcomes.

关键词： Neutrophil-lymphocyte ratio Red blood cell distribution width Type 2 diabetes Heart failure Early diagnosis

Enhancing photoresponsiveness of metal-organic polyhedra by modifying microenvironment

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Nano Research 2024年第6期17卷 5712-5717页

作者： Long Zheng Peng Tan qian Song Sheng-Tao Wang Min Li xiao-Qin Liu lin-Bing Sun State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

Photoresponsiveness of materials is critical to their tunability and efficiency in terminal *** metal-organic polyhedra(PMOPs)feature intrinsic pores and remote controllability,but aggregation of PMOPs in solid state hampers their photoresponsiveness ***,we report the construction of a new PMOP(Cu_(24)(C_(16)H_(12)N_(2)O_(4))_(12)(C_(18)H_(22)O_(5))12,denoted as MOP-PR-LA),where long alkyl(LA)chains act as the intermolecular poles,propping against adjacent PMOP molecules to create individual microenvironment benefiting the isomerization of photoresponsive(PR)*** ultraviolet(UV)-and visible-light irradiation,MOP-PR-LA is much easier to isomerize than the counterpart MOP-PR without *** propylene adsorption,MOP-PR has a low change of adsorption capacity(9.9%),while that of MOP-PR-LA reaches 58.6%.Density functional theory calculations revealed that PR in the cis state has a negative effect on adsorption,while the trans state of PR favors *** work might open an avenue for the construction of photoresponsive materials with high responsiveness and controllability.

关键词： photoresponsive adsorption metal-organic polyhedra azobenzene long alkyl chains propylene capture

Rhodium-catalyzed Doyle-Kirmse rearrangement reactions of sulfoxoniun ylides

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Chinese Chemical Letters 2024年第4期35卷 363-366页

作者： Ying-Di Hao Zhi-qian lin xiao-Yu Guo Jiao Liang Can-Kun Luo qian-Tao Wang Li Guo Yong Wu Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Department of Medicinal Chemistry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Doyle-Kirmse rearrangement reactions have received continuous attention as an important method for constructing complex chemical structures. Herein, we disclosed an efficient rhodium-catalyzed DoyleKirmse rearrangement reaction, which can simultaneously construct C–C bonds and C–X(X = S/Se) bonds using sulfoxonium ylides as starting materials to obtain sulfur-or selenium-containing compounds. This strategy is characterized by the safer and greener carbene precursor, high yields and broad substrate scope, possessing a wide range of application.

关键词： Sulfoxonium ylides Rhodium(Ⅱ)-catalyzed Carbene Rearrangement reactions One-pot process

Selective N-Methylation of N-Methylaniline with CO_(2) and H_(2) over Cu/In_(2)O_(3) Catalyst

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Chinese Journal of Chemistry 2024年第3期42卷 276-282页

作者： Huan Zheng Bo qian lin He State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhouGansu730000 China University of Chinese Academy of Sciences Beijing100049 China

N-Methylation of amines with CO_(2) and H2 is a potential approach for CO_(2) utilization because N-methylated amines can be used as solvents and organic intermediates. In_(2)O_(3)-supported Cu (Cu/In_(2)O_(3)) acts as an effective heterogeneous catalyst for N-methylation reaction of N-methylaniline (MA) with CO_(2) and H_(2),showing higher N,N-dimethylaniline (DMA) selectivity than other supported Cu catalysts. On one hand,the dispersion of Cu can be improved by the defective In_(2)O_(3) support. On the other hand,In_(2)O_(3) support is active in the dissociative adsorption of CO_(2) through C—O bond breaking. In addition,the H_(2) dissociation ability of In_(2)O_(3) can also be enhanced by Cu. The combination of Cu and In_(2)O_(3) is effective in the activation of CO_(2),the adsorption of intermediate N-methylformanilide (MFA),the hydrogenation of MFA to DMA and the prohibition of C—N bond cleavage side reactions,thereby enhancing the reaction rate of MA conversion and the selectivity to DMA.

关键词： N-Methylation CO_(2) Cu/In_(2)O_(3) Supported catalysts Heterogeneous catalysis

Synthesis,Crystal Structure and Biological Activity of 2-(1-(3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carbonyl)piperidin-4-yl)-N-isopropyl-1,3-thiazole-4-carboxamide

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Chinese Journal of Structural Chemistry 2015年第5期34卷 659-666页

作者： LI Feng-Yun ZHU Yu-Jiea FAN Zhi-Jin XU Jing-Hua GUO xiao-Feng ZONG Guang-Ning SONG Hai-Bin CHEN Lai SONG Yin-Qi qian xiao-lin MA Liu-Yong WANG Jia-Ran State Key Laboratory of Elemento-Organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)Nankai University

The title compound 2-（1-（3-bromo-1-（3-chloropyridin-2-yl）-1H-pyrazole-5-carbonyl）piperidin-4-yl）-N-isopropylthiazole-4-carboxamide（C21H22Br Cl N6O2 S,Mr = 536.04） has been synthesized,and its structure was characterized by IR spectra,1H-NMR,13C-NMR,EA,and single-crystal X-ray *** crystal of the title compound belongs to monoclinic system,space group P/c with a = 15.146（3）,b = 11.573（2）,c = 26.937（5） A,β = 103.64（3）°,V = 1839.0（6） A^3,Z = 4,Dc = 1.557 g/cm^3,μ（Mo Ka） = 0.71073 mm^-1,F（000） = 2192,R = 0.0601 and w R = *** exist one intramolecular hydrogen bond at N–H···N and four intermolecular weak interactions at O（2）···H（1）,Cl（1）···H（12）,O（1）···Cl（1） and S（1）···O（2）.Bioassay results indicated that the title compound had good fungicidal and antiviral activities against tobacco mosaic virus.

关键词： pyrazole thiazole crystal structure biological activity

Experimental and numerical investigation of the impacts of rotor tip-rake on excitation forces of pump-jet propulsors

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Journal of Hydrodynamics 2024年第1期36卷 142-157页

作者： Xue-qin Ji xiao-song Zhang Chen-jun Yang xiao-qian Dong State Key Laboratory of Ocean Engineering Marine Numerical Experiment CentreSchool of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China CSSC Shanghai Marine Energy Saving Technology Co. Ltd.Shanghai200011China China Ship Scientific Research Center Shanghai Branch Shanghai200011China

The tip-clearance flow in a pump-jet propulsor exerts great impacts on the fluctuating pressures and resultant unsteady forces,which are important sources of structural vibrations and radiated noise *** blade geometry close to the tip is an important factor determining the vortex strength in the tip-clearance *** the open-water condition,the effects of raking the rotor tips on the duct-surface fluctuating pressures and the resultant unsteady forces acting on different components of the propulsor are investigated via physical model experiments and the numerical solution of Reynolds-averaged Navier-Stokes(RANS)equations coupled with the SST k-ωturbulence *** measured and simulated results of hydrodynamic pressures are consistent to each other,and the simulated flows help better understand why the fluctuating pressures change with the tip *** strong fluctuations of duct-surface pressures are caused by intensive tip separation *** duct-surface pressure fluctuations are effectively reduced by using the rake distribution near the tip towards blade back side and,for the combination of the five-bladed rotor and the seven-bladed stator,the resultant unsteady horizontal(and vertical)forces acting on the duct and stator are also reduced;while increasing rake leads to negative effect on pressure fluctuations and unsteady horizontal(and vertical)forces acting on all the components of the propulsor.

关键词： Pump-jet tip-clearance tip-rake fluctuating pressures excitation forces