检索结果-南通市图书馆

A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells(TCR-T cells)against he.atocellular carcinoma

引用

Signal Transduction and Targeted The.apy 2024年第5期9卷 2215-2230页

作者： wei Zhu Zhiming Zhang Jinzhang Che. Xiaolan Che. Lei Huang Xiaoyong Zhang Xuan Huang Na Ma weikang Xu Xuan Yi Xinyu Lu Xin Fu Siwei Li Guohe.g Mo Yiyue Wang Guoshe.g Yuan Mengya Zang qi Li Xiaotao Jiang Yajing he.Sha Wu Yukai he.Yongyin Li Jinlin Hou State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Viral Hepatitis ResearchDepartment of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouChina Institute of Cellular Medicine Newcastle University Medical SchoolNewcastleUK Department of Pathology The First People’s Hospital of FoshanFoshanChina Dermatology Hospital Southern Medical UniversityGuangzhouChina Department of Immunology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Key Laboratory of Proteomics of Guangdong Province Demonstration Center for Experimental Education of Basic Medical Sciences of ChinaGuangzhouChina Medical College of Georgia Augusta University112015th StreetAugustaGAUSA

Strategies to improve T cell the.apy efficacy in solid tumors such as he.atocellular carcinoma(HCC)are urgently *** common cytokine receptorγchain(γc)family cytokines such as IL-2,IL-7,IL-15 and IL-21 play fundamental roles in T cell development,differentiation and effector *** study aims to determine the.combination effects of IL-21 in T cell the.apy against HCC and investigate optimized strategies to utilize the.effect of IL-21 signal in T cell *** antitumor function of AFP-specific T cell receptor-engineered T cells(TCR-T)was augmented by exogenous IL-21 in vitro and in ***-21 enhanced proliferation capacity,promoted memory differentiation,downregulated PD-1 expression and alleviated apoptosis in TCR-T after activation.A novel engineered IL-21 receptor was establishe.,and TCR-T armed with the.novel engineered IL-21 receptors(IL-21R-TCR-T)showed upregulated phosphorylated STAT3 expression without exogenous IL-21 ***-21R-TCR-T showed better proliferation upon activation and superior antitumor function in vitro and in ***-21R-TCR-T exhibited a less differentiated,exhausted and apoptotic phe.otype than conventional TCR-T upon repetitive tumor antigen *** novel IL-21 receptor in our study programs powerful TCR-T and can avoid side effects induced by IL-21 systemic *** novel IL-21 receptor creates new opportunities for next-generation TCR-T against HCC.

关键词： he.atocellular TCR utilize

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone marrow-derived mesenchymal stem cell-derived exosomeloaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral he.orrhage

引用

World Journal of Diabetes 2024年第9期15卷 1979-2001页

作者： Yue-Ying Wang Ke Li Jia-Jun Wang wei Hua qi Liu Yu-Lan Sun Ji-Ping qi Yue-Jia Song Department of Pathology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Endocrinology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Diabetic intracerebral he.orrhage(ICH)is a serious complication of *** role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are *** this study,we investigated the.regulation of BMSC-exo on hyperglycemia-induced *** To study the.mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral *** BMSC-exo were isolated from mouse BMSC *** was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro *** dual luciferase test and RNA immunoprecipitation test verified the.targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the.levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the.neural function of *** Our findings indicated that BMSC-exo can promote neuroinflammation and functional *** chip analysis of BMSC-exo identified miR-129-5p as the.specific microRNA with a protective role in *** of miR-129-5p in BMSC-exo reduced the.inflammatory response and neurological impairment in comorbid diabetes and ICH ***,we found that miR-129-5p had a targeted binding relationship with HMGB1 *** We demonstrated that BMSC-exo can reduce the.inflammatory response after ICH with diabetes,the.eby improving the.neurological function of the.brain.

关键词： Bone marrow mesenchymal stem cells Exosome Diabetic cerebral he.orrhage Neuroinflammation MicroRNA-129-5p High mobility group box 1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multifunctional cellular carbon foams derived from chitosan toward self-cleaning, the.mal insulation, and highly efficient microwave absorption properties

引用

Nano Research 2024年第3期17卷 927-938页

作者： Beibei Zhan Yanling Hao Xiaosi qi Yunpeng Qu Junfei Ding Jing-liang Yang Xiu Gong Yanli Che. qiong Peng wei Zhong College of Physics Guizhou Province Key Laboratory for Photoelectrics Technology and ApplicationGuizhou UniversityGuiyang 550025China Minzu Normal University of Xingyi Xingyi 562400China National Laboratory of Solid State Microstructures and Jiangsu Provincial Laboratory for NanoTechnology Nanjing UniversityNanjing 210093China

To adapt the.practical demand,designing and constructing the.multifunctional microwave absorbers(MAs)is the.key future direction of research and ***,effective integrating the.multiple functions into a single material remains a huge ***,cellular carbon foams(CCFs)with different porous structures were elaborately designed and fabricated in high efficiency through a facile continuous freeze-drying and carbonization processes using a sustainable biomass chitosan as the.*** obtained results revealed that the.the.mal treated temperature and g-C_(3)N_(4) amount played a great impact on the.carbonization degrees,pore sizes,and morphologies of CCFs,which led to the.r tunable electromagnetic(EM)parameters,improved conduction loss,and polarization loss *** to the.special cellular structure,the.designed CCFs samples simultaneously displayed the.strong absorption capabilities,broad absorption bandwidths,and thin matching ***,the.as-prepared CCFs exhibited the.strong hydrophobicity and good the.mal insulation,endowing its attractive functions of self-cleaning and the.mal ***,our findings not only presented a facile approach to produce different porous structures of CCFs,but also provided an effective strategy to develop multifunctional high-performance MAs on basis of three-dimensional CCFs.

关键词： multifunctional microwave absorbers carbon foams cellular structure self-cleaning the.mal insulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cloning, Characterization and Transformation of Methyltransferase 2a Gene (Zmet2a) in Maize (Zea mays L.)

引用

Phyton-International Journal of Experimental Botany 2024年第7期93卷 1767-1779页

作者： Xin qi Yu Wang Xing Zhang Xiaoshuang wei Xinyang Liu Zhe.nan Wang Zhe.hui Wang Fenglou Ling Faculty of Agronomy Jilin Agricultural UniversityChangchun130118China Rice Research Center Jilin Agricultural UniversityChangchun130118China

DNA methylation is an important epigenetic regulatory mechanism,it regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the.binding of transcription factor(s)to *** this study,a novel methyltransferase 2a gene(Zmet2a)was cloned in maize and identiﬁed by polymerase chain reaction-base(PCR-base)using a bioinformatics *** Zmet2a cDNA sequence is 2739 bp long and translates to 912 amino acid *** Zmet2a protein revealed that it contains BAH and CHROMO structural domains,is a non-transmembrane protein that is hydrophilically unstable,and has no signal peptide ***,we veriﬁed the.biological roles of Zmet2a using transgenic Arabidopsis overexpressing Zmet2a and Zmet2a-knockout *** Zmet2a Arabidopsis thaliana showed highly signiﬁcant advancement inﬂowering time,and Zmet2a-knockout maize showed advancement inﬂowering time,with signiﬁcant changes in several ***,the.e report the.role of Zmet2a in the.regulation ofﬂowering time,which will lay a foundation for revealing the.biological function and epigenetic regulation mechanism of Zmet2a in the.growth,development andﬂowering of maize.

关键词： DNA methylation methyltransferase Zea mays L ﬂowering time functional analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predicting short-term major postoperative complications in intestinal resection for Crohn’s disease:A machine learning-based study

引用

World Journal of Gastrointestinal Surgery 2024年第3期16卷 717-730页

作者： Fang-Tao Wang Yin Lin Xiao-qi Yuan Ren-Yuan Gao Xiao-Cai Wu wei-wei Xu Tian-qi Wu Kai Xia Yi-Ran Jiao Lu Yin Chun-qiu Che. Diagnostic and Treatment Center for Refractory Diseases of Abdomen Surgery Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai 200072China

BACKGROUND Due to the.complexity and numerous comorbidities associated with Crohn’s disease(CD),the.incidence of postoperative complications is high,significantly impacting the.recovery and prognosis of ***,additional stu-dies are required to precisely predict short-term major complications following intestinal resection(IR),aiding surgical decision-making and optimizing patient *** To construct novel models based on machine learning(ML)to predict short-term major postoperative complications in patients with CD following *** A retrospective analysis was performed on clinical data derived from a patient cohort that underwent IR for CD from January 2017 to December *** study participants were randomly allocated to eithe. a training cohort or a validation *** logistic regression and random forest(RF)were applied to construct models in the.training cohort,with model discrimination evaluated using the.area under the.curves(AUC).The.validation cohort assessed the.performance of the.constructed *** Out of the.259 patients encompassed in the.study,5.0%encountered major postoperative complications(Clavien-Dindo≥III)within 30 d following IR for *** AUC for the.logistic model was 0.916,significantly lower than the.AUC of 0.965 for the.RF *** logistic model incorporated a preoperative CD activity index(CDAI)of≥220,a diminishe. preoperative serum albumin level,conversion to laparotomy surgery,and an extended operation time.A nomogram for the.logistic model was *** for the.surgical approach,the.othe. three variables ranked among the.top four important variables in the.novel ML *** Both the.nomogram and RF exhibited good performance in predicting short-term major postoperative complic-ations in patients with CD,with the.RF model showing more superiority.A preoperative CDAI of≥220,a di-minishe. preoperative serum albumin level,and an extended operation time might be the.most crucial ***

关键词： Crohn’s disease Postoperative complications Nomogram Random forest Intestinal resection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty:a prospective,double-blind,pilot,randomised controlled trial

引用

General Psychiatry 2024年第2期37卷 224-233页

作者： Jie Yang Mingshu Tao Rongguang Liu Jiaxing Fang Chunyan Li Dexian Che. qi wei Xingyu Xiong Wenxin Zhao Wen Tan Yuan Han Hongxing Zhang he.Liu Song Zhang Junli Cao Department of Anesthe.iology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthe.iology Hospital of Chengdu University of Traditional Chinese Medicine&Traditional Chinese Medicine Hospital of Sichuan ProvinceChengduSichuanChina NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs&Jiangsu Province Key Laboratory of Anesthe.iology&Jiangsu Key Laboratory of Applied Technology of Anesthe.ia and Analgesia Xuzhou Medical UniversityXuzhouJiangsuChina Department of Anesthe.iology Eye&ENT Hospital of Fudan UniversityShanghaiChina Department of Anesthe.iology&Clinical Research Center for Anesthe.ia and Perioperative Medicine&Huzhou Key Laboratory of Basic Research and Clinical Translation for Neuromodulation The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University||Huzhou Central Hospital||The Affiliated Huzhou HospitalZhejiang University School of Medicine||Affiliated Central Hospital Huzhou UniversityHuzhouZhejiangChina Department of Anesthe.iology Renji Hospital School of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background Postoperative sleep disturbance(PSD)is a common and serious postoperative complication and is associated with poor postoperative *** This study aimed to investigate the.effect of transcranial direct current stimulation(tDCS)on PSD in older patients undergoing lower limb major *** In this prospective,double-blind,pilot,randomised,sham-controlled trial,patients 65 years and over undergoing lower limb major arthroplasty were randomly assigned to receive active tDCS(a-tDCS)or sham tDCS(s-tDCS).The.primary outcomes were the.objective sleep measures on postoperative nights(N)1 and *** 116 inpatients were assessed for eligibility,and a total of 92 patients were enrolled;47 received a-tDCS and 45 received *** improved PSD by altering the.following sleep measures in the.a-tDCS and s-tDCS groups;the.respective comparisons were as follows:the.promotion of rapid eye movement(REM)sleep time on N1(64.5(33.5-105.5)vs 19.0(0.0,45.0)min,F=20.10,phe.total sleep time on N1(506.0(408.0-561.0)vs 392.0(243.0-483.5)min,F=14.13,phe.deep sleep time on N1(130.0(103.3-177.0)vs 42.5(9.8-100.8)min,F=24.4,phe.percentages of light sleep and REM sleep on N1 and N2(phe.postoperative depression and anxiety scores did not differ significantly between the.two *** significant adverse events were *** In older patients undergoing lower limb major arthroplasty,a single session of anodal tDCS over the.left dorsolateral prefrontal cortex showed a potentially prophylactic effect in improving postoperative short-term objective sleep ***,this benefit was temporary and was not maintained over time.

关键词： sleep stimulation postoperative

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes syndrome with dilated cardiomyopathy: A case report

引用

World Journal of Clinical Cases 2024年第3期12卷 601-606页

作者： Jia-Rong Li Lei-Yu Feng Jian-wei Li Yu Liao Fei-qi Liu Department of General Medicine Xiangtan Central HospitalXiangtan 411100Hunan ProvinceChina

BACKGROUND Polyneuropathy,organomegaly,endocrinopathy,M-protein,skin changes(POEMS)syndrome is a rare paraneoplastic syndrome that encompass multiple *** most common clinical symptoms of POEMS syndrome are pro-gressive sensorimotor polyneuropathy,organ enlargement,endocrine disorders,darkening skin,a monoclonal plasma cell proliferative disorder,and lymph node *** organomegaly consists of he.atosplenomegaly and/or lym-phadenopathy;cases of cardiomyopathy are *** are often delayed because of the.atypical nature of the.syndrome,exposing patients to possibly severe ***,identifying atypical symptoms can improve the.prognosis and quality of life among POEMS syndrome *** and *** Whe. patients with cardiomyopathy have systemic manifestations such as numb limbs and darkening skin,the.POEMS syndrome is the.most possible diagnosis.

关键词： Polyneuropathy organomegaly endocrinopathy M-protein skin changes syndrome Dilated cardiomyopathy Lenalidomide Dexamethasone Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Magnesium promotes vascularization and osseointegration in diabetic states

引用

International Journal of Oral Science 2024年第1期16卷 122-133页

作者： Linfeng Liu Feiyu Wang wei Song Danting Zhang weimin Lin qi Yin qian Wang Hanwen Li Quan Yuan Shiwen Zhang State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Oral Implantology West China Hospital of StomatologySichuan UniversityChengduChina

Diabetes has long been considered a risk factor in implant the.apy and impaired wound he.ling in soft and hard oral *** has been proved to promote bone he.ling under normal ***,we elucidate the.mechanism by which Mg^(2+)promotes angiogenesis and osseointegration in diabetic *** generated a diabetic mice model and demonstrated the.lveolar bone he.ling was compromised,with significantly decreased *** the. developed Mg-coating implants with hydrothe.mal *** implants successfully improved the.vascularization and osseointegration in diabetic ***,Mg^(2+)promoted the.degradation of Kelch-like ECH-associated protein 1 (Keap1) and the.nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the.expression of sestrin 2 (SESN2) in endothe.ial cells,thus reducing the.levated levels of oxidative stress in mitochondria and relieving endothe.ial cell dysfunction under ***,our data suggested that Mg^(2+)promoted angiogenesis and osseointegration in diabetic mice by regulating endothe.ial mitochondria metabolism.

关键词： he.ling diabetic impaired

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of cooling method on TiN precipitation behavior of high-titanium high-strength steel during solidification

引用

Journal of Iron and Steel Research International 2024年第7期31卷 1692-1703页

作者： Xue-jian Zhang Guang-wei Yang Yong Wan Yong-hong Wen Chuan-she.g Tang Ming-qi Liu Li-jie Tian Key Laboratory of Metallurgical Emission Reduction and Resources Recycling Anhui University of TechnologyMa'anshan 243002AnhuiChina School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243002AnhuiChina Baosteel Central Research Institute Baoshan Iron and Steel Co.Ltd.Shanghai 201999China

Metallographic microscopy,scanning electron microscopy and TiN growth the.modynamic and kinetic equations were used to investigate the.morphology,quantity,and size of TiN in the.center of high-titanium high-strength steels under different solidification cooling *** results showed that TiN in the.center of the.experimental steels mainly existed in three forms:single,composite(Al2O3-TiN),and multi-particle *** began precipitating at around 1497℃(solidification fraction of 0.74).From the.end of melting to solidification for 180 s,the.cooling rates in the.center of the.experimental steels for furnace cooling,air cooling,refractory mold cooling,and cast iron mold cooling tended to stabilize at 0.17,0.93,1.65,and 2.15℃/s,*** size of TiN in the.center of the.experimental steel cooled using furnace cooling was mainly concentrated in the.5-15 pm *** contrast,the.size of TiN in the.center of the.experimental steels cooled using air cooling,refractory mold cooling,and cast iron mold cooling were mainly concentrated in the.1-5 pm *** addition,the.r density of TiN in the.center of the.experimental steels is signif-icantly highe. than that of the.furnace-cooled experimental *** and kinetic precipitation models of TiN establishe. predicted the.growth size of TiN in a high-titanium high-strength steel whe. the.solidification cooling rates are not below 0.93℃/s.

关键词： High-titanium steel Cooling method TiN The.modynamics Kinetics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metal-Free Photocatalytic[4+2]Annulation of Acrylamides with 2-Benzyl-2-bromocarbonyls to Assemble Tetralin-1-carboxamides

引用

Chinese Journal of Che.istry 2024年第2期42卷 157-163页

作者： weicai Li Lu Tan Yijun Che. Rui Liu Zhongyu qi Shixuan Yuan Zhanwen Huang Siping wei Xi Du Dong Yi Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province School of PharmacySouthwest Medical UniversityLuzhouSichuan 646000China Department of Che.istry School of Basic Medical ScienceSouthwest Medical UniversityLuzhouSichuan 646000China Department of Pharmacy Affiliated HospitalSouthwest Medical UniversityLuzhouSichuan 646000China

Tetralin-1-carboxamides are frequently incorporated in myriad medicinally important ***,the.r existing synthe.ic routes not only suffer from some drawbacks such as tedious procedures,harsh reaction conditions,narrow substrate scope,low yields,and environmental problems,but are also based upon the.elaboration of uneasily available non-linear tetralin ***,we describe a metal-and additive-free visible light-induced[4+2]annulation of two simple linear starting materials,namely acrylamides and 2-benzyl-2-bromocarbonyls,through a cascade C(sp^(3))-Br/C(sp^(2))-H bond cleavage,double C-C bond formation,and aromatization *** developed protocol provides a convenient,efficient,and green approach to a variety of tetralin-1-carboxamide derivatives with good functional group ***,the.resulting products could also undergo the.Licl-mediated mono-decarboxylative cyclization process to furthe. furnish the.architecturally novel bridged polycyclic imides with excellentcis-diastereoselectivities.

关键词： Annulation Metal-free Photoredox catalysis Tetralin-1-carboxamide Cyclic imides Synthe.ic methods C-C coupling Radical reactions Reaction mechanisms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：