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Zinc oxide nanoparticles reduce the chemoresistance of gastric cancer by inhibiting autophagy

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World Journal of Gastroenterology 2021年第25期27卷 3851-3862页

作者： You-Han Miao Li-Ping Mao Xiao-Juan Cai Xiao-Ying Mo qi-qi zhu Fei-Tong Yang Mei-Hua Wang Department of Infectious Disease Nantong Third People’s HospitalNantong 226006Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is a common malignancy that results in a high rate of cancerrelated ***(DDP)-based chemotherapy is the first-line clinical treatment for GC therapy,but chemotherapy resistance remains a severe clinical *** oxide nanoparticle(ZnO-NP)has been identified as a promising anti-cancer agent,but the function of ZnO-NP in GC development is still *** To explore the effect of ZnO-NP on chemotherapy resistance during GC *** ZnO-NP was synthesized,and the effect and underlying mechanisms of ZnO-NP on the malignant progression and chemotherapy resistance of GC cells were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assays,colony formation assays,transwell assays,wound healing assays,flow cytometry,and Western blot analysis in GC cells and DDP-resistant GC cells,and by tumorigenicity analyses in nude *** Our data revealed that ZnO-NP was able to inhibit proliferation,migration,and invasion and induce apoptosis of GC ***,ZnO-NP significantly reduced the half maximal inhibitory concentration(IC50)of DDP for the inhibition of cell proliferation of DDP-resistant SGC7901/DDP cell *** was increased in DDP-resistant GC cells,as demonstrated by elevated light chain 3-like protein 2(LC3II)/LC3I and Beclin-1 expression and repressed p62 expression in SGC7901/DDP cells compared to SGC7901 ***,ZnO-NP inhibited autophagy in GC cells and treatment with DDP induced autophagy,which was reversed by ***,ZnO-NP attenuated the tumor growth of DDP-resistant GC cells in *** We conclude that ZnO-NP alleviates the chemoresistance of GC cells by inhibiting *** findings present novel insights into the mechanism by which ZnO-NP regulates the chemotherapy resistance of ***-NP may serve as a potential therapeutic candidate for GC *** potential role of ZnO-NP in the clinical treatment of GC needs clarif

关键词： Gastric cancer Progression Chemoresistance Zinc oxide nanoparticle Autophagy MTT assays

Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao Jiang Zengxin qi Huixian zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan Xin Cao Liang Chen qianxing zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

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甲烷气相均相选择氧化合成甲醇

石油化工 2003年第3期32卷 195-199页

作者：张昕贺德华张启俭朱起明清华大学化学系一碳化学与化工国家重点实验室北京100084

在特殊设计的不同尺寸的微型反应器和模试反应器中考察了反应温度、气体流速、压力、CH4/O2体积比、反应器恒温段长度以及运行时间等因素对CH4气相均相选择氧化合成CH3OH的影响。结果表明:430～470℃、较高的反应压力、较高的V(CH4)/V(O... 详细信息

在特殊设计的不同尺寸的微型反应器和模试反应器中考察了反应温度、气体流速、压力、CH4/O2体积比、反应器恒温段长度以及运行时间等因素对CH4气相均相选择氧化合成CH3OH的影响。结果表明:430～470℃、较高的反应压力、较高的V(CH4)/V(O2),较大的反应气体流量的条件下,甲烷转化率为10%～13%,甲醇选择性为55%～65%,收率为7%～8%。反应尾气中还含有相当量的CO和H2,CO2选择性可以被控制在较低水平(≤5%)。提出了以管道天然气为原料一次通过直接氧化法合成CH3OH的新构想。

关键词：甲烷合成甲醇选择氧化气相均相反应一次通过法

Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： Jun Jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang Xue Wenyao Zhang Pan Xiong Xin Wang Junwu zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Ductility

加强青年教师队伍建设,不断提高科研服务水平——测试人才队伍建设研究

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实验技术与管理 2011年第11期 364-367页

作者：齐红梁齐朱新远金承钰上海交通大学分析测试中心

在对上海交通大学分析测试中心技术队伍的现状做了充分分析的基础上,找出存在的问题和关键点,提出建设青年人才队伍的必要性和建设方法,从加强分析测试能力和提升科研水平等方面提出了一些见解,同时也在政策扶持方面做了有益的探索。

关键词：分析测试队伍建设青年人才

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群逆的初等变换计算方法

聊城大学学报（自然科学版） 2010年第4期23卷 49-51页

作者：戚其祝赵建立潍坊中学山东潍坊261000 聊城大学数学科学学院山东聊城252059

通过矩阵秩方法工具给出了使用初等变换计算矩阵群逆的方法,从理论上统一了奇异矩阵群逆和可逆矩阵逆的计算方法,并给出算例.

关键词：秩方法群逆初等变换

A New Fast Matching Algorithm by Trans-Scale Search for Remote Sensing Image

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Chinese Journal of Electronics 2015年第3期24卷 654-660页

作者： qi Youjie zhu En College of Information Science and Engineering Southeast University

A new fast matching algorithm for remote sensing images is proposed. The algorithm adopts a coarse to fine matching process. A remote sensing image is decomposed into multi-scale images which form a wavelet image pyramid by the way of DWT(Discrete wavelet transform).Extract a low frequency sub-image from the wavelet image pyramid to carry out a rough matching operation between the sub-image and target image, and then get a rough position after cluster analysis. Get a suitable position with center at the rough position from remote sensing image to accomplish fine matching operation. The algorithm has been analyzed theoretically from the signal processing point of view, and a sufficient condition is given to select wavelet filter. Simulation results testify that proposed algorithm not only distinguishes remote sensing images precisely, but also cuts down matching time greatly. It is only 25.04% of SIFT algorithm, and 35.36% of SURF algorithm for matching time.

关键词： Image matching SIFT DWT Remote sensing

Time-Efficient Power Allocation Scheme for Two-Way Multi-relay Cognitive Radio Networks

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Chinese Journal of Electronics 2016年第2期25卷 357-363页

作者： ZHOU Zhikang zhu qi The Key Wireless Lab of Jiangsu Province School of Telecommunication and Information EngineeringNanjing University of Posts and Telecommunications Key Lab on Wideband Wireless Communications and Sensor Network Technology of Ministry of Education

Cooperative relaying has been emerging as a key technology in Cognitive radio(CR) networks. A two-way Amplify-and-forward(AF) based multi-relay CR network is considered, where a primary user coexists with a pair of secondary users and multiple relays. A Timeefficient sub-optimal power allocation scheme(TESOPA)based on Cauchy-Schwarz inequality is provided to maximize the total end-to-end transmission rate of the secondary system. TESOPA is proposed under maximal transmission power constraints, while ensuring the quality of service of the primary user during the whole communication process. The computational complexity is sharply decreased by using the Cauchy-Schwarz inequality. Simulation results show that the proposed TESOPA scheme performs very close to the near-optimal Interior point method based power allocation(IPMPA), especially in interference dominant networks where interference constraints play a key role in determining power allocation results instead of maximal transmission power constraints.

关键词： Power allocation Relay network Cognitive radio Amplify-and-forward Two-way communication

A design of T-foil and trim tab for fast catamaran based on NSGA-II

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Journal of Hydrodynamics 2020年第1期32卷 161-174页

作者： qi-dan zhu Yu Ma Collge of Automation Harbin Engineering UniversityHarbin 150001China

This paper proposed an optimization design for a ride control system(RCS)for fast *** ship vertical motions are predicted by 2.5-D *** hydrodynamic characteristics of T-foil and trim tab are given,and the dynamic stability of the system is *** this basis,the ride control system optimization model in regular and irregular waves is established for a specific *** optimal solution is obtained by using non-dominated sorting genetic algorithm-II(NSGA-II).

关键词： Deep neural network channel flow turbulence model Reynolds stress