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FibroScan-aspartate transaminase:A superior non-invasive model for diagnosing high-risk metabolic dysfunction-associated steatohepatitis

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World Journal of Gastroenterology 2024年第18期30卷 2440-2453页

作者： Jing-Ya Yin Tian-Yuan Yang bing-qing Yang Chen-Xue Hou Jun-Nan Li Yue Li qi wang Center of Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Pathology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing institute of infectious disease Beijing 100015China Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)with hepatic histological NAFLD activity score≥4 and fibrosis stage F≥2 is regarded as“at risk”non-alcoholic steatohepatitis(NASH).Based on an international consensus,NAFLD and NASH were renamed as metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH),respectively;hence,we introduced the term“high-risk MASH”.Diagnostic values of seven non-invasive models,including FibroScan-aspartate transaminase(FAST),fibrosis-4(FIB-4),aspartate transaminase to platelet ratio index(APRI),etc.for high-risk MASH have rarely been studied and compared in MASLD.AIM To assess the clinical value of seven non-invasive models as alternatives to liver biopsy for diagnosing high-risk MASH.METHODS A retrospective analysis was conducted on 309 patients diagnosed with NAFLD via liver biopsy at Beijing Ditan Hospital,between January 2012 and December 2020.After screening for MASLD and the exclusion criteria,279 patients wereincluded and categorized into high-risk and non-high-risk MASH groups.Utilizing threshold values of each model,sensitivity,specificity,positive predictive value(PPV),and negative predictive values(NPV),were calculated.Receiver operating characteristic curves were constructed to evaluate their diagnostic efficacy based on the area under the curve(AUROC).RESULTS MASLD diagnostic criteria were met by 99.4%patients with NAFLD.The MASLD population was analyzed in two cohorts:Overall population(279 patients)and the subgroup(117 patients)who underwent liver transient elastography(FibroScan).In the overall population,FIB-4 showed better diagnostic efficacy and higher PPV,with sensitivity,specificity,PPV,NPV,and AUROC of 26.9%,95.2%,73.5%,72.2%,and 0.75.APRI,Forns index,and aspartate transaminase to alanine transaminase ratio(ARR)showed moderate diagnostic efficacy,whereas S index and gamma-glutamyl transpeptidase to platelet ratio(GPR)were relatively weaker.In the subgroup,FAST had the highest diagnostic efficacy,i

关键词： Metabolic dysfunction-associated steatotic liver disease High-risk metabolic dysfunction-associated steatohepatitis Non-invasive models Liver biopsy Diagnostic value

MicroRNAs:A novel signature in the metastasis of esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2024年第11期30卷 1497-1523页

作者： qi-Ying Wei Feng Jin Zhong-Yu wang bing-Jie Li Wen-Bo Cao Zhi-Yan Sun Sai-Jun Mo Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Perioperative Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Division of Special Service Department of Basic OncologySchool of Basic MedicineZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Esophageal squamous cell carcinoma(ESCC)is a malignant epithelial tumor,characterized by squamous cell differentiation,it is the sixth leading cause of cancer-related deaths globally.The increased mortality rate of ESCC patients is predominantly due to the advanced stage of the disease when discovered,coupled with higher risk of metastasis,which is an exceedingly malignant charac-teristic of cancer,frequently leading to a high mortality rate.Unfortunately,there is currently no specific and effective marker to predict and treat metastasis in ESCC.MicroRNAs(miRNAs)are a class of small non-coding RNA molecules,approximately 22 nucleotides in length.miRNAs are vital in modulating gene expression and serve pivotal regulatory roles in the occurrence,progression,and prognosis of cancer.Here,we have examined the literature to highlight the intimate correlations between miRNAs and ESCC metastasis,and show that ESCC metastasis is predominantly regulated or regulated by genetic and epigenetic factors.This review proposes a potential role for miRNAs as diagnostic and therapeutic biomarkers for metastasis in ESCC metastasis,with the ultimate aim of reducing the mortality rate among patients with ESCC.

关键词： MicroRNAs Esophageal squamous cell carcinoma Metastasis Signaling pathway Epigenetics mechanism

Chromosome-level genome assembly of the Asian citrus psyllid,Diaphorina citri

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Insect Science 2024年第1期31卷 13-27页

作者： Shuang Lei Shi-Jiang Yu qi Pan Li-Li Ding Si-Chen Li Lu-Yan Cheng Shu-qi wang bing-Hai Lou Jun He Cui-Yun Lei Lin Cong Hao-qiang Liu Xue-Feng wang Chun Ran Citrus Research Institute Southwest University/Chinese Academy of Agricultural SciencesNational Engineering Research Center for CitrusChongqingChina

Diaphorina citri is a global citrus pest.As a vector insect,it can transmit the causative agents of citrus huanglongbing,causing irreversible losses to the citrus industry.The acquisition of genomic information can provide a molecular genetic basis for effective control of D.citri.Here,the DNBSEQ™,Oxford Nanopore Technologies,and Hi-C technologies are applied to generate a high-quality chromosome-level genome of D.citri.The genome size of D.citri was 523.78 Mb with a scaffold N50 of 47.05 Mb distributed on 13 chromosomes.A total of 250.64 Mb(47.85%)repeat sequences and 24048 protein-coding genes were predicted.Genome resequencing of female and male individuals indicated that the sex chromosome system of D.citri is XO.Phylogenetic analysis demonstrated that D.citri and Pachypsylla venusta,which separated from their most recent common ancestor about 336.62 million years ago,were the most closely related.Additionally,we identified genes potentially involved in detoxification metabolism,pathogen transmission,and honeydew secretion for further investigation.The high-quality genome provides an important reference for developing effective management strategies of D.citri.

关键词： Asian citrus psyllid chromosome-level genome comparative genomics cytochrome P450 detoxification Huanglongbing

Remaining Useful Life Prediction Method for Multi-Component System Considering Maintenance:Subsea Christmas Tree System as A Case Study

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China Ocean Engineering 2024年第2期38卷 198-209页

作者： WU qi-bing CAI Bao-ping FAN Hong-yan wang Guan-nan RAO Xi GE Weifeng SHAO Xiao-yan LIU Yong-hong CNOOC Safety Technology Services Co. Ltd.Tianjin 300456China College of Mechanical and Electronic Engineering China University of PetroleumQingdao 266580China CNOOC EnerTech Safety&Environmental Protection BranchTianjin 300456China

Maintenance is an important technical measure to maintain and restore the performance status of equipment and ensure the safety of the production process in industrial production,and is an indispensable part of prediction and health management.However,most of the existing remaining useful life(RUL)prediction methods assume that there is no maintenance or only perfect maintenance during the whole life cycle;thus,the predicted RUL value of the system is obviously lower than its actual operating value.The complex environment of the system further increases the difficulty of maintenance,and its maintenance nodes and maintenance degree are limited by the construction period and working conditions,which increases the difficulty of RUL prediction.An RUL prediction method for a multi-omponent system based on the Wiener process considering maintenance is proposed.The performance degradation model of components is established by a dynamic Bayesian network as the initial model,which solves the uncertainty of insufficient data problems.Based on the experience of experts,the degree of degradation is divided according to Poisson process simulation random failure,and different maintenance strategies are used to estimate a variety of condition maintenance factors.An example of a subsea tree system is given to verify the effectiveness of the proposed method.

关键词： remaining useful life Wiener process dynamic Bayesian networks maintenance subsea Christmas tree system

Development of a high-repetition-rate lumped-inductance kicker magnet prototype for the beam switchyard of SHINE

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Nuclear Science and Techniques 2024年第2期35卷 20-31页

作者： Yong-Fang Liu Rui-Ping wang Jin Tong Bo Zhang Si Chen qi-bing Yuan Hai-Xiao Deng Ming Gu Bo Liu Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201412People’s Republic of China

The Shanghai high-repetition-rate X-ray free-electron laser and extreme light facility(SHINE)operates at a maximum repetition rate of 1 MHz.Kicker magnets are key components that distribute electron bunches into three different undulator lines in a bunch-by-bunch mode.The kicker field width must be less than the time interval between bunches.A lumpedinductance kicker prototype was developed using a vacuum chamber with a single-turn coil.The full magnetic field strength was 0.005 T.This paper presents the requirements,design considerations,design parameters,magnetic field calculations,and measurements of the kicker magnets.The relevant experimental results are also presented.The pulse width of the magnetic field was approximately 600 ns,and the maximum operation repetition rate was 1 MHz.The developed kicker satisfies the requirements for the SHINE project.Finally,numerous recommendations for the future optimization of kicker magnets are provided.

关键词： X-ray free-electron laser Kicker magnet Beam switchyard High repetition rate Ni-Zn ferrites

Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer

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National Science Review 2024年第4期11卷 216-227页

作者： Da-Yong Hou Ni-Yuan Zhang Lu wang Mei-Yu Lv Xiang-Peng Li Peng Zhang Yue-Ze wang Lei Shen Xiu-Hai Wu Bo Fu Peng-Yu Guo Zi-qi wang Dong-bing Cheng Hao wang Wanhai Xu NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in Urology Harbin Medical University Department of Urology Harbin Medical University Cancer Hospital CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST) School of Chemistry Chemical Engineering & Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan University of Technology

Mitochondriopathy inspired adenosine triphosphate(ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration(IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites,leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like damages.Briefly, the reported transformable nucleopeptide(NLS-FF-T) self-assembled into nuclear-targeted nanoparticles with ATP binding sites encapsulated inside under aqueous conditions. By interaction with KPNA2, the NLS-FF-T transformed into a nanofibrous-based ATP trapper on the surface of tumor nuclei,which prevented the production of intracellular energy. As a result, multiple bladder tumor cell lines(T24,EJ and RT-112) revealed that the half-maximal inhibitory concentration(IC50) of NLS-FF-T was reduced by approximately 4-fold when compared to NLS-T. Following intravenous administration, NLS-FF-T was found to be dose-dependently accumulated at the tumor site of T24 xenograft mice. More significantly, this IAS system exhibited an extremely antitumor efficacy according to the deterioration of T24 tumors and simultaneously prolonged the overall survival of T24 orthotopic xenograft mice. Together, our findings clearly demonstrated the therapeutic advantages of intracellular ATP sequestration-induced mitochondriopathy-like damages, which provides a potential treatment strategy for malignancies.

关键词： self-assembly nucleopeptide nanomaterial bladder cancer mitochondriopathy

A Fibonacci View on the Galois NFSR Used in Trivium

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Journal of Systems Science & Complexity 2024年第3期37卷 1326-1350页

作者： wang Hongyu ZHENG Qunxiong qi Wenfeng PLA Strategic Support Force Information Engineering University Zhengzhou 450001China

Trivium is an international standard of lightweight stream ciphers(ISO/IEC 29192-3:2012).In this paper,the Trivium-like NFSRs,a class of Galois NFSRs generalized from the Galois NFSR of Trivium,are studied from the perspective of Fibonacci NFSRs.It is shown that an n-stage Trivium-like NFSR cannot be equivalent to an n-stage Fibonacci NFSR,which is proved by showing the existence of“collision initial states”.As an intermediate conclusion,a necessary and sufficient condition for a kind of linear degeneracy of a Trivium-like NFSR is obtained from the persepective of interleaved sequences.Moreover,the smallest stage number of a Fibonacci NFSR that can generate all the output sequences of an n-stage Trivium-like NFSR is shown to be greater than n-7 and this value is no less than 371=287+min{93,84,111}specifically for the 288-stage Galois NFSR used in Trivium.These results contradict the existence of a equivalent Fibonacci model of Trivium NFSR of small stage,which implies that Trivium algorithm possesses a fair degree of immunity against“structure attack”.

关键词： Fibonacci NFSR galois NFSR interleaved sequence linear degeneracy trivium

Adaptive fault-tolerant control for non-minimum phase hypersonic vehicles based on adaptive dynamic programming

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Chinese Journal of Aeronautics 2024年第3期37卷 290-311页

作者： Le wang Ruiyun qi Bin JIANG State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China

In this paper,a novel adaptive Fault-Tolerant Control(FTC)strategy is proposed for non-minimum phase Hypersonic Vehicles(HSVs)that are affected by actuator faults and parameter uncertainties.The strategy is based on the output redefinition method and Adaptive Dynamic Programming(ADP).The intelligent FTC scheme consists of two main parts:a basic fault-tolerant and stable controller and an ADP-based supplementary controller.In the basic FTC part,an output redefinition approach is designed to make zero-dynamics stable with respect to the new output.Then,Ideal Internal Dynamic(IID)is obtained using an optimal bounded inversion approach,and a tracking controller is designed for the new output to realize output tracking of the nonminimum phase HSV system.For the ADP-based compensation control part,an ActionDependent Heuristic Dynamic Programming(ADHDP)adopting an actor-critic learning structure is utilized to further optimize the tracking performance of the HSV control system.Finally,simulation results are provided to verify the effectiveness and efficiency of the proposed FTC algorithm.

关键词： Hypersonic vehicle Fault-tolerant control Non-minimum phase system Adaptive control Nonlinear control Adaptive dynamic programming

Chaotic Map-Based Authentication and Key Agreement Protocol with Low-Latency for Metasystem

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Computers, Materials & Continua 2024年第3期78卷 4471-4488页

作者： Guojun wang qi Liu School of Electronics&Information Engineering Nanjing University of Information Science&TechnologyNanjing210044China Yancheng Polytechnic College Yancheng224000China Jiangsu Province Engineering Research Center of Advanced Computing and Intelligent Services School of SoftwareNanjing University of Information Science and TechnologyNanjingChina

With the rapid advancement in exploring perceptual interactions and digital twins,metaverse technology has emerged to transcend the constraints of space-time and reality,facilitating remote AI-based collaboration.In this dynamic metasystem environment,frequent information exchanges necessitate robust security measures,with Authentication and Key Agreement(AKA)serving as the primary line of defense to ensure communication security.However,traditional AKA protocols fall short in meeting the low-latency requirements essential for synchronous interactions within the metaverse.To address this challenge and enable nearly latency-free interactions,a novel low-latency AKA protocol based on chaotic maps is proposed.This protocol not only ensures mutual authentication of entities within the metasystem but also generates secure session keys.The security of these session keys is rigorously validated through formal proofs,formal verification,and informal proofs.When confronted with the Dolev-Yao(DY)threat model,the session keys are formally demonstrated to be secure under the Real-or-Random(ROR)model.The proposed protocol is further validated through simulations conducted using VMware workstation compiled in HLPSL language and C language.The simulation results affirm the protocol’s effectiveness in resisting well-known attacks while achieving the desired low latency for optimal metaverse interactions.

关键词： Metasystem authentication and key agreement chaotic map secure communication