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Astrocytic calcium waves:unveiling their roles in sleep and arousal modulation

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Neural Regeneration Research 2024年第5期19卷 984-987页

作者： Erxi Wu Dan qi Damir Nizamutdinov Jason H.huang Department of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTXUSA Texas A&M University School of Medicine TempleTXUSA Texas A&M University School of Pharmacy College StationTXUSA LIVESTRONG Cancer Institutes and Department of Oncology Dell Medical Schoolthe University of Texas at AustinAustinTXUSA Department of Neurosurgery Baylor College of MedicineTempleTXUSA

Neuron-astrocyte interactions are vital for the brain’s *** astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in different cortical states and associated behaviors in *** on animal sleep and wakefulness have revealed distinct cortical synchrony patterns between ***,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic *** research on astrocyte activation during cortical state transitions has emphasized the influence of norepinephrine as a neurotransmitter and calcium waves as key components of ion channel *** summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring the involvement of noradrenaline signaling,ion channels,and glutamatergic signaling in different cortical *** findings highlight the significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and *** astrocytic signaling pathways shows promise for treating sleep disorders and arousal *** research is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future human studies to comprehensively investigate neuron-astrocyte interactions and pave the way for therapeutic interventions in sleep-and arousal-related disorders.

关键词： arousal astrocyte calcium waves locus coeruleus neuron-astrocyte interaction norepinephrine sleep wakefulness

A Temporal Convolutional Network Based Hybrid Model for Short-term Electricity Price Forecasting

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1119-1130页

作者： Haoran Zhang Weihao Hu Di Cao qi huang Zhe Chen Frede Blaabjerg School of Mechanical and Electrical Engineering University of Electronic Science and Technology of ChinaChengduChina Department of Energy Technology Aalborg UniversityAalborgDenmark IEEE

Electricity prices have complex features,such as high frequency,multiple seasonality,and *** factors will make the prediction of electricity prices ***,accurate electricity price prediction is important for energy producers and consumers to develop bidding *** improve the accuracy of prediction by using each algorithms’advantages,this paper proposes a hybrid model that uses the Empirical Mode Decomposition(EMD),Autoregressive Integrated Moving Average(ARIMA),and Temporal Convolutional Network(TCN).EMD is used to decompose the electricity prices into low and high frequency *** frequency components are forecasted by the ARIMA model and the high frequency series are predicted by the TCN *** results using the realistic electricity price data from Pennsylvania-New Jersey-Maryland(PJM)electricity markets show that the proposed method has a higher prediction accuracy than other single methods and hybrid methods.

关键词： Autoregressive integrated moving average model electricity price forecasting empirical mode decomposition temporal convolutional network

Predicting transformer temperature field based on physics-informed neural networks

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High Voltage 2024年第4期9卷 839-852页

作者： Pengfei Tang Zhonghao Zhang Jie Tong Tianhang Long Can huang Zihao qi China Electric Power Research Institute BeijingChina

The safe operation of oil-immersed transformers is critical to the safety and stability of the power *** the operating time increases,the failure rate of oil-immersed transformers shows an increasing trend,posing serious challenges to safe *** is necessary to investigate the internal state of the oil-immersed transformer to improve the digital degree and achieve digitalisation and intelligent operation and maintenance.A physics-informed neural network(PINN)for oil-immersed transformers was introduced to reconstruct the temperature distribution inside the *** to the approach,the loss function of the network would be optimised by incorporating physical constraint loss terms including heat transfer equations,initial conditions and boundary *** results show that the method proposed can be used to reconstruct and predict the temperature field of transformers in a few seconds with satisfactory *** conclusion,the PINN proposed outperforms deep neural networks in terms of accuracy,reliability and interpretability,especially in data-poor cases.

关键词： immersed conclusion constraint

Evaluation of lightning-induced overvoltage on a 10 kV distribution line based on electromagnetic return-stroke model using finite-difference time-domain

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High Voltage 2024年第2期9卷 356-366页

作者： Pan Duan Lianfang Zhang Xiaogang huang Jian Sun Yue qi qing Yang School of Automation Chongqing University of Posts and TelecommunicationsChongqingChina Chongqing Power Co Tongnan BurChongqingChina China Southern Power Grid Science Research Institute GuangzhouChina State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqingChina

Accurate simulation of lightning-induced overvoltage for overhead distribution lines is helpful to prevent lightning trip *** electromagnetic return-stroke model was used to represent lightning and then a 3D finite-difference time-domain(FDTD)method was adopted to simulate the lightning-induced overvoltage on a distribution line without a field-line coupling *** lightning-induced overvoltage behave for different ground conductivity and varying distance between the distribution line and the lightning channel was *** results showed that the overvoltage waveforms at the centre point of the line corresponding to lightning strikes on the lossy ground and an ideal ground(σ=∞)were similar;however,the peak amplitudes of the waveform were affected by soil conductivity at a close *** relationship between magnitude of the overvoltage and distance can be described by a second-order exponential decay ***,the overvoltage calculated using the proposed model was compared with those obtained based on Agrawal's model and measurements made using the newly developed intelligent insulator on *** these comparisons,it could be concluded that the FDTD method with the electromagnetic return-stroke model produces reasonably accurate results of the attenuated oscillation waveform,which can better reproduce the overvoltage on operational distribution lines.

关键词： lightning distribution return

Metal-free Optical Pressure Sensor with High Sensitivity and Extensive Range

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 1291-1300页

作者： Mao Ji Meng huang Haomin Lyu Sheng Shi Bo qi Chengrong Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China IEEE CSEE

Pressure monitoring of a transformer oil tank can grasp the pressure change process caused by gas production when severe internal defects occur and take timely measures to ensure the safe operation of the *** pressure sensors generally use metal encapsulation or have an air cavity structure,threatening the transformer’s insulation if it is directly used inside the *** this end,this paper proposes a method for developing a high-sensitivity,large-range,and metallizationfree optical pressure sensing device with temperature *** grating is encapsulated by fluorosilicone rubber and supplemented by an epoxy resin shielding shell on the *** the same time,a double-grating vertical arrangement is adopted to improve pressure measurement sensitivity,further avoiding the influence of temperature rise caused by a defect of the transformer on the measurement result of the *** addition,by optimizing the geometric structure of the internal sensitizing element,pre-stretching length of the fiber grating,gap distance,and other parameters,probe size can be reduced while ensuring the sensor’s *** show the proposed method can meet the requirements of sensor fabrication with different sensitivities and ranges,and to a certain extent,both high sensitivity and extensive ranges can be taken into *** sensitivity of the fabricated prototype is 15 pm/kPa,and the range is about 0.2 *** the same time,the metal-free feature of the sensor makes it suitable for use in various oil-immersed power *** records oil pressure changes caused by oil discharge breakdown,making it sensitive to small pressure changes in early failures.

关键词： Highly sensitive extensive range optical sensing no metallization pressure perception temperature compensation transformer

The short and long-term effect of polystyrene nanoplastics on nitrifying sludge at high nitrite concentrations

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Journal of Environmental Sciences 2024年第1期135卷 222-231页

作者： Xiaolong Wang Jialu huang Zhiqiang qi Ruiqin Kang Chao Du Da Li School of Chemical and Environmental Engineering Anyang Institute of TechnologyAnyang 455000China Henan Licheng Environmental Technology Co. Ltd.Anyang 455000China State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

The effect of nanoplastics(NPs)on nitrite oxidation bacteria(NOB)community in treating high-strength wastewater remains unclear,which seriously affects the stability of nitrogen removal *** this study,highly active nitrifying sludge was enriched and exposed to 50nm polystyrene NPs(PS-NPs)for short-term(1,100,500,and 1000 mg/L,1.5 hr)and long-term(1,10,100 mg/L,40 days)at high nitrite *** contrast to previous studies,our results showed that the exposures to PS-NPs had little effect on nitrifying *** long-term exposure,the protein/polysaccharide ratios in extracellular polymeric substances(EPS)were positively correlated with PS-NPs concentrations(0.78–0.99).The produced reactive oxygen species(ROS)were gradually removed,and PS-NPs higher than 10 mg/L caused damage to membrane ***-term exposure for 40 days increased the community diversity and caused significant differences between the control and exposed *** control group were dominated by Nitrobacter and Exiguobacterium,while the exposure group was dominated by Bacillus,Mycobacterium,and Nitrospira.A noticeable shift in the NOB community from Nitrobacter(26.5%to 3.4%)to Nitrospira(1.61%to 14.27%)was observed.A KEGG analysis indicated a decrease in cell growth and death,cell motility and energy *** appeared that NOB could adapt to PS-NPs stress through enhanced secretion and removal of oxidative ***,this study provided new insights into the response mechanism of NOB to PS-NPs exposure.

关键词： Nanoplastics Nitrifying activity Extracellular polymeric substance(EPS) Exposure Community analysis

Effect of ceramic work rolls on surface roughness of rolled SUS304 ultra-thin strips

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Journal of Iron and Steel Research International 2024年第7期31卷 1704-1718页

作者： Peng-cheng Li Tao Wang Chen-chen Zhao qi Liu qing-xue huang College of Mechanical and Vehicle Engineering Taiyuan University of TechnologyTaiyuan 030024ShanxiChina Engineering Research Center of Advanced Metal Composites Forming Technology and Equipment of Ministry of Education Taiyuan University of TechnologyTaiyuan 030024ShanxiChina National Key Laboratory of Metal Forming Technology and Heavy Equipment Taiyuan University of TechnologyTaiyuan 030024ShanxiChina

Surface morphology and roughness are important parameters of surface quality of cold-rolled ultra-thin strip *** order to study the effect of Si_(3)N_(4) ceramic work rolls on the surface roughness of SUS304 ultra-thin strip,ABAQUS finite element model calculation,3D laser profilometry,and other methods were adopted based on the physical characteristics of Si_(3)N_(4) ceramic roll and 9Cr2MoV steel roll,like anti-flattening performance and oil *** surface morphology and roughness of SUS304 ultra-thin strip rolled by different material work rolls under oil lubrication conditions were *** results showed that under the rolling force of 10 kN,the maximum flattening amount of Si_(3)N_(4) ceramic roll was reduced by 35.14%compared to that of 9Cr2MoV steel *** reduction rate of SUS304 ultra-thin strip rolled by ceramic roll was 34.19%,while that rolled by steel roll was only 22%;Si_(3)N_(4) ceramic roll can further increase the number of alternating convex peaks and concave valleys in the rolled thin strip,reduce the profile steepness,reduce surface roughness,and enhance the planarization effect of surface micro-convex bodies,with improving surface quality and surface ***,the mechanism of Si_(3)N_(4) ceramic roll significantly improving the surface roughness of rolled SUS304 ultra-thin strip was proposed.

关键词： Ceramic work roll-Steel roll SUS304 ultra-thin strip Reduction Surface roughness

Novel milestones for early esophageal carcinoma:From bench to bed

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1104-1118页

作者： Ji-Han qi Shi-Ling huang Shi-Zhu Jin Department of Gastroenterology and Hepatology The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086Heilongjiang ProvinceChina

Esophageal cancer(EC)is the seventh most common cancer worldwide,and esophageal squamous cell carcinoma(ESCC)accounts for the majority of cases of *** effectively diagnose and treat ESCC and improve patient prognosis,timely diagnosis in the initial phase of the illness is *** article offers a detailed summary of the latest advancements and emerging technologies in the timely identification of *** biology and epigenetics approaches involve the use of molecular mechanisms combined with fluorescence quanti-tative polymerase chain reaction(qPCR),high-throughput sequencing technology(next-generation sequencing),and digital PCR technology to study endogenous or exogenous biomolecular changes in the human body and provide a decision-making basis for the diagnosis,treatment,and prognosis of *** invest-igation of the microbiome is a swiftly progressing area in human cancer research,and microorganisms with complex functions are potential components of the tumor *** intratumoral microbiota was also found to be connected to tumor *** application of endoscopy as a crucial technique for the early identification of ESCC has been essential,and with ongoing advancements in technology,endoscopy has continuously *** the advancement of artificial intelligence(AI)technology,the utilization of AI in the detection of gastrointestinal tumors has become increasingly *** implementation of AI can effectively resolve the discrepancies among observers,improve the detection rate,assist in predicting the depth of invasion and differentiation status,guide the pericancerous margins,and aid in a more accurate diagnosis of ESCC.

关键词： Early esophageal squamous cell carcinoma Epidemiology and risk factors Molecular biology Epigenetic Microbiology Endoscopy and artificial intelligence

Integrated multi-omics analysis reveals liver metabolic reprogramming by fish iridovirus and antiviral function of alpha-linolenic acid

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Zoological Research 2024年第3期45卷 520-534页

作者： Lin Liu Ya Zhang Meng-Di Yuan Dong-Miao Xiao Wei-Hua Xu qi Zheng qi-Wei qin You-Hua huang Xiao-Hong huang College of Marine Sciences South China Agricultural UniversityGuangdong Laboratory for Lingnan Modern AgricultureGuangzhouGuangdong 510642China Nansha-South China Agricultural University Fishery Research Institute GuangzhouGuangdong 511464China Southern Marine Science and Engineering Guangdong Laboratory ZhuhaiGuangdong 519082China

Iridovirus poses a substantial threat to global aquaculture due to its high mortality rate;however,the molecular mechanisms underpinning its pathogenesis are not well ***,a multi-omics approach was applied to groupers infected with Singapore grouper iridovirus(SGIV),focusing on the roles of key *** showed that SGIV induced obvious histopathological damage and changes in metabolic enzymes within the ***,SGIV significantly reduced the contents of lipid droplets,triglycerides,cholesterol,and *** analysis indicated that the altered metabolites were enriched in 19 pathways,with a notable down-regulation of lipid metabolites such as glycerophosphates and alpha-linolenic acid(ALA),consistent with disturbed lipid homeostasis in the *** of transcriptomic and metabolomic data revealed that the top enriched pathways were related to cell growth and death and nucleotide,carbohydrate,amino acid,and lipid metabolism,supporting the conclusion that SGIV infection induced liver metabolic *** integrative transcriptomic and proteomic analysis indicated that SGIV infection activated crucial molecular events in a phagosome-immune depression-metabolism dysregulation-necrosis signaling *** note,integrative multi-omics analysis demonstrated the consumption of ALA and linoleic acid(LA)metabolites,and the accumulation of L-glutamic acid(GA),accompanied by alterations in immune,inflammation,and cell death-related *** experimental data showed that ALA,but not GA,suppressed SGIV replication by activating antioxidant and anti-inflammatory responses in the ***,these findings provide a comprehensive resource for understanding host response dynamics during fish iridovirus infection and highlight the antiviral potential of ALA in the prevention and treatment of iridoviral diseases.

关键词： Iridovirus Liver damage Metabolic reprogramming SGIV Alpha-linolenic acid Antiinflammatory