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Intermedin/adrenomedullin2: an autocrine/paracrine factor in vascular homeostasis and disease

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Science China(Life Sciences) 2014年第8期57卷 781-789页

作者： NI Xianqiang ZHANG JinSheng TANG ChaoShu qi yongfen Laboratory of Cardiovascular Bioactive Molecule School of Basic Medical SciencesPeking University Key Laboratory of Molecular Cardiovascular Science Ministry of EducationPeking University Health Science Center Department of Microbiology and Parasitology School of Basic Medical SciencePeking University

Intermedin(IMD)or adrenomedullin 2 is a novel peptide related to the calcitonin gene-related peptide(CGRP)*** calcitonin receptor-like receptor/receptor activity modifying proteins,the common receptor complexes of CGRP,IMD exerts a wide range of biological effects,especially regulation of cardiovascular *** processing of a larger IMD precursor yields a series of biologically active C-terminal fragments,IMD1–53,IMD1–47 and IMD8–*** and its receptors are present in the cardiovascular system,and IMD is present at low levels in *** the cardiovascular system,IMD has multiple functions such as regulation of blood pressure and cardiac function,pro-angiogenesis,endothelial barrier function protection,anti-oxidative stress,and anti-endoplasmic reticulum *** participates widely in the pathogenesis of atherosclerosis,hypertension,pulmonary arterial hypertension and vascular *** is a vascular regulatory factor of homeostasis and a vital endogenous protective factor against vascular diseases.

关键词： intermedin vessel homeostasis vascular diseases

血管外膜旁/自分泌的生物活性多肽及其在血管损伤性疾病中的作用

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中国动脉硬化杂志 2022年第10期30卷 837-845页

作者：赵杰齐永芬北京大学基础医学院心血管生物活性分子研究室北京市100083 北京大学医学部分子心血管学教育部重点实验室北京市100083 北京大学基础医学院病原生物学系北京市100083

血管外膜属疏松结缔组织,其组织学构成主要包括外弹力层、滋养血管、神经末梢及周围疏松结缔组织,成纤维细胞是其主要的细胞成分。既往认为血管外膜仅发挥滋养血管、维持血管张力与结构稳态的功能。近年的研究发现血管外膜旁/自分泌多... 详细信息

血管外膜属疏松结缔组织,其组织学构成主要包括外弹力层、滋养血管、神经末梢及周围疏松结缔组织,成纤维细胞是其主要的细胞成分。既往认为血管外膜仅发挥滋养血管、维持血管张力与结构稳态的功能。近年的研究发现血管外膜旁/自分泌多种生物活性多肽,这些生物活性多肽在血管稳态维持和损伤性疾病如动脉粥样硬化、腹主动脉瘤、高血压、肺动脉高压、血管钙化、血管成形术后再狭窄中发挥至关重要的作用。关注并加强对血管外膜旁/自分泌的生物活性多肽的生物学效应以及在血管稳态维持和损伤性疾病中作用的研究,对于血管稳态的维持和血管损伤性疾病发病机制的认识具有重要意义。

关键词：血管外膜血管周围脂肪组织成纤维细胞旁/自分泌生物活性多肽血管损伤性疾病

The Study of Two Geomagnetic Jerks in China

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Earthquake Research in China 2009年第2期23卷 192-199页

作者： Zhang Suqin Yang Dongmei Li qi Zhao yongfen Institute of Geophysics China Earthquake Administration Beijing 100081 China

This paper analyzes the first differences of the annual means (annual rate) for the Y and Z components of the geomagnetic field from nine magnetic observatories in China, measured from 1985 to 2003. The 1991 jerk was obvious in the Y component measured but not clear for the Z component. Rapid changes in the Z components were ubiquitous around 2000-2001, but not seen for the Y component. External effects were removed from the monthly means by comparing the monthly mean of the geomagnetic field components at the observatories with the monthly time series of the A_p geomagnetic index. However, some examples were analyzed and showed whether external effects were removed or not, there was no marked distinction in determining the jerks in China for the Y component and the Z component of the geomagnetic field. Finally, the isolines of the first differences of the annual means were used to analyze the spatial and temporal distributions of the jerks.

关键词： Jerk Annual rate External field Isolines Ap index

Contradictory role of apelin in vascular calcification

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Contradictory role of apelin in vascular calcification

Alterations of adreuomedullin and its receptor system in calcified myocardium and aorta of rats（C03）

中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：滕旭 Zhengfei Lu Yebo Zhou Yan Cai Chaoshu Tang yongfen qi Department of Physiology Hebei Medical University Hebei Key Laboratory of Laboratory Animal Science Hebei Medical University Laboratory of Cardiovascular Bioactive Molecule Peking University

Apelin is a cardiovascular peptide with multiple functions regulating homeostasis of the circulatory system and is the endogenous ligand of angiotensin receptor AT1（APJ）.The role of apelin/APJ system in vascular calcification（VC）was *** SD rats（200±10 g）were used.A rat aorta VC model was induced by vitamin D3 plus nicotine（VDN）in vivo,and cultured vascular smooth muscle cell（VSMC）calcification of rat thoracic aortic arteries was induced in vitro by *** Kossa staining,calcium content and alkaline phosphatase（ALP）activity was *** assessment was used to detect ***-PCR was used to detect m RNA expression of apelin and APJ,and Western blot was used to detect protein expression of apelin and *** Kossa staining revealed dispersed calcified nodules among the elastic fibres in calcified aortas but not in control aortas（n=6）.As compared with controls,media from arteries with calcification showed significantly decreased level of alpha-actin on Western blot analysis（-18.4%,P＜0.05,n=3,repeated three times）.The m RNA relative level of apelin in the aorta of rats with vascular calcification was increased by 91.6%（P＜0.05,n=3,reperated three times）.However,the APJ m RNA expression have not significantly difference between two *** further investigate the effects of apelin,calcified VSMCs induced by beta-glycerophosphate were *** with control group,protein expression of alpha-actin was significantly down-regulated in calcification group（P＜0.05,n=3,repeated three times）.Calcium content and ALP acitivity increased by 109.6%and 83.7%,resprectively in calcification VSMCs（all P＜0.05,n=6）.Von Kossa staining showed dispersed calcified nodules in calcification group but not in control group（n=6）.10-9 mol/L apelin could further promote calcium content,ALP activity and calcified nodules than calcification alone（all P＜0.05,n=6）.However,10-7 mol/L apelin ameliorated the calcified-induced augmentati

关键词： vascular calcification apelin APJ smooth muscle cell

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Alterations of adreuomedullin and its receptor system in cal...

第四届国际骨质疏松研讨会暨第二届国际骨矿研究会议

作者： PAN Chunshui qi yongfen WU Shengying JIANF Wei LI Guizhong TANG Chaoshu Institute of Cardiovascular Diseases Peking University First Hospital Depariment of Physiology Peking University Health Science Center

＜正＞Objective Recent studies point out that cardiovascular calcification is an active,regulated process,similar to osteogenesis and *** development of vascular calcification vascular cells including vascular smooth muscle cell（VSMC）,pericytes,and macrophages,transform into an osteoblast-like phenotype,characterized by an increase in alkaline phosphatase（ALP） activity matrix vesicle formation and overexpression of bone morphogenetic proteins（BMPs） including BMP-2 and bone matrix proteins such as osteopontin,osteonectin,and *** （ADM） has been shown to have vasodilatory,hypotensive and growth regulating properties,and is considered as an important regulatory peptide contributed to cardiovascular homeostasis and is considered to have potent

关键词： Calcification Adrenomedullin Calcitonin receptor like receptor Receptor activity modifying protein heart and vessel

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氧化应激在肝纤维化发生发展中的作用

临床肝胆病杂志 2019年第9期35卷 2067-2071页

作者：赵杰齐永芬鱼艳荣北京大学医学部基础医学院病原生物学系

肝纤维化是一种创伤愈合反应,它是由各种致病因素所致的慢性肝损伤后的纤维结缔组织沉积,若不及时治疗,会进展为肝硬化甚至肝癌,危害生命。肝星状细胞激活后转化为肌成纤维细胞进而分泌大量的细胞外基质是肝纤维化最重要的病理特征。越... 详细信息

肝纤维化是一种创伤愈合反应,它是由各种致病因素所致的慢性肝损伤后的纤维结缔组织沉积,若不及时治疗,会进展为肝硬化甚至肝癌,危害生命。肝星状细胞激活后转化为肌成纤维细胞进而分泌大量的细胞外基质是肝纤维化最重要的病理特征。越来越多的证据表明,氧化应激在肝纤维化的发生发展过程中发挥着重要作用,在各种疾病所致的肝纤维化过程中均有不同程度的氧化应激参与。多数情况下,氧化应激是与其他因素相互影响共同参与肝纤维化这一病理生理过程。因此,就氧化应激对肝纤维化的影响及其与其他因素如炎症、凋亡、自噬等相互作用共同影响肝纤维化的最新进展进行阐述。

关键词：肝硬化氧化性应激炎症细胞凋亡自噬

多学科协作联合精益管理方法在肾病患者血液透析感染管理中的应用

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中国医药导报 2022年第12期19卷 164-167页

作者：侯珂君祁永芬张凤琴马岩青海省第五人民医院院感科青海西宁810007

目的探究多学科协作与精益管理联合在肾病患者血液透析感染管理中的作用。方法选取2019年4月至2021年3月青海省第五人民医院血液透析肾病患者90例为研究对象,根据随机数字表法将其分为对照组和观察组,每组各45例。对照组予传统肾病血液... 详细信息

目的探究多学科协作与精益管理联合在肾病患者血液透析感染管理中的作用。方法选取2019年4月至2021年3月青海省第五人民医院血液透析肾病患者90例为研究对象,根据随机数字表法将其分为对照组和观察组,每组各45例。对照组予传统肾病血液透析感染管理,观察组行多学科协作联合精益管理。比较两组临床疗效、生理指标、生存状态、并发症发生率、满意度差异。结果干预后,观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。两组收缩压(SBP)较治疗前降低,观察组舒张压(DBP)、血红蛋白(HGB)、白蛋白(ALB)较治疗前升高,且观察组SBP低于对照组,DBP、HGB、ALB高于对照组,差异有统计学意义(P<0.05)。两组心理状态、躯体恢复情况、社会状态评分较干预前升高,且观察组心理状态、躯体恢复情况、社会状态评分高于对照组,差异有统计学意义(P<0.05)。观察组满意度优于对照组,差异有统计学意义(P<0.05)。结论多学科协作联合精益管理方法可显著增强肾病血液透析患者临床疗效,改善其生理指标、生存状态,还可降低并发症发生率,提高患者满意度。

关键词：多学科协作精益管理肾病血液透析

跑台运动对高脂饮食诱导的肥胖大鼠腓肠肌肌肉生长抑制素的影响

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中国运动医学杂志 2014年第5期33卷 446-452页

作者：张靓杨洪涛曹玉仙齐永芬北京师范大学体育与运动学院北京100875 北京大学医学部分子心血管学教育部重点实验室

目的:观察跑台运动对高脂饮食诱导的肥胖大鼠腓肠肌结构重塑及肌肉生长抑制素(myostatin,MSTN)表达的影响。方法:5周龄健康雄性SD大鼠随机分成对照组和高脂喂养组,分别进行普通饲料和高脂饲料喂养,12周后筛选肥胖大鼠16只,随机分为高脂... 详细信息

目的:观察跑台运动对高脂饮食诱导的肥胖大鼠腓肠肌结构重塑及肌肉生长抑制素(myostatin,MSTN)表达的影响。方法:5周龄健康雄性SD大鼠随机分成对照组和高脂喂养组,分别进行普通饲料和高脂饲料喂养,12周后筛选肥胖大鼠16只,随机分为高脂安静组和高脂运动组。跑台训练持续8周,每周5次,每次60分钟,跑速26米/分钟。测定大鼠腓肠肌重量,HE染色观察腓肠肌纤维横截面积,免疫组化方法测定慢肌肌球蛋白重链(myosin heavy chain,MHC)含量。分别采用realtime PCR技术和western blot方法测定腓肠肌MSTN mRNA和蛋白表达。结果:与对照组相比,高脂饮食喂养大鼠体重和体脂显著增加(P<0.01),TG、TC和LDL水平显著升高,HDL水平显著降低(P<0.05)。持续8周跑台运动显著降低大鼠体重和体脂(P<0.01),改善血脂。与对照组相比,肥胖大鼠腓肠肌重量减轻(P<0.05),肌纤维横截面积减小,慢肌MHC显著增多。与单纯高脂组相比,高脂运动组大鼠腓肠肌/胫骨长明显恢复(P<0.01),肌纤维横截面积显著增加,未发现慢肌MHC染色。此外,肥胖大鼠腓肠肌MSTN mRNA和蛋白表达显著增加(P<0.01)。与单纯高脂组相比,高脂运动组大鼠腓肠肌MSTN mRNA和蛋白表达水平显著降低(P<0.01)。结论:8周跑台运动明显逆转了高脂饮食诱导的肥胖大鼠腓肠肌结构重塑,其机制可能与MSTN的表达调节相关。

关键词：跑台运动肌肉生长抑制素骨骼肌结构肥胖

Inhibition of angiotensin Ⅱ and blockade of endothelin receptors reduce arterial calcification in rats

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Journal of Geriatric Cardiology 2004年第2期1卷 108-113页

作者： Juxiang LI~1 Shengying WU~1 Chunshui PAN~2 yongfen qi~2 Bin GENG~1 Xiuhna LIU~~(1,2) Chaoshu TANG~1 1 Department of Physiology and Pathophysiology,Peking University Health Science Center,Beijing 100083,China 2 Insitiute of Cardiovascular Research,Peking University First Hospital,Beijing 100034,China Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100083 China Insitiute of Cardiovascular Research Peking University First Hospital Beijing 100034 China Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100083 China Insitiute of Cardiovascular Research Peking University First Hospital Beijing 100034 China

Objective To examine whether the two vascular paracrine/autocrine factors,angiotensin Ⅱ(Ang Ⅱ)and endothelin,participate in the pathogenesis of arterial *** Nicotine and vitamin D_3 treated rats were *** calcification was confirmed by using Von Kossa staining,measurement of calcium content, ^(45)Ca^(2+)uptake assay and alkaline phosphatase(ALP)*** plasma and vascular Ang Ⅱ and endothelin levels were measured by using *** and endothehn mRNA levels were determined by RT- *** The arterial calcium content,^(45)Ca^(2+)uptake and ALP activity were increased in calcification groups compared with control(P<0.01).Administration of the angiotensin receptor antagonist losartan,the endothelin receptor antagonist bosentan,and the angiotensin-converting enzyme inhibitor captopril reduced significantly the arterial calcium content,^(45)Ca^(2+)uptake and ALP *** addition,the plasma and aortic Ang Ⅱ and endothelin contents,and vascular angiotensinngen and endothelin mRNA expression were significantly up-regulated(P<0.05). Conclusions These findings suggest that functional renin-angiotensin system and endothelin pathway are involved in vascular calcification,and that activation of these systems could potentiate pathogenesis of arterial calcification.(J Geriatr Cardiol 2004;1(2):108-113.)

关键词： aorta angiotensin Ⅱ endothelin-1 calcification