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气体二氧化氯对葡萄表面青霉的杀菌效果及营养成分的变化规律

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食品科技 2010年第11期35卷 67-70页

作者：顾宁胡双启晋日亚李宁中北大学化工与环境学院太原030051

研究了不同浓度的气体ClO2在30 min杀菌时间下对葡萄致腐菌青霉的杀灭效果。实验结果表明,随气体ClO2浓度（5、10、15 mg/m3）增加杀菌率增加（分别为2.62、3.05 log和3.21 log）;研究了经气体ClO2作用后葡萄中Vc、还原糖和可滴定酸含... 详细信息

研究了不同浓度的气体ClO2在30 min杀菌时间下对葡萄致腐菌青霉的杀灭效果。实验结果表明,随气体ClO2浓度（5、10、15 mg/m3）增加杀菌率增加（分别为2.62、3.05 log和3.21 log）;研究了经气体ClO2作用后葡萄中Vc、还原糖和可滴定酸含量变化规律。结果表明：当气体ClO2浓度为5、10 mg/m3时,葡萄中Vc的含量随着作用时间（10~60 min）的延长,出现先减少后上升的变化趋势;当气体ClO2浓度为15 mg/m3时,葡萄中Vc和还原糖的含量随着作用时间（10~60min）的延长呈上升趋势;可滴定酸的含量随ClO2浓度增加和作用时间延长出现上升趋势。

关键词：二氧化氯青霉葡萄营养成分杀菌

4kPa下长间隙工频放电等离子体发展机理研究

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科学技术与工程 2017年第3期17卷 223-226页

作者：杨亚奇李卫国夏喻袁创业陈艳华北电力大学电气与电子工程学院北京102206

为研究低气压下长空气间隙工频放电等离子体发展机理,利用低气压放电试验平台对4 k Pa下600 mm棒-板间隙进行了放电试验研究,得到该条件下等离子体发展特征并对其机理进行分析。研究结果表明:4 k Pa下棒电极下行等离子体发展的同时板电... 详细信息

为研究低气压下长空气间隙工频放电等离子体发展机理,利用低气压放电试验平台对4 k Pa下600 mm棒-板间隙进行了放电试验研究,得到该条件下等离子体发展特征并对其机理进行分析。研究结果表明:4 k Pa下棒电极下行等离子体发展的同时板电极出现电晕亮斑,板电极上行等离子体通道对周围放电的抑制作用较弱可同时发展多条等离子体通道,且等离子体通道自棒电极发展的速度较板电极大;间隙击穿后等离子体通道出现"飘弧"现象且在发展路径上具有选择性。研究结果为低气压下工频放电特性研究提供试验参考。

关键词：低气压工频放电等离子体长间隙

牙周基础治疗对吸烟者和非吸烟者龈沟液成分及临床指标的影响

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北京口腔医学 2020年第5期28卷 270-273页

作者：齐雅丽李雅胡永青李淑娟杨冬茹河北医科大学口腔医院牙周一科河北省口腔医学重点实验室石家庄050000

目的探讨吸烟对龈沟液中IL-17和TGF-β的表达水平的影响。方法慢性牙周炎患者27例分成两组:未吸烟组12例,吸烟组15例。于基础治疗前后检查患者探诊深度、附着丧失,采集龈沟液标本,用EliSA检测IL-17及TGF-β水平。结果基础治疗前IL-17及T... 详细信息

目的探讨吸烟对龈沟液中IL-17和TGF-β的表达水平的影响。方法慢性牙周炎患者27例分成两组:未吸烟组12例,吸烟组15例。于基础治疗前后检查患者探诊深度、附着丧失,采集龈沟液标本,用EliSA检测IL-17及TGF-β水平。结果基础治疗前IL-17及TGF-β浓度吸烟组高于未吸烟组,差异有统计学意义。探诊深度及附着丧失两组无明显差异。基础治疗后探诊深度、L-17及TGF-β浓度两组均明显降低,且吸烟组高于未吸烟组,有统计学意义。附着丧失两组无明显差异。结论吸烟升高牙周炎龈沟液中IL-17和TGF-β的浓度。

关键词：牙周炎牙周基础治疗 IL-17 TGF-β 龈沟液

Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na li Yue-Yue Ren Ying Tang qi yang Tian-Tian Meng Song li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan qi Robert Chunhua Zhao Jiao Wang School of life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

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牙周内窥镜辅助牙周基础治疗效果分析

河北医科大学学报 2021年第3期42卷 320-323页

作者：齐雅丽梁向阳李淑娟李雅刘冰杨冬茹河北医科大学口腔医院牙周一科河北石家庄050017

目的利用牙周内窥镜去除基础治疗后残留的龈下牙石,比较牙周内窥镜辅助治疗前后不同牙位的探诊深度、松动度变化,探讨牙周内窥镜辅助牙周基础治疗的适用范围。方法按照纳入标准,选择被确诊为慢性牙周炎患者12例,患者均在牙周基础治疗后... 详细信息

目的利用牙周内窥镜去除基础治疗后残留的龈下牙石,比较牙周内窥镜辅助治疗前后不同牙位的探诊深度、松动度变化,探讨牙周内窥镜辅助牙周基础治疗的适用范围。方法按照纳入标准,选择被确诊为慢性牙周炎患者12例,患者均在牙周基础治疗后3个月复诊时发现残存≥4 mm牙周袋,对残存牙周袋进行牙周内窥镜辅助治疗,3个月时复诊,每次复诊时采用Florida探针系统记录牙周情况,包括探诊深度(probing depth,PD)、探诊出血(bleeding on probing,BOP)、牙齿松动度等。以牙周基础治疗后3个月为基线,根据牙根形态、探诊深度及牙齿松动度分组,分析基线时与内窥镜治疗后3个月时每组的变化。结果经内窥镜治疗后3个月,残留中度牙周袋(4 mm≤PD<6 mm)的单根牙和多根牙PD值及BOP位点百分比与基线时相比明显降低,差异有统计学意义;但对于重度牙周袋,6 mm≤PD<8 mm时,单根牙及多根牙PD值及BOP位点百分比均较基线时降低,单根牙比多根牙降低更明显,差异有统计学意义;PD≥8 mm时,单根牙及多根牙PD值及BOP位点百分比均改善不明显,差异无明显统计学意义。牙齿松动度总改善率为55.29%(47/85),并随松动度加重改善率下降。结论牙周内窥镜辅助牙周基础治疗可改善牙周袋深度,探诊出血,松动度,尤其是单根牙PD<8 mm时效果良好,在一定程度上可避免牙周手术。

关键词：牙周炎内窥镜牙周袋

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免疫组化法检测美国青蛙组织中的蛙虹彩病毒

水生生物学报 2002年第5期26卷 438-443页

作者：谢简李正秋张奇亚李文鑫武汉大学生命科学院武汉430072 中国科学院水生生物研究所武汉430072

分不同时间 ,收集经人工感染了蛙病毒的样蛙 ,取其心、肺、肾、肠、脾、肝六种组织 ,并通过免疫组化方法进行检测。结果分别在感染了病毒 3d、9d、1 1d后的幼蛙这六种组织中 ,由表及里观察到了深色的阳性信号 ,从而测定了病毒在入侵组... 详细信息

分不同时间 ,收集经人工感染了蛙病毒的样蛙 ,取其心、肺、肾、肠、脾、肝六种组织 ,并通过免疫组化方法进行检测。结果分别在感染了病毒 3d、9d、1 1d后的幼蛙这六种组织中 ,由表及里观察到了深色的阳性信号 ,从而测定了病毒在入侵组织中的存在部位。其中 ,肺和肠组织中阳性信号最强 ,呈灶性分布 ,其余四种组织中的阳性信号则呈散在分布。在未注射病毒的幼蛙阴性对照组六种组织中没有检测到阳性信号。

关键词：免疫组化法检测美国青蛙组织蛙虹彩病毒

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang yan Sun lingxiao Deng Melissa Walker Chen Chen Heqiao Dai qi Han Ying Ding Yongzhi Xia George Smith Rui li Nai-Kui liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin