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Association of complement components with risk of colorectal cancer:A systematic review and meta-analysis

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2168-2180页

作者： xiao-Lin Zhu Lu Zhang Su-xia qi Department of Gastroenterology Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina Department of Medical Administration Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina

BACKGROUND Complement components could contribute to the tumor microenvironment and the systemic immune ***,their role in colorectal cancer(CRC)remains a contentious *** To elucidate the relationship between complement components and CRC risk and clinical *** Searches were conducted in PubMed,the Cochrane Library,and the China National Knowledge Infrastructure database until June 1,*** included cohort studies encompassing participants aged≥18 years,investigating the association between complement components and *** studies were of moderate quality or above,as determined by the Agency for Healthcare Research and *** meta-analysis employed fixed-effects or random-effects models based on the I^(2)test,utilizing risk ratio(RR)and their corresponding 95%confidence interval(CI)for *** and subgroup analyses were performed to validate the robustness of the collective estimates and identify the source of *** Data from 15 studies,comprising 1631 participants that met the inclusion criteria,were included in the *** findings indicated that protein levels of cluster of differentiation 46(CD46)(RR=3.66,95%CI:1.75-7.64,P<0.001),CD59(RR=2.86,95%CI:1.36-6.01,P=0.005),and component 1(C1)(RR=5.88,95%CI:1.75-19.73,P=0.004)and serum levels of C3(standardized mean difference=1.82,95%CI:0.06-3.58,P=0.040)were significantly elevated in patients with CRC compared to healthy *** expression of CD55 or CD59 was associated with a higher incidence of lymph node metastasis,whereas strong CD46 expression correlated with a higher incidence of tumor differentiation compared to low CD46 expression(P<0.05 for all).Although specific pooled results demonstrated notable heterogeneity,subgroup analyses pointed to regional differences as the primary source of inconsistency among the *** Our analysis underscores that increased levels of specific complement components are

关键词： Complement components Colorectal cancer Lymph node metastasis Systematic review Meta-analysis

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Bilateral Filter for the Optimization of Composite Structures

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Computer Modeling in Engineering & Sciences 2021年第6期127卷 1087-1099页

作者： Yuhang Huo Ye Tian Shiming Pu Tielin Shi qi xia State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhanChina State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalianChina

In the present study,we propose to integrate the bilateral filter into the Shepard-interpolation-based method for the optimization of composite *** bilateral filter is used to avoid defects in the structure that may arise due to the gap/overlap of adjacent fiber tows or excessive curvature of fiber *** to the bilateral filter,sensitivities at design points in the filter area are smoothed by both domain filtering and range ***,the filtered sensitivities are used to update the design *** several numerical examples,the effectiveness of the method was verified.

关键词： Design optimization composite structure fiber angle optimization bilateral filtering Shepard interpolation manufacturability constraints

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Quantitative Analysis of Non-Crystalline and Crystalline Solids in Blast Furnace Slag

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Journal of Iron and Steel Research International 2011年第1期18卷 8-10页

作者： WANG Hai feng ZHANG Chun-xia qi Yuan hong State Key l.aboratory ot Advanced Steel Processes and Products Central Iron and Steel Research Institute Beijing 100081 China

The granulation of blast furnace slag （BFS） with water quenching treatment has some disadvantages, such as high water consumption and difficulty for recovery heat. So developing a new dry granulation technique to treat BFS is very important. The applicability of BFS directly depends on the content of non-crystalline solids in the slag after treatment. So it is of theoretical and practical significance to analyze the content of non-crystalline solids in the slag quantitatively and simply. Metallographical test is mainly adopted to quantify the non-crystalline in BFS so far with the shortages such as complex sample, difficult determination, ect. The diffraction intensity of non-crystalline is proportionate to the content of non-crystalline in BFS, ~ray diffraction method was adopted to quantify the noncrystalline and the crystalline solids in BFS. The quantitative coefficient between the crystalline and the non-crystalline solids of BFS is 0.70 of BFS whose main composition （mass percent, %） is： CaO 38.2, SiO2 35.7, Al2Oa 16.3, and MgO 8.3. The relative error of X-ray diffractometer for quantitatively analyzing non-crystalline content of BFS is less than 1%.

关键词： blast furnace slag non crystalline crystalline quantitative analysis

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Buckling Optimization of Curved Grid Stiffeners through the Level Set Based Density Method

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 711-733页

作者： Zhuo Huang Ye Tian Yifan Zhang Tielin Shi qi xia State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan430074China

Stiffened structures have great potential for improvingmechanical performance,and the study of their stability is of great *** this paper,the optimization of the critical buckling load factor for curved grid stiffeners is solved by using the level set based density method,where the shape and cross section(including thickness and width)of the stiffeners can be optimized *** grid stiffeners are a combination ofmany single stiffenerswhich are projected by the corresponding level set *** thickness and width of each stiffener are designed to be independent variables in the projection applied to each level set ***,the path of each single stiffener is described by the zero iso-contour of the level set *** the single stiffeners are combined together by using the p-norm method to obtain the stiffener *** proposed method is validated by several numerical examples to optimize the critical buckling load factor.

关键词： Stiffener buckling optimization shape and cross section level set based density

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Molecular Dipole Moment Computed with Ab Initio MKS Charges

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Chinese Journal of Structural Chemistry 2002年第2期21卷 139-141页

作者： FAN Jian-Fen WANG Qu-xia xia qi-Ying xiaO He-Ming B.van de Graaf Department of Chemistry Suzhou UniversitySuzhou 215006China Department of Chemistry University of Science and TechnologyNanjing 210094China Faculty of Chemical Engineering and Material Science Delft University of TechnologyJulianalaan 1362628 DelfThe Netherlands

Molecular dipole moments computed at the levels of HF/STO-3G, HF/6-31G(d, p), HF/6-311+G(2d, 2p), MP2/6-31G(d, p) and MP2/6-311+G(2d, 2p) have been investigated. HF/6-311+G(2d, 2p) was found to be the relatively good choice to compute MKS charges for reproducing the experimental values of molecular dipole moments. Root mean square deviation of computed dipole moments for 21 small polar molecules is about 0.1969 D.

关键词： molecular dipole moment MKS charge HF/6-311+G(2d 2p)

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Self-adaptive behavior of nunchakus-like tracer induced by active Brownian particles

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Chinese Physics B 2022年第4期31卷 90-95页

作者： Yi-qi xia Guo-qiang Feng Zhuang-Lin Shen Department of Physics and Electronic Engineering Yancheng Teachers UniversityYancheng 224007China Center for Soft Condensed Matter Physics&Interdisciplinary Research School of Physical Science and TechnologySoochow UniversitySuzhou 215006China Department of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060China

We design a nunchakus-like tracer and investigate its self-adaptive behavior in an active Brownian particle(ABP)bath via systematically tuning the self-propelled capability and density of ***,the nunchakus-like tracer will have a stable wedge-like shape in the ABP bath when the self-propelled force is high *** analyze the angle between the two arms of the tracer and the velocity of the joint point of the *** angle exhibits a non-monotonic phenomenon as a function of active ***,it increases with density of ABPs increasing monotonically.A simple linear relationship between the velocity and the self-propelled force is found under the highly active *** other words,the joint points of the tracer diffuse and the super-diffusive behavior can make the relation between the self-propelled force and the density of ABPs persist *** addition,we find that the tracer can flip at high density of *** results also suggest the new self-adaptive model research of the transport properties in a non-equilibrium medium.

关键词： tracer self-adaptive super-diffusion active Brownian particles

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Highly dispersed metal incorporated hexagonal mesoporous silicates for catalytic cyclohexanone oxidation to adipic acid

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Chinese Journal of Chemical Engineering 2020年第10期28卷 2542-2548页

作者： Wenjuan Yan Wenxiang Zhang qi xia Shuaishuai Wang Shuxia Zhang Jian Shen Xin Jin State Key Laboratory of Heavy Oil Processing Center for Chemical Engineering Experimental TeachingChina University of PetroleumQingdao 266580China College of Environment and Resources Xiangtan UniversityXiangtan 411105China

Adipic acid is a dicarboxylic acid of great industrial importance,mainly used in the production of nylon-6,6 and *** use of nitric acid as an oxidant in the industrial production of adipic acid poses significant carbon footprint to the *** adipic acid synthesis methods using a heterogeneous catalyst with H2O2 as oxidant and water as solvent have potential advantages of low catalyst cost,easy synthesis and recovery,cleanness and environmental *** this work,hexagonal mesoporous silicate materials were synthesized by a sol–gel method and evaluated for cyclohexanol/cyclohexanone oxidation to adipic *** physical and chemical properties of Fe-HMS were characterized by XRD,HR-TEM,BET and UV–*** experimental results showed that Fe-HMS materials show pore sizes ranging from 2–3 nm.W-and Mo-based polyoxometalates were also evaluated and compared to the Fe-based HMS *** improve the adipic acid yield,the influence of the transition metal as well as the effect of metal loading,reaction temperature and catalyst amount on the catalytic performances of Fe-HMS have been investigated in *** Si/Fe atomic ratio=100,Fe-HMS catalyst shows the highest activity,with a cyclohexanone conversion of 92.3%and adipic acid selectivity of 29.4%.The reaction pathway of cyclohexanone oxidation was further proposed based on experimental data.

关键词： Oxidation Adipic acid Hexagonal mesoporous silicates hydrogen peroxide

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Lie-Form Invariance of a Type of Non-holonomic Singular Systems

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Communications in Theoretical Physics 2007年第3期47卷 409-412页

作者： WANG Jing LI Yuan-Cheng HOU qi-Bao xia Li-Li College of Physical Science and Technology China University of Petroleum Dongying 257061 China

In this paper, the Lie-form invariance of a type of non-holonomic singular systems is studied. The differential equations of motion of the systems are given. The definition and the criterions of the Lie-form invariance for the systems are presented. The Hojman conserved quantity and the Mei conserved quantity are obtained. An example is given to illustrate the application of the results.

关键词： non-holonomic constraint singular system symmetry conserved quantity

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The involvement of proline-rich protein Mus musculus predicted gene 4736 in ocular surface functions

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1121-1126页

作者： xia qi Sheng-Wei Ren Feng Zhang Yi-qiang Wang State Key Laboratory Cultivation Base Shandong Provincial Key Laboratory of Ophthalmology Shandong Eye InstituteShandong Academy of Medical Sciences Linyi People's Hospital Henan Eye Institute & Henan Eye Hospital Eye Department of Henan People's Hospital People's Hospital of Zhengzhou University MOH Key Lab of Thrombosis and Hemostasis Collaborative Innovation Center of Hematology Jiangsu Institute of Hematology the First Affiliated Hospital of Soochow University

AIM: To research the two homologous predicted proline -rich protein genes, Mus musculus predicted gene 4736 (MP4) and proline-rich protein BstNI subfamily 1 (Prb1) which were significantly upregulated in cultured corneal organs when encountering fungal pathogen preparations. This study was to confirm the expression and potential functions of these two genes in ocular surface. METHODS: A Pseudomonas aeruginosa keratitis model was established in Balb/c mice. One day post infection, mRNA level of MP4 was measured using real-time polymerase chain reaction (PCR), and MP4 protein detected by immunohistochemistry (IHC) or Western blot using a customized polyclonal anti -MP4 antibody preparation. Lacrimal glands from normal mice were also subjected to IHC staining for MP4. An online bioinformatics program, BioGPS, was utilized to screen public data to determine other potential locations of MP4. RESULTS: One day after keratitis induction, MP4 was upregulated in the corneas at both mRNA level as measured using real -time PCR and protein levels as measured using Western blot and IHC. BioGPS analysis of public data suggested that the MP4 gene was most abundantly expressed in the lacrimal glands, and IHC revealed that normal murine lacrimal glands were positive for MP4 staining. CONCLUSION: MP4 and Prb1 are closely related with the physiology and pathological processes of the ocular surface. Considering the significance of ocular surface abnormalities like dry eye, we propose that MP4 and Prb1 contribute to homeostasis of ocular surface, and deserve more extensive functional and disease correlation studies.

关键词： proline-rich protein Mus musculus predicted gene 4736 ocular surface Pseudomonas aeruginosa keratitis

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A survey of federated learning for edge computing:Research problems and solutions

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High-Confidence Computing 2021年第1期1卷 55-67页

作者： qi xia Winson Ye Zeyi Tao Jindi Wu Qun Li Department of Computer Science College of William and Mary 251 Jamestown Rd.WilliamsburgVA 23185USA

Federated Learning is a machine learning scheme in which a shared prediction model can be collaboratively learned by a number of distributed nodes using their locally stored *** can provide better data privacy be-cause training data are not transmitted to a central *** learning is well suited for edge computing applications and can leverage the the computation power of edge servers and the data collected on widely dis-persed edge *** build such an edge federated learning system,we need to tackle a number of technical *** this survey,we provide a new perspective on the applications,development tools,communication efficiency,security&privacy,migration and scheduling in edge federated learning.

关键词： Federated learning Edge computing

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