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Effect of Continuous Positive Airway Pressure Therapy on Glycemic Excursions and Insulin Sensitivity in Patients with Obstructive Sleep Apnea-hypopnea Syndrome and Type 2 Diabetes

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Chinese Medical Journal 2015年第17期128卷 2301-2306页

作者： Li-Xin Guo Xin Zhao qi pan Xue Sun Hui Li Xiao-Xia Wang Li-Na Zhang Yao Wang Department of Endocrinology Beijing Hospital Beijing 100730 China Department of General Medicine First Hospital of China Medical University Shenyang Liaoning 110001 China

Background： For patients with obstructive sleep apnea-hypopnea syndrome （OSAHS） and type 2 diabetes mellitus （T2DM）, the night sleep interruption and intermittent hypoxia due to apnea or hypopnea may induce glycemic excursions and reduce insulin sensitivity. This study aimed to investigate the effect of continuous positive airway pressure （CPAP） therapy in patients with OSAHS and T2DM. Methods： Continuous glucose monitoring system （CGMS） was used in 40 patients with T2DM and newly diagnosed OSAHS. The measurements were repeated after 30 days of CPAP treatment. Subsequently, insulin sensitivity and glycohemoglobin （HbAlc） were measured and compared to the pretreatment data. Results： After CPAP therapy, the CGMS indicators showed that the 24-h mean blood glucose （MBG） and the night time MBG were significantly reduced （P 〈 0.05 and P = 0.03, respectively）. The mean ambulatory glucose excursions （MAGEs） and the mean of daily differences were also significantly reduced （P 〈 0.05 and P = 0.002, respectively） compared to pretreatment levels. During the night, MAGE also significantly decreased （P = 0.049）. The differences between the highest and lowest levels of blood glucose over 24 h and during the night were significantly lower than prior to CPAP treatment （P 〈 0.05 and P = 0.024, respectively）. The 24 h and night time durations of high blood glucose （〉7.8 mmol/L and 〉 11.1 mmol/L） decreased （P 〈 0.05 and P 〈 0.05, respectively） after the treatment. In addition, HbA 1 c levels were also lower than those before treatment （P 〈 0.05）, and the homeostasis model assessment index of insulin resistance was also significantly lower than before CPAP treatment （P = 0.034）. Conclusions： CPAP therapy may have a beneficial effect on improving not only blood glucose but also upon insulin sensitivity in T2DM patients with OSAHS. This suggests that CPAP may be an effective treatment for T2DM in addition to intensive diabetes management.

关键词： Continuous Glucose Monitoring System Continuous Positive Airway Pressure Obstructive Sleep Apnea-hypopnea Syndrome Type 2 Diabetes Mellitus

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Cost Analysis of Cervical Cancer Patients with Different Medical Payment Modes Based on Gamma Model within a Grade A Tertiary Hospital

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Chinese Medical Journal 2018年第4期131卷 389-394页

作者： Suo-Wei Wu Tong Chen qi pan Liang-Yu Wei qin Wang Jing-Chen Song Chao Li Ji Luo Department of Medical Administration Beijing Hospital National Center of Gerontology Beijing 100730 China

Background： Cervical cancer shows a growing incidence and medical cost in recent years that has increased severe financial pressure on patients and medical insurance institutions. This study aimed to investigate the medical economic characteristics of cervical cancer patients with different payment modes within a Grade A tertiary hospital to provide evidence and suggestions for inpatient cost control and to verily the application of Gamma model in medical cost analysis. Methods： The basic and cost information of cervical cancer cases within a Grade A tertiary hospital in the year 2011-2016 were collected. The Gamma model was adopted to analyze the differences in each cost item between medical insured patient and uninsured patients. Meanwhile, the marginal means of different cost items were calculated to estimate the influence of payment modes toward different medical cost items among cervical cancer patients in the study. Results： A total of 1321 inpatients with cervical cancer between the 2011 and 2016 were collected through the medical records system. Of the 1321 cases~ 65.9% accounted for medical insured patients and 34.1% were uninsured patients. The total inpatient medical expenditure of insured patients was RMB 29,509.1 Yuan and uninsured patients was RMB 22,114.3 Yuan, respectively. Payment modes, therapeutic options as well as the recurrence and metastasis of tumor toward the inpatient medical expenditures between the two groups were statistically significant. To the specifics, drug costs accounted for 37.7% and 33.8% of the total, surgery costs accounted for 21.5% and 25.5%, treatment costs accounted for 18.7% and 16.4%, whereas the costs of imaging and laboratory examinations accounted for 16.4% and 15.2% for the insured patient and uninsured patients, respectively. As the effects of covariates were controlled, the total hospitalization costs, drug costs, treatment costs as well as imaging and laboratory exainination costs showed statistical significance. The total hospitalization costs, drug costs, tre

关键词： Cervical Cancer Cost Analysis Medical Insurance Medical Management

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Establishment of a Quantitative Medical Technology Evaluation System and Indicators within Medical Institutions

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Chinese Medical Journal 2018年第11期131卷 1327-1332页

作者： Suo-Wei Wu Tong Chen qi pan Liang-Yu Wei qin Wang Chao Li Jing-Chen Song Ji Luo Department of Medical Administration Beijing Hospital National Center of Gerontology Beijing 100730 China

Background： The development and application of medical technologies reflect the medical quality and clinical capacity of a hospital. It is also an effective approach in upgrading medical service and core competitiveness among medical institutions. This study aimed to build a quantitative medical technology evaluation system through questionnaire survey within medical institutions to perforna an assessment to medical technologies more objectively and accurately, and promote the management of medical quality technologies and ensure the medical safety of various operations among the hospitals. Methods： A two-leveled quantitative medical technology evaluation system was built through a two-round questionnaire survey of chosen experts. The Delphi method was applied in identifying the structure of evaluation system and indicators. The judgment of the experts on the indicators was adopted in building the matrix so that the weight coefficient and maximum eigenvalue （λ. max）, consistency index （CI）, and random consistency ratio （CR） could be obtained and collected. The results were verified through consistency tests, and the index weight coefficient of each indicator was conducted and calculated through analytical hierarchy process. Results： Twenty-six experts of different medical fields were involved in the questionnaire survey, 25 of whom successfully responded to the two-round research. Altogether, 4 primary indicators （safety, effectiveness, innovativeness, and benefits）, as well as 13 secondary indicators, were included in the evaluation system. The matrix is built to conduct the λ max, CI, and CR of each expert in the survey, and the index weight coefficients of primary indicators were 0.33, 0.28, 0.27, and 0.12, respectively, and the index weight coefficients of secondary indicators were conducted and calculated accordingly. Conclusions： As the two-round questionnaire survey of experts and statistical analysis were performed and credibility of the results was verified through consistency evaluation test, the study

关键词： Evaluation System Medical Management Medical Technology

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Establishment of a Comprehensive Evaluation System on Medical Quality Based on Cross-examination of Departments within a Hospital

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Chinese Medical Journal 2017年第23期130卷 2872-2877页

作者： Suo-Wei Wu Tong Chen qi pan Liang-Yu Wei Yong Xuan Chao Li qin Wang Jing-Chen Song Medical Administration Department Beijing HospitalNational Center of Gerontology Beijing 100730 China

INTRODUCTIONThe management of medical quality is the core element of hospital management, and it is reflected in every part and aspect of medical behavior. Strengthening the management on medical quality is crucial in ensuring medical safety, promoting the ability of clinical diagnoses and treatments as well as the increasing the efficiency of medical service, Oil this basis, the establishment and operation of a comprehensive evaluation system on medical quality is not only the foundation in ensuring the orderly operation of the medical behavior and medical safety but also an effective means in continuously improving the quality of medical management.

关键词： Medical Management： Medical Quality： Medical Safetv

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Research of Medical Expenditure among Inpatients with Unstable Angina Pectoris in a Single Center

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Chinese Medical Journal 2017年第13期130卷 1529-1533页

作者： Suo-Wei Wu qi pan Tong Chen Liang-Yu Wei Yong Xuan qin Wang Chao Li Jing-Chen Song Department of Medical Administration Beijing Hospital National Center of Gerontology Beijing 100730 China

Background： With the rising incidence as well as the medical expenditure among patients with unstable angina pectoris, the research aimed to investigate the inpatient medical expenditure through the combination of diagnosis-related groups （DRGs） among patients with nnstable angina pectoris in a Grade A tertiary hospital to conduct the referential standards of medical costs for the diagnosis. Methods： Single-factor analysis and multiple linear stepwise regression method were used to investigate 3933 cases between 2014 and 2016 in Beijing Hospital （China） whose main diagnosis was defined as unstable angina pectoris to determine the main factors influencing the inpatient medical expenditure,and decision tree method was adopted to establish the model of DRGs grouping combinations. Results： The major influential factors of inpatient medical expenditure included age, operative method, therapeutic effects as well as comorbidity and complications （CCs） of the disease, and the 3933 cases were divided into ten DRGs by four factors： age, CCs, therapeutic effects, and the type of surgery with corresponding inpatient medical expenditure standards setup. Data of nonparametric test on medical costs among different groups were all significant （P 〈 0.001, by Kruskal-Wallis test）, with R2 = 0.53 and coefficient of variation （CV） 0.524. Conclusions： The classification of DRGs by adopting the type of surgery as the main branch node to develop cost control standards in inpatient treatment of unstable angina pectoris is conducive in standardizing the diagnosis and treatment behaviors of the hospital and reducing economic burdens among patients.

关键词： Angina, Unstable Decision Trees Diagnosis-related Groups Health Care Costs

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Smartphone-based rapid and visual pathological diagnosis of glioma using perovskite probes

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InfoMat 2023年第11期5卷 40-48页

作者： Dongdong Wu Jimei Chi Junzhen Fan Lijun Cheng Xuning Wang Xu Yang Meng Zhang Zewei Lian Zengqi Huang Huadong Wang Hongfei Xie Sisi Chen qi pan Zeying Zhang Bingda Chen Guochen Sun Bainan Xu Meng Su Yanlin Song Department of Neurosurgery The First Medical CentreChinese PLA General Hospital BeijingBeijingthe People's Republic of China Medical School of Chinese PLA Beijingthe People's Republic of China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Beijingthe People's Republic of China University of Chinese Academy of Sciences Beijingthe People's Republic of China Department of Pathology Third Medical CenterChinese PLA General HospitalBeijingthe People's Republic of China Department of General Surgery The Air Force Hospital of Northern Theater PLAShenyangthe People's Republic of China Department of Neurosurgery The Second Hospital of Southern District of Chinese NavySanyathe People's Republic of China

Histopathology plays a great role in diagnosing various diseases,which is considered as a golden standard for tumor identification.The tissue constituents must be stained by visible labels for microscopic analysis by medical experts.However,this process is time-consuming,labor-intensive,and expensive,which requires rapid pathological approaches for diagnosis in the operating room.Here,we present an easy-to-process and high-performance perovskite biological probes for rapid and visual pathological diagnosis of glioma.Perovskite quantum dots can be encapsulated by the copolymer into nanocrystals(PNCs)with a diameter of 100 nm,which is modified with chlorotoxin to achieve the specific recognition of glioma.Benefiting from the super photoluminescence quantum yield(above 93%)of EVA@PNCs aqueous solution,the glioma can be clearly imaged and captured via a smartphone under the excitation of a handheld UV lamp.To demonstrate the visualization and efficiency of PNC probes,different malignant grades of brain tumor sections can be distinguished in no more than 5 min.This strategy provides a general auxiliary diagnosis platform for achieving the histopathology analysis near the operating bed,which is currently not feasible with standard histochemical staining methods.

关键词： glioma pathological diagnosis perovskite nanocrystal smartphone-based imaging

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一种冗余式导航分发设备设计

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计算机测量与控制 2024年第4期32卷 328-333页

作者：潘奇齐共新岳俊峰南京电子技术研究所南京210039

针对多个不同体制、工作方式的电子系统协同工作、信息融合的应用需求,设计了一种冗余式导航分发设备,通过对外部多个信息源提供的时间、导航及参数信息进行信息综合处理,为电子系统内的设备提供实时、统一的导航、时间和参数信息,应用... 详细信息

针对多个不同体制、工作方式的电子系统协同工作、信息融合的应用需求,设计了一种冗余式导航分发设备,通过对外部多个信息源提供的时间、导航及参数信息进行信息综合处理,为电子系统内的设备提供实时、统一的导航、时间和参数信息,应用情况表明,该设备实现了整个电子系统内部各设备间μs级的信息同步。通过分析信息同步需求,采用冗余架构,使用FC时间同步服务实现精确对时功能,通过双冗余FC接口实现时间、导航及参数信息的分发,并提供秒脉冲等时间基准信号,由各电子系统内部的时间处理单元实现电子系统与本设备之间的时间同步功能。

关键词： FC 同步精确对时时钟同步服务冗余分发

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Management of Medical Technology under the New Medical Policy Background in China

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Chinese Medical Journal 2016年第22期129卷 2745-2748页

作者： Suo-Wei Wu Tong Chen Ming Wu qi pan Yong Xuan Liang-Yu Wei qin Wang Chao Li Jing-Chen Song Department of Medical Administration Beijing Hospital Beijing 100730 China Department of Party Committee Beijing Hospital Beijing 100730 China

INTRODUCTIONThe National Health and Family Planning Commission of People＇s Republic of China released the ＂Regulations on canceling the admission approval of the third class medical technologies and relevant works＂ in July 2015. According to the new regulation, the obligations and responsibilities of health administration departments for the admission approval of the clinical applications on the third- and the second-class medical technologies will be transferred to medical institutions that perform the operations.

关键词： Admission Approval Medical Technology Medical Technology Assessment New Policy Background ProceduralSupervision

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合理应用持续葡萄糖监测

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中华全科医师杂志 2024年第3期23卷 320-324页

作者：谢婷陈鑫大赵佩伊王伟好潘琦北京医院内分泌科国家老年医学中心北京100730 中国医学科学院北京协和医学院研究生院北京100730

糖尿病是一种以高血糖为特征的代谢性疾病。截至2021年,我国成年糖尿病人数接近1.41亿例,患病率为12.8%。全球糖尿病人数约为5.37亿例,预计到2030和2045年,将分别增加到6.43亿例和7.83亿例[1]。糖尿病及其并发症极大地降低了患者生活质... 详细信息

糖尿病是一种以高血糖为特征的代谢性疾病。截至2021年,我国成年糖尿病人数接近1.41亿例,患病率为12.8%。全球糖尿病人数约为5.37亿例,预计到2030和2045年,将分别增加到6.43亿例和7.83亿例[1]。糖尿病及其并发症极大地降低了患者生活质量[2],并造成较高的经济负担,预计到2030年,亚太地区将成为糖尿病花费最高的地区,绝对成本约为7961.1亿美元[3]。

关键词：糖尿病持续葡萄糖监测指标适用人群

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鄂尔多斯盆地新安边地区延10辫状河相砂体构型研究

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西安文理学院学报（自然科学版） 2024年第1期27卷 32-39页

作者：潘琦郭峰张力升西安石油大学地球科学与工程学院西安710065 西安石油大学陕西省油气成藏地质学重点实验室西安710065 西北大学地质学系大陆动力学国家重点实验室西安710069

对于辫状河相砂体构型的研究,以新安边地区延10储层为例,运用铸体薄片、压汞法和常规的物性分析,结合岩心和测井曲线资料等对沉积相的确定以及对隔夹层的识别.结果表明:新安边地区延10储层发育砂质辫状河相,其微相包括心滩、河道和泛滥... 详细信息

对于辫状河相砂体构型的研究,以新安边地区延10储层为例,运用铸体薄片、压汞法和常规的物性分析,结合岩心和测井曲线资料等对沉积相的确定以及对隔夹层的识别.结果表明:新安边地区延10储层发育砂质辫状河相,其微相包括心滩、河道和泛滥平原,岩性发育以长石石英砂岩和岩屑石英砂岩为主;储集空间主要是以粒间孔和长石溶孔为主;研究区隔夹层较为分布且隔夹层具有明显的区别,泥质隔夹层较多其次为物性隔夹层和钙质隔夹层,且泥质隔夹层厚度相对较大;辫状河砂体构型以多期型M和两期型D为主,其中河道微相以D2和S发育为主,厚度多在5~8 m之间,心滩微相以M型发育为主,其厚度大于9 m.该研究成果对于砂质辫状河相后期油气勘探开发具有重要意义.

关键词：辫状河相砂体构型隔夹层储层

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