检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

基于核岭回归的非线性系统辨识及其应用

系统仿真学报 2009年第8期21卷 2152-2155,2194页

作者：李琦邵诚大连理工大学先进控制技术研究所大连116024

利用满足Mercer条件的核函数改进线性岭回归算法,提出一种新的直接优化的非线性核岭回归算法。与SVM算法相比,该方法的特点是通过对二次损失函数的优化计算,简化了不确定参数的数量,而且由于采用直接优化计算,能有效减少建模的时间,提... 详细信息

利用满足Mercer条件的核函数改进线性岭回归算法,提出一种新的直接优化的非线性核岭回归算法。与SVM算法相比,该方法的特点是通过对二次损失函数的优化计算,简化了不确定参数的数量,而且由于采用直接优化计算,能有效减少建模的时间,提高计算效率。仿真实验结果和对航煤干点的软测量应用结果都验证了该算法的有效性。

关键词：核岭回归非线性系统系统辨识软测量

在线全文

学校读者我要写书评

暂无评论

气体分馏装置精馏过程的动态建模与仿真

系统仿真学报 2009年第14期21卷 4492-4496页

作者：李琦邵诚大连理工大学辽宁省工业装备先进控制系统重点实验室大连116024

以某炼油厂气体分馏装置动态模拟系统开发为背景,以脱丙烷塔为例,建立了精馏过程的严格动态机理模型,并基于动态机理模型进行了系统的动态模拟与分析。针对以往动态模型求解算法中采用迭代计算多组分混合物泡点时,存在运算量大、模型难... 详细信息

以某炼油厂气体分馏装置动态模拟系统开发为背景,以脱丙烷塔为例,建立了精馏过程的严格动态机理模型,并基于动态机理模型进行了系统的动态模拟与分析。针对以往动态模型求解算法中采用迭代计算多组分混合物泡点时,存在运算量大、模型难以收敛的问题,提出了一种基于支持向量机回归模型计算混合物泡点的新算法,以提高机理模型的计算效率。为避免动态模型不收敛,模型的初值采用稳态模型计算得到。仿真结果表明,新模型能较好的模拟装置生产操作状况,模型的计算效率有较大提高,为动态模拟系统的开发应用与装置优化提供了支持。

关键词：精馏过程机理模型动态模拟支持向量机

Investigations of liquid-liquid transitions in metallic melts by fast differential scanning calorimetry

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年

作者： qi cheng Yonghao Sun Weihua Wang Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular Engineering Peking University School of Physics and Electronic Information Anhui Normal University Institute of Physics Chinese Academy of Sciences Songshan Lake Materials Lab

liquid-liquid transition in metallic melts is an intriguing phenomenon often confused with liquid-liquid separation, oxidation or precipitation. Here, we employ a state-of-the-art ultrafast chip-based differential scanning calorimeter to investigate the thermal behavior of six metallic melts, ranging from unary to quinary systems, at temperatures above their liquidus. Calorimetric signals of liquid-liquid transition vary across systems: Sn melts showed no direct endothermic or exothermic events, though liquid-liquid transition influenced solidification and melting temperatures, while Yb-Zn melts exhibited an exothermic peak during cooling,indicating liquid-liquid transition. Thermal signals in other systems including li, Pd-Ni-P, Yb-Mg-Zn-Cu and Au-Ag-Pd-Cu-Si,are primarily driven by compositional changes. Our in-situ analysis provides new insights into the structural and compositional evolution of metallic melts, offering significant implications for the design and processing of novel materials.

关键词：

Single-cell omics: experimental workflow, data analyses and applications

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan li Dongqing Sun Shaliu Fu Lei Gu Xin shao qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han qi liu Xiaohui Fan Chen li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of life Science Chinese Academy of Sciences Peking-Tsinghua Center for life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China life Sciences 2025年

作者： Dake Xiao Haowen Ran lishu Chen Yuanyuan li Yan Cai Songyang Zhang qinghui qi Huiran Wu cheng Zhang Shuailiang Cao Lanjuan Mi Haohao Huang Ji qi qiuying Han Haiqing Tu Huiyan li Tao Zhou Fangye li Ailing li Jianghong Man Nanhu Laboratory National Center of Biomedical Analysis School of Traditional Chinese Medicine Capital Medical University Department of Neurosurgery General Hospital of Central Theater Command of Chinese PLA School of life and Health Sciences Huzhou College Department of Neurosurgery Beijing Fengtai Hospital Department of Neurosurgery First Medical Center of PLA General Hospital

The infiltration of glioblastoma multiforme(GBM) is predominantly characterized by diffuse spread, contributing significantly to therapy resistance and recurrence of GBM. In this study, we reveal that microtubule deacetylation, mediated through the downregulation of fibronectin type III and SPRY domain-containing 1(FSD1), plays a pivotal role in promoting GBM diffuse infiltration. FSD1 directly interacts with histone deacetylase 6(HDAC6) at its second catalytic domain, thereby impeding its deacetylase activity on α-tubulin and preventing microtubule deacetylation and depolymerization. This inhibitory interaction is disrupted upon phosphorylation of FSD1 at its Ser317 and Ser324 residues by activated CDK5, leading to FSD1 dissociation from microtubules and facilitating HDAC6-mediated α-tubulin deacetylation. Furthermore, increased expression of FSD1 or interference with FSD1 phosphorylation reduces microtubule deacetylation, suppresses invasion of GBM stem cells, and ultimately mitigates tumor infiltration in orthotopic GBM xenografts. Importantly, GBM tissues exhibit diminished levels of FSD1 expression, correlating with microtubule deacetylation and unfavorable clinical outcomes in GBM patients. These findings elucidate the mechanistic involvement of microtubule deacetylation in driving GBM cell invasion and offer potential avenues for managing GBM infiltration.

关键词：

Tunable non-Markovian and quantum coherence in the single-qubit dephasing noise channel

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年

作者： Na-Na Zhang Chao-Yi Wu Xu Zhou qi-Yuan liu cheng-Ge liu Yong-Rui Guo Ren-Pu li School of Optoelectronic Engineering Chongqing University of Posts and Telecommunications Department of Physics Applied Optics Beijing Area Major Laboratory Beijing Normal University

In this paper, we construct a single-qubit dephasing noise channel based on the nuclear magnetic resonance（NMR） system by employing the bath-engineering technology, and achieve the construction of the tunable non-Markovian environment in the dephasing noise channel. Our findings indicate that for the single-qubit system, the transition of system dynamics from Markovian to non-Markovian can be achieved by adjusting the base frequency of the noise power spectrum. However, the base frequency corresponding to this phase transition point is not fixed, and there is a certain relationship between it and the total evolution time of the single-qubit system. Through our research, we discovered a fundamental relationship: if the single-qubit system dynamics undergoe a transition from Markovian to non-Markovian at ω0within 0-2t ms, shortening the evolution time to 0-t ms results in an increase of the phase transition point to 2ω0. This insight offers crucial guidance for artificially crafting non-Markovian environments across arbitrary time scales in single-qubit systems, and it is not limited by the type of noise. Apart from system dynamics, quantum coherence is also a focal point of our research. We find that when the system dynamics exhibit non-Markovian behavior, the quantum coherence of the single-qubit system experiences revivals. Notably, the timing of these coherence revivals aligns with the instants of the non-Markovianity enhancement. Therefore, our research also serves as a pivotal foundation for the artificial manipulation and realization of quantum coherence revivals within diverse single-qubit systems.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

城市社区卫生服务可持续发展的思考

中国卫生经济 2009年第9期28卷 71-73页

作者：李小芡江启成李绍华刘国旗汤质如陶洁安徽医科大学卫生管理学院医疗保险系合肥230032

确立城市社区卫生服务可持续发展的理念,不仅是我国城市社区卫生服务发展模式的选择,也是正确审视现阶段我国城市社区卫生服务发展状况、研究城市社区卫生服务发展后劲、把脉城市社区卫生服务发展方向的问题。现阶段我国社区卫生服务存... 详细信息

确立城市社区卫生服务可持续发展的理念,不仅是我国城市社区卫生服务发展模式的选择,也是正确审视现阶段我国城市社区卫生服务发展状况、研究城市社区卫生服务发展后劲、把脉城市社区卫生服务发展方向的问题。现阶段我国社区卫生服务存在不少问题,这些问题影响着城市社区卫生服务健康有续持久地发展,因此要调动一切力量,多方寻求合作,"示范区"的创建,以特色促发展,为城市社区卫生服务可持续发展奠定基础。

关键词：社区卫生服务可持续发展示范区

Primary parenchymal squamous cell carcinoma of the kidney:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo shao Chao-Min Xu Ke Wang Jia-Zhu Wen li-Kang Luo Jia-cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

One-dimensional iridium-based nanowires for efficient water electrooxidation and beyond

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2022年第2期15卷 1087-1093页

作者： Leigang li Pengtang Wang Zifang cheng qi shao Xiaoqing Huang State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

The sluggish reaction kinetics of oxygen evolution reaction(OER)has largely lowered the efficiency of electrochemical water *** represents one of the state-of-the-art electrocatalysts for promoting OER especially in acidic ***,it remains a formidable challenge to synthesize high-quality one-dimensional(1D)Ir-based nanostructures for improved electrocatalytic ***,a template-assisted synthesis method is reported wherein 1D porous Ir-Te nanowires(Ir-Te NWs)are synthesized with Te NWs serving as the *** Ir-Te NWs exhibit highly enhanced OER performance compared to commercial IrO_(2) and Ir/*** detail,the overpotentials to reach 10 mA cm^(-2) are 248 and 284 mV in 1 M KOH and 0.5 M H2S04,respectively,much lower than those of commercial *** Ir-Te NWs also show smaller Tafel slopes than commercial IrO_(2) and Ir/C,signifying faster reaction ***,much more durable OER activity can be maintained for Ir-Te NWs with negligible decay during 25 and 20 h stability tests in 1 M KOH and 0.5 M H_(2)SO_(4),*** analysis indicates that the significantly improved OER performance of Ir-Te NWs could be ascribed to the larger electrochemical surface area and smaller electrical *** significantly,the templated synthesis of Ir-Te NWs can be facilely extended to the fabrication of other metal-Te NWs including Ru-Te,Rh-Te and Pt-Te *** design and synthesis of 1D metal-based NWs in this work provide important inspiration for the synthesis of diversified 1D metallic nanostructures with distinctly enhanced catalytic performance and beyond.

关键词： Ir template nanowire water splitting oxygen evolution reaction