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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-hua qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Periocular skin“tattooing”caused by gel pen pigment mistaken for periorbital bruising:a case of missed diagnosis of traumatic intraorbital pen core foreign body

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 366-369页

作者： Chao Xiong Zhang-Jun Ren Xue-Mei Li Jin-Hai Yu Yue Li Yun-Xiu Chen qi Jin Ze-Xi Sang Si-Yi Wang An-An Wang Pu-Ying Gan qi-hua Xu Yao-hua Wang Hong-Fei Liao Department of Orbital Diseases Tumor and Ocular TraumaThe Affiliated Eye HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330000Jiangxi ProvinceChina

Dear Editor,We are writing this letter to report a special missed diagnosis case of pediatric ocular trauma with intraorbital pencil core foreign *** an eye trauma occurs,orbital foreign bodies are *** most common typ... 详细信息

关键词： diagnosis foreign letter

民用煤燃烧排放亚微米颗粒物数浓度粒径分布和排放因子

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中国环境科学 2025年第2期45卷 593-605页

作者：覃旭菁孔少飞吴剑郑淑睿严沁祁士华中国地质大学环境学院湖北武汉430078 湖北省大气复合污染研究中心湖北武汉430078 中国地质大学生物地质与环境地质国家重点实验室湖北武汉430074

基于实验室模拟燃烧以及稀释通道采样系统,利用扫描电迁移率粒径谱仪,采集分析了不同地区7种蜂窝煤和11种块煤燃烧排放亚微米颗粒物的数浓度和粒径分布特征,并获得了分粒径段数浓度排放因子和呼吸道沉积通量.结果表明,蜂窝煤和块煤燃烧... 详细信息

基于实验室模拟燃烧以及稀释通道采样系统,利用扫描电迁移率粒径谱仪,采集分析了不同地区7种蜂窝煤和11种块煤燃烧排放亚微米颗粒物的数浓度和粒径分布特征,并获得了分粒径段数浓度排放因子和呼吸道沉积通量.结果表明,蜂窝煤和块煤燃烧过程中会排放大量亚微米颗粒物.亚微米颗粒物数浓度在核模态以及爱根核模态内下降趋势明显,在积聚模态低粒径段(100nm≤Dp≤200nm)下降趋势减弱,在积聚模态高粒径段(200nm≤Dp)颗粒物数浓度随粒径增长逐渐上升.蜂窝煤和块煤燃烧排放颗粒物总数浓度排放因子分别为(9.9×10^(14)±5.3×10^(14))个/kg和(1.4×10^(15)±7.9×10^(14))个/kg.块煤燃烧排放的三模态平均数浓度排放因子分别为(1.0×10^(15)±5.9×10^(14))、(2.8×10^(14)±2.5×10^(14))和(6.4×10^(13)±3.5×10^(13))个/kg,块煤在3个模态当中的数浓度排放因子分别是蜂窝煤1.3倍、1.9倍以及1.5倍.采用ICRP计算模型得出,蜂窝煤和块煤的总沉积通量(RDF)分别为7.6×10^(12)~4.7×10^(13)个/min和5.7×10^(12)~3.3×10^(13)个/min.燃烧排放的亚微米颗粒物中核模态与爱根核模态颗粒在呼吸道的沉积量占比超过90%.在呼吸系统的3个区域中,颗粒RDF尺寸分布均呈递减分布.本研究对比分析了不同地区民用煤燃烧排放不同粒径段颗粒物数浓度粒径分布、排放因子和吸入暴露,可为数浓度清单构建、效应模拟改进和健康风险评估等提供基础数据和有效支撑.

关键词：民用煤燃烧颗粒物数浓度粒径分布排放因子吸入暴露

Quantile Regression under Local Misspecification

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Acta Mathematicae Applicatae Sinica 2020年第4期36卷 790-802页

作者： Xiao-gang DUAN qi-hua WANG School of Statistics Beijing Normal UniversityBeijing 100875Chin Academy of Mathematics and System Science Chinese Academy of SciencesBeijing 100190China

The frequentist model averaging(FMA)and the focus information criterion(FIC)under a local framework have been extensively studied in the likelihood and regression setting since the seminal work of Hjort and Claes kens in *** inconvenience,however,of the existing works is that they usually require the involved criterion function to be twice differentiable which thus prevents a direct application to the case of quantile regression(QR).This as well as some other intrinsic merits of QR motivate us to study the FIC and FMA in a locally misspecified linear QR ***,we derive in this paper the explicit asymptotic risk expression for a general submodel-based QR estimator of a focus *** based on this asymptotic result,we develop the FIC and FMA in the current *** theoretical development depends crucially on the convexity of the objective function,which makes possible to establish the asymptotics based on the existing convex stochastic process *** studies are presented to illustrate the finite sample performance of the proposed *** low birth weight data set is analyzed.

关键词： frequentist model averaging focus information criterion local framework quantile regression

Aero-engine fault diagnosis applying new fast support vector algorithm

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航空动力学报 2012年第7期27卷 1604-1612页

作者： XU qi-hua GENG Shuai SHI Jun College of Electronic Engineering Huaihai Institute of Technology Lianyungang Jiangsu 222005 China No. 365 Institute Northwestern Polytechnical University Xi'an 710072 China

A new fast learning algorithm was presented to solve the large-scale support vector machine ( SVM ) training problem of aero-engine fault *** relative boundary vectors ( RBVs ) instead of all the original training samples were used for the training of the binary SVM fault *** pruning strategy decreased the number of final training sample significantly and can keep classification accuracy almost *** , the training time was shortened to 1 / 20compared with basic SVM *** , owing to the reduction of support vector number , the classification time was also *** sample aliasing existed , the aliasing sample points which were not of the same class were eliminated before the relative boundary vectors were *** , the samples near the relative boundary vectors were selected for SVM training in order to prevent the loss of some key sample points resulted from *** can improve classification accuracy effectively.A simulation example to classify 5classes of combination fault of aero-engine gas path components was finished and the total fault classification accuracy reached 96.1%.Simulation results show that this fast learning algorithm is effective , reliable and easy to be implemented for engineering application.

关键词： aero-engine support vector machines fault diagnosis large-scale training set relative boundary vector sample pruning

Effect of Growth Temperature on Carbon Nanotube Grafting Morphology and Mechanical Behavior of Carbon Fibers and Carbon] Carbon Composites

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Journal of Materials Science & Technology 2017年第1期33卷 65-70页

作者： Lei Feng Ke-Zhi Li Jin-hua Lu Le-hua qi State Key Laboratory of Solidification Processing Carbon/Carbon Composites Research Center Northwestern Polytechnical University Xi'an 710072 China School of Mechatronic Engineering Northwestern Polytechnical University Xi'an 710072 China

High-purity carbon nanotubes （CNTs） with different orientation and lengths were grafted on carbon fibers （CFs） in woven fabrics by using double injection chemical vapor deposition and adjusting the growth temperature. Scanning electron microscopy （SEM）, transmission electron microscopy （TEM） and Raman investigations reveal that the grafted CNTs change from being predominantly aligned and uniform in di- ameter to absolutely disordered and variable in diameter, whilst they show significantly increased crystallinity, as the growth temperature is increased from 730 ~C to 870 ~C. In tensile tests of fiber bundles, much more strength degradation of CFs was observed after the growth process at higher temperature than that at lower temperature. These hybrid preforms produced at different growth temperatures were used to reinforce carbon/carbon （C/C） composites. An increment of 34.4% in out-of-plane compressive strength （OCS） was obtained for the composites containing CNTs grown at 730℃, while the OCS increment exhibits an obvious decrease with increasing the growth temperature. Compared with the higher growth temperature, the lower temperature contributes to the decrease in the strength loss of reinforcing fibers and meanwhile the growth of large extending length of CNTs, which can provide long reinforcement to the pyrocarbon matrix, and thus increase the compressive strength better.

关键词： Carbon nanotubes Carbon fibers Chemical vapor deposition Carbon/carbon composites Mechanical strength

A Berry-Essen Inequality for the Kaplan-Meier L-Estimator

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Acta Mathematica Sinica,English Series 2001年第1期17卷 169-180页

作者： qi hua WANG Li Xing ZHU Institute of Applied Mathematics. Academy of Mathematics and Systems Sciences Chinese Academy of Sciences Institute of Applied Mathematics Academy of Mathematics and Systems Sciences Chinese Academy of Sciences Department of Statistice and Actuarial Science The University of Hong Kong

Let F_n be the Kaplan-Meier estimator of distribution function F. Let J(·) be a measureable real-valued function. In this paper, a U-statistic representation for the Kaplan-Meier L-estimator, T(F_n)=∫xJ( _n(x))d _n(... 详细信息

关键词： Kaplan-Meier L-estimator U-statistic representation Berry-Essen Inequality

Autophagy in plants: Physiological roles and post-translational regulation

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Journal of Integrative Plant Biology 2021年第1期63卷 161-179页

作者： hua qi Fan-Nv Xia Shi Xiao State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory of Plant ResourcesSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China

In eukaryotes, autophagy helps maintain cellular homeostasis by degrading and recycling cytoplasmic materials via a tightly regulated *** the past few decades, significant progress has been made towards understanding the physiological functions and molecular regulation of autophagy in plant cells. Increasing evidence indicates that autophagy is essential for plant responses to several developmental and environmental cues, functioning in diverse processes such as senescence, male fertility, root meristem maintenance, responses to nutrient starvation,and biotic and abiotic stress. Recent studies have demonstrated that, similar to nonplant systems,the modulation of core proteins in the plant autophagy machinery by posttranslational modifications such as phosphorylation, ubiquitination,lipidation, S-sulfhydration, S-nitrosylation, and acetylation is widely involved in the initiation and progression of autophagy. Here, we provide an overview of the physiological roles and posttranslational regulation of autophagy in plants.

关键词： autophagy physiological roles post-translational regulation

前沿科研成果融入工程化学实验教学-电化学测试桑白皮提取物在1 M HCl溶液中对碳钢的缓蚀性能

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安徽化工 2025年第1期51卷 162-166,176页

作者：张青华张宇戚华涛许宁安徽工程大学化学与环境工程学院安徽芜湖241000

为满足社会发展的需要,培养复合型人才已成为我国的重要战略目标。工程化学作为一门将化学的基本原理和方法应用于相关工程领域的学科,是化学与工程技术的大融合,专注于培养学生思考问题、解决问题和分析问题的能力,为国家的发展培养复... 详细信息

为满足社会发展的需要,培养复合型人才已成为我国的重要战略目标。工程化学作为一门将化学的基本原理和方法应用于相关工程领域的学科,是化学与工程技术的大融合,专注于培养学生思考问题、解决问题和分析问题的能力,为国家的发展培养复合型人才。将前沿科研成果融入工程化学实验教学的设计中。利用电化学工作站测试碳钢在酸性环境中的腐蚀速率及桑白皮提取物对碳钢的缓蚀性能,使学生深入了解石油天然气、化工、航空航天、海洋和建筑等领域材料的腐蚀监测及腐蚀防护,并将电化学腐蚀理论知识与实际工况联系起来。

关键词：金属材料电化学腐蚀桑白皮提取物缓蚀剂科学前沿实验教学