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On Pattern Avoiding Flattened Set Partitions

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Acta Mathematica Sinica,English Series 2015年第12期31卷 1923-1928页

作者： Thomas Y.H.LIU Andy q.zhang Department of Foundation Courses Southwest Jiaotong University Center for Combinatorics LPMC-TJKLCNankai University

Let Π = B1/B2/… /Bk be any set partition of[n]= {1,2,...,n} satisfying that entries are increasing in each block and blocks are arranged in increasing order of their first *** Callan defined the flattened Π to be the permutation of[n]obtained by erasing the divers between its blocks,and Callan also enumerated the number of set partitions of[n]whose flattening avoids a single3-letter *** posed the question of counting set partitions of[n]whose flattening avoids a pattern of length *** this paper,we present the number of set partitions of[n]whose flattening avoids one of the patterns：1234,1243,1324,1342,1423,1432,3142 and 4132.

关键词： Set partition pattern avoidance flattened partition

A personal journey on cracking the genomic codes

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quantitative Biology 2021年第1期9卷 8-22页

作者： Michael q.zhang Department of Biological Sciences Center for Systems Biologythe University of Texas at DallasRichardsonTX 75080-3021USA MOE Key Laboratory of Bioinformatics and Bioinformatics Division Center for Synthetic and System BiologyDepartment of AutomationBeijing National Research Center for Information Science and TechnologyTsinghua UniversityBeijing 100084China

In February 2001,the IHGSC(International Human Genome Sequencing Consortium)[1]and Celera Genomics[2]each reported draft sequences providing a first overall view of the human *** the occasion of the 20th anniversary celebration,I would like to provide some of my personal account on how the HGP(Human Genome Project)has impacted my academic research interests and to offer some candid advice for the new comers.1.

关键词： Genome cracking Human

Dialog between artificial intelligence&natural intelligence

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quantitative Biology 2023年第4期11卷 359-362页

作者： Michael q.zhang Department of Biological Sciences Center for Systems BiologyUniversity of TexasDallasTexasUSA

Recently,quantitative Biology(qB)held a discussion on"Al(artificial intelligence)for Life Science"among editorial board members and interested scholars in anticipation of rapid development of this growing area after AlphaGo and ChatGPT *** young people tend to get confused between facts and fictions;heated debates are unavoidable even among their *** deep learning as represented by convolutional neural networks and LSTM(long shortterm memory)was made available for bioinformatics students,many of them rushed into this research field and tried to adopt these methods in all their projects without knowing the history that these tools were becoming successful consistently with Moore's Law(relating to rapid computer technology advances)

关键词： tried becoming heated

Surface modification of tungsten oxide by oxygen vacancies for hydrogen adsorption

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Journal of Materials Science & Technology 2022年第22期117卷 23-35页

作者： q.zhang F.W.Tang Z.Zhao Z.R.Nie X.Y.Song Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing 100124China

A model for describing the adsorption process of hydrogen on surface of tungsten oxide was proposed based on the first-principle calculations. Multiple factors such as type of active surface, adsorption site and distribution of oxygen vacancies were considered to evaluate the hydrogen adsorption capability of tungsten oxide. The adsorption Gibbs free energies, electronic structures and bonding characteristics under various conditions were examined to reveal the influence of oxygen vacancies on the surface. It is found that the capability of hydrogen adsorption of tungsten oxide can be significantly enhanced by adjusting the oxygen vacancy on the outermost layer of certain active surfaces. The modeling predicts that the surface structure stability and gas adsorption ability of tungsten oxide can be simultaneously improved through the formation of W–H bonds. The proposed strategy for moderating surface provides a new approach to obtain excellent gas-sensitive metal oxide materials.

关键词： Metal oxide Gas-sensitive material Surface adsorption Oxygen vacancy First-principles calculation

Enhanced oxidation resistance of Ce by addition of Ga and nanocrystallization

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Journal of Materials Science & Technology 2023年第16期147卷 26-36页

作者： T.S.Liang Y.F.Jiang H.Y.Li W.Wang q.zhang B.zhang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China The 404 Company Limited China National Nuclear CorporationLanzhou 732850China State Key Laboratory of Material Processing and Die&Mould Technology School of Material Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Ce is prone to catastrophic oxidation at room temperature and its oxidation resistance is difficult to be improved by ***,we found that the oxidation resistance of active metal Ce can be significantly improved by the addition of 20 at.%*** ion beam lift-out technique and scanning transmission electron microscopy analysis disclosed that a discontinuous Ga-rich layer was generated beneath the oxide layer in the coarse-grained Ce-Ga *** Ga-rich layer formed by selective oxidation of Ce acts as a diffusion barrier for Ce outward diffusion and ceases the O/M interfacial reaction when a critical concentration of Ga(75 at.%)is *** nanocrystallization,uniform distribution of Ga was *** oxidation,a relatively continuous Ga-rich layer was formed which further enhanced the oxidation *** introduction of noble elements combining with nanocrystallization may provide a novel strategy for the protection of metals with high activity and poor oxidation resistance.

关键词： Ce-Ga alloy Oxidation resistance Diffusion barrier Nanocrystallization

Drosophila homolog of the intellectual disability-related long-chain acyl-CoA synthetase 4 is required for neuroblast proliferation

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Journal of Genetics and Genomics 2019年第1期46卷 5-17页

作者： Mingyue Jia Danqing Meng Mo Chen Tingting Li Yong q.zhang Aiyu Yao State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences University of Chinese Academy of Sciences

Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) are associated with non-syndromic X-linked intellectual disability (ID). However, the neural functions of ACSL4 and how loss of ACSL4 leads to ID remain largely unexplored. We report here that mutations in Acsl, the Drosophila ortholog of human ACSL3 and ACSL4, result in developmental defects of the mushroom body (MB), the center of olfactory learning and memory. Specifically, Acsl mutants show fewer MB neuroblasts (Nbs) due to reduced proliferation activity and premature differentiation. Consistently, these surviving Nbs show reduced expression of cyclin E, a key regulator of the G1-to S-phase cell cycle transition, and nuclear mislocalization of the transcriptional factor Prospero, which is known to repress self-renewal genes and activate differentiating genes. Furthermore, RNA-seq analysis reveals downregulated Nb-and cell-cyclerelated genes and upregulated neuronal differentiation genes in Acsl mutant Nbs. As Drosophila Acsl and human ACSL4 are functionally conserved, our findings provide novel insights into a critical and previously unappreciated role of Acsl in neurogenesis and the pathogenesis of ACSL4-related ID.

关键词： ACSL4 Drosophila Mushroom body Neuroblast Neural stem cell Premature differentiation

HCSGD：An integrated database of human cellular senescence genes

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Journal of Genetics and Genomics 2017年第5期44卷 227-234页

作者： qiongye Dong Hongqing Han Xuehui Liu Lei Wei Wei zhang Zhen Zhao Michael q.zhang Xiaowo Wang Ministry of Education Key Laboratory of Bioinformatics Center for Synthetic and Systems Biology Department of Automation Tsinghua University Beijing100084 China Bioinformatics Division Tsinghua National Laboratory for Information Science and Technology Beijing 100084 China Department of Basic Medical Sciences School of Medicine Tsinghua University Beijing 100084 China

Cellular senescence is an irreversible cell cycle arrest program in response to various exogenous and endogenous stimuli like telomere dysfunction and DNA *** has been widely accepted as an antitumor program and is also found closely related to embryo development,tissue repair,organismal aging and age-related degenerative *** the past decades,numerous efforts have been made to uncover the gene regulatory mechanisms of cellular *** is a strong demand to integrate these data from various resources into one open *** facilitate researchers on cellular senescence,we have developed Human Cellular Senescence Gene Database（HCSGD） by integrating multiple online published data sources into a comprehensive senescence gene annotation platform（http：//***/member/xwwang/HCSGD）.Potential Human Cellular Senescence Genes（HCSGS）were collected by combining information from published literatures,gene expression profiling data and Protein-Protein Interaction ***,genes are annotated with gene ontology annotation and microRNA/drug/compound target *** provides a valuable resource to visualize cellular senescence gene networks,browse annotated functional information,and retrieve senescenceassociated genes with a user-friendly web interface.

关键词： Cellular senescence Meta-analysis Text-mining

LncRNA Platr22 promotes super-enhancer activity and stem cell pluripotency

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Journal of Molecular Cell Biology 2021年第4期13卷 295-313页

作者： Pixi Yan Yuyang Lu Jing Niu Juntao Gao Michael q.zhang Yafei Yin Xiaohua Shen Tsinghua-Peking joint Center for Life Sciences School of Medicine and School of Life SciencesTsinghua UniversityBeijingChina Department of Cell Biology Zhejiang University School of MedicineHangzhouChina t These authors contributed equally to this work

Super-enhancers(SEs)comprise large clusters of enhancers,which are co-occupied by multiple lineage-specific and master tran-scription factors,and play pivotal roles in regulating gene expression and cell fate ***,it is still largely un-known whether and how SEs are regulated by the noncoding portion of the ***,through genome-wide analysis,wefound that tpng noncoding RNA(IncRNA)genes preferentially lie next to *** mouse embryonic stem cells(mESCs),depletionof$E-associated IlncRNA transcripts dysregulated the activity of their nearby ***,we revealed a critical regulatoryrole of the IncRNA gene Platr22 in modulating the activity of a nearby SE and the expression of the nearby pluripotency *** these regulatory events,Platr22 contributes to pluripotency maintenance and proper differentiation of ***,Platr22 transcripts coat chromatin near the SE region and interact with DDX5 and ***5 further recruitsp300 and other factors related to active *** propose that these factors assemble into a transcription hub,thus pro-moting an open and active epigenetic chromatin state.0ur study highlights an unanticipated role for a class of lncRNAs in epige-netically controlling the activity and vulnerability to perturbation of nearby SEs for cell fate determination.

关键词： IncRNA Platr22t super-enhancer pluripotency

Succinate: A microbial product that modulates Drosophila nutritional physiology

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Insect Science 2022年第1期29卷 315-318页

作者： Freya q.zhang John G.McMullen II Angela E.Douglas Nana Y.D.Ankrah Department of Entomology Cornell UniversityIthacaNY 14853USA Department of Molecular Biology and Genetics Cornell UniversityIthacaNY 14853USA Department of Biological Sciences State University of New York at PlattsburghPlattsburghNY 12901USA

Dear Editor,Gut microorganisms process food in animal guts and release many metabolic by-products,which are predicted to influence host physiological processes such as energy and lipid ***,we investigate how succi-nate,a TCA cycle intermediate that is a major predicted release product of gut bacteria in Drosophila,influences the nutritional physiology of its Drosophila *** ad-ministered succinate as a dietary supplement to microbe-free Drosophila,and quantified key nutritional *** succinate significantly reduced fly lipid levels by up to~50%.This response was not replicated in paral-lel experiments conducted with dietary fumarate supple-ment,indicating that it could not be attributed to a gen-eral effect of TCA *** hypothesize that microbe-derived succinate may contribute to the reduced lipid content of Drosophila bearing gut bacteria,relative to axenic *** generally,this study high-lights the importance of microbial-derived metabolites as regulators of host metabolism.

关键词： release intermediate attributed