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关于L-函数一类特殊二次均值的计算问题

西北大学学报（自然科学版） 2019年第2期49卷 302-308页

作者：段然西北大学数学学院陕西西安710127

研究模q Dirichlet L-函数一类二次均值的计算问题。利用解析方法及Dedekind和的互反公式以及M?bius反转公式,给出其二次均值■的一个精确的计算公式,其中■表示对模q的所有偶特征求和,χ_6为模6的非主特(6,q)=1且。结论促进了Dirichlet... 详细信息

研究模q Dirichlet L-函数一类二次均值的计算问题。利用解析方法及Dedekind和的互反公式以及M?bius反转公式,给出其二次均值■的一个精确的计算公式,其中■表示对模q的所有偶特征求和,χ_6为模6的非主特(6,q)=1且。结论促进了Dirichlet L-函数的研究。

关键词： Dirichlet L-函数 Dedekind和偶特征二次均值计算公式

基于模糊神经网络的强化学习及其在机器人导航中的应用

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控制与决策 2007年第5期22卷 525-529,534页

作者：段勇徐心和东北大学信息科学与工程学院沈阳110004

研究基于行为的移动机器人控制方法.将模糊神经网络与强化学习理论相结合,构成模糊强化系统.它既可获取模糊规则的结论部分和模糊隶属度函数参数,也可解决连续状态空间和动作空间的强化学习问题.将残差算法用于神经网络的学习,保证了函... 详细信息

研究基于行为的移动机器人控制方法.将模糊神经网络与强化学习理论相结合,构成模糊强化系统.它既可获取模糊规则的结论部分和模糊隶属度函数参数,也可解决连续状态空间和动作空间的强化学习问题.将残差算法用于神经网络的学习,保证了函数逼近的快速性和收敛性.将该系统的学习结果作为反应式自主机器人的行为控制器。

关键词：强化学习模糊神经网络 q(λ)学习机器人导航

Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in qGY7701 and Hep G2 hepatoma cells

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World Journal of Gastroenterology 2017年第34期23卷 6242-6251页

作者： Cai-Jie Lu Yi-Feng He Wei-Zhuang Yuan Li-Jun Xiang Jian Zhang Yan-Rui Liang Juan duan Yun-He He Ming-Yi Li Laboratory of Hepatobiliary Surgery Affiliated Hospital of Guangdong Medical University the First Clinical Medical College Southern Medical University Department of Gastrointestinal Surgery. The Second Affiliated Hospital of Guangzhou Medical University TCM-Integrated Hospital Southern Medical University

AIM To investigate whether Dihydromyricetin(DHM) inhibits cell proliferation and promotes apoptosis by downregulating Notch1 *** The correlation between Notch1 and Hes1(a Notch1 target molecule) expression in hepatoma samples was confirmed by q RT-PCR. In addition, MTT assays, flow cytometry and TUNEL analysis showed that DHM possessed strong anti-tumor properties, evidenced not only by reduced cell proliferation but also by enhanced apoptosis in qGY7701 and Hep G2 hepatocellular carcinoma(HCC) cells. The expressions of Notch1, Hes1, Bcl-2 and Bax were determined by Western *** Among the tested samples(n = 64), the expression levels of Notch1(75% of patients) and Hes1(79.7% of patients) m RNA in tumor tissues were higher than in the normal liver tissues. There was a negative correlation between the expression of Notch1 and the degree of differentiation and positively correlated with the Alpha Fetal Protein concentration. The viability of HCC cells treated with DHM was significantly inhibited in a dose and time-dependent manner. Apoptosis was induced in Hep G2 and qGY7701 cell lines following 24 h of DHM treatment. After treatment with DHM, the protein expression of Notch1 was downregulated, the apoptosis-related protein Bax was upregulated and Bcl2 was downregulated. Notch1 si RNA further enhanced the anti-tumor properties of DHM. CONCLUSION Notch1 is involved in the development of HCC and DHM inhibits cell proliferation and promotes apoptosis by down-regulating the expression of Notch1.

关键词： Dihydromyricetin Apoptosis Hepatocellular carcinoma Notch1

广义Besov类B_(p,θ)~Ω在一致和随机框架下的Gel'fand逼近

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数学物理学报（A辑） 2012年第1期32卷 148-160页

作者：段立芹杭州电子科技大学数学研究所杭州310018

该文研究了广义Besov类Bp,θ^Ω在一致和随机框架下由Gel’fand方法的逼近问题．利用Maiorov的离散化方法和pseudo—S—scale的性质，给出了这一逼近问题在某些情况下的渐近阶.

关键词： Gel’fand逼近宽度广义Besov类渐近阶

First-Stokes Wavelengths at 1175.8 and 1177.1 nm Generated in a Diode End-Pumped Nd:YVO_4/LuVO_4 Raman Laser

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Chinese Physics Letters 2019年第1期36卷 32-35页

作者： qing-qing Zhou Shen-Cheng Shi Si-Meng Chen Yan-Min duan Xi-Mei Zhang Jing Guo Bin Zhao Hai-Yong Zhu College of Mathematics Physics and Electronic Information Engineering Wenzhou University International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education College of Optoelectronic Engineering Shenzhen University College of Chemistry and Chemical Engineering Fuzhou University

A diode end-pumped acousto-optic q-switched Nd:YVO_4/LuVO_4 Raman laser is demonstrated. Both YVO_4 and LuVO_4 can work as Raman gain, and slightly different active vibration modes of both crystals can result in different first-Stokes wavelengths. The output characteristic as the Raman competition between YVO_4 and LuVO_4 crystals for the laser systems with both shared cavity and coupled cavity is experimentally *** the shared cavity, simultaneous Raman conversion in both YVO_4 and LuVO_4 crystals is achieved with dualwavelength emission at 1175.8 and 1177.1 nm. The maximum output power of 1.03 W and the conversion efficiency of 10.3% are obtained. The 0.84 W single first Stokes wavelength at 1177.1 nm with LuVO_4 Raman conversion is achieved with the coupled cavity. The results show that the coupled cavity with short Raman cavity can obtain a narrow pulse width. The separated laser crystal and Raman gain media with different vanadates in shared cavity have advantages in achieving dual-wavelength lasers with small frequency intervals.

关键词： Tox wavelength Diode side pump Raman laser

HIRA Gene is Lower Expressed in the Myocardium of Patients with Tetralogy of Fallot

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Chinese Medical Journal 2016年第20期129卷 2403-2408页

作者： Zhao-Ru Ju Hui-Jun Wang Xiao-Jing Ma duan Ma Guo-Ying Huang Pediatric Cardiovascular Center Children's Hospital of Fudan UniversityShanghai 201102China Laboratory of Congenital Heart Disease Shanghai Key Laboratory of Birth DefectsShanghai 201102China

Background：The most typical cardiac abnormality is conotruncal defects （CTDs） in patients with 22q11 deletion syndrome （22q11DS）.HIRA （histone cell cycle regulator） gene,as one of the candidate genes located at the critical region of 22q11DS,was reported as possibly relevant to CTD in animal *** study aimed to analyze the level of expression of the HIRA gene in tetralogy of Fallot （TOF） patients and the potential DNA sequence variations in the promoter ***：The messenger RNA （mRNA） expression was examined with quantitative real-time polymerase chain reaction in 39 myocardial tissues of the right ventricular outflow tract （RVOT） from TOF patients and 4 myocardial tissues of RVOT from noncardiac death *** protein expression was detected using immunohistochemistry in 12 TOF patients and 4 controls.A total of 100 TOF cases and 200 healthy controls were recruited for DNA ***：The mRNA and protein expressions of the HIRA gene in the myocardium of the TOF patients were both significantly lower as compared to the controls （P 〈 0.05）.Five single nucleotide polymorphisms （SNPs）,including g.4111A〉G （rs1128399）,g.4265C〉A （rs4585115）,g.4369T〉G （rs2277837）,g.4371C〉A （rs148516780）,and g.4543T〉C （rs111802956）,were found in the promoter region of the HIRA *** were no significant differences of frequencies in these SNPs between the TOF patients and the controls （P 〉 0.05）.Conclusion：The abnormal lower expression of the HIRA gene in the myocardium may participate in the pathogenesis of TOF.

关键词： Congenital Heart Defects Gene Expression HIRA Single Nucleotide Polymorphism Tetralogy of Fallot

Emergent ultra-high temperature ferromagnetism in La_(2)CoO_(4±x) thin films

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Nano Research 2024年第8期17卷 7250-7255页

作者： Ziang Meng Han Yan Peixin qin Zhuo Yin Peiheng Jiang Xiaorong Zhou Xiaoning Wang Hongyu Chen Li Liu Zhiyuan duan Guojian Zhao Weisheng Zhao Fengxia Hu qinghua Zhang Zhicheng Zhong Zhiqi Liu School of Materials Science and Engineering Beihang UniversityBeijing 100191China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China CAS Key Laboratory of Magnetic Materials and Devices and Zhejiang Province Key Laboratory of Magnetic Materials and Application Technology Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Fert Beijing Institute School of Integrated Circuit Science and EngineeringBeihang UniversityBeijing 100191China

Searching for novel ferromagnetic oxides with high Curie temperature(TC)has been one of the main goals for oxide *** well-known perovskite cobaltate LaCoO_(3) is a classical ferromagnet in its thin-film form;however,it suffers from a low TC(~85 K).Here we report a new type of ferromagnetic La-Co-O films with an ultrahigh TC of~820 *** are fabricated by pulsed laser deposition from a LaCoO_(3) target at low oxygen partial *** structural analysis indicates that they crystallize in terms of the Ruddlesden–Popper phase of La_(2)CoO_(4±x).In sharp contrast to the antiferromagnetism of bulk La_(2)CoO_(4),the strong ferromagnetism in the La_(2)CoO_(4±x) thin films is firmly demonstrated by magnetometry measurements,X-ray magnetic circular dichroism characterization,and magnetotransport *** importantly,density functional theory calculations indicate that the nonstoichiometric oxygen induces an antiferromagnetic-to-ferromagnetic phase transition,accompanied by the orbital reconstruction of Co 3d ***,our study provides an attractive strategy for designing or synthesizing exotic magnetic oxides with high ordering temperatures.

关键词： ferromagnetic oxides ultra-high Curie temperature La_(2)CoO_(4) spin current transport oxygen engineering

Synthesis, crystal structures, photoluminescence properties and DNA binding of triazine-nickel（Ⅱ） complexes for ct-DNA detection

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Synthesis, crystal structures, photoluminescence properties ...

Low expression of centrosomal protein 78(CEP78)is associated with poor prognosis of colorectal cancer patients

中国化学会第九届全国无机化学学术会议

作者： Wei Wang Xiao-hua Zhou Ran-ran duan College of Materials and Energy South China Agricultural University

We report here the synthesis of three new nickel（II） complexes: [Ni（Pz TA）2CO3]·5H2O（Pz TA = 2,4-diamio-6-（2′-pyrazin）-1,3,5-triazine） in 1, [Ni q（Py TA）（H2O）2]Cl·H2O（Hq = 8-hydroxyquinoline, Py TA = 2,4-diamino-6-（2′-pyridyl）-1,3,5-triazine） in 2, [Ni q（Pz TA）（H2O）2]Cl·H2O in 3, and they were characterized by UV spectroscopy, elemental analysis, molar conductivity and X-ray single crystal diffraction（CCDC number of 2 and 3 are 996889 and 996892, respectively）. Binding of the complexes to ct-DNA was investigated with electronic spectroscopy, ethidium bromide displacement from DNA, viscometry and cyclic voltammetry. The results depicted the DNA binding mode of the three complexes was intercalation, and complex 1 together with external static-electricity. Moreover, the three complexes also presented potential anti-oxidant activity. Interestingly, we found 1 was sensitive to oxygen and to the polarity of nonaqueous solvents in fluorescence spectroscopy. Fluorescence of complex 2 and 3 is weak in neutral aqueous solvents, but is greatly enhanced by addition of ct-DNA. Thus, 2 and 3 can be used to DNA detection as DNA fluorescence probes with a LOD of 1.61 ng·mL-1, 4.90 ng·mL-1 for the relative wide linear range of 0.010- 20 μg·mL-1, 0.020- 30 μg·mL-1, respectively. These findings indicate 1 may be a potential optical probe for oxygen-free environments in nonaqueous form, while 2 and 3 were DNA-targeted probes.

关键词： nickel(Ⅱ) complex 8-hydroxyquinoline 1,3,5-triazine DNA interaction fluorescent probe

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Chinese Journal of Cancer 2016年第10期35卷 509-517页

作者： Meifang Zhang Tingmei duan Li Wang Jianjun Tang Rongzhen Luo Ruhua Zhang Tiebang Kang State Key Laboratory of Oncology in South China Collaborative Innova-tion Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China. Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China. Research Department Sun Yat-sen University Cancer CenterGuang-zhou 510060GuangdongP.R.China.

Background: Centrosomal protein 78(CEP78) has been characterized as a component of the centrosome required for the regulation of centrosome-related events during the cell cycle, but its role in human cancers remains unclear. This study aimed to investigate the role and the clinical value of CEP78 in colorectal cancer(CRC).Methods: quantitative real-time polymerase chain reaction(q RT-PCR) and immunohistochemistry were performed to examine CEP78 expression in CRC tissues and adjacent noncancerous tissues. The association between CEP78 expression and clinical outcomes of CRC patients was determined. The effect of CEP78 on cell growth was examined in vitro by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide(MTT) assay, colony formation, and flow cytometry assays and in vivo using a nude mouse ***: The expression level of CEP78 was significantly lower in tumor tissues than in the adjacent normal tissues(P < 0.01). Low CEP78 expression was significantly associated with poor differentiation(P etastasis(P = 0.003), large tumor size(P = 0.017), lymphatic mtient= 0.034), distant metastasis(P s with low CEP78 expression h= 0.029), and advanced stage(P Meier analysis indicated that paad shorter survival than those wit= 0.011). Kaplan–h high CEP78 expression(P < 0.01). Overexpression of CEP78 in CRC cells significantly reduced cell viability and colony formation in vitro and halted tumor growth in vivo. Further study showed that CEP78 reintroduction in CRC cells resulted in G2/M phase arrest rather than cell ***: CEP78 might function as a tumor suppressor and serve as a novel prognostic marker in CRC.

关键词：中心体蛋白结直肠癌预后患者细胞周期聚合酶链反应 RT-PCR 实验检测