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绿色供应链技术创新与合作伙伴选择决策研究

计算机集成制造系统 2023年第9期29卷 3086-3099页

作者：段炼袁柳洋武汉科技大学理学院湖北武汉430065 武汉科技大学湖北省冶金工业过程系统科学重点实验室湖北武汉430081

绿色技术是提高绿色供应链竞争力的关键,对于绿色供应链成员选择合作伙伴的决策也具有重要影响。基于绿色技术创新与技术共享两个重要因素,采用非合作—合作两型博弈模型分析了由1个供应商和3个制造商组成的两级绿色供应链绿色技术创新... 详细信息

绿色技术是提高绿色供应链竞争力的关键,对于绿色供应链成员选择合作伙伴的决策也具有重要影响。基于绿色技术创新与技术共享两个重要因素,采用非合作—合作两型博弈模型分析了由1个供应商和3个制造商组成的两级绿色供应链绿色技术创新与合作伙伴选择的问题。在合作博弈阶段采用宗系解对绿色供应链成员进行收益分配,在非合作博弈阶段得出绿色供应链成员共享绿色技术或进行绿色技术创新的最优决策并得到纯策略纳什均衡。研究结果表明:在不考虑制造商进行绿色技术创新的情况下,供应商优先选择本身实力强劲的制造商作为合作伙伴;进一步地,只有在共享绿色技术成本较低时供应商才会选择技术共享以增加绿色供应链的整体利润。另一方面,在考虑制造商进行绿色技术创新的情况下,实力强的制造商依然具有较大的优势,而相对较弱的制造商只有在绿色技术创新收益高出强劲制造商时,供应商才会选择其作为合作伙伴。研究结论有助于展现绿色供应链伙伴选择的内在机理,对绿色供应链的管理实践有一定的理论和现实意义。

关键词：绿色供应链两型博弈宗系解绿色技术创新

Natural Variation in the Promoter of GSE5 Contributes to Grain Size Diversity in Rice

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Molecular Plant 2017年第5期10卷 685-694页

作者： Penggen duan Jinsong Xu Dali Zeng Baolan Zhang Mufan Geng Guozheng Zhang Ke Huang Luojiang Huang Ran Xu Song Ge qian qian Yunhai Li State Key Laboratory of Plant Cell and Chromosome Engineering CAS Centre for Excellence in Molecular Plant Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 P. R. China State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences Beijing 100093 P. R. China University of Chinese Academy of Sciences Beijing 100039 P. R. China These authors contributed equally to this article

The utilization of natural genetic variation greatly contributes to improvement of important agronomic traits in crops. Understanding the genetic basis for natural variation of grain size can help breeders develop high- yield rice varieties. In this study, we identify a previously unrecognized gene, named GSE5, in the qSW5/ GW5 locus controlling rice grain size by combining the genome-wide association study with functional analyses. GSE5 encodes a plasma membrane-associated protein with ｜q domains, which interacts with the rice calmodulin protein, OsCaMl-1. We found that loss of GSE5 function caused wide and heavy grains, while overexpression of GSE5 resulted in narrow grains. We showed that GSE5 regulates grain size predominantly by influencing cell proliferation in spikelet hulls. Three major haplotypes of GSE5 （GSE5, GSE5DELl＋IN1, and GSESDEL~ in cultivated rice were identified based on the deletion/insertion type in its pro- moter region. We demonstrated that a 950-bp deletion （DELl） in indica varieties carrying the GSE5DELl＋IN1 haplotype and a 1212-bp deletion （DEL2） in japonica varieties carrying the GSE5DEL2 haplotype associated with decreased expression of GSE5, resulting in wide grains. Further analyses indicate that wild rice acces- sions contain all three haplotypes of GSE5, suggesting that the GSE5 haplotypes present in cultivated rice are likely to have originated from different wild rice accessions during rice domestication. Taken together, our results indicate that the previously unrecognized GSE5 gene in the qSW5/GW5 locus, which is widely utilized by rice breeders, controls grain size, and reveal that natural variation in the promoter region of GSE5 contributes to grain size diversity in rice.

关键词： rice natural variation GSE5 grain size cell proliferation

Studies of the 2α and 3α channels of the ^(12)C+^(12)C reaction in the range of E_(c.m.)=8.9 MeV to 21 MeV using the active target Time Projection Chamber

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Chinese Physics C 2022年第10期46卷 116-125页

作者： X.Y.Wang N.T.Zhang Z.C.Zhang C.G.Lu T.L.Pu J.L.Zhang L.M.duan B.S.Gao K.A.Li Y.T.Li Y.qian L.H.Ru B.Wang X.D.Xu H.Y.Zhao W.P.Lin Z.W.Cai B.F.Ji q.T.Li J.Y.Xu X.D.Tang Joint department for nuclear physics Institute of Modern Physics and Lanzhou UniversityChinese Academy of SciencesLanzhou 730000China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China School of Physics and State Key Laboratory of Nuclear Physics and Technology Peking UniversityBeijing 100871China

The ^(12)C+^(12)C fusion reaction was studied in the range of E_(c.m.)=8.9 to 21 MeV using the active-target Time Projection *** full information on all tracks of the reaction products,cross sections of the^(12)C(^(12)C,^(8)Be)^(16)O_(g.s.)channel and the ^(12)C(^(12)C,3a)^(12)C channel could be measured down to the level of a few *** ^(12)C(^(12)C,^(8)Be)^(16)O_(g.s.)reaction channel was determined to be 10_(-8)^(+24) mb at E_(c.m.)=11.1 MeV,supporting the direct a transfer reaction *** ^(12)C(^(12)C,3α)^(12)C reaction channel was studied for the first time using an exclusive *** result does not confirm the anomaly behavior reported in the previous inclusive measurement by Kolata et al.[***.C 21,579(1980)].Our comparisons with statistical model calculations suggest that the 3 a channel is dominated by the fusion evaporation process at E_(c.m.)>19 *** additional contribution of the 3 a channel increases the fusion reaction cross section by 10% at energies above 20 *** also find that an additional reaction mechanism is needed to explain the measured cross section at E_(c.m.)<15 MeV at which point the statistical model prediction vanishes.

关键词： fusion cross section Coulomb barrier Time Projection Chamber active target

Macrophages-mediated tumor accumulation and deep penetration of bismuth/manganese biomineralized nanoparticles for enhanced radiotherapy

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Chinese Chemical Letters 2024年第12期35卷 198-205页

作者： Jiahao Liu Peng Liu Junhong duan qiongxuan Xie Jie Feng Hongpei Tan Ze Mi Ying Li Yunjie Liao Pengfei Rong Wenhu Zhou Xiang Gao Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Department of Radiology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Department of Nuclear Medicine XiangYa HospitalCentral South UniversityChangsha 410008China Key Laboratory of Biological Nanotechnology NHCChangsha 410013China Department of Oncology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Nursing Hunan Provincial People’s Hospital(The First Affiliated Hospital of Hunan Normal University)Changsha 410005China State Key Laboratory of Toxicology and Medical Countermeasures Institute of Pharmacology and ToxicologyBeijing 100050China

Radiotherapy(RT)is a widely used cancer treatment,and the use of metal-based nano-radiotherapy sensitizers has shown promise in enhancing its ***,efficient accumulation and deep penetration of these sensitizers within tumors remain *** this study,we present the development of bismuth/manganese biomineralized nanoparticles(Bi Mn/BSA)with multiple radiosensitizing mechanisms,including high atomic number element-mediated radiation capture,catalase-mimic oxygenation,and activation of the stimulator of interferon genes(STING)***,we demonstrate that low-dose RT induces the recruitment of macrophages and subsequent upregulation of Matrix metalloproteinases(MMP)-2 and MMP-9 that degrade the extracellular matrix(ECM).This dynamic process facilitates the targeted delivery and deep penetration of Bi Mn/BSA nanoparticles within tumors,thereby enhancing the effectiveness of *** combining low-dose RT with Bi Mn/BSA nanoparticles,we achieved complete suppression of tumor growth in mice with excellent *** study provides a novel and clinically relevant strategy for targeted nanoparticle delivery to tumors,and establishes a safe and effective sequential radiotherapy approach for cancer *** findings hold great promise for improving the outcomes of RT and advancing the field of nanomedicine in cancer therapy.

关键词： Radiotherapy sensitizers Metal-based nanoparticles Targeted nanoparticle delivery STING pathway activation Sequential radiotherapy

Current insights into the oncogenic roles of lncRNA LINC00355

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Cancer Innovation 2023年第6期2卷 448-462页

作者： Jinze Shen Xinming Su Ming Pan Zehua Wang Yufei Ke qurui Wang Jingyin Dong Shiwei duan Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhouZhejiangChina

Long noncoding RNAs(lncRNAs)are a class of nonprotein-coding transcripts that are longer than 200 ***00355 is a lncRNA located on chromosome 13q21.31 and is consistently upregulated in various *** regulates the expression of downstream genes at both transcriptional and posttranscriptional levels,including eight microRNAs(miR-15a-5p,miR-34b-5p,miR-424-5p,miR-1225,miR-217-5p,miR-6777-3p,miR-195,and miR-466)and three protein-coding genes(ITGA2,RAD18,and UBE3C).LINC00355 plays a role in regulating various biological processes such as cell cycle progression,proliferation,apoptosis,epithelial-mesenchymal transition,invasion,and metastasis of cancer *** is involved in the regulation of the Wnt/β-catenin signaling pathway and p53 signaling *** of LINC00355 has been identified as a high-risk factor in cancer patients and its increased expression is associated with poorer overall survival,recurrence-free survival,and disease-free ***00355 upregulation has been linked to several unfavorable clinical characteristics,including advanced tumor node metastasis and World Health Organization stages,reduced Karnofsky Performance Scale scores,increased tumor size,greater depth of invasion,and more extensive lymph node ***00355 induces chemotherapy resistance in cancer cells by regulating five downstream genes,namely HMGA2,ABCB1,ITGA2,WNT10B,and CCNE1 *** summary,LINC00355 is a potential oncogene with great potential as a diagnostic marker and therapeutic target for cancer.

关键词： ceRNA chemotherapy resistance lncRNA LINC00355 miRNA prognosis

计算机辅助手术系统在小儿胰腺实性假乳头状瘤手术中的应用

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中华实用儿科临床杂志 2019年第21期34卷 1658-1661页

作者：王英明周显军陈鑫张虹董蒨郝希伟李富江段于河青岛大学附属医院小儿外科山东青岛266003

目的研究海信计算机辅助手术系统(CAS)在小儿胰腺实性假乳头状瘤手术中的应用价值及临床意义。方法对青岛大学附属医院2015年6月至2018年9月收治的5例胰腺实性假乳头状瘤行上腹部64排螺旋CT增强扫描,应用CAS进行三维重建,基于数字化三... 详细信息

目的研究海信计算机辅助手术系统(CAS)在小儿胰腺实性假乳头状瘤手术中的应用价值及临床意义。方法对青岛大学附属医院2015年6月至2018年9月收治的5例胰腺实性假乳头状瘤行上腹部64排螺旋CT增强扫描,应用CAS进行三维重建,基于数字化三维模型制定手术方案,术前模拟肿瘤切除,术中辅助指导;分析手术时间、术中出血量、输血率等。结果数字化三维重建结果可清晰显示胰腺肿瘤与周围血管、脏器的毗邻关系,基于个性化模型虚拟手术,实现精准切除。术后病理结果均为胰腺实性假乳头状瘤。5例肿瘤中2例位于胰头,1例位于胰颈,2例位于胰体尾。手术时间为150~360 min,平均279 min,术中出血量平均40 mL,最少出血量为5 mL,输血率40%(2/5例),5例患儿均成功切除肿瘤,康复出院;随访6个月~3年,均未见复发和转移。结论CAS三维重建能清晰显示肿瘤与周围血管、脏器的毗邻关系,术前制定最佳手术方案,提高手术的精准性与安全性。

关键词：胰腺实性假乳头状瘤外科手术计算机辅助成像三维

Priming with FLO8-deficient Candida albicans induces Th1-biased protective immunity against lethal polymicrobial sepsis

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Cellular & Molecular Immunology 2021年第8期18卷 2010-2023页

作者： quan-Zhen Lv De-Dong Li Hua Han Yi-Heng Yang Jie-Lin duan Hui-Hui Ma Yao Yu Jiang-Ye Chen Yuan-Ying Jiang Xin-Ming Jia Clinical Medicine Scientific and Technical Innovation Center Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai200092China School of Pharmacy Second Military Medical UniversityShanghai200433China State Key Laboratory of Molecular Biology Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai200031China

The morphological switch between yeast and hyphae of Candida albicans is essential for its interaction with the host defense ***,the lack of understanding of host-pathogen interactions during *** infection greatly hampers the development of effective ***,we found that priming with the *** FLO8-deficient(flo8)mutant,locked in yeast form,protected mice from subsequent lethal *** *** of Dectin-2,a fungus-derivedα-mannan recognition receptor,completely blocked flo8 mutant-induced ***,the flo8 mutant-induced Dectin-2/CARD9-mediated IL-10 production in DCs and macrophages to block thymus atrophy by inhibiting the ***-induced apoptosis of thymic T cells,which facilitated the continuous output of naive T cells from the thymus to the *** recruitment of naive T cells to the spleen enhanced Th1-biased antifungal immune ***,depletion of CD4^(+)T cells or blockade of IL-10 receptor function using specific antibodies in mice completely blocked the protective effects of flo8 mutant priming against *** ***,mannans exposed on the surface of the flo8 mutant were responsible for eliciting protective immunity by inhibiting the ***-induced apoptosis of thymic T cells to sustain the number of naive T cells in the ***,priming with the flo8 mutant extensively protected mice from polymicrobial infection caused by cecal ligation and puncture(CLP)by enhancing Th1-biased immune ***,our findings imply that targeting FLO8 in *** elicits protective immune responses against polymicrobial infections and that mannans extracted from the flo8 mutant are potential immunotherapeutic candidate(s)for controlling infectious diseases.

关键词： Fungi infection Candida albicans Protective immunity Thymus atrophy Apoptosis

Precision study of W^-W^+H production including parton shower effects at CERN Large Hadron Collider

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Chinese Physics C 2019年第12期43卷 24-37页

作者： Huan-Yu Bi Ren-You Zhang Wen-Gan Ma Yi Jiang Xiao-Zhou Li Peng-Fei duan State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modem Physics University of Science and Technology of ChinaHefei 230026China City College Kunming University of Science and TechnologyKunming 650051China

The precision study of W^-W^+H production with subsequent W^±→l^±vl^(-)and H→bb decays at the Large Hadron Collider(LHC)aids in the investigation of Higgs gauge couplings and the search for new physics beyond the standard *** this study,we calculate the shower-matched next-to-leading order qCD and electroweak(EW)corrections from the qq annihilation and photon-induced channels to the W^-W^+H production at the 14 TeV *** deal with the subsequent decays of Higgs and W^±bosons by adopting the MADSPIN *** the integrated cross section and some kinematic distributions of W^±,H,and their decay products are *** find that the qCD correction significantly enhances the leading-order differential cross section,while the EW correction from the qq annihilation channel obviously suppresses it,especially in the high energy phase-space region,due to the Sudakov *** qy-and yy-induced relative corrections are positive and insensitive to the transverse momenta of W^±,H,and their decay *** photon-induced corrections compensate the negative qq-initiated EW correction,and become the dominant EW contribution as the increment of the pp colliding *** parton shower(PS)effects on kinematic distributions are not *** relative PS correction to the b-jet transverse momentum distribution can exceed 100%in the high p_(T,b)***,we investigate the scale and PDF uncertainties,and find that the theoretical error of the qCD+EW+qγ+γγ-corrected integrated cross section mainly originates from the renormalization scale dependence of the qCD correction.

关键词： Higgs gauge coupling qCD+EW correction parton shower

Atomic mass,Bjorken variable,and scale dependence of quark transport coefficient in Drell-Yan process for proton incident on nucleus

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Chinese Physics C 2023年第4期47卷 122-131页

作者：许卫杰白天星段春贵 College of Physics and Hebei Advanced Thin Film Laboratory Hebei Normal UniversityShijiazhuang 050024China Hebei University of Environmental Engineering Qinhuangdao 066102China

By means of the nuclear parton distributions determined without the fixed-target Drell-Yan experimental data and the analytic expression of quenching weight based on the BDMPS formalism,next-to-leading order analyses were performed on the Drell-Yan differential cross section ratios from the Fermilab E906 and E866 *** was found that the results calculated only with the nuclear effects of the parton distribution were not in agreement with the E866 and E906 experimental *** incoming parton energy loss effect cannot be ignored in the nuclear Drell-Yan *** predicted results indicate that,with the quark transport coefficient as a constant,the suppression due to the target nuclear geometry effect is approximately 16.85%for the quark transport *** was shown that we should consider the target nuclear geometry effect in studying the Drell-Yan reaction on nuclear *** the basis of the Bjorken variable and scale dependence of the quark transport coefficient,the atomic mass dependence was *** quark transport coefficient was determined as a function of the atomic mass,Bjorken variablex_(2),and scale q^(2)by the global fit of the experimental *** determined constant factor q_(0)of the quark transport coefficient is 0.062±0.006 GeV^(2)/*** was found that the atomic mass dependence has a significant impact on the constant factor q_(0)in the quark transport coefficient in cold nuclear matter.

关键词： quark transport coefficient Drell-Yan energy loss