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强记汤通过激活AMPKα/SIRT1/PGC-1α信号通路减轻D-半乳糖诱导的认知损伤和线粒体功能障碍

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中国病理生理杂志 2024年第10期40卷 1906-1915页

作者：何丽玲胡慧湖北民族大学医学部湖北恩施445000 湖北中医药大学护理学院湖北武汉430065

目的:探讨强记汤对D-半乳糖诱导的线粒体功能障碍的作用及其机制。方法:80只C57BL/6小鼠被随机分配至空白组、模型组、二甲双胍组和强记汤组。对空白组以外的其他3组小鼠背颈部皮下注射D-半乳糖(100 mg·kg^(-1)·d^(-1)),连续8周,以建... 详细信息

目的:探讨强记汤对D-半乳糖诱导的线粒体功能障碍的作用及其机制。方法:80只C57BL/6小鼠被随机分配至空白组、模型组、二甲双胍组和强记汤组。对空白组以外的其他3组小鼠背颈部皮下注射D-半乳糖(100 mg·kg^(-1)·d^(-1)),连续8周,以建立衰老相关的认知损伤模型。强记汤组给予强记汤水煎液(24.96 g·kg^(-1)·d^(-1))灌胃,二甲双胍组给予二甲双胍(0.2 g·kg^(-1)·d^(-1))灌胃,空白组和模型组灌胃等体积生理盐水(20 mL·kg^(-1)·d^(-1)),连续灌胃4周,每天1次。Morris水迷宫实验和新物体识别实验评估小鼠的学习记忆力;Fluoro-Jade B(FJB)染色观察海马区受损的神经元;透射电镜观察海马区线粒体的超微结构;试剂盒检测活性氧(ROS)水平;JC-1染色检测海马神经细胞线粒体膜电位水平;试剂盒检测海马组织线粒体ATP及线粒体呼吸链复合体Ⅰ、Ⅲ、Ⅳ含量;Western blot检测海马组织中AMP活化蛋白激酶α(AMPKα)、第172位苏氨酸磷酸化的AMPKα(p-AMPKα-Thr172)、沉默信息调节因子1(SIRT1)、过氧化物酶体增殖物受体γ辅激活因子1α(PGC-1α)、核呼吸因子1(NRF1)、NRF2和线粒体转录因子A(TFAM)水平。结果:Morris水迷宫实验和新物体识别实验结果显示,与模型组比较,二甲双胍组和强记汤组小鼠逃避潜伏期显著缩短(P<0.05或P<0.01),穿越平台次数、目标象限驻留时间及新物体识别指数显著增加(P<0.05或P<0.01)。FJB染色结果显示,与模型组比较,二甲双胍组和强记汤组小鼠海马CA1和CA3区FJB标记的神经元数量显著减少(P<0.05或P<0.01)。透射电镜显示,与模型组比较,二甲双胍组和强记汤组小鼠海马神经细胞中线粒体损伤减轻,且线粒体的长度和面积显著增加(P<0.05或P<0.01)。与模型组比较,二甲双胍组和强记汤组小鼠海马神经细胞中ROS水平显著降低(P<0.05或P<0.01)。JC-1染色结果显示,与模型组比较,二甲双胍组和强记汤组小鼠海马神经细胞线粒体膜电位显著升高(P<0.05或P<0.01)。与模型组比较,二甲双胍组和强记汤组小鼠海马组织线粒体ATP及线粒体呼吸链复合体Ⅰ、Ⅲ、Ⅳ水平显著升高(P<0.05或P<0.01)。Western blot结果显示,与模型组比较,二甲双胍组和强记汤组小鼠海马p-AMPKα-Thr172、SIRT1、PGC-1α、NRF1、NRF2和TFAM水平显著升高(P<0.05或P<0.01)。结论:强记汤可通过激活AMPKα/SIRT1/PGC-1α信号通路减轻D-半乳糖诱导的认知障碍、神经元损伤及线粒体功能障碍。

关键词：强记汤衰老认知线粒体 AMPKα/SIRT1/PGC-1α信号通路

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黑龙江流域植被覆盖度时空动态及其对气候变化的响应

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应用生态学报 2024年第6期35卷 1518-1524页

作者：胡蓉董灵波东北林业大学林学院森林生态系统可持续经营教育部重点实验室哈尔滨150040

探究黑龙江流域植被覆盖度时空动态特征及其对气候变化的响应,可为该地区3个国家(蒙古国、中国和俄罗斯)开展流域综合治理提供理论依据和数据支撑。本研究以黑龙江流域为对象,基于Google Earth Engine(GEE)平台提供的2000—2020年的MOD1... 详细信息

探究黑龙江流域植被覆盖度时空动态特征及其对气候变化的响应,可为该地区3个国家(蒙古国、中国和俄罗斯)开展流域综合治理提供理论依据和数据支撑。本研究以黑龙江流域为对象,基于Google Earth Engine(GEE)平台提供的2000—2020年的MOD13q1遥感数据,按最大值法合成归一化植被指数(NDVI),并利用像元二分模型计算植被覆盖度(FVC),采用Sen+MK趋势法分析植被覆盖度动态变化,利用皮尔逊相关系数量化植被覆盖度对气候变化的响应。结果表明:2000—2020年间,黑龙江流域FVC整体呈轻微减少趋势,年际变化率为0.1%,其中,蒙古国FVC呈波动上升趋势(0.13%),而俄罗斯(0.15%)和中国(0.08%)则呈轻微减少趋势;区域内FVC以轻微退化和严重退化为主,面积占比分别为34%和17%,而显著改善区域仅占9%;降水对研究区FVC的影响显著大于气温,降水和气温对FVC影响显著的面积占比分别为8.2%和2.2%,其中,降水与蒙古国区FVC的相关系数最高(r=0.446,P<0.05),而与俄罗斯区FVC的相关系数最低(r=-0.442,P<0.05)。

关键词：植被覆盖度 MODIS 归一化植被指数像元二分模型相关性分析

Passive structural control with inerters for a floating offshore wind turbine

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Passive structural control with inerters for a floating offs...

Sol-gel derived HA/TiO_2 double coatings on Ti scaffolds for orthopaedic applications

第36届中国控制会议

作者： Yinlong hu Michael Z.q.Chen College of Energy and Electrical Engineering Hohai University School of Automation Nanjing University of Science and Technology

ISBN: (纸本)9781538629185

This paper investigates an inerter-based passive structural control problem for a floating offshore wind turbine to reduce the loads induced by wind and *** proposed inerter-based system is composed of a passive spring,a damper,and a parallel-connected passive network.A parameter tuning method by maximizing the minimal modal damping of a linear design model is proposed,and the nonlinear wind turbine simulation code FAST-SC is *** simulations are conducted to show the effectiveness and the performance benefits of the proposed inerter-based structural control *** is shown that the proposed inerter-based system can effectively reduce the wind-and wave-induced loads compared with the conventional spring-damper system.

关键词： Inerter offshore wind turbine floating platform FAST inerter-based dynamic vibration absorber(IDVA)

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中国有色金属学会会刊：英文版 2006年第B1期16卷 209-216页

作者： XU W hu W Y LI M H MA q q P. D. HODGSON WEN C E Department of Applied Physics Hunan University Changsha 410082 China Centre for Material and Fibre Innovation Deakin University Geelong Vic 3217 Australia

Hydroxyapatite/titania (HA/TiO2) double layers were coated onto Ti scaffolds throughout for orthopaedic applications by sol-gel method. Differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray diffractometry (XRD) were used for the characterisation of the phase transformations of the dried gels and coated surface structures. Scanning electron microscope (SEM) equipped with energy dispersive spectrometry (EDS) was used for the observation and evaluation of the morphology and phases of the surface layers and for the assessment of the in vitro tests. The in vitro assessments were performed by soaking the HA/TiO2 double coated samples into the simulated body fluid (SBF) for various periods. The TiO2 dipping-coating method at a speed of 12 cm/min, followed by a heat treatment at 600 ℃ for 20 min. The HA la lyaeyre wr wasa ssu cbosaetqeude bnytl ya dipping-coated on the outer surface at the same speed and then heat-treated at difference temperatures. The results indicat that the HA phase begins to crystallize after a heat treatment at 560 ℃. The crystallinity increases obviously at 760 ℃. SEM observations find no delamination or crack at the interfaces of HA/TiO2 and TiO2/Ti. The HA/TiO2 coated Ti scaffolds displays excellent bone-like apatite forming ability when it is soaked into SBF. Ti scaffolds after HA/TiO2 double coatings can be anticipated as promising implant materials for orthopaedic

关键词：钛支架溶胶-凝胶法羟基磷灰石/二氧化钛涂层医学整形外科应用

Basic features of the multiscale interaction between tearing modes and slab ion-temperature-gradient modes

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Chinese Physics B 2019年第12期28卷 237-247页

作者： L Wei Z X Wang J q Li Z q.hu Y Kishimoto Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of PhysicsDalian University of TechnologyDalian 116024China Southwestern Institute of Physics Chengdu 610041China Graduate School of Energy Science Kyoto UniversityGokashoUjiKyoto 1-0011Japan

Nonlinear interaction between tearing modes(TM) and slab ion-temperature-gradient(ITG) modes is numerically investigated by using a Landau fluid model. It is observed that the energy spectra with respect to wavenumbers become broader during the transition phase from the ITG-dominated stage to TM-dominated stage. Accompanied with the fast growth of the magnetic island, the frequency of TM/ITG with long/short wavelength fluctuations in the electron/ion diamagnetic direction decreases/increases respectively. The decrease of TM frequency is identified to result from the effect of the profile flattening in the vicinity of the magnetic island, while the increase of the frequencies of ITG fluctuations is due to the eigenmode transition of ITG induced by the large scale zonal flow and zonal current related to TM. Roles of zonal current induced by the ITG fluctuations in the instability of TM are also analyzed. Finally, the electromagnetic transport features in the vicinity of the magnetic island are discussed.

关键词： magnetic reconnection tearing modes magnetohydrodynamics drift waves nonlinear phenomena

A transcriptional cascade involving BBX22 and HY5 finely regulates both plant height and fruit pigmentation in citrus

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Journal of Integrative Plant Biology 2024年第8期66卷 1752-1768页

作者： Jialing Fu Li Liao Jiajing Jin Zhihao Lu Juan Sun Lizhi Song Yue huang Shengjun Liu Ding huang Yuantao Xu Jiaxian He Bin hu Yiqun Zhu Fangfang Wu Xia Wang Xiuxin Deng qiang Xu National Key Laboratory for Germplasm Innovation and Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070P.R.China hubei Hongshan Laboratory Wuhan 430070P.R.China Science and Technology Innovation Research Center of Majia Pomelo Shangrao 334000China

Dwarfing is a pivotal agronomic trait affecting both yield and *** species exhibit substantial variation in plant height,among which internode length is a core ***,the molecular mechanism governing internode elongation remains ***,we unveiled that the transcriptional cascade consisting of B-BOX DOMAIN PROTEIN 22(BBX22)and ELONGATED HYPOCOTYL 5(HY5)finely tunes plant height and internode elongation in ***-of-function mutations of BBX22 in an early-flowering citrus(Citrus hindsii“SJG”)promoted internode elongation and reduced pigment accumulation,whereas ectopic expression of BBX22 in SJG,sweet orange(***),pomelo(***)or heterologous expression of BBX22 in tomato(Solanum lycopersicum)significantly decreased internode ***,exogenous application of gibberellin A3(GA3)rescued the shortened internode and dwarf phenotype caused by *** experiments revealed that BBX22 played a dual role in regulation internode elongation and pigmentation in *** the one hand,it directly bound to and activated the expression of HY5,GA metabolism gene(GA2 OXIDASE 8,GA2ox8),carotenoid biosynthesis gene(PHYTOENE SYNTHASE 1,PSY1)and anthocyanin regulatory gene(Ruby1,a MYB DOMAIN PROTEIN).On the other hand,it acted as a cofactor of HY5,enhancing the ability of HY5 to regulate target genes ***,our results reveal the critical role of the transcriptional cascade consisting of BBX22 and HY5 in controlling internode elongation and pigment accumulation in *** the crosstalk regulatory mechanism between internode elongation and fruit pigmentation provides key genes for breeding of novel types with both dwarf and health-beneficial fortification in citrus.

关键词： anthocyanins BBX22 carotenoids citrus HY5 internode elongation plant height

Short-term train arrival delay prediction:a data-driven approach

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Railway Sciences 2024年第4期3卷 514-529页

作者： qingyun Fu Shuxin Ding Tao Zhang Rongsheng Wang Ping hu Cunlai Pu Postgraduate Department China Academy of Railway SciencesBeijingChina Signal and Communication Research Institute China Academy of Railway Sciences Corporation LimitedBeijingChina Traffic Management Laboratory for High-Speed Railway National Engineering Research Center of System Technology for High-Speed Railway and Urban Rail TransitBeijingChina Scientific and Technological Information Research Institute China Academy of Railway Sciences Corporation LimitedBeijingChina Yibin Track Signal and Communication DepotChina Railway Chengdu Group Co.LtdChengduChina School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjingChina

Purpose-To optimize train operations,dispatchers currently rely on experience for quick adjustments when delays ***,delay predictions often involve imprecise shifts based on known delay ***-time and accurate train delay predictions,facilitated by data-driven neural network models,can significantly reduce dispatcher stress and improve adjustment *** current train operation data,these models enable swift and precise predictions,addressing challenges posed by train delays in high-speed rail networks during unforeseen ***/methodology/approach-This paper proposes CBLA-net,a neural network architecture for predicting late arrival *** combines CNN,Bi-LSTM,and attention mechanisms to extract features,handle time series data,and enhance information *** on operational data from the Beijing-Tianjin line,it predicts the late arrival time of a target train at the next station using multidimensional input data from the target and preceding ***-This study evaluates our model’s predictive performance using two data approaches:one considering full data and another focusing only on late *** show precise and rapid *** with full data achieves aMAEof approximately 0.54 minutes and a RMSEof 0.65 minutes,surpassing the model trained solely on delay data(MAE:is about 1.02 min,RMSE:is about 1.52 min).Despite superior overall performance with full data,the model excels at predicting delays exceeding 15 minutes when trained exclusively on late *** enhanced adaptability to real-world train operations,training with full data is ***/value-This paper introduces a novel neural network model,CBLA-net,for predicting train delay *** innovatively compares and analyzes the model’s performance using both full data and delay data ***,the evaluation of the network’s predictive capabilities considers different scenarios,providing a comprehensive demonstra

关键词： Train delay prediction Intelligent dispatching command Deep learning Convolutional neural network Long short-term memory Attention mechanism

Effect of Solid/Liquid Interface Morphology on Microstructure and Segregation of DSX40M Superalloy

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Journal of Materials Science & Technology 1995年第1期11卷 56-60页

作者： SUN, LL WU, q ZHANG, ZY hu, ZG

The effect of solid/liquid interface morphologies on the microstructure and segregation of a new type superalloy, DSX40M, was studied. It has been found that the primary arm spacing presents maximum value as the solid/liquid interface shape transforms from cellular to cellular-dendritic. As the alloy solidifies with a coarse dendritic interface, the solute segregation degree and the average size of the carbide reach the maximum values because of the widest mushy zone. A Zr-rich phase forms at this range. Within the solidification rate range of dendritic interface, the primary dendritic arm spacing and solute segregation decrease with the increasing of solidification rate and the Zr-rich phase disappears. It should be indicated that the change of the solid/liquid interface does not vary the carbide type, but greatly affects the average size of the carbides. The quantitative results of the carbide size change in this alloy system with different solid/liquid interfaces is presented.

关键词： Effect of Solid/Liquid Interface Morphology on Microstructure and Segregation of DSX40M Superalloy

青藏高原及其周边前成冰纪综合地层、生物群与古地理演化

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中国科学：地球科学 2024年第4期54卷 915-935页

作者：胡培远翟庆国赵国春 Peter A.CAWOOD 唐跃刘一鸣中国地质科学院地质研究所北京100037 香港大学地球科学系中国香港999077 大陆动力学国家重点实验室西北大学地质学系西安710069 School of Earth Atmosphere&EnvironmentMonash UniversityMelbourneVIC 3800Australia

青藏高原及邻区前成冰纪物质组成及其地质演化过程,在地球早期超大陆形成演化过程的研究中扮演了重要角色.本文系统梳理和总结了青藏高原及邻区前成冰纪沉积岩、古生物、岩浆和变质作用特征.根据现有资料,青藏高原及邻区前成冰纪沉积岩... 详细信息

青藏高原及邻区前成冰纪物质组成及其地质演化过程,在地球早期超大陆形成演化过程的研究中扮演了重要角色.本文系统梳理和总结了青藏高原及邻区前成冰纪沉积岩、古生物、岩浆和变质作用特征.根据现有资料,青藏高原及邻区前成冰纪沉积岩和古生物记录主要集中于中~新元古代,古元古代及更早的记录相对较少,最古老的地质记录为喜马拉雅和昌都地区前寒武纪变质沉积岩中的冥古宙碎屑锆石(约4.0Ga).青藏高原及邻区保存了凯诺兰超级克拉通以及哥伦比亚、罗迪尼亚和冈瓦纳超大陆形成演化过程的记录,其前成冰纪基底可划分为3种类型:塔里木型、扬子型和拉萨型.塔里木型基底与澳大利亚和印度大陆北缘具有古地理亲缘性,且不发育罗迪尼亚超大陆聚合相关的碎屑锆石年龄峰值和岩浆-变质记录(约1.3~0.9Ga);扬子型基底发育与前成冰纪最晚期全球变冷密切相关的火山活动记录,可见中~新元古代叠层石和微古植物化石,以及约1.1~1.0Ga与罗迪尼亚超大陆聚合相关的岩浆-变质作用记录;拉萨型基底发育新元古代早期大陆裂谷沉积记录(约900Ma)和晚期高压变质事件(约650Ma),具有明显的1.2~1.1Ga碎屑锆石年龄峰值,它很可能与非洲大陆具有古地理亲缘性.

关键词：青藏高原前成冰纪沉积地层古生物群古地理演化