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深圳市24家医院极/超早产儿产房过渡期管理的横断面调查

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中国当代儿科杂志 2024年第3期26卷 250-257页

作者：无吴本清杨传忠深圳新生儿数据协作网深圳市光明区人民医院深圳市妇幼保健院

目的了解深圳市极/超早产儿产房过渡期管理实施现状。方法2022年11月对深圳新生儿数据协作网的24家三级医院的极/超早产儿产房过渡期管理实施情况进行横断面调查,调查内容包括产前准备、产房复苏实施和新生儿重症监护室复苏后管理。根... 详细信息

目的了解深圳市极/超早产儿产房过渡期管理实施现状。方法2022年11月对深圳新生儿数据协作网的24家三级医院的极/超早产儿产房过渡期管理实施情况进行横断面调查,调查内容包括产前准备、产房复苏实施和新生儿重症监护室复苏后管理。根据胎龄将所纳入早产儿分为4组:<26周、26~28^(+6)周、29~30^(+6)周和31~31^(+6)周组,对结果进行描述性分析。结果共纳入140例极/超早产儿,其中<26周组10例,26~28^(+6)周组45例,29~30^(+6)周组49例,31~31^(+6)周组36例。140例极/超早产儿中,99例(70.7%)接受了产前咨询,提供产前咨询的人员以产科医生为主,占比为79.8%;产时参与复苏的人员主要为助产士(96.4%)和新生儿科住院医师(62.1%);52例(37.1%)实施了延迟脐带结扎,平均延迟时间为(45±17)s;137例(97.9%)生后采用了预热辐射台保暖;110例(78.6%)需要正压通气,其中67例(60.9%)采用T组合复苏器,42例(38.2%)应用了空氧混合仪;119例(85.0%)复苏中进行了血氧饱和度监测;完成过渡期各项措施至关闭温箱门时间的中位数为87min。结论在深圳新生儿数据协作网医院中,极/超早产儿的产房过渡期管理实施与我国相应专家共识的要求存在不同程度的差异,需要通过多中心协作的持续质量改进缩小差距,从而改善极/超早产儿产房过渡期管理的质量和结局。

关键词：过渡期管理横断面调查深圳极早产儿超早产儿

Long-chain acyl-CoA synthetase regulates systemic lipid homeostasis via glycosylation-dependent lipoprotein production

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Life Metabolism 2024年第2期3卷 38-54页

作者： Jie Li Yue Dong Tianxing Zhou He Tian Xiahe Huang Yong q.Zhang Yingchun Wang Sin Man Lam Guanghou Shui State Key Laboratory of Molecular Developmental biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Lipidall Technologies Company Limited ChangzhouJiangsu 213000China

Interorgan lipid transport is crucial for organism development and the maintenance of physiological ***,we demonstrate that Drosophila long-chain acyl-CoA synthetase(dAcsl),which catalyzes the conversion of fatty acids into acyl-coenzyme As(acyl-CoAs),plays a critical role in regulating systemic lipid *** deficiency in the fat body led to the ectopic accumulation of neutral lipids in the gut,along with significantly reduced lipoprotein contents in both the fat body and *** aberrant phenotypes were rescued by fat body-specific overexpression of apolipophorin.A multi-omics investigation comprising lipidomics,metabolomics,and proteomics in conjunction with genetic screening revealed that glycosylation processes were suppressed in dAcsl knockdown *** of CG9035,human ortholog of which is implicated in the congenital disorder of glycosylation,ame-liorated gut lipid accumulation in *** lipoprotein glycosylation led to accelerated proteasome-related degradation and induced ER stress in dAcsl knockdown flies,impairing lipoprotein release into the circulation which compromised interorgan lipid transport between the fat body and the *** of ub.q.itin-proteasome-dependent degradation alleviated the phenotype of gut ectopic fat accumulation in dAcsl knockdown ***,we verified that ACSL4,the human homolog of dAcsl,also regulated lipoprotein levels in HepG2 cells,indicating that the role of dAcsl in modulating lipoprotein secretion and systemic lipid homeostasis is possibly conserved in humans.

关键词： lipid homeostasis apolipoprotein glycosylation lipidomics metabolomics proteomics

bilateral Retinal Nerve Fiber Layer Loss and Recovery with Teprotumumab in Thyroid Eye Disease

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Open Journal of Ophthalmology 2024年第3期14卷 196-203页

作者： Christine Wang Abdulaziz Alsumait Nikisha q. Richards Surbhi bansal Department of Ophthalmology Virginia Commonwealth University School of Medicine Richmond VA USA School of Medicine Virginia Commonwealth University Richmond VA USA

background: Thyroid Eye Disease (TED) is known to alter tissues of the orbital cavity, including the optic nerve. However, its effect on measured global Retinal Nerve Fiber Layer (gRNFL) is not well elucidated. This case evaluates the effect of teprotumumab on gRNFL in a patient with moderate TED. Observations: A 60-year-old female with controlled ocular hypertension and moderate TED received 8 standard IV teprotumumab infusions. Comprehensive ocular evaluations were performed pre-, during-, and post-treatment. bilateral gRNFL thickness decreased (10 m OD;12 m OS) at 4 months post-treatment start, persisting at 8 months, but recovered at 20 months. Conclusions and Importance: Teprotumumab treatment in patients with TED led to a transient bilateral decrease in gRNFL thickness, which was restored to baseline levels with no adverse events reported. Monitoring gRNFL changes in teprotumumab-treated patients is crucial as gRNFL thinning indicates retinal ganglion cell damage. Teprotumumabs ability to dampen the IGF-IR inflammatory cascade may have reduced retinal inflammation, leading to recovery.

关键词： Teprotumumab Thyroid Eye Disease RNFL Clinical Activity Score Ocular Hypertension

The Implantation and Transmission of Plague Culture by the Five Plague Gods in Shuilu Murals

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Chinese Medicine and Culture 2024年第3期7卷 185-191页

作者： Yi b. Zhou q. Shi H. Institute for History of Science and Technology Shanxi University Taiyuan 030006 China

The Five Plague Immortals (五瘟神) in Shuilu murals in Ming and qing dynasties is a kind of plague immortal image developed under the pedigree of Taoist immortals. As an important expel disaster immortal system in Shuilu, the modeling of Five plague Immortals shows a combination of human beings and livestocks. This shape, to a large extent, draws on the image of Nuo (儺). which is also an imagination of the host of plague pathogens. In terms of the quantities of immortals, it aligns with the conceptual framework of Wu Xing (五行 the five elements), a foundational principle in traditional Chinese medicine. The internal connection of this culture reflects the means of plague preventions and controls in China, as well as the external reflection of plague culture. Through multi-dimensional interpretations with the double proof method, this article dissects the formation, core elements, and cultural characteristics of the beliefs in the Five Plague Immortals reflected in the Shuilu murals, and moves beyond from simplistic visual semantics. © 2024 Lippincott Williams and Wilkins. All rights reserved.

关键词： Five Plague Immortals Plague culture Religion Shuilu murals Traditional Chinese medicine Wu Xing

Magnetic Topological Dirac Semimetal Transition Driven by SOC in EuMg_(2)bi_(2)

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Chinese Physics Letters 2024年第1期41卷 63-67页

作者：王佳萌钱浩吉姜琦乔山叶茂 State Key Laboratory of Functional Materials for Informatics Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Research Center for Intelligent Chips and Devices Zhejiang LabHangzhou 311121China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China

Magnetic topological semimetals have been at the forefront of condensed matter physics due to their ability to exhibit exotic transport *** the interplay between magnetic and topological orders in systems with broken time-reversal symmetry is crucial for realizing non-trivial quantum *** delve into the electronic structure of the rare-earth-based antiferromagnetic Dirac semimetal EuMg_(2)bi_(2) using first-principles calculations and angle-resolved photoemission *** calculations reveal that the spin-orbit coupling(SOC)in EuMg_(2)bi_(2) prompts an insulator to topological semimetal transition,with the Dirac bands protected by crystal *** linearly dispersive states near the Fermi level,primarily originating from bi 6p orbitals,are observed on both the(001)and(100)surfaces,confirming that EuMg_(2)bi_(2) is a three-dimensional topological Dirac *** research offers pivotal insights into the interplay between magnetism,SOC and topological phase transitions in spintronics applications.

关键词： spectroscopy topological Dirac

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铁磁绝缘体中磁振子的非平衡稳态输运性质

物理学报 2024年第14期73卷 214-221页

作者：杨栋超易立志丁林杰刘敏朱丽娅许云丽何雄沈顺清潘礼庆 John q.Xiao 三峡大学理学院湖北省弱磁探测工程技术研究中心宜昌443002 三峡学院物理系重庆404100 香港大学物理系中国香港999077 Department of Physics and Astronomy University of DelawareNewark 19716USA

玻色子体系中的非平衡输运过程研究是极具挑战性的工作.磁振子是玻色子,具有与电子等费米子截然不同的自旋输运行为.本文以钇铁石榴石(YIG)铁磁绝缘体为研究对象,聚焦影响稳态下YIG中磁振子非平衡输运过程的关键因素.通过将具有非零化... 详细信息

玻色子体系中的非平衡输运过程研究是极具挑战性的工作.磁振子是玻色子,具有与电子等费米子截然不同的自旋输运行为.本文以钇铁石榴石(YIG)铁磁绝缘体为研究对象,聚焦影响稳态下YIG中磁振子非平衡输运过程的关键因素.通过将具有非零化学势μm的玻色-爱因斯坦统计函数引入到玻尔兹曼输运方程中,获得了以为幂次的输运方程严格解析表达式(当α(=-μm/(k_(b)T))<1时).结果显示,当α<<1时,我们得到了与以往研究不同的化学势μm与非平衡粒子浓度δn_(m)之间的非线性关系δn_(m)∝-α^(1/2)α-(-μm)^(1/2)α;较大时,则还须考虑其高阶项.正因这种非线性关系,导致磁振子扩散方程显著不同于电子自旋扩散特性,其由线性微分方程演变为更复杂的非线性微分方程.本文重点研究了在两种极端温度梯度(即■T~1K/mm和10^(4)K/mm)下非平衡磁振子浓度δn_(m)和化学势μm的空间分布,它们分别对应于μm的值约为-0.1μeV和-6.2meV,均满足前提条件α<1.在远离平衡态的大温度梯度分布下,本文理论计算与实验结果吻合很好.这些理论研究结果将加深人们对铁磁绝缘体中磁振子非平衡输运行为的认识.

关键词：磁振子非平衡输运化学势磁振子扩散方程玻尔兹曼输运方程

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Higher-order mode analysis for SOLEIL-type superconducting cavity

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中国科学技术大学学报 2024年第7期54卷 0706-1-0706-11页

作者： Chai X. Li q. Xu Y. Tang Y. Tan M. Wu C.-F. National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230029 China

A 499.8 MHz SOLEIL-type superconducting cavity was simulated and designed for the first time in this paper. The higher-order mode (HOM) properties of the cavity were investigated. Two kinds of coaxial HOM couplers were designed. Using 4 L-type and 4 T-type HOM couplers, the longitudinal impedance was suppressed to 3 kΩ, and the transverse impedance below 30 kΩ/m. The HOM damping requirements of Hefei Advanced Light Facility (HALF) were satisfied. This paper conducts an in-depth study on the radio frequency (RF) design, multipacting optimization, and thermal analysis of these coaxial couplers. Simulation results indicated that under operating acceleration voltage, the optimized couplers does not exhibit multiplicating or thermal breakdown phenomena. The cavity has the potential to reach a higher acceleration gradient.

关键词：高次模耦合器超导腔高频系统二次电子倍增热仿真

Generation of polarized electron beams through self-injection in the interaction of a laser with a pre-polarized plasma

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High Power Laser Science and Engineering 2024年第3期 67-73页

作者： L.R.Yin X.F.Li Y.J.Gu N.Cao q.Kong M.büscher S.M.Weng M.Chen Z.M.Sheng Key Laboratory of Nuclear Physics and Ion-beam Application (Mo E) Institute of Modern Physics Department of Nuclear Science and Technology Fudan University State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences SANKEN (Institute of Scienti?c and Industrial Research) Osaka University Sichuan Research Institute Shanghai Jiao Tong University Peter Grünberg Institut (PGI-6) Forschungszentrum Jülich Institut für Laser- und Plasmaphysik Heinrich-Heine-Universit?t Düsseldorf Key Laboratory for Laser Plasmas (Mo E) School of Physics and Astronomy Shanghai Jiao Tong University Collaborative Innovation Center of IFSA Shanghai Jiao Tong University Tsung-Dao Lee Institute Shanghai Jiao Tong University

Polarized electron beam production via laser wakefield acceleration in pre-polarized plasma is investigated by particlein-cell simulations. The evolution of the electron beam polarization is studied based on the Thomas±bargmann±Michel±Telegdi equation for the transverse and longitudinal self-injection, and the depolarization process is found to be influenced by the injection schemes. In the case of transverse self-injection, as found typically in the bubble regime, the spin precession of the accelerated electrons is mainly influenced by the wakefield. However, in the case of longitudinal injection in the quasi-1D regime (for example, F. Y. Li et al., Phys. Rev. Lett. 110, 135002 (2013)), the direction of electron spin oscillates in the laser field. Since the electrons move around the laser axis, the net influence of the laser field is nearly zero and the contribution of the wakefield can be ignored. Finally, an ultra-short electron beam with polarization of 99%can be obtained using longitudinal self-injection.

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顾颉刚的边疆史地研究:个人情爱与民族情感的交汇

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社会科学研究 2024年第2期 173-185页

作者：王晴佳美国罗文大学历史系新泽西州葛拉斯堡罗08028-2235

九一八事变之后,顾颉刚的学术生涯出现了一个新的面向,从之前专注上古历史的考证、辨伪转而从事研究中国的历史疆域和边疆民族。1934年《禹贡半月刊》的出版和禹贡学会的成立,便是一个标志。顾颉刚本人指出此乃中日关系恶化、民族危机... 详细信息

九一八事变之后,顾颉刚的学术生涯出现了一个新的面向,从之前专注上古历史的考证、辨伪转而从事研究中国的历史疆域和边疆民族。1934年《禹贡半月刊》的出版和禹贡学会的成立,便是一个标志。顾颉刚本人指出此乃中日关系恶化、民族危机深重所致,但从他当时留下的日记和书信,又可以看出他之从事边疆史地的研究,与他长期爱慕谭慕愚(又名谭惕吾)有着密切的关系。谭慕愚的爱国热忱和行动是促使顾颉刚学术兴趣转向的重要契机,而且顾颉刚与谭慕愚的来往还间接地影响了顾颉刚的古史研究。探讨顾颉刚、谭慕愚及殷履安(顾颉刚妻子)之间的三角关系不仅呈现了顾颉刚学术生涯中民族情感和个人情爱的交互作用,而且有助于展现五四学人婚恋和情感生活的复杂和多面,为从情感史的角度考察中国近代学术变迁提供了一个实例。

关键词：顾颉刚谭慕愚(谭惕吾) 殷履安《禹贡》和禹贡学会边疆史地情感史