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Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2970-2983页

作者： qi Yang Bao xue Fengjiang Liu Yongzhi Lu Jielin Tang Mengrong Yan qiong Wu Ruyi Chen Anqi Zhou Lijie Liu Junjun Liu Changbin qu qingxin Wu Muqing Fu Jiayi Zhong Jianwei Dong Sijie Chen Fan Wang Yuan Zhou Jie Zheng Wei Peng Jinsai Shang Xinwen Chen Guangzhou National Laboratory Guangzhou 510005China State Key Laboratory of Respiratory Disease Guangzhou Medical UniversityGuangzhou 511436China Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China School of Basic Medical Sciences Guangzhou Medical UniversityGuangzhou 511436China GMUGIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 511436China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201203China School of Pharmaceutical Science and Technology Hangzhou lnstitute for Advanced StudyUCASHangzhou 310024China

Respiratory syncytial virus(RSV)is the major cause of bronchiolitis and pneumonia in young children and the *** are currently no approved RSV-specific therapeutic small molecules *** high-throughput antiviral screening,we identified an oral drug,the prenylation inhibitor lonafarnib,which showed potent inhibition of the RSV fusion *** exhibited antiviral activity against both the RSV A and B genotypes and showed low cytotoxicity in HEp-2 and human primary bronchial epithelial cells(HBEC).Time-of-addition and pseudovirus assays demonstrated that lonafarnib inhibits RSV entry,but has farnesyltransferase-independent antiviral ***-electron microscopy revealed that lonafarnib binds to a triple-symmetric pocket within the central cavity of the RSV F metastable pre-fusion *** at the RSV F sites interacting with lonafarnib showed resistance to lonafarnib but remained fully sensitive to the neutralizing monoclonal antibody ***,lonafarnib dose-dependently reduced the replication of RSV in BALB/c ***,lonafarnib could be a potential fusion inhibitor for RSV infection.

关键词： neutral metastable approved

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基于UHPLC-q-Exactive Orbitrap-MS技术分析土茯苓苯丙素类化学成分及其对类风湿关节炎特征基因的干预

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科学技术与工程 2024年第27期24卷 11586-11593页

作者：杨欣黄聪姚血明贵州中医药大学基础医学院贵阳550025 贵州中医药大学第二附属医院贵阳550025

通过超高效液相色谱-四极杆-静电场轨道阱高分辨质谱联用技术(UHPLC-q Exactive Orbitrap-MS)鉴定土茯苓苯丙素类化合物,筛选与特定免疫细胞浸润相关的类风湿关节炎(rheumatoid arthritis,RA)诊断标志物及苯丙素类化合物。以正离子和负... 详细信息

通过超高效液相色谱-四极杆-静电场轨道阱高分辨质谱联用技术(UHPLC-q Exactive Orbitrap-MS)鉴定土茯苓苯丙素类化合物,筛选与特定免疫细胞浸润相关的类风湿关节炎(rheumatoid arthritis,RA)诊断标志物及苯丙素类化合物。以正离子和负离子模式采集数据分析土茯苓苯丙素类化学成分。通过GEO(gene expression omnibus)数据库获取RA基因芯片,基于“一致性聚类”进行共识聚类且区分RA不同的分子亚型。通过R软件绘制特征基因受试者工作特征曲线(receiveroperating characteristic curve,ROC),并计算ROC曲线下的面积。通过单样本基因集富集分析特征基因与免疫细胞的相关性。基于SYBYL2.1.1分子对接分析苯丙素类化合物与特征基因的结合情况。对RA差异表达基因进行过滤,获得5个特征基因,其中RAC2、ITGB7、CD52、ITGB2基因的ROC曲线面积通过验证,4特征基因能影响8种免疫细胞(活化的CD4+T细胞,活化的CD8+T细胞,中央记忆CD4+T细胞,效应记忆CD4+T细胞,骨髓源性抑制细胞,单核细胞,调节性T细胞,效应记忆CD8+T细胞),且呈正相关(P<0.05,P<0.01,P<0.001)。土茯苓苯丙素类化合物26个,能共同干预4个免疫特征基因。基于免疫细胞浸润的模型可用于预测RA的发病机制,土茯苓苯丙素类化合物对免疫特征基因具有干预作用,研究结果为RA免疫调节治疗和早期诊断提供科学依据。

关键词： UHPLC-q-Exactive Orbitrap-MS 类风湿关节炎土茯苓苯丙素免疫细胞浸润分析分子对接

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GATIS score for predicting the prognosis of rectal neuroendocrine neoplasms:A Chinese multicenter study of 12-year experience

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World Journal of Gastroenterology 2024年第28期30卷 3403-3417页

作者： Xin-Yu Zeng Ming Zhong Guo-Le Lin Cheng-Guo Li Wei-Zhong Jiang Wei Zhang Li-Jian Xia Mao-Jun Di Hong-xue Wu Xiao-Feng Liao Yue-Ming Sun Min-Hao Yu Kai-Xiong Tao Yong Li Rui Zhang Peng Zhang Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074Hubei ProvinceChina Department of Gastrointestinal Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China Department of Colorectal Surgery Fujian Medical UniversityFuzhou 350401Fujian ProvinceChina Department of Colorectal Surgery Changhai HospitalShanghai 200433China Department of Gastrointestinal Surgery The First Affiliated Hospital of Shandong First Medical UniversityJinan 250118Shandong ProvinceChina Department of Gastrointestinal Surgery Taihe HospitalHubei University of MedicineShiyan 442099Hubei ProvinceChina Department of Gastrointestinal Surgery I Section Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of General Surgery Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021Hubei ProvinceChina Department of Colorectal Surgery Jiangsu Province HospitalNanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Gastrointestinal Surgery School of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of General Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina Department of Colorectal Surgery Liaoning Cancer HospitalShenyang 110042Liaoning ProvinceChina

BACKGROUND There is currently a shortage of accurate,efficient,and precise predictive instruments for rectal neuroendocrine neoplasms(NENs).AIM To develop a predictive model for individuals with rectal NENs(R-NENs)using data from a large *** Data from patients with primary R-NENs were retrospectively collected from 17 large-scale referral medical centers in *** forest and Cox proportional hazard models were used to identify the risk factors for overall survival and progression-free survival,and two nomograms were *** A total of 1408 patients with R-NENs were *** grade,T stage,tumor size,age,and a prognostic nutritional index were important risk factors for *** GATIS score was calculated based on these five *** overall survival prediction,the respective C-indexes in the training set were 0.915(95%confidence interval:0.866-0.964)for overall survival prediction and 0.908(95%confidence interval:0.872-0.944)for progression-free survival *** to decision curve analysis,net benefit of the GATIS score was higher than that of a single *** time-dependent area under the receiver operating characteristic curve showed that the predictive power of the GATIS score was higher than that of the TNM stage and pathological grade at all time *** The GATIS score had a good predictive effect on the prognosis of patients with R-NENs,with efficacy superior to that of the World Health Organization grade and TNM stage.

关键词： Rectal neuroendocrine neoplasm Nomogram Random forest Prognosis Overall survival Progression-free survival

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Buxu Tongyu Granule Alleviates Myocardial Ischemia by Activating Vascular Smooth Muscle Cell Soluble Guanylate Cyclase to Inhibit Abnormal Vasomotion

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Engineering 2024年第7期38卷 133-143页

作者： Shuang Yang Yixiu Zhao Xiaoling Cheng Tingting Zhan Jiaying Tian xue Liu Chunyue Ma Zhiqi Wang Luying Jin qian Liu Yanli Wang Jian Huang Jinhui Wang Yan Zhang Baofeng Yang Department of Pharmacology&Key Laboratory of Cardiovascular Medicine Research Ministry of Education of the People’s Republic of ChinaCollege of PharmacyHarbin Medical UniversityHarbin 150081China National Key Laboratory of Frigid Zone Cardiovascular Diseases(NKLFZCD) Harbin Medical UniversityHarbin 150081China Department of Medicinal Chemistry and Natural Medicine Chemistry College of PharmacyHarbin Medical UniversityHarbin 150081China Research Unit of Noninfectious Chronic Diseases in Frigid Zones Chinese Academy of Medical SciencesHarbin 150081China

Myocardial ischemia is a serious threat to human health,and vascular dysfunction is its main *** Tongyu(BXTY)Granule is an effective traditional Chinese medicine(TCM)for treating myocardial ***,the underlying mechanism of BXTY is still *** this study,we demonstrate that BXTY ameliorates myocardial ischemia by activating the soluble guanylate cyclase(sGC)-30,50-cyclic guanosine monophosphate(cGMP)-protein kinase G(PKG)signaling pathway in vascular smooth muscle cells(VSMCs)to dilate the *** was given by gavage for ten consecutive days before establishing an animal model of acute myocardial ischemia in mice via the intraperitoneal injection of *** results showed that BXTY alleviated the symptoms of myocardial ischemia induced by pituitrin in mice,including electrocardiogram abnormalities and changes in plasma *** addition,BXTY dilated pre-constricted blood vessels and inhibited the vasoconstriction of the superior mesenteric artery in a dose-dependent but endothelial-independent *** effects were eliminated by preincubating vascular rings with the sGC inhibitors NS 2028 or ODq,or with the PKG inhibitor KT ***,BXTY increased the protein expression of sGC-b1 and the intracellular second messenger cGMP level in mouse aortic vascular smooth muscle cells(MOVAs).NS 2028 or ODq reversed these effects of *** expression level of the cGMP downstream effector protein PKG-1 increased after treating MOVAs with *** 2028,ODq,or KT 5823 also reversed this effect of *** conclusion,BXTY can improve the symptoms of acute myocardial ischemia in mice,and activating the sGC-cGMP-PKG pathway in VSMCs to induce vasodilation is its key pharmacodynamic mechanism.

关键词： Myocardial ischemia Vasomotion Soluble guanylate cyclase Buxu Tongyu Granule

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中药调控组蛋白乙酰化防治阿尔茨海默病的研究进展

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中国实验方剂学杂志 2024年第13期30卷 271-278页

作者：李雪周妍妍王琪李全黑龙江中医药大学基础医学院哈尔滨150040

阿尔茨海默病(AD)是一种以记忆与认知功能进行性丧失为主要临床表现的神经退行性疾病,其发病机制复杂,难以治愈。AD的发生与基因异常表达、转录密切相关,组蛋白乙酰化在不改变基因编码序列的条件下,影响基因转录活性进而调控基因表达与... 详细信息

阿尔茨海默病(AD)是一种以记忆与认知功能进行性丧失为主要临床表现的神经退行性疾病,其发病机制复杂,难以治愈。AD的发生与基因异常表达、转录密切相关,组蛋白乙酰化在不改变基因编码序列的条件下,影响基因转录活性进而调控基因表达与染色体结构重塑,在调控β淀粉样蛋白(Aβ)沉积与Tau蛋白磷酸化、神经元生长、突触可塑性等方面发挥重要作用,参与AD病理过程。中药防治AD具有多靶点、多环节、整体调节的特点,大量的动物与细胞实验验证中药可调控组蛋白乙酰化改善AD,该文聚焦组蛋白乙酰化在AD中的关键作用,从中药有效成分及中药复方两方面对近5年相关研究进行归纳分析,发现其主要作用机制涉及拮抗细胞凋亡、阻抑氧化应激、改善Tau蛋白与Aβ沉积、维持突触功能、营养保护神经元、修复髓鞘等多方面,主要药理功效为益肾安神、补脾和中、开窍化痰,中药复方中常用中药包括茯苓、甘草、川芎、石菖蒲、白芍等,该发现进一步验证了中药防治AD的巨大潜力,为AD临床治疗与实验研究提供了科学的理论依据。

关键词：阿尔茨海默病组蛋白乙酰化中药机制研究进展

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Typical atmospheric haze during crop harvest season in northeastern China：A case in the Changchun region

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Journal of Environmental Sciences 2017年第4期29卷 101-113页

作者： Wei Wei Chen Daniel q.Tong Mo Dan Shi Chun Zhang xue Lei Zhang Yue Peng Pan Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and Agroecology Chinese Academy of Sciences Changchun 130102 China . Cooperative Institute for Climate & Satellites University of Maryland College Park MD 20740 USA Center for Spatial Information Science and Systems George Mason University Fairfax VA 22030 USA Beijing Municipal Institute of Labor Protection Beijing 100054 China State key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China

This study presents the mass concentrations of PM（2.5）,O3,SO2 and NOxat one urban,one suburban and two rural locations in the Changchun region from September 25 to October 272013. Major chemical components of PM（2.5）at the four sites were daily sampled and analyzed. Most of daily concentrations of SO2（7–82 μg/m^3）,O3（27–171 μg/m^3） and NOx（14–213 μg/m^3） were below the limits of the National Ambient Air quality Standard（NAAqS）in China. However,PM（2.5）concentrations（143–168 μg/m^3） were 2-fold higher than *** PM（2.5）concentrations（~ 150 μg/m^3） were measured during the pre-harvest and harvest at the urban site,while PM（2.5）concentrations significantly increased from 250 to400 μg m^（-3） at suburban and rural sites with widespread biomass burning. At all sites,PM（2.5）components were dominated by organic carbon（OC） and followed by soluble component sulfate（SO4^（2-））,ammonium（NH4~＋） and nitrate（NO3^-）. Compared with rural sites,urban site had a higher mineral contribution and lower potassium（K~＋and K） contribution to PM（2.5）.Severe atmospheric haze events that occurred from October 21 to 23 were attributed to strong source emissions（e.g.,biomass burning） and unfavorable air diffusion ***,coal burning originating from winter heating supply beginning on October 18 increased the atmospheric pollutant emissions. For entire crop harvest period,the Positive Matrix Factorization（PMF） analysis indicated five important emission contributors in the Changchun region,as follows： secondary aerosol（39%）,biomass burning（20%）,supply heating（18%）,soil/road dust（14%） and traffic（9%）.

关键词： Aerosol Air quality Agriculture Biomass burning PM(2.5) PMF

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STCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.M.Cai H.Cai J.J.Cao q.H.Cao X.Cao Z.Cao q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.q.Hao J.B.He S.q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang q.Y.Huang W.q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.S.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas S.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov S.L.Olsen q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.qi Y.q.qi W.B.qian Y.qian C.F.qiao J.J.qin J.J.qin L.q.qin X.S.qin T.L.qiu J.Rademacker C.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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基于不确定性估计的离线确定型Actor-Critic

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计算机学报 2024年第4期47卷 717-732页

作者：冯涣婷程玉虎王雪松中国矿业大学信息与控制工程学院江苏徐州221116 江苏信息职业技术学院智能工程学院江苏无锡214153

Actor-Critic是一种强化学习方法,通过与环境在线试错交互收集样本来学习策略,是求解序贯感知决策问题的有效手段.但是,这种在线交互的主动学习范式在一些复杂真实环境中收集样本时会带来成本和安全问题离线强化学习作为一种基于数据驱... 详细信息

Actor-Critic是一种强化学习方法,通过与环境在线试错交互收集样本来学习策略,是求解序贯感知决策问题的有效手段.但是,这种在线交互的主动学习范式在一些复杂真实环境中收集样本时会带来成本和安全问题离线强化学习作为一种基于数据驱动的强化学习范式,强调从静态样本数据集中学习策略,与环境无探索交互,为机器人、自动驾驶、健康护理等真实世界部署应用提供了可行的解决方案,是近年来的研究热点.目前,离线强化学习方法存在学习策略和行为策略之间的分布偏移挑战,针对这个挑战,通常采用策略约束或值函数正则化来限制访问数据集分布之外(Out-Of-Distribution,OOD)的动作,从而导致学习性能过于保守,阻碍了值函数网络的泛化和学习策略的性能提升.为此,本文利用不确定性估计和OOD采样来平衡值函数学习的泛化性和保守性,提出一种基于不确定性估计的离线确定型Actor-Critic方法(Offline Deterministic Actor-Critic based on UncertaintyEstimation,ODACUE).首先,针对确定型策略,给出一种q值函数的不确定性估计算子定义,理论证明了该算子学到的q值函数是最优q值函数的一种悲观估计.然后,将不确定性估计算子应用于确定型Actor-Critic框架中,通过对不确定性估计算子进行凸组合构造Critic学习的目标函数.最后,D4RL基准数据集任务上的实验结果表明:相较于对比算法,ODACUE在11个不同质量等级数据集任务中的总体性能提升最低达9.56%,最高达64.92%.此外,参数分析和消融实验进一步验证了ODACUE的稳定性和泛化能力.

关键词：离线强化学习不确定性估计分布外采样凸组合 Actor-Critic

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Reverse-blocking modular multilevel converter for battery energy storage systems

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Journal of Modern Power Systems and Clean Energy 2017年第4期5卷 652-662页

作者： Xiaofeng YANG Yao xue Bowei CHEN Yajie MU Zhiqin LIN Trillion q.ZHENG Seiki IGARASHI School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China Fuji Electric Co. Ltd.Tokyo 141-0032Japan

Energy storage systems with multilevel converters play an important role in modern electric power systems with large-scale renewable energy *** paper proposes a reverse-blocking modular multilevel converter for a battery energy storage system(RB-MMCBESS). Besides integrating distributed low-voltage batteries to medium or high voltage grids, with the inherited advantages of traditional MMCs, the RB-MMC-BESS also provides improved DC fault handling capability. This paper analyzes such a new converter configuration and its operating principles. Control algorithms are developed for AC side power control and the balancing of battery state of charge. The blocking mechanism to manage a DC pole-topole fault analyzed in depth. Comprehensive simulation results validate both the feasibility of the RB-MMC-BESS topology and the effectiveness of the control and fault handling strategies.

关键词： Reverse blocking Modular multilevel converter Battery energy storage system SOC control Fault blocking

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辽东地区金矿床成因与资源潜力

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中国科学：地球科学 2024年第3期54卷 677-692页

作者：朱日祥杨进辉王功文曾庆栋薛国强徐涛李兴辉张朋雷达朱光中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029 中国地质大学(北京)地球科学与资源学院北京100083 中国地质调查局沈阳地质调查中心沈阳110034 合肥工业大学资源与环境工程学院合肥230009

华北东部广泛分布着与晚中生代克拉通破坏相关的金矿床,但不同地区金矿床在研究程度、成矿特征、探明储量等方面存在显著差异.华北东部的辽东具有与胶东相似的区域地质特征,并共同经历了晚中生代克拉通破坏作用,但其金成矿的理论研究和... 详细信息

华北东部广泛分布着与晚中生代克拉通破坏相关的金矿床,但不同地区金矿床在研究程度、成矿特征、探明储量等方面存在显著差异.华北东部的辽东具有与胶东相似的区域地质特征,并共同经历了晚中生代克拉通破坏作用,但其金成矿的理论研究和探明的黄金资源量却存在巨大差异.本文在分析研究辽东区域地质、中生代岩浆-构造演化和矿床地质基础上,通过深部-浅部综合地球物理探测和大数据AI资源量预测,提出了辽东晚中生代金元素富集主体来自于克拉通破坏诱发的幔源熔流体,金矿床主要受北东-北北东向断裂控制,金矿类型以破碎带蚀变岩型和含硫化物石英脉型为主.明确了鸭绿江主断裂带及相关的次级断裂、已知矿集区外围与深部是未来金矿资源勘查的重要区域,预测鸭绿江成矿带黄金资源潜力巨大,具备新增数千吨级黄金资源的潜力.

关键词：辽东金矿综合地球物理勘查找矿潜力找矿突破方向

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