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Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization

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World Journal of Gastroenterology 2016年第47期22卷 10406-10414页

作者： Yazan Abuodeh Arash O Naghavi Kamran A Ahmed puja s venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes sarah E Hoffe Ghassan El-Haddad Department of Radiation Oncology H Lee Moffitt Cancer Center and Research Institute Department of Interventional Radiology H Lee Moffitt Cancer Center and Research Institute Department of Gastrointestinal Oncology H Lee Moffitt Cancer Center and Research Institute

AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver *** We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFs) and overall survival(Os).REsULTs The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with sUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFs(P sing multivariate analysis, FDG avidity predicted for LLC, DLC, and PFs(all P sION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFs following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization.

关键词： F-18 fluorodeoxyglucose PET Hepatocellular carcinoma Radioembolization Prognosis Biomarker

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