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First report on chlorophyllin to protect mammalian and fish muscle cells from pesticide toxicity via activation of p53 and PARP

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Aquaculture and Fisheries 2021年第4期6卷 393-399页

作者： Asmita Samadder Swatilekha Das Bakul Pal Sweta Das Anindita Mandal priyanka Biswas Sujoy Ghosh Shamim Hossain Mandal priyanka sow Ruchira Das Souvik Biswas Ashis Kumar Panigrahi Cytogenetics and Molecular Biology Laboratory Department of ZoologyUniversity of KalyaniKalyaniNadia741235India Cell and Developmental Biology Special Department of ZoologyUniversity of KalyaniKalyaniNadia741235India Department of Zoology Dum Dum Motijheel CollegeKolkata700074India Eco-Toxicology Fisheries and Aquaculture Extn.LaboratoryDepartment of ZoologyUniversity of KalyaniKalyaniNadia741235India

Objectives:Pesticide toxicity has become one of the major environmental menaces affecting all types of life forms of the *** get washed off from agricultural fields into nearby water bodies and enter the aquatic *** bio-accumulated form finally reaches the human race,through consumption of pesticide infested aquatic animals,causing several physiological *** it becomes necessary to find a therapeutic cure/a preventive measure to stop the health hazard issues of *** this projection a search for a phyto-based-product was made whose primary objective would be to lower the pesticidal toxicity in fish and simultaneously in the human ***:In this study we tried to check whether the phyto-chemical,Chlorophyllin(CHL),known for its anti-genotoxic,anti-oxidant activities,could render any kind of protection against Cypermethrin(CM)induced-toxicity in fish model and mammalian cell line *** the model L6 and fish were pre-treated with CHL prior to exposure of *** scientific parameters like%cellular cytotoxicity,reactive oxygen species(ROS)generation,nuclear condensation,etc were checked to validate the possibility of CHL in protecting CM-induced ***:The overall results revealed that pre-treatment with CHL could restrict the ROS generation leading to modulation in associated cytokine proteins expression NFkβand IFNγ.Further,CHL lowered nuclear condensation and elevated expression of DNA repair proteins p53 and PARP,showing a kind of pre-activation of signalling cascades for overall protection against the severity of pesticidal ***:Thus,this phyto-based preventive approach would possibly solve many areas of human health issues related to pesticide toxicity in future.

关键词： Cypermethrin Chlorophyllin Fish L6 cells DNA damage ROS generation

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CD9 role in proliferation, rejuvenation, and therapeutic applications

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Genes & Diseases 2024年第3期11卷 95-97页

作者： Sai priyanka Kodam Neda Baghban Mujib Ullah Institutefor Immunityand Transplantation Stem Cell Biology and Regenerative MedicineSchool of MedicineMolecular Medicine Department of MedicineStanford UniversityPaloAltoCA94304USA

The CD9 gene,also known as the Tspan29 gene,codes for a protein called CD9,which is a member of the tetraspanin family of transmembrane proteins.^(1) The CD9 protein is involved in various cellular processes,including cell proliferation,differentiation,adhesion,and migration.^(1,2) CD9 has also been found to play a role in the regulation of stem cell proliferation and differentiation.

关键词： migration. therapeutic CD9

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Multi-omics:Powerful accelerator for uncovering plant specialized metabolic pathways:The case of leonurine

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Molecular Plant 2024年第1期17卷 13-15页

作者： priyanka Gupta Anuj Sharma Dinesh A.Nagegowda Molecular Plant Biology and Biotechnology Lab CSIR-Central Institute of Medicinal and Aromatic PlantsResearch CentreBengaluru 560065India Academy of Scientific and Innovative Research Ghaziabad 201002India

As sessile organisms,plants employ a unique adaptive strategy to survive harsh terrestrial environments and defend against or interact with coevolving animals and *** strategy involves expanding their metabolic systems,resulting in the production of plant specialized metabolites(PSMs)or natural ***,PSMs constitute a highly diverse group of compounds based on their common core structure,comprising terpenoids,phenylpropanoids,benzenoids,alkaloids and nitrogen-containing compounds,glucosinolates,indoles and sulfur-containing indole compounds,phenolics,and fatty acid derivatives(Garagounis et al.,2021).

关键词： expanding alkaloids sulfur

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Combinations of electron and proton donors in transition-metal complex mediated nitrogen reduction reactions

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Science China Chemistry 2024年第7期67卷 2136-2154页

作者： Delong Han Li Yang Hao Huang priyanka Chakraborty Shashikant U.Dighe Kuo-Wei Huang KAUST Catalysis Center and Division of Physical Science and Engineering King Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia Agency for Science Technologyand ResearchInstitute of Materials Research and Engineering and Institute of Sustainability for ChemicalsEnergy and EnvironmentSingapore 138634Singapore

Nitrogen fixation is a complex process involving the transfer of six electrons and *** from the conventional Haber-Bosch process,which relies on hydrogen(H_(2))to provide both electrons and protons to reduce nitrogen(N_(2)),homogeneous transition metal complex-catalyzed N_(2)reduction reactions(NRR)employ an array of electron and proton donors or even electron donors combined with *** the synthesis of diverse catalytic progress,the categories of donors have seen rapid ***,existing literature only provides summaries regarding the metal,ligands,and *** the significance of electron and proton donor combinations in nitrogen reduction reactions,no literature has thoroughly reviewed this ***,we hereby compiled a comprehensive list of commonly used reagents in N_(2)reduction and classified them according to their specific donor *** review presents clear and organized information about these combinations,along with a summary of their general performance trend in NRR with related ***,we conclude the discussion by highlighting key points for researchers to consider when selecting catalysts and donor combinations,with the ultimate goal of advancing the field of nitrogen fixation.

关键词： dinitrogen reduction reaction reducing donor combination transition metal complexes homogeneous catalysis

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Pharmacological potential of Manilkara zapota(L.)***(Sapodilla):a narrative review

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Journal of Traditional Chinese Medicine 2024年第2期44卷 403-407页

作者： priyanka Sharma Aakash Deep Harish Kumar Nitin Bansal Sanjiv Kumar Arun Davinder Kumar Department of Pharmaceutical Sciences Chaudhary Bansi Lal UniversityBhiwani 127021India Department of Pharmaceutical Sciences Maharishi Dayanand UniversityRohtak 124001India

Herbal medicine is safe and effective in treating various *** herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications,hence herbal medicine requires remarkable attention in further research for the development of numerous active formulations for treatment of health *** plant needs special consideration for development and research of unidentified compound and characterization of novel active molecules that overcome multiple pathological *** genus Manilkara contains 135 plants around the *** overview discusses all the virtues of most important and commonly used plant Manilkara zapota(L.)***(***),also known as *** has various traditional beneficial effects in treatment of various diseases and disorders dating back to prehistoric times and used in ancient traditional system of herbal medicine.

关键词： herbal medicine Manilkara zapota phytoconstituents pharmacological activity review

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The landscape of epigenetic regulation and therapeutic application of N^(6)-methyladenosine modifications in non-coding RNAs

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Genes & Diseases 2024年第5期11卷 236-251页

作者： Gui-e Xu Xuan Zhao Guoping Li priyanka Gokulnath Lijun Wang Junjie Xiao Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)and School of Life SciencesShanghai UniversityNantongJiangsu 226011China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA

RNA N^(6)-methyladenosine(m^(6)A)methylation is the most abundant and conserved RNA modification in *** participates in the regulation of RNA metabolism and various pathophysiological ***-coding RNAs(ncRNAs)are defined as small or long transcripts which do not encode proteins and display numerous biological regulatory *** to mRNAs,m^(6)A deposition is observed in *** RNA m^(6)A modifications on ncRNAs is of great importance specifically to deepen our understanding of their biological roles and clinical *** this review,we summarized the recent research findings regarding the mutual regulation between RNA m^(6)A modification and ncRNAs(with a specific focus on microRNAs,long non-coding RNAs,and circular RNAs)and their *** also discussed the challenges of m^(6)A-containing ncRNAs and RNA m^(6)A as therapeutic targets in human diseases and their future perspective in translational roles.

关键词： Circular RNA Epigenetic regulation Long non-coding RNA MicroRNA Non-coding RNA RNA m^(6)A modification

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A hybrid system to predict brain stroke using a combined feature selection and classifier

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Intelligent Medicine 2024年第2期4卷 75-82页

作者： priyanka Bathla Rajneesh Kumar Department of Computer Science&Engineering Maharishi Markandeshwar UniversityMullanaAmbalaHaryanaIndia

Background Brain stroke is a serious health issue that requires timely and accurate prediction for effective treatment and *** study described a hybrid system that used the best feature selection method and classifier to predict brain *** The Stroke Prediction Dataset from Kaggle was used for this *** minority over-sampling technique(SMOTE)analysis was used to accomplish class ***,sensitivity,specificity,precision,and the F-Measure were the main performance parameters considered for *** determine the best combination for predicting brain stroke,the performance of five classifiers,Naïve Bayes(NB),support vector machine(SVM),random forest(RF),adaptive boosting(Adaboost),and extreme gradient boosting(XGBoost),was compared along with three feature selection techniques,mutual information(MI),Pearson correlation(PC),and feature importance(FI).The performance parameters were assessed using k-fold *** The hybrid system proposed in this study identified a reduced set of features that were able to effectively predict brain *** provided a feature reduction ratio of 36.3%.The most successful hybrid system for predicting brain stroke used FI as the feature selection technique and RF as the classifier,achieving an accuracy of 97.17%.Conclusion The proposed system predicted brain stroke with high *** findings could be used to inform the early detection and prevention of brain stroke,allowing healthcare professionals to provide timely and targeted care to at-risk patients.

关键词： Machine learning Naive Bayes Extreme gradient boosting Support vector machine Adaptive boosting Random forest

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Direct-Seeded Rice: Genetic Improvement of Game-Changing Traits for Better Adaption

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Rice science 2024年第4期31卷 417-433页

作者： priyanka NEGI Jagadish RANE Rajendra Sadashiv WAGH Tukaram Jayaram BHOR Dipti Digambar GODSE priyanka JADHAV C.ANILKUMAR Dasari SREEKANTH K.SAMMI REDDY Sharad Ramrao GADAKH K.M.BORAIH C.B.HARISHA P.S.BASAVARAJ Indian Council of Agricultural Research(ICAR)-National Institute of Abiotic Stress Management Baramati 413115India Mahatma Phule Krishi Vidyapeeth Rahuri 413722India ICAR-Central Institute for Arid Horticulture Bikaner 334006India ICAR-National Rice Research Institute Cuttack 753006India ICAR-Directorate of Weed Research Jabalpur 482004India Dr.Panjabrao Deshmukh Krishi Vidyapeeth Akola 444104India

The sustainability of rice production continues to be a subject of uncertainty and inquiry attributed to shifts in climatic conditions. In light of the impending climate change crisis and the high labor and water costs accompanying it, direct-seeded rice(DSR) is unquestionably one of the most practical solutions. Despite its resource and climate-friendly advantages, early maturing rice faces weed competitiveness and seedling establishment challenges. Resolving these issues is crucial for promoting its wider adoption among farmers, presenting it as a more effective sustainable rice cultivation method globally. Diverse traditional and contemporary breeding methods are employed to mitigate the limitations of the DSR approach, leveraging advanced techniques such as speed breeding and genome editing. Focusing on key traits like mesocotyl length elongation, early seedling vigor, root system architecture, and weed competitiveness holds promise for transformative improvements in DSR adaptation at a broader scale within farming communities. This review aims to summarize how these features contribute to increased crop production in DSR conditions and explore the research efforts focusing on enhancing DSR adaptation through these traits. Emphasizing the pivotal role of these game-changing traits in DSR adaptation, our analysis sheds light on their potential transformative impact and offers valuable insights for advancing DSR practices.

关键词： climate change direct-seeded rice aerobic rice early vigor trait

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Data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

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Food Science and Human Wellness 2024年第3期13卷 1322-1335页

作者： Emmanuel Kemmler Julian Braun Florent Fauchère Sabine Dölle-Bierke Kirsten Beyer Robert Preissner Margitta Worm priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany Member of the KFO339 FOOD@Berlin 10115Germany Si-M/“Der Simulierte Mensch”a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin Berlin 10115Germany Charité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany Division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and ***,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic *** results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Knowledge-graph Data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

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Dust-Holding Capacity and Bio-Chemical Changes of Plant Species Growing in an Around Opencast Mining Area of Bundelkhand Region of Uttar Pradesh, India

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American Journal of Plant Sciences 2024年第8期15卷 677-698页

作者： priyanka Singh Amit Pal Institute of Environment and Development Studies Bundelkhand University Jhansi India

The present study has been carried out on a total of 50 available plant species to assess their dust-capturing capacity and biochemical performances in and around open cast granite mine areas of Jhansi district and Bundelkhand University campus treated as control site. Plant species existing under a polluted environment for a long time may be considered as potentially resistant species and recommended for green belt design in mining areas, especially to cope with dust pollution. Results showed the pollution level, especially of mining-originated dust particles holding capacity of leaves and effects of different biochemical parameters (Total Chlorophyll, Protein and Carotenoid) of existing plant species both from mining areas as well as from Bundelkhand University campus. Based on their performances, Tectona grandis L., Ficus hispida L., Calotropis procera Aiton., Butea monosperma Lam. and Ficus benghalensis L., etc. are highly tolerant species while Ficus infectoria L., Artocarpus heterophyllus Lam., Ipomoea purpurea L., Allianthus excelsa Roxb. and Bauhinia variegata L. are intermediate tolerant species. T. grandis had shown the highest dust-holding capacity (2.566 ± 0.0004 mg/cm2) whereas Albizia procera (0.018 ± 0.0002 mg/cm2) was found to be the lowest dust-holding capacity. Our findings also showed that the T. grandis and F. hispida have significant dust deposition with minimal effect of dust on their leaf chlorophyll (17.447 ± 0.019 mg/g and 14.703 ± 0.201 mg/g), protein (0.699 ± 0.001 mg/g and 0.604 ± 0.002 mg/g) and carotenoid (0.372 ± 0.003 mg/g and 0.354 ± 0.003 mg/g) content respectively among all selected plant species. Therefore, in the present investigation, plant species with high tolerance to high dust-holding capacity on their leaf surfaces are preferable for green corridors as open cast granite mines and their adjacent areas.

关键词： Bundelkhand Region Biochemical Changes Dust-Holding Capacity Chlorophyll Content Open Cast Granite Mining

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