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Communications in Theoretical Physics 2024年第11期 163-176页

作者： K Thulasidharan N Sinthuja N Vishnu priya M Senthilvelan Department of Physics Vellore Institute of Technology Department of Physics Anna University Department of Mathematics Indian Institute of Science Department of Nonlinear Dynamics Bharathidasan University

We introduce a novel neural network structure called strongly constrained theory-guided neural network(SCTgNN), to investigate the behaviour of the localized solutions of the generalized nonlinear Schr?dinger(NLS) equation. This equation comprises four physically significant nonlinear evolution equations, namely, the NLS, Hirota, Lakshmanan–Porsezian–Daniel and fifth-order NLS equations. The generalized NLS equation demonstrates nonlinear effects up to quintic order, indicating rich and complex dynamics in various fields of physics. By combining concepts from the physics-informed neural network and theory-guided neural network(TgNN)models, the SCTgNN aims to enhance our understanding of complex phenomena, particularly within nonlinear systems that defy conventional patterns. To begin, we employ the TgNN method to predict the behaviour of localized waves, including solitons, rogue waves and breathers, within the generalized NLS equation. We then use the SCTgNN to predict the aforementioned localized solutions and calculate the mean square errors in both the SCTgNN and TgNN in predicting these three localized solutions. Our findings reveal that both models excel in understanding complex behaviour and provide predictions across a wide variety of situations.

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Preparedness,knowledge,and perception of nursing students about climate change and its impact on human health in India

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Regional Sustainability 2024年第1期5卷 107-118页

作者： Ramya Kundayi RAVI priya BABY Nidhin ELIAS Jisa George THOMAS Kathyayani Bidadi VEERABHADRAIAH Bharat PAREEK College of Nursing Medical and Health Sciences UniversityRas Al Khaimah11172United Arab Emirates College of Nursing National Institute of Mental Health and Neuro sciencesBangalore560011India College of Nursing Amrita Institute of Medical SciencesKochi682041India College of Nursing All India Institute of Medical SciencesBhopal462020India Saraswati Professional and Higher Education College of Nursing Mohali140413India

Higher education plays an important role in all aspects of *** climate change and sustainability into the curriculum is important to prepare future health-care professionals for climate change and sustainability actions to build resilient health *** this study,we evaluated the preparedness,knowledge,and perception regarding climate change and its impact on human health among Indian nursing students.A quantitative descriptive survey was conducted among 644 undergraduate nursing students studying in three institutes in the southern,northern,and western parts of *** used a structured online questionnaire with established validity and reliability to collect *** data were analyzed using Statistical Package for the Social Sciences version 26 *** results showed that more than half of the students reported experiencing excessive increase(362;56.2%)and decrease(374;58.1%)in temperature in recent *** more than three quarters of the students(494;76.7%)accepted the general truth that climate change is mainly caused by human activities,only less than half of the students(309;48.0%)perceived the impact of climate change to be *** quarters of the students(483;75.0%)had a high level of knowledge regarding climate *** students who had a high level of knowledge about climate change exerted a high perceived impact of climate change(χ^(2)=75.47;P<0.01).More than half of the students(50.9%)felt that they needed information about climate change to be included in the nursing curriculum,and only one sixth of the students(16.1%)were highly confident about engaging in climate change-related conversation with *** of the students who participated in the study had basic knowledge about climate change and its impact on human ***,there is an observed gap between knowledge and their preparedness and confidence to engage in climate change ***,we propose to strengthen the nursing curriculum by integra

关键词： Climate change Curriculum Nursing students Human health India

Cancer treatment with biosimilar drugs:A review

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Cancer Innovation 2024年第2期3卷 45-62页

作者： Shilpa Malakar Emmanuel Nuah Gontor Moses YDugbaye Kamal Shah Sakshi Sinha priya Sutaoney Nagendra Singh Chauhan Department of Microbiology Kalinga UniversityRaipurChhattisgarhIndia Institute of Pharmaceutical Research GLA UniversityMathuraUttar PradeshIndia Drug Testing Laboratory Avam Anusandhan KendraRaipurChhattisgarhIndia

Biosimilars are biological drugs created from living organisms or that contain living *** share an identical amino-acid sequence and *** drugs are considered to be cost-effective and are utilized in the treatment of cancer and other endocrine *** primary aim of biosimilars is to predict biosimilarity,efficacy,and treatment costs;they are approved by the Food and Drug Administration(FDA)and have no clinical *** involve analytical studies to understand the similarities and dissimilarities.A biosimilar manufacturer sets up FDA-approved reference products to evaluate *** contribution of next-generation sequencing is evolving to study the organ tumor and its progression with its impactful therapeutic approach on cancer patients to showcase and target rare *** study shall help to understand the future perspectives of biosimilars for use in gastro-entero-logic diseases,colorectal cancer,and thyroid *** also help target specific organs with essential mutational categories and drug prototypes in clinical practices with blood and liquid biopsy,cell treatment,gene therapy,recombinant therapeutic proteins,and personalized *** derivatives such as monoclonal antibodies like trastuzumab and rituximab are common drugs used in cancer *** coli produces more than six antibodies or antibody-derived proteins to treat cancer such as filgrastim,epoetin alfa,and so on.

关键词： biologics biosimilars cancer Escherichia coli monoclonal antibody next-generation sequencing pharmacovigilance

Optimized protoplast isolation and transfection with a breakpoint:accelerating Cas9/sgRNA cleavage efficiency validation in monocot and dicot

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aBIOTECH 2024年第2期5卷 151-168页

作者： Debasmita Panda Subhasis Karmakar Manaswini Dash Swagat Kumar Tripathy priya Das Sagar Banerjee Yiping Qi Sanghamitra Samantaray Pradipta Kumar Mohapatra Mirza J.Baig Kutubuddin A.Molla ICAR National Rice Research Institute CuttackOdisha 753006India Department of Botany Ravenshaw UniversityCuttackOdisha 753003India Department of Plant Science and Landscape Architecture University of MarylandCollege ParkMD 20742USA

The CRISPR-Cas genome editing tools are revolutionizing agriculture and basic biology with their simplicity and precision ability to modify target genomic ***-predicted guide RNAs(gRNAs)often fail to induce efficient cleavage at target *** target loci are inaccessible due to complex chromatin ***,there is no suitable tool available to predict the architecture of genomic target sites and their ***,significant time and resources are spent on performing editing experiments with inefficient *** in vitro-cleavage assay could provide a rough assessment of gRNA efficiency,it largely excludes the interference of native genomic *** in-vivo testing gives a proper assessment of the cleavage ability of editing reagents in a native genomic ***,we developed a modified protocol that offers highly efficient protoplast isolation from rice,Arabidopsis,and chickpea,using a sucrose gradient,transfection using PEG(polyethylene glycol),and validation of single guide RNAs(sgRNAs)cleavage efficiency of *** have optimized various parameters for PEG-mediated protoplast transfection and achieved high transfection efficiency using our protocol in both monocots and *** introduced plasmid vectors containing Cas9 and sgRNAs targeting genes in rice,Arabidopsis,and chickpea *** dual sgRNAs,our CRISPRdeletion strategy offers straightforward detection of genome editing success by simple agarose gel *** sequencing of PCR products confirmed the editing efficiency of specific ***,we demonstrated that isolated protoplasts can be stored for up to 24/48 h with little loss of viability,allowing a pause between isolation and *** high-efficiency protocol for protoplast isolation and transfection enables rapid(less than 7 days)validation of sgRNA cleavage efficiency before proceeding with stable *** isolation and transfection method can als

关键词： Protoplast Genome editing Transgene-free edited plants Rice Chickpea

Management of Strawberry Grey Mold Disease Using Biocontrol Agents and Plant Extracts

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American Journal of Plant Sciences 2024年第7期15卷 538-551页

作者： P. Sakthi priya Srushtideep Angidi Uday Kumar Thera S. V. Nandeesha Thangaswamy Rajesh Department of Plant Pathology College of Post Graduate Studies in Agricultural Sciences Central Agricultural University Imphal India Department of Plant Pathology North Dakota State University Fargo ND USA Department of Plant Science and Landscape Architecture University of Maryland College Park MD USA

Strawberry (Fragaria × ananassa Duch.) is a significant global soft fruit crop, prized for its nutrient content and pleasant flavor. However, diseases, particularly grey mold caused by Botrytis cinerea Pers. Fr. poses major constraints to strawberry production and productivity. Grey mold severely impacts fruit quality and quantity, diminishing market value. This study evaluated five B. cinerea isolates from various locations in the Ri-Bhoi district of Meghalaya. All isolates were pathogenic, with isolate SGM 2 identified as highly virulent. Host range studies showed the pathogen-producing symptoms in the fava bean pods, marigold, gerbera, and chrysanthemum flowers and in the fava bean, gerbera, and lettuce leaves. In vitro tests revealed that neem extract (15% w/v) achieved the highest mycelial growth inhibition at 76.66%, while black turmeric extract (5% w/v) had the lowest inhibition at 9.62%. Dual culture methods with bio-control agents indicated that Bacillus subtilis recorded the highest mean inhibition at 77.03%, while Pseudomonas fluorescens had the lowest at 20.36% against the two virulent isolates. Pot evaluations demonstrated that B. subtilis resulted in the lowest percent disease index at 20.59%, followed by neem extract at 23.31%, with the highest disease index in the control group at 42.51%. Additionally, B. subtilis significantly improved plant growth, yielding an average of 0.32 kg compared to 0.14 kg in the control. The promising results of B. subtilis and neem leaf extract from this study suggest their potential for eco-friendly managing grey mold in strawberries under field conditions.

关键词： Strawberry Grey Mold BCA Plant Extracts Botrytis cinerea

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另类的白肉

商业周刊（中文版） 2024年第3期 68-73页

作者： Deena Shanker priya Anand 王湛(译) 不详

Upside Foods等硅谷支持的初创公司承诺通过实验室培养鸡肉来解决肉类问题然而这一解决方案似乎不太靠谱,10年前,在伦敦的一场新闻发布会上,一位荷兰科学家、一位芝加哥美食作家和一位奥地利的研究人员分享了一块价值33万美元的牛肉饼... 详细信息

Upside Foods等硅谷支持的初创公司承诺通过实验室培养鸡肉来解决肉类问题然而这一解决方案似乎不太靠谱,10年前,在伦敦的一场新闻发布会上,一位荷兰科学家、一位芝加哥美食作家和一位奥地利的研究人员分享了一块价值33万美元的牛肉饼。这块汉堡代表了全世界对实验室培养肉类最认真的尝试,通过从牛身上提取细胞并在实验室中培养制作而成。(此前曾有过为宇航员提供金鱼肉片的实验,以及把青蛙牛排制成“生物艺术品”的尝试。)荷兰科学家兼教授马克·波斯特(MarkPost)花了六周时间,在培养皿和试管中培养出2万根肌肉纤维。完成后,这些细小的肌肉组织被手工取出,压制成一块汉堡。

关键词：肌肉纤维初创公司实验室培养牛肉饼肌肉组织牛排新闻发布会鸡肉

Evaluation of Phytochemical Analysis and Total Phenol Content of Proso Millet and Barnyard Millet

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Proceedings of Anticancer Research 2024年第2期8卷 13-19页

作者： Deepa priya Ramadoss Kirubanandan Shanmugam Department of Biotechnology School of BioengineeringSRM Institute of Science and TechnologyKattankulathur 603203KancheepuramTamil NaduIndia Independent Research Professional ChennaiTamil NaduIndia

Whole grains of proso and barnyard millets were sequentially extracted using different solvents(hexane,chloroform,ethyl acetate,and methanol).Phytochemical analysis was performed qualitatively,and the total phenolic content in the extracts of proso and barnyard millets was *** and cardiac glycosides were identified in all solvent extracts of both *** and glycosides yielded negative results in all solvent extracts of both *** all the solvent extracts,methanol extracts of proso and barnyard millets showed the presence of major compounds such as flavonoids,terpenoids,amino acids,tannins,and phenolics *** maximum amount of phenols was found in methanolic extracts of proso and barnyard millets(0.669±0.003 and 0.625±0.003),followed by the chloroform extract of proso and barnyard millets(0.284±0.002 and 0.257±0.003).The minimum amount of phenolics was found in the acetone extract of proso and barnyard *** methanol extract of both millets showed the presence of major compounds with high phenolic content.

关键词： Proso millet Barnyard millet Sequential solvent extraction Phytochemical analysis Total phenolic content

Boundary Element Modeling of Multiconnected Ocean Basin in Visakhapatnam Port Under the Resonance Conditions

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China Ocean Engineering 2021年第5期35卷 662-675页

作者： Prashant KUMAR Prachi priya RAJNI Department of Applied Sciences National Institute of Technology DelhiDelhi 110040India Jindal Global Business School O P Jindal Global UniversitySonipatHaryana 131001India

A mathematical model has been developed to analyze the influence of extreme water waves over multiconnected regions in Visakhapatnam Port,India by considering an average water depth in each multiconnected *** addition,partial reflection of incident waves on coastal boundary is also *** domain of interest is divided mainly into two regions,i.e.,open sea region and harbor region namely as Region-I and Region-II,***,Region-II is divided into multiple connected *** 2-D boundary element method(BEM)including the Chebyshev point discretization is utilized to solve the Helmholtz equation in each region separately to determine the wave *** numerical convergence is performed to obtain the optimum numerical accuracy and the validation of the current numerical approach is also conducted by comparing the simulation results with existing *** four key spots based on the moored ship locations in Visakhapatnam Port are identified to perform the numerical *** wave amplification at these locations is estimated for monochromatic incident waves,considering approximate water depth and different reflection coefficients on the wall of port under the resonance *** addition,wave field analysis inside the Visakhapatnam Port is also conducted to understand resonance *** current numerical model provides an efficient tool to analyze the amplification on any realistic ports or harbors.

关键词： boundary element method amplification factor Helmholtz equation reflection coefficient Visakhapatnam Port

Mathematical Modeling of Moored Ship Motion in Arbitrary Harbor utilizing the Porous Breakwater

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China Ocean Engineering 2023年第5期37卷 738-752页

作者： Prachi priya Prashant Kumar Gulshan Rajni Government Model Sanskriti Senior Secondary School Ganaur Sonipat 131101India Department of Applied Sciences(Mathematics) National Institute of TechnologyDelhi 110036India JindalGobal Business School O.P.Jindal Global UniversitySonepat 131001India

The motion of the moored ship in the harbor is a classical hydrodynamics problem that still faces many challenges in naval operations,such as cargo transfer and ship pairings between a big transport ship and some small ships.A mathematical model is presented based on the Laplace equation utilizing the porous breakwater to investigate the moored ship motion in a partially absorbing/reflecting *** motion of the moored ship is described with the hydrodynamic forces along the rotational motion(roll,pitch,and yaw)and translational motion(surge,sway,and heave).The efficiency of the numerical method is verified by comparing it with the analytical study of Yu and Chwang(1994)for the porous breakwater,and the moored ship motion is compared with the theoretical and experimental data obtained by Yoo(1998)and Takagi et al.(1993).Further,the current numerical scheme is implemented on the realistic Visakhapatnam Fishing port,India,in order to analyze the hydrodynamic forces on moored ship motion under resonance *** model incorporates some essential strategies such as adding a porous breakwater and utilizing the wave absorber to reduce the port’s *** has been observed that these tactics have a significant impact on the resonance inside the port for safe maritime ***,the current numerical model provides an efficient tool to reduce the resonance within the arbitrarily shaped ports for secure anchoring.

关键词： boundary element method Laplace equation porous breakwater partially reflecting/absorbing harbor wall moored ship motion

Nano structured spinel Co3O4-catalyzed four component reaction:A novel synthesis of Ugi adducts from aryl alcohols as a key reagent

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Chinese Chemical Letters 2017年第7期28卷 1619-1624页

作者： priya Chacko Kalegowda Shivashankar P.G.Department of Chemistry Central College CampusBangalore UniversityBangalore560 001KarnatakaIndia

A simple one pot procedure for the synthesis of α-amino acyl amide with chromone,indole,and napthalene substitution pattern is *** protocol involves the nano structured spinel Co3O4catalysed coupling of aryl alcohols,anilines,carboxylic acids and tert-butyl *** salient features of this protocol were simple procedure,mild reaction condition and high yield.

关键词： Chromone Indole Naphthalene Co3O4 Ugi reaction Multicomponent