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Structural and functional insights into the TEAD-YAP complex in the Hippo signaling pathway

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Protein & Cell 2010年第12期1卷 1073-1083页

作者： Liming Chen Portia Gloria loh Haiwei Song Cancer and Developmental Cell Biology Division Institute of Molecular and Cell BiologyA*STAR(Agency for ScienceTechnology and Research)61 Biopolis DriveSingapore 138673Republic of Singapore Department of Biological Sciences National University of Singapore14 Science Drive 4Singapore 117543Republic of Singapore School of Biological Sciences Nanyang Technological University50 Nanyang AvenueSingapore 639798Republic of Singapore

The control of organ size growth is one of the most fundamental aspects of *** the past two decades,a highly conserved Hippo signaling pathway has been identified as a key molecular mechanism for governing organ size *** the middle of this pathway is a kinase cascade that negatively regulates the downstream component Yes-associated protein(YAP)/transcriptional coactivator with PDZ-binding motif(TAZ)/Yorkie through *** of YAP/TAZ/Yorkie promotes its cytoplasmic localization,leads to cell apoptosis and restricts organ size *** the Hippo pathway is inactivated,YAP/TAZ/Yorkie translocates into the nucleus to bind to the transcription enhancer factor(TEAD/TEF)family of transcriptional factors to promote cell growth and *** this review,we will focus on the structural and functional studies on the downstream transcription factor TEAD and its coactivator YAP.

关键词： Hippo Yes-associated protein(YAP) transcription enhancer factor(TEAD) Yki phosphorylation crystal structure

Sensors, Biosensors, and Analytical Technologies for Aquaculture Water Quality

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Research 2020年第1期2020卷 1521-1535页

作者： Xiaodi Su Laura Sutarlie Xian Jun loh Institute of Materials Research and Engineering Agency for ScienceTechnology and Research2 Fusionopolis Way.Innovis#08-03Singapore 138634 Department of Chemistry National University of SingaporeBlock S8Level 33 Science Drive 3Singapore 117543

In aquaculture industry,fish,shellfish,and aquatic plants are cultivated in fresh,salt,or brackish *** increasing demand of aquatic products has stimulated the rapid growth of aquaculture *** to effectively monitor and control water quality is one of the key concerns for aquaculture industry to ensure high productivity and high *** are four major categories of water quality concerns that affect aquaculture cultivations,namely,(1)physical parameters,e.g.,pH,temperature,dissolved oxygen,and salinity,(2)organic contaminants,(3)biochemical hazards,e.g.,cyanotoxins,and(4)biological contaminants,i.e.,*** the physical parameters are affected by climate changes,the latter three are considered as environmental *** this review,we provide a comprehensive summary of sensors,biosensors,and analytical technologies available for monitoring aquaculture water *** include low-cost commercial sensors and sensor network setups for physical *** also include chromatography,mass spectrometry,biochemistry,and molecular methods(e.g.,immunoassays and polymerase chain reaction assays),culture-based method,and biophysical technologies(e.g.,biosensors and nanosensors)for environmental contamination *** to the different levels of sophistication of various analytical techniques and the information they can provide(either fine fingerprint,highly accurate quantification,semiquantification,qualitative detection,or fast screening),we will comment on how they may be used as complementary tools,as well as their potential and gaps toward current demand of real-time,online,and/or onsite detection.

关键词： qualitative latter Quality

Current perspectives on dengue episode in Malaysia

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 386-392页

作者： Ee Leen Pang Hwei-San loh School of Biosciences.Faculty of Science.The University of Nottingham Malaysia Campus Biotechnology Research Centre The University of Nottingham Malaysia Campus

To Prevalence of dengue transmission has been alarmed by an estimate of 390 million infections per *** encroachment,ecological disruption and poor sanitation are all contributory factors of increased *** however arises from the fact that dengue virus inherently exists as four different *** infection is often manifested in the more severe form,such that antibody-dependent enhancement(ADE) could aggravate ailment by allowing pre-existing antibodies to form complexes with infecting viruses as means of ***,increased viraemic litter and suppression of antiviral response are *** concerns are thus expressed in regards to escalating trend of hospitalisation and mortality *** Malaysia,situation is exacerbated by improper clinical management and pending vector control *** a preparedness strategy against the potential deadly dengue pandemic,the call for development of a durable and costeffective dengue vaccine against all infecting serotypes is *** though several vaccine candidates are currently being evaluated in clinical trials,uncertainties in regards to serotypes interference,incomplete protection and dose adequacy have been *** of sole reliance on outsourcing,production of local vaccine should be considered in coherent to government's efforts to combat against dengue.

关键词： Dengue Antibody-dependent enhancement Pandemic Vaccine Malaysia

Endoscopic management of refractory gastrointestinal non-variceal bleeding using Histoacryl(N-butyl-2-cyanoacrylate)glue

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Gastroenterology Report 2016年第3期4卷 232-236,I0002,I0003页

作者： Damien CK loh Robert B Wilson Department of Upper Gastrointestinal Surgery Liverpool HospitalSydneyAustralia

Background:Histoacryl glue(N-butyl-2-cyanoacrylate)has well-established utility in the endoscopic management of gastrointestinal variceal *** role of Histoacryl glue in non-variceal bleeding is less clear,and there are few articles describing its use in this ***:Six patients with intractable non-variceal gastrointestinal bleeding were managed using injection of Histoacryl *** patients had previously failed conventional endostasis and/or interventional angioembolization and were not suitable for emergency salvage surgery due to serious comorbidities or unacceptable anaesthetic *** endoscopic Lipiodol-Histoacryl-Lipiodol sandwich injection technique was used in these *** clinical outcomes and complications were ***:There were four females and two males with a mean age of 55 *** lesions included gastric ulcers(n=2),duodenal ulcers(n=2),duodenal gastrointestinal stromal tumor(GIST)(n=1)and rectal ulcers(n=1).All patients had successful Histoacryl endostasis without the requirement for salvage *** was no treatment-related morbidity and no *** patients had further bleeding after initial Histoacryl endostasis,which was successfully controlled with further endoscopic Histoacryl ***:Histoacryl endostasis should be included in the treatment algorithm for refractory non-variceal gastrointestinal bleeding.

关键词： Histoacryl glue N-butyl-2-cyanoacrylate endoscopy non-variceal upper gastrointestinal bleeding

PI3K/Akt/mTOR inhibitors in breast cancer

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Cancer Biology & Medicine 2015年第4期12卷 342-354页

作者： Joycelyn JX Lee Kiley loh Yoon-Sim Yap Department of Medical Oncology National Cancer Center Singapore

Activation of the phosphoinositide 3 kinase(PI3K)/Akt/mammalian target of rapamycin(mTOR) pathway is common in breast cancer. There is preclinical data to support inhibition of the pathway, and phase Ⅰ to Ⅲ trials involving inhibitors of the pathway have been or are being conducted in solid tumors and breast cancer. Everolimus, an mTOR inhibitor, is currently approved for the treatment of hormone receptor(HR)-positive, human epidermal growth factor receptor 2(HER2)-negative breast cancer. In this review, we summarise the efficacy and toxicity findings from the randomised clinical trials, with simplified guidelines on the management of potential adverse effects. Education of healthcare professionals and patients is critical for safety and compliance. While there is some clinical evidence of activity of mTOR inhibition in HR-positive and HER2-positive breast cancers, the benefits may be more pronounced in selected subsets rather than in the overall population. Further development of predictive biomarkers will be useful in the selection of patients who will benefit from inhibition of the PI3K/Akt/mTOR(PAM) pathway.

关键词： Breast cancer phosphoinositide 3 kinase(PI3K)/Akt/ mammalian target of rapamycin(mTOR) everolimus

Artificial Intelligence-Based Semantic Segmentation of Ocular Regions for Biometrics and Healthcare Applications

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Computers, Materials & Continua 2021年第1期66卷 715-732页

作者： Rizwan Ali Naqvi Dildar Hussain Woong-Kee loh Department of Unmanned Vehicle Engineering Sejong UniversitySeoul05006Korea School of Computational Science Korea Institute for Advanced Study(KIAS)Seoul02455Korea Department of Software Gachon UniversitySeongnam13120Korea

Multiple ocular region segmentation plays an important role in different applications such as biometrics,liveness detection,healthcare,and gaze ***,segmentation techniques focus on a single region of the eye at a *** the number of obvious advantages,very limited research has focused on multiple regions of the ***,accurate segmentation of multiple eye regions is necessary in challenging scenarios involving blur,ghost effects low resolution,off-angles,and unusual ***,the available segmentation methods cannot address these *** this paper,to address the accurate segmentation of multiple eye regions in unconstrainted scenarios,a lightweight outer residual encoder-decoder network suitable for various sensor images is *** proposed method can determine the true boundaries of the eye regions from inferior-quality images using the high-frequency information flow from the outer residual encoder-decoder deep convolutional neural network(called ORED-Net).Moreover,the proposed ORED-Net model does not improve the performance based on the complexity,number of parameters or network *** proposed network is considerably lighter than previous state-of-theart *** experiments were performed,and optimal performance was achieved using SBVPI and UBIRIS.v2 datasets containing images of the eye *** simulation results obtained using the proposed OREDNet,with the mean intersection over union score(mIoU)of 89.25 and 85.12 on the challenging SBVPI and UBIRIS.v2 datasets,respectively.

关键词： Semantic segmentation ocular regions biometric for healthcare sensors deep learning

Towards development of a universal dengue vaccine-how close are we?

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 209-218页

作者： Ee Leen Pang Hwei-San loh School of Biosciences Faculty of ScienceThe University of Nottingham Malaysia Campus Biotechnology Research Centre The University of Nottingham Malaysia Campus

Dengue has been ranked as one of the top emerging diseases in Asia and Latin *** epidemiological data may not even reflect the true burden of disease due to underreported *** control programmes have failed to contain the disease and worst of all,no specific treatment is available at the ***,this pushes the demand for a dengue vaccine as a long-term protective *** there are numerous vaccine candidates ahead,they could be held back by different aspects in promoting vaccine *** for developing nations,logistics and cost are the major hurdles that need to be addressed in order to provide a quick yet affordable medical *** an alternative,plantbased vaccine production system is able to offer an attractive prospect given to its advantages of biocontainment warranty,low operation cost,rapid scalability and logistics *** that have embarked on this scope are laid out and reviewed in terms of the feasibility of plant system to serve as a biofactory for dengue vaccine.

关键词： Dengue vaccine Protective efficacy Developing countries Plant molecular pharming

Toward a more open and collaborative climate change policy framework in Hong Kong and Macao within the Guangdong-Hong Kong-Macao Greater Bay Area

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Chinese Journal of Population,Resources and Environment 2020年第3期18卷 179-187页

作者： Coco Du Christine loh Institute for Public Policy and InnovationPolicy and Entrepreneurship Thrust AreaThe Hong Kong University of Science and Technology(Guangzhou)Guangzhou511458China Institute for the Environment The Hong Kong University of Science and TechnologyHong KongChina

The special administrative regions of Hong Kong and Macao enjoy a high degree of autonomy from the national policy system in devising their local policies,including measures related to climate *** Kong and Macao each have their own climate change policies,some aspects of which are more advanced than policies in China's *** their high degree of policy autonomy has advantages,this has also isolated them from China's larger environmental management and practices that continue to advance at *** paper reviews the climate change policies of the two special administrative regions and analyzes their strengths and innovations,particularly in *** also identifies areas where there could be closer engagement,collaboration,and capacity-building with the China's Mainland,which has the potential for greater positive impacts,especially on a regional basis.

关键词： Climate change policy High degree of autonomy Hong Kong Macao Guangdong-Hong Kong-Macao Greater Bay Area Collaboration

Sources and distribution of sedimentary organic matter along the northern Bering and Chukchi Seas

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Journal of Environmental Sciences 2017年第2期29卷 66-75页

作者： Fanglu Xu Haiyan Jin Zhongqiang Ji Jianfang Chen Pei Sun loh Institute of Marine Chemistry and Environment Department of Marine Sciences Ocean College Zhejiang University Laboratory of Marine Ecosystem and Biogeochemistry Second Institute of OceanographyThe State Oceanic Administration

In this study, lignin-derived phenols were used to determine the sources and distribution of sedimentary organic matter along the northern Bering Sea and Chukchi Sea of the Arctic Ocean. The lignin parameter syringyl/vanillyl（S/V） and cinnamyl/vanillyl（C/V） ratios are used to indicate vegetation sources; and the ratios of vanillic acid/vanillin,（Ad/Al）v and syringic acid/syringaldehyde,（Ad/Al）s are used as indicators of lignin diagenesis. Results showed the predominance of woody gymnosperm signal at the easternmost location in the northern Bering Sea, a mixture of refractory non-woody angiosperm and fresher gymnosperm tissues in the Chukchi Sea, and signal of fresher woody gymnosperm tissues in the northernmost locations in the Chukchi Sea. The lignin materials showed gradual increase in decomposition stage during transport along the northern Bering Sea. Hydrodynamic sorting process, which is the retention of coarser materials nearshore and transportation of finer particles farther offshore, most probably occurred along the east coast of the northern Bering Sea. In Chukchi Sea, the non-woody angiosperm tissues could have originated from the Canadian Arctic and gymnosperm tissues could be from the Russian Arctic side. The fresher materials in the northernmost Chukchi Sea could have been transported here via the ice-rafting *** of fresh lignin materials and the occurrence of lignin decomposition mean that this region could be sensitive to the impact of climate change.

关键词： Lignin-derived phenols Northern Bering Sea Chukchi Sea