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Flexible polymeric patch based nanotherapeutics against non-cancer therapy

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Bioactive Materials 2022年第12期7卷 471-491页

作者： Houjuan Zhu Justin Mah Jian Qiang Chen Gang Wang Chui Yu Chan Qiang Zhu Enyi Ye Zibiao Li Xian Jun loh Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)Singapore138634Singapore Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore637371Singapore Institute of Sustainability for Chemicals Energy and Environment(ISCE2)A*STAR(Agency for ScienceTechnology and Research)1 Pesek RoadJurong IslandSingapore627833Singapore

Flexible polymeric patches find widespread applications in biomedicine because of their biological and tunable features including excellent patient compliance,superior biocompatibility and biodegradation,as well as high loading capability and permeability of *** polymeric patches are classified into microneedles(MNs),hydrogel,microcapsule,microsphere and fiber depending on the formed *** combination of nanomaterials with polymeric patches allows for improved advantages of increased curative efficacy and lowered systemic toxicity,promoting on-demand and regulated drug administration,thus providing the great potential to their clinic *** this review,the category of flexible polymeric patches that are utilized to integrate with nanomaterials is briefly presented and their advantages in bioapplications are further *** applications of nanomaterials embedded polymeric patches in non-cancerous diseases were also systematically reviewed,including diabetes therapy,wound healing,dermatological disease therapy,bone regeneration,cardiac repair,hair repair,obesity therapy and some immune disease ***,the limitations,latest challenges and future perspectives of such biomedical therapeutic devices are addressed.

关键词： Flexible polymeric patches Microneedle Hydrogel Nanomaterials Non-cancer therapy Biomedical scaffolds

Spatiotemporal Analysis of COVID-19 Lockdown Impact on the Land Surface Temperatures of Different Land Cover Types in Louisiana

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Journal of Geographic Information System 2023年第5期15卷 458-481页

作者： priscilla M. loh Yaw A. Twumasi Zhu H. Ning Matilda Anokye Diana B. Frimpong Judith Oppong Abena B. Asare-Ansah Recheal N. D. Armah Caroline Y. Apraku Department of Urban Forestry Environment and Natural Resources Southern University and A&M College Baton Rouge USA

The COVID-19 pandemic posed a serious threat to life on the entire planet, necessitating the imposition of a lockdown mechanism that restricted people’s movements to stop the disease’s spread. This period experienced a decline in air pollution emissions and some environmental changes, offering a rare opportunity to understand the effects of fewer human activities on the earth’s temperature. Hence, this study compares the changes in Land Surface Temperature (LST) that were observed prior to the pandemic (March & April 2019) and during the pandemic lockdown (March & April 2020) of three parishes in Louisiana. The data for this study was acquired using Landsat 8 Thermal Infrared Sensor (TIRS) Level 2, Collection 2, Tier 2 from the Google Earth Engine Catalog. For better visualization, the images that were derived had a cloud cover of less than 10%. Also, images for the three study areas were processed and categorized into four main classes: water, vegetation, built-up areas, and bare lands using a Random Forest Supervised Classification Algorithm. To improve the accuracy of the image classifications, three Normalized Difference Indices namely the Normalized Difference Vegetation Index (NDVI), Normalized Difference Water Index (NDWI) and Normalized Difference Built-Up Index (NDBI) were employed using the Near Infrared (NIR), Red, Green and SWIR bands for the calculations. After, these images were processed in Google Earth Engine to generate the LST products gridded at 30 m with a higher spatial resolution of 100 m according to the pre-pandemic (2019) and lockdown (2020) periods for the three study areas. Results of this study showed a decrease in LST values of the land cover classes from 2019 to 2020, with LST values in East Baton Parish decreasing from 44°C to 38°C, 42°C to 38°C in Lafayette Parish, and 43°C to 38°C in Orleans Parish. The variations in the LST values therefore indicate the impact of fewer anthropogenic factors on the earth’s temperature which requires

关键词： Urban Heat Island Anthropogenic Activities Greenhouse Gas Greenspace Wetlands

Bioenergy: Examining the Efficient Utilization of Agricultural Biomass as a Source of Sustainable Renewable Energy in Louisiana

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Journal of Sustainable Bioenergy Systems 2023年第3期13卷 99-115页

作者： priscilla M. loh Yaw A. Twumasi Zhu H. Ning Matilda Anokye Recheal N. D. Armah Caroline Y. Apraku Judith Oppong John B. Namwamba Lucinda Kangwana Janeth Mjema Department of Urban Forestry Environment and Natural Resources Southern University and A&M College Baton Rouge USA

The use of renewable energy is steadily being adopted as a mitigative measure for reducing greenhouse gas emissions. By assessing biomass production and consumption estimates from Louisiana parishes, this study examines the utilization of agricultural biomass as a convenient renewable energy source, and the potential of marginal lands for growing bioenergy crops in Louisiana. This was achieved by retrieving parish-level acreage production of some biofuel crops recorded in 2021 using the Quick Stats Database, to map out the spatial locations and distribution of the biofuel crops. To examine the potential of Louisiana’s marginal lands in bioenergy crop production, data was obtained from the Soil Survey Geographic (SSURGO) database and mapped-out according to the eight Land Capability Classes numbered I-VIII. The results of the mapped-out acreage data revealed that 25% of the 64 parishes including Morehouse recorded high corn production estimates, while 43%, such as East Carroll, recorded high soybean production. Meanwhile, cotton production estimates were relatively low, as recorded in only 9 parishes, with one parish, Tensas, having the highest acreage production of around 23,000. Although the identified marginal lands in parishes such as Allen and Vernon had no records of corn, soybean, or cotton production, the soil survey database revealed that these marginal lands have high nutrient soils like Alfisols, Entisols and Inceptisols with optimal nutrient balance essential for high yield bioenergy crop production. Hence, this paper highlights Louisiana’s agricultural biomass to be leveraged as sustainable renewable sources while adhering to clear production guidelines, biofuel sustainability certification, and internationally agreed sustainability criteria.

关键词： Biofuels Agricultural Crops Ethanol Biodiesel Marginal Lands Louisiana

An Occupational Perspective of Occupational Therapy and the Medical Hegemony System in Malaysia—Exploration for Further Research

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Health 2021年第11期13卷 1285-1302页

作者： Siew Yim loh Gail Boniface Sharon Brintnell Faculty of Medicine University of Malaya Kuala Lumpur Malaysia School of Occupational Therapy University of Wales Cardiff UK Faculty of Rehabilitation Medicine University of Alberta Edmonton Canada

Occupational Therapy is critically underdeveloped in many developing countries in Asia. There are many internal and external barriers to the growth of the profession, including lack of willpower and lack of professional representation in the government. This article aims to communicate the postulations for its stagnation across developing countries in Asia. An analytical reflection and historical review of the barriers to the growth of occupational therapy in Malaysia was conducted. Leaders in the field who met the inclusion criteria, collaborated to shape the reconstructions using an occupational reconstruction approach. The reconstruction guided key critical reflections on the roots of daily experiences to relive the cooperative action to problem solve the issues encountered by the profession in Malaysia. Medical hegemony was found as the active suppressor of the health professions, and can be seen as being beyond reproach in the Asian’s medical model that created occupational injustices. These occupational injustices hinder the growth of Occupational Therapy, do not serve the patients, science or the overall healthcare system. Autocratic governance has a debilitating impact on health sciences and its workforce especially around badly oppressed Asian countries. A greater systematic approach is needed to examine the extent, effect, problem solve and remediate the magnitude of injustices over the last decade—to make way for an inclusive and affordable care system.

关键词： Medical Hegemony Professional Autonomy Occupational Therapy Elitism Healthcare Communication Literacy Asia

Copper Catalyzed Highly Regioselective Silylcupration of Terminal Alkynes to Form α-Vinylsilanes

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Copper Catalyzed Highly Regioselective Silylcupration of Ter...

氟化学与美好生活——中国化学会第十一届全国氟化学会议

作者： Teck-Peng loh Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological University

＜正＞A highly regioselective synthesis of branched vinylsilanes through silicon-copper additions to terminal alkynes catalyzed by copper（Ⅰ）was developed using methanol as *** corresponding vinylsilanes were obtain...

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Enantioselective Addition of Methailyitributyitin to Aldehydes Catalyzed by Chiral In（Ⅲ）-PYBOX Complex

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Enantioselective Addition of Methailyitributyitin to Aldehyd...

中国化学会第四届有机化学学术会议

作者： loh,Teck-Peng Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical EngineeringSuzhou UniversitySuzhou 215006China Division of Chemistry and Biological ChemistryNanyang Technological UniversitySingapore 637616Singapore

＜正＞The synthesis of enantiomerically enriched homoallylic alcohols is an important goal in organic synthesis. This is because homoallylic alcohols are versatile intermediates which can be converted to a wide variety of synthetically useful compounds. Therefore, there has been intense research activity in this area in recent years, leading to the development of a large and diverse array of chiral catalysts, especially chiral Lewis acid-catalyzed addition of the allyl transfer reagents to carbonyl functionality.

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Novel Fluorescent and Phosphorescent Light Emitting Materials for Organic Light Emitting Diodes

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Novel Fluorescent and Phosphorescent Light Emitting Material...

2006年全国高分子材料科学与工程研讨会

作者： Kian-Ping loh Department of Chemistry National University of SingaporeSingapore 119260Republic of Singapore

＜正＞In this talk, we will report our recent research progress in development of highly efficient fluorescent and phosphorescent organic light emitting materials, including both polymers and small molecules, for deep blue, green, red and white light emitting diode application. Firstly, novel poly（p-phenylenevinylene）s （PPVs） with bulky substituents have been developed to solve the two major issues in this kind of materials: （1） structure defects in the polymer backbone and （2）

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Biomimetic Cationic Polyene cyclization

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Biomimetic Cationic Polyene cyclization

中国化学会第28届学术年会

作者： Teck-Peng loh Department of Chemistry University of Science and Technology of China Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological University

＜正＞The biosynthetic cationic polyene cyclizations of acyclic precursors squalene and（3S）-2,3-oxidosqualene lead to a vast array of known tricyclic,tetracyclic and pentacyclic natural products.2 In particular,lanosterol is biosynthesized in a single,economical and effective step from （3S）-2,3-oxidosqualene by a single 83-kDa *** impressive part about this reaction is the ability

关键词： polyene acetal-initiated natural products aqueous media high enantioselectivies

低开关频率下LCL型并网变流器复矢量分析及改进解耦控制

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电网技术 2018年第9期42卷 2821-2829页

作者：肖琦唐芬辛振周家宇陈鹏飞 Poh Chiang loh 姜久春国家能源主动配电网技术研发中心(北京交通大学) 北京市海淀区100044 香港中文大学电子工程系香港999077 北京电动车辆协同创新中心(北京交通大学) 北京市海淀区100044

同步旋转坐标系（dq）下的比例积分控制在并网变流器中得到广泛应用。由于滤波器和数字延迟的dq模型均存在轴间耦合并且两者相互影响,低开关频率下LCL型并网变流器的建模和解耦控制变得极具挑战。针对该问题,在对同步旋转坐标系下的LCL... 详细信息

同步旋转坐标系（dq）下的比例积分控制在并网变流器中得到广泛应用。由于滤波器和数字延迟的dq模型均存在轴间耦合并且两者相互影响,低开关频率下LCL型并网变流器的建模和解耦控制变得极具挑战。针对该问题,在对同步旋转坐标系下的LCL型并网变流器采用复矢量进行建模的基础上,通过双边频响特性曲线和零极点图对传统状态反馈和相位补偿进行了系统分析,揭示了不同位置相位补偿对系统相位裕度和解耦性能的影响关系,在此基础上提出了一种改进解耦控制方法,通过在状态反馈环内和调节器输出端依次设计相位补偿,在有效调节和改善动态性能的同时保证系统具有较好的解耦性能。最后,仿真及实验结果表明所提方法具有很好的解耦效果,同时能有效减小系统超调量和调节时间。

关键词：解耦控制相位补偿状态反馈低开关频率 LCL滤波器复矢量