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Adaptation of a Brazilian Version of the North/Northeast Region for the Brief Pain Inventory

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Pain Studies and Treatment 2017年第3期5卷 21-36页

作者： Catarina Nívea Bezerra Menezes Juliana Almeida da Silva priscila de Medeiros Renato Leonardo de freitas Da Silva José Aparecido Universidade de Fortaleza (UNIFOR) e Centro Universitário Unichristus Fortaleza Brasil Laboratório de Neuroanatomia e Neuropsicobiologia Departamento de Farmacologia Faculdade de Medicina de Ribeir&atilde o Preto Universidade de S&atilde o Paulo (FMRP-USP) Ribeir&atilde o Preto City Brasil Laboratório de Neuroanatomia e Neuropsicobiologia Departamento de Farmacologia (FMRP-USP) S&atilde o Paulo Brasil Centro Multiusuário de Neuroeletrofisiologia Laboratório de Dor & Emo&ccedil &otilde es Departamento de Cirurgia e Anatomia Depto de Farmacologia da FMRP-USP Ribeir&atilde o Preto City Brasil departamento de Psicologia Unidade de Psicobiologia Campus da USP de Ribeir&atilde o Preto Ribeir&atilde o Preto Brasil

Purpose: The adaptation of BPI-B into North/Northeast of Brazil. The purpose of this study was the translation and adaptation of the BPI to Portuguese language, as spoken in Brazil, aiming at its posterior usage to measure both intensity and interference of pain in cancer patients’ life. Methods: The BPI-B was developed from the original BPI, using back-translation and committee review. The Back Translation was compared to the original BPI, as a result, the North/Northeast Brazilian version proved to have the same goals, and is similar to other current versions, observing its psychometrics properties. The inventory presented a final sample of 475 patients, whose average age was 54.37 years old (DP = 14.56), most female (58.9%). One hundred ninety-six patients in elementary school took part. It had its objective to group multiple indicators that responded to validation, precision and parsimony criteria. The patients answered the BPI at the very moment they were diagnosed as cancer cases. All of them were above 18 years old and they were also undergoing treatment at Cancer Ambulatory in a Hospital in Ceará, Brazil. The retest was carried, after about a month of the first application. In order to verify the reliability of inventory adaptation, the exploratory factorial analysis was used as the oblique rotation axis. Results: Exploratory factor analysis confirmed two underlying dimensions, pain severity, and pain interference, with Cronbach’s α 0.833 and 0.733, respectively. Conclusion: A proposition of a north/northeast Brazilian version of BPI turned out to be adequate, gathering evidences of adaptation and internal consistency similar to already validated versions.

关键词： Pain Evaluation. Brief Pain Inventory. Cancer Pain. Pain Intensity. Pain Interference Reliability

Experiencing a traumatic spinal cord injury—Analysis on the view of the theory of Watson’s transpersonal caring

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Journal of Biomedical Science and Engineering 2013年第7期6卷 14-20页

作者： Zuila Maria de Figueiredo Carvalho Juan Jose Tirado Darder priscila Alencar Mendes Reis Samira Rocha Magalhaes Samia Jardelle Costa de freitas Maniva New University of Lisbon LisbonPortugal Federal University of Ceará FortalezaBrazil The National Council for Scientific and Technological development(CNPq) BrasiliaBrazil Nupen/deNF/FFOE/UFC FortalezaBrazil School of Nursing Cardenal Herrera UniversityValenciaSpain Clinical Care Health State University of Ceará FortalezaBrazil

This is an inquiry that seeks to understand the meaning of experiencing a spinal cord injury for hospitalized Brazilian and Portuguese patients. A quailtative study was achieved in two care services to spinal cord injury in Fortaleza-Brazil and Lisboa-Portugal. The subjects were 30 patients with complete spinal cord injury. The findings were obtained through a semi-structured interview, which took place at different times and it was used the following guiding question: What does it mean for you to experience a spinal cord injury? The data were organized by Bardin technique and analysis based on the assumptions of the theory of Jean Watson’s care. The speeches of the patients show a diversity of meanings such as: to lose the freedom of going and coming, sexuality and to become dependent on others. It is concluded that this situation of loss overbalances the person’s existence, which is expressed by feelings of sadness, grief, discontent, isolation, anxiety, crying, pain and emotional suffering. These feelings were expressed by the two groups despite being from different cultures. The research enabled the description of multiple dimensions of the meaning of spinal cord injury. It fills the theoretical gap, not yet sufficiently addressed to the practice of caring people with spinal cord injury.

关键词： Spinal Cord Injury Comprehensive Analysis Jean Watson’s Theory

Evaluation of Antinociceptive and Anti-Inflammatory Effects of Synthetic O-Prenylated Phenolic derivatives

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Pharmacology & Pharmacy 2012年第3期3卷 348-357页

作者： Niraldo Paulino Amarilis Scremin Paulino priscila Vautier Laura Pisco Carolina Passarelli Jose Matheus de freitas Costa Dirk Michalik Paulo Celso Pardi Jose Agustín Quincoces Suarez Grupo de Pesquisa e desenvolvimento de Biomedicamentos(BIOMED) Programa de Mestrado Profissional em FarmaciaUniversidade Bandeirante de Sao PauloSao PauloBrasil Programa de Pos-Graduacao em Farmacia Universidade Federal de Santa CatarinaFlorianopolisBrasil Laboratorio de Síntese Organica Universidade Bandeirante de Sao PauloSao PauloBrasil Leibniz-Institut für Katalyse an der Universitat Rostock RostockGermany

This work describes the synthesis, antinociceptive and anti-inflammatory effect of O-prenyl derivatives: O-prenyl derivatives 2-(3-methylbut-2-enyloxy)acetophenone (L1) and 3-methoxy-4-(3-methylbut-2-enyloxy)benzaldehyde (V1). Treatment with L1- or V1-produced antinociceptive effect on classical pain models: acetic acid abdominal contortions and formalin test (first and second phases), and in hot plate or tale flick models in mice without changing the locomotors performance, and anti-oedematogenic or anti-inflammatory effect in vivo: carrageenan-induced paw oedema and peritonitis in mice. In addition, L1 and V1 derivatives reduced nitric oxide production on RAW 264.7 cells stimulated with lipopolysaccharide without changing the cell viability. Taken together, our results show for the first time that L1 and V1 can produce antinociception and modulate inflammatory response when administered in mice.

关键词： Anti-Inflammatory Antinociception Synthesis O-Prenyl Compounds

Energy Efficiency in Smart Grid: A Prospective Study on Energy Management Systems

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Smart Grid and Renewable Energy 2015年第8期6卷 250-259页

作者： Hermes José Loschi Julio Leon Yuzo Iano Ernesto Ruppert Filho Fabrizzio Daibert Conte Telmo Cardoso Lustosa priscila Oliveira freitas department of Communications Faculty of Electrical and Computer Engineering University of Campinas (UNICAMP) Campinas/SP Brazil

The term Smart Grid has become a term to represent the benefits of a smart and sophisticated electrical grid, which can meet various social expectations related to sustainability and energy efficiency. The Smart Grid promises to enable a better power management for energy utilities and consumers, to provide the ability to integrate the power grid, to support the development of micro grids, and to involve citizens in energy management with higher levels of responsibility. However, this context comes with potential pitfalls, such as vulnerabilities to cyber-security and privacy risks. In this article, a prospective study about energy management, and exploring critical issues of modeling of energy management systems in a context Smart. Grid is presented along with background of energy management systems. An analysis of the demand response condition is also presented. Finally, the advantages and disadvantages of the implementation of energy management systems, and a comparison with the Brazilian electricity system are discussed.

关键词： Smart Grid Management Cloud Computing Energy Efficiency

The Primary Motor Cortex Stimulation Attenuates Cold Allodynia in a Chronic Peripheral Neuropathic Pain Condition in <i>Rattus norvegicus</i>

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World Journal of Neuroscience 2019年第3期9卷 138-152页

作者： priscila Medeiros Sylmara Esther Negrini-Ferrari Ana Carolina Medeiros Lais Leite Ferreira Josie Resende Torres da Silva José Aparecido da Silva Norberto Cysne Coimbra Renato Leonardo de freitas Neurosciences aboratory of Pain & Emotions and Multi-User Centre of Neuroelectrophysiology Department of Surgery and Anatomy Ribeir&atilde o Preto Medical School of the University of S&atilde o Paulo Ribeir&atilde o Preto S&atilde o Paulo Brazil Laboratory of Neuroanatomy and Neuropsychobiology Department of Pharmacology Ribeir&atilde o Preto Medical School of the University of S&atilde o Paulo (FMRP-USP) Ribeir&atilde o Preto (SP) Brazil Biomedical Sciences Institute Federal University of Alfenas (UNIFAL-MG) Alfenas Minas Gerais (MG) Brazil Motricity Sciences Institute UNIFAL-MG Alfenas MG Brazil Post-Graduate Program of Biosciences Applied to Health (PPGB) UNIFAL Biomedical Sciences Institute Alfenas MG Brazil department of Psychology Ribeir&atilde o Preto School of Philosophy Sciences and Literature of the University of S&atilde o Paulo FFCLRP-USP Ribeir&atilde o Preto Brazil department of Psychology Federal University of Juiz de Fora (UFJF-MG) Juiz de Fora (MG) Brazil Behavioural Neurosciences Institute (INeC) Ribeir&atilde o Preto (SP) Brazil

Background: The primary motor cortex (M1) stimulation (MCS) is a useful tool for attenuation of the peripheral neuropathic pain in patients with pharmacologically refractory pain. Furthermore, that neurological procedure may also cause antinociception in rodents with neuropathic pain. Cold allodynia is a frequent clinical finding in patients with neuropathic pain, then, we evaluated if an adapted model of neuropathy induced by chronic constriction injury (CCI) of the ischiadicus nervus (sciatic nerve) produces cold allodynia in an animal model of chronic pain. In addition, we also investigated the effect of the electrical stimulation of the M1 on chronic neuropathic pain condition in laboratory animals. Methods: Male Wistar rats were used. An adapted model of peripheral mononeuropathy induced by CCI was carried out by placing a single loose ligature around the right sciatic nerve. The acetone test was used to evaluate the cold allodynia in CCI or Sham (without ligature) rats. The MCS (M1) was performed at low-frequency (20 μA, 100 Hz) during 15 s by deep brain stimulation (DBS-Thomas Recording device) 21 days after CCI or Sham procedures. The cold allodynia was measured before and immediately after the neurostimulation of M1 in the following time-window: 0, 15 and 30 min after MCS. Results: Cold allodynia threshold increased in animals with chronic neuropathic pain submitted to the acetone test 21 days after the CCI surgery. The M1-stimulation by DBS procedure decreased the cold allodynia immediately and until 30 min after M1-stimulation in rats with chronic neuropathic pain. Conclusion: The current proposal for a CCI model by a single loose ligature of the sciatic nerve can be employed as an experimental model of chronic neuropathic pain in rats submitted to peripheral nervous system injury. The M1-stimulation produced antinociception in rats with chronic neuropathic pain. Thus, we reinforced that the MCS decreases cold allodynia in laboratory animals submitted to

关键词： Peripheral Neuropathic Pain Chronic Pain Sciatic Nerve Chronic Constriction Injury Cold Allodynia Primary Motor Cortex Stimulation Antinociception

Altered Expression in Patients with Heart Failure of Circulating MicroRNAs Related to Lipoprotein Metabolism

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Journal of Pharmacy and Pharmacology 2018年第5期6卷 466-474页

作者： priscila O. Carvalho Fatima R. freitas Ana Elisa M. Martinelli Bruna M. O. Silva Milena N. C. Curiati Roberto Kalil-Filho Antonio C. Pereira Barretto Raul C. Maranhao Lipid Metabolism Laboratory Heart Institute (InCor) Medical School Hospital University of Sao Paulo Sao Paulo 05403-000Brazil Santa Marcelina Hospital Sao Paulo 08270-070 Brazil Prevention and Rehabilitation Service Heart Institute (InCor) Medical School Hospital University of Sao Paulo So Paulo 05403-000 Brazil Faculty of Pharmaceutical Sciences University of Sao Paulo Sao Paulo 05508-000 Brazil