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Piperine,an active ingredient of black pepper attenuates acetaminophen-induced hepatotoxicity in mice

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Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 971-976页

作者： Evan prince Sabina Annie Deborah Harris Souriyan Deborah Jackline Mahaboob Khan Rasool School of Biological Sciences and Technology VIT University Vellore - 632 014Tamil NaduIndia

Objective:To explore the hepatoprotective and antioxidant effects of piperine against acetaminophen-induced hepatotoxicity in ***:In mice,hepatotoxicity was induced by a single dose of acetaminophen(900 mg/kg b.w.i.p.).Piperine(25 mg/kg b.w.i.p.) and standard drug silymarin(25 mg/kg b.w.i.p.) were given to mice,30 min after the single injection of *** 4 h,the mice were *** of liver marker enzymes [(aspartate transaminase(AST),alanine transaminase(ALT),and alkaline phosphatase(ALP)]and inflammatory mediator tumour necrosis factor-alpha(TNF-α) were estimated in serum,while lipid peroxidation and antioxidant status(superoxide dismutase,catalase,glutathione peroxidase, glutathione reductase,glutathione-s-transferase and glutathione) were determined in liver homogenate of control and experimental ***:Acetaminophen induction(900 mg/kg b.w.i.p.) significantly increased the levels of liver marker enzymes,TNF-α,and lipid peroxidation,and caused the depletion of antioxidant *** and silymarin treatment to acetaminophen challenged mice resulted in decreased liver marker enzymes activity,TNF-αand lipid peroxidation levels with increase in antioxidant ***:The results clearly demonstrate that piperine shows promising hepatoprotective effect as comparable to standard drug silymarin.

关键词： Pipeline Hepatoprotective Antioxidant enzymes Lipid peroxidation TNF-α

An analysis of land use development city using imagery pattern in the industrial high resolution satellite

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Journal of Geographical Sciences 2011年第1期21卷 79-88页

作者： John prince Soundranayagam P. Sivasubramanian N. Chandrasekar K.S.P. Durairaj Centre for GeoTechnology Manonmaniam Sundaranar University Tirunelveli-627012 India Department of Geology V.O.Chidambaram College Tuticorin-628008 India The controller Manonmaniam Sundaranar University Tirunelveli-627012 India

The spatial differentiation of land use changes of Tuticorin is studied using high resolution LISS III satellite imagery and Maximum Likelihood algorithms. The classification accuracy of 95.2% was obtained. In this study,the land use of Tuticorin is classified as settlement,salt pan,agricultural land,wasteland,water bodies and shrubs. The settlement area is increased to 4.6 km2 during the year 2001 and 2006. The settlement area change is mainly driven by growth of industries and migration of people from peripheral villages. Shrub is increased to 3.63 km2 in the six year period. Water logging due to growth of shrubs in Tuticorin leads to several environmental and health hazard. This study warrants proper urban planning for Tuticorin for sustainable use of resource and environment.

关键词： land use urban planning remote sensing environment health hazard

Removing barriers to healthcare through an intercultural healthcare system:Focus group evidence

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Journal of Integrative Medicine 2021年第1期19卷 29-35页

作者： prince Peprah Williams Agyem ang-Duah Abdul Wahid Arimiyaw Anthony Kwame Morgan Stephen Uwum bordo Nachibi Social Policy Research Centre University of New South WalesSydney 2052Australia Department of Planning Kwame Nkrumah University of Science and TechnologyKumasi 233Ghana Department of Geography and Rural Development Kwame Nkrumah University of Science and TechnologyKumasi 233Ghana

Objective:Barriers to healthcare in Ghana are *** people,including patients and providers,face them at different *** address these barriers,there is a need to explore the role of an intercultural healthcare *** paper explores and provides the first evidence on ways through which an intercultural healthcare system can reduce the sociocultural and economic barriers to healthcare in ***:Focus group discussions with 35 participants comprising 17 healthcare users,11 formal healthcare providers and 7 alternative healthcare providers were conducted to gather *** analyses were performed on the transcribed data and presented based on a posteriori inductive reduction ***:Findings reveal that an intercultural healthcare system in Ghana can help reduce barriers to healthcare,especially cultural,social and economic barriers,by fostering an enhanced relationship between culture and healthcare,promoting affordable healthcare and promoting effective communication between healthcare providers and *** institutional support,lack of strong political will and commitment,lack of training to meet standards of practice,poor registration and regulatory measures,and lack of universal acceptance inhibit implementation of an intercultural healthcare system in ***:The support for intercultural healthcare system and the agreement on its perceived ability to reduce social,cultural and economic healthcare barriers for service users offer an opportunity for policymakers to demonstrate a stronger political will and improved commitment for effective education and training,enforcement of regulatory measures,inclusion of intercultural healthcare in medical school curricula across the country,and community engagement.

关键词： Intercultural health Health system Healthcare barriers Focus group Ghana

Traditional agroecological knowledge and practices:The drivers and opportunities for adaptation actions in the northern region of Ghana

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Regional Sustainability 2022年第4期3卷 294-308页

作者： Enoch YELELIERE Thomas YEBOAH Philip ANTWI-AGYEI prince PEPRAH Department of Environmental Science College of ScienceKwame Nkrumah University of Science and TechnologyKumasiGhana The Bureau of Integrated Rural Development(BIRD) Kwame Nkrumah University of Science and TechnologyKumasiGhana Centre for Primary Health care and Equity/Social Policy Research Centre University of New South WalesNew South Wales 2052SydneyAustralia

Agroecological practices are promoted as a more proactive approach than conventional agriculture to achieving a collective global response to climate change and variability while building robust and resilient agricultural systems to meet food needs and protect the integrity of *** is relatively limited evidence on the key traditional agroecological knowledge and practices adopted by smallholder farmers,the factors that influence smallholder farmers’decision to adopt these practices,and the opportunities it presents for building resilient agricultural *** a multi-scale mixed method approach,we conducted key informant interviews(n=12),focus group discussions(n=5),and questionnaire surveys(N=220)to explore the traditional agroecological knowledge and practices,the influencing factors,and the opportunities smallholder farmers presented for achieving resilient agricultural *** findings suggest that smallholder farmers employ a suite of traditional agroecological knowledge and practices to enhance food security,combat climate change,and build resilient agricultural *** most important traditional agroecological knowledge and practices in the study area comprise cultivating leguminous crops,mixed crop-livestock systems,and crop rotation,with Relative Importance Index(RII)values of 0.710,0.708,and 0.695,*** is reported that the choice of these practices by smallholder farmers is influenced by their own farming experience,access to market,access to local resources,information,and expertise,and the perceived risk of climate ***,the results further show that improving household food security and nutrition,improving soil quality,control of pest and disease infestation,and support from NonGovernmental Organizations(NGOs)and local authorities are opportunities for smallholder farmers in adopting traditional agroecological knowledge and practices for achieving resilient agricultural *** findings call into questi

关键词： Climate change Food security Adaptation actions Traditional agroecological knowledge and practices Resilient agricultural systems

Etiopathogenesis of primary biliary cirrhosis

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World Journal of Gastroenterology 2008年第21期14卷 3328-3337页

作者： Ana Lleo Pietro Invernizzi Ian R Mackay Harry prince Ren-Qian Zhong M Eric Gershwin Division of Internal Medicine and Liver Unit San Paolo Hospital School of Medicine University of Milan Milan 20142 Italy Division of Rheumatology Allergy and Clinical Immunology University of California at Davis Davis CA 95616 United States Department of Biochemistry & Molecular Biology Monash University Clayton Victoria 3800 Australia Focus Diagnostics 5785 Corporate Avenue Cypress CA 90630 United States Laboratory Diagnostics of Changzheng Hospital Second Military Medical University and Clinical Immunology Center of PLA Shanghai 200003 China

Primary biliary cirrhosis(PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver *** serological hallmark of the disease is the presence of circulating antimitochondrial antibodies(AMA).These reflect the presence of autoreactive T and B cells to the culprit antigens,the E2 subunits of mitochondrial 2-oxo-acid dehydrogenase enzymes,chiefly pyruvate dehydrogenase(PDC-E2).The disease results from a combination of genetic and environmental risk *** predisposition is indicated by the higher familial incidence of the disease particularly among siblings and the high concordance rate among monozygotic *** triggering events appear crucial to disrupt a pre-existing unstable immune tolerance of genetic origin allowing,after a long latency,the emergence of clinical *** mimetopes of the vulnerable epitope of the PDC-E2 autoantigen can be derived from microbes that utilize the PDC enzyme or,alternatively,environmental xenobiotics/chemical compounds that modify the structure of native proteins to make them immunogenic.A further alternative as a source of antigen is PDC-E2 derived from apoptotic *** the effector phase the biliary ductular cell,by reason of itsproclivity to express the antigen PDC-E2 in the course of apoptosis,undergoes a multilineage immune attack comprised of CD4+ and CD8+ T cells and *** this article,we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data,new developments and theories,and nominate directions for future research.

关键词： Autoantibodies Autoreactive T cells 2-oxoacid dehydrogenase Biliary epithelial cells Primary biliary cirrhosis

Intestinal Stoma Prolapse and Surgical Treatments of This Condition in Children: A Systematic Review and a Retrospective Study

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Surgical Science 2016年第9期7卷 400-426页

作者： prince Johnson University of Oslo Nesoddtangen Norway

Background: An intestinal stoma is a surgical opening of the intestine, mostly sutured to the anterior abdominal wall. Stoma prolapse is one of the common complications of stoma. A significant number of stoma prolapse patients require surgical correction. Aim: The first part of this thesis is a literature review of intestinal stoma prolapse and its surgical treatments. The second part is an evaluation of the effect of surgical treatments of this condition on children at OUS-R. Methods: Literature—A literature search was performed. Fifty-seven English-language studies were selected. Methods: Patients evaluation: Design, Setting, and Participants—A retrospective review of pediatric patients (<13 years) surgically treated for intestinal stoma prolapse at OUS-R. Results: Literature—Incidence of intestinal stoma prolapse for children varies from 8.1% to 25.6%. Many proposed surgical repair procedures for stoma prolapse are available and vary from being ineffective to 100% effective. Results: Patients evaluation at OUS-R—From 2001 to 2013, 14 of the 304 children with stoma (4.6%), experienced stoma prolapse. Nine stoma prolapse were surgically corrected: Median age at stoma formation for the 9 patients was 1.7 years. Surgical procedures and success rate: Median 2, range 1 - 9 operations/person;varies from being ineffective to 50% effective. Conclusion: Limited data suggests stoma prolapse repair is a surgical challenge. Thus, preferably when possible, closure of the stoma would be most suitable. Incidence of stoma prolapse in our series of pediatric patients at Oslo University Hospital is lower than most published incidence in the pediatric medical literature.

关键词： Stoma Children Neonates Stoma Complications Stoma Prolapse Surgical Management

Deterministic epidemic model for (SVC_(Sy)C_(Asy)IR) pneumonia dynamics, with vaccination and temporal immunity

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Infectious Disease Modelling 2020年第1期5卷 42-60页

作者： Dominic Otoo Patrick Opoku Sebil Charles Asekiya prince Kingsley Department of Mathematics&Statistics School of ScienceUniversity of Energy&Natural ResourcesSunyaniGhana Department of Mathematics Faculty of Physical and Computational ScienceCollege of ScienceKwame Nkrumah University of Science&TechnologyKumasiGhana

Streptococcus pneumonia is one of the leading causes of mobility and mortality in children under 6 years and the elderly especially in developing countries in which Ghana,the study area is not an *** this paper,a model of the spread and control of bacterial pneumonia that include symptomatic carriers,asymptomatic carriers and vaccination is formulated and analyzed to determine the effect of the vaccination *** of the system show that the disease free equilibrium is stable if and only if the basic reproductive number R0<*** R01,the endemic equilibrium is globally stable and the disease *** simulation on the system show that with effective vaccine intervention pneumonia infection can be eradicated in the long term.

关键词： Asymptomatic carriers Morbidity Mortality Pneumonia Symptomatic carriers Vaccination

Unraveling the mark of surface defects on a spinterface： The nitronyl nitroxide/TiO2（110） interface

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Nano Research 2016年第11期9卷 3515-3527页

作者： Reza Kakavandi Arrigo Calzolari Yulia B. Borozdina prince Ravat Thomas Chasse Martin Baumgarten M. Benedetta Casu Institute of Physical and Theoretical Chemistry University of Tubingen Auf der Morgenstelle 18 72076 Tubingen Germany CNR-NANO Istituto Nanoscienze Centro S3 41125 Modena Italy Max Planck Institute for Polymer Research Ackermannweg 10 55128 Mainz Germany

Metal-free organic radicals are fascinating materials owing to their unique properties. Having a stable magnetic moment coupled to light elements makes these materials central to develop a large variety of applications. We investigated the magnetic spinterface coupling between the surface of a single rutile TiO2（110） crystal and a pyrene-based nitronyl nitroxide radical, using a combination of thickness-dependent X-ray photoelectron spectroscopy and ab initio calculations. The radicals were physisorbed, and their magnetic character was preserved on the （almost） ideal surface. The situation changed completely when the molecules interacted with a surface defect site upon adsorption. In this case, the reactivity of the defect site led to the quenching of the molecular magnetic moment. Our work elucidates the crucial role played by the surface defects and demonstrates that photoemission spectroscopy combined with density functional theory calculations can be used to shed light on the mechanisms governing complex interfaces, such as those between magnetic molecules and metal oxides.

关键词： organic spinterface photoemission spectroscop density functional theory calculations

Protective role of Triphala, an Indian traditional herbal formulation, against the nephrotoxic effects of bromobenzene in Wistar albino rats

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Journal of Integrative Medicine 2015年第2期13卷 115-121页

作者： Udhaya Lavinya Baskaran Sherry Joseph Martin Rasool Mahaboobkhan Sabina Evan prince School of Biosciences and Technology VIT University

OBJECTIVE： The purpose of the present study was to evaluate the nephroprotective and antioxidant properties of Triphala against bromobenzene-induced nephrotoxicity in female Wistar albino rats. METHODS： Animals were divided into five groups of six rats and treated as follows： Group I was a normal control and received no treatment, Group II received only bromobenzene （10 mmol/kg）, Groups III and IV received bromobenzene and Triphala （250 and 500 mg/kg, respectively）, Group V received Triphala alone （500 mg/kg）, and Group VI received bromobenzene and silymarin （100 mg/kg） Antioxidant status and serum kidney functional markers were analyzed. RESULTS： Bromobenzene treatment resulted in significant （P 〈 0.05） decreases in the activities of antioxidant enzymes such as catalase, superoxide dismutase, glutathione-S-transferase and glutathione peroxidase as well as total reduced glutathione. There was a significant （P 〈 0.05） increase in lipid peroxidation in kidney tissue homogenates. There were significant （P 〈 0.05） reductions in the levels of serum total protein and albumin as well as significant （P 〈 0.05） increases in serum creatinine, urea and uric acid. The oral administration of two different doses （250 and 500 mg/kg） of Triphala in bromobenzene-treated rats normalized the tested parameters. The histopathological examinations of kidney sections of the experimental rats support the biochemical observations. CONCLUSION： Triphala treatment alleviated the nephrotoxic effects of bromobenzene by increasing the activities of antioxidant enzymes and reducing the levels of lipid peroxidation and kidney functional markers.

关键词： bromobenzene Triphala plant extracts antioxidants rats