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Perturbations in the earthworm metabolite profile during a two-week exposure to metformin

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Emerging Contaminants 2024年第3期10卷 221-229页

作者： J.D.gillis g.w.price S.O.Prasher Department of Bioresource Engineering McGill UniversityFaculty of Agricultural and Environmental SciencesMacdonald-Stewart Building MS1-02721111 Lakeshore RoadSainte-Anne-de-BellevueQuebecH9X 3V9Canada Department of Engineering Dalhousie UniversityFaculty of Agriculture39 Cox RoadPO Box 550TruroNova ScotiaB2N 5E3Canada

Metformin is among the most prescribed pharmaceuticals in many countries,and as a result has shown up in biosolids derived from municipal wastewater treatment that are destined for land *** humans taking metformin,the effects include reduced glucose uptake in the intestine,a reduction in gluconeogenesis,increased oxidation of fatty acids,and reduced fatty acid *** effects of metformin on soil-dwelling organisms are not well *** study tested the effects of metformin exposure(0,10,40,160,640μg g^(-1))on the earthworm(***)at four time points(6 h,2 d,7 d,and 14 d)using gC-MS to reveal sub-lethal effects and elucidate potential modes of action for *** were no mortalities observed,and earthworms exposed to the highest concentrations(160 and 640μg g^(-1))gained weight relative to the control on days 7 and *** reductions on day 7 were observed for glucose and malic acid(consistent with a reduction in gluconeogenesis),and for palmitic and margaric acid(consistent with increased oxidation and reduced synthesis of fatty acids).Lactic acid ranked first and second among canonicals 1 and 2 respectively and led to significant differences in discriminant scores across concentration and *** levels increased to equal or greater than the control on day 14,likely caused by reduced exposure as metformin is reported to be readily transformed by microorganisms under aerobic *** observations were consistent with the known effects of metformin in humans,and suggests that a similar mode of action exists in earthworms.

关键词： Metabolites Toxicity Earthworms Metformin gC-MS

Acetabular cup size trends in total hip arthroplasty

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world Journal of Orthopedics 2024年第1期15卷 39-44页

作者： Daniel Patrick McKenna Alex price Timothy McAleese Darren Dahly Paul McKenna May Cleary Department of Trauma and Orthopaedics University Hospital WaterfordWaterford X91 ER8EIreland Department of Epidemiology and Public Health University College CorkCork T12 XF62Ireland

BACKgROUND Total hip arthroplasty(THA)is a common procedure for end stage *** learning curve for THA is complex and *** of the most difficult skills to master is acetabular *** wish to identify if experience in arthroplasty leads to preservation of more bone *** To investigate if increasing surgeon experience will predict an ever decreasing acetabular cup *** A retrospective case series of four attending orthopaedic surgeons was *** uncemented elective total hip arthroplasties since appointment were selected for *** size of acetabular cup used was noted and logistic regression was used to identify if a trend to smaller cups *** A total of 1614 subjects were included with a mean age of 64 *** cups were on average 0.18mm smaller per year(95%confidence interval-0.25 to-0.11,Pgeon trends showed cup sizes to decrease 0.27 mm/year for surgeon A,0.02 mm/year for surgeon B,0.15 mm/year for surgeon C and 0.29 mm/year for surgeon *** of the four surgeons had a more pronounced trend to smaller cups for male subjects than their female *** we found increasing surgeon experience to be associated with an ever-decreasing acetabular cup *** acetabular cup size may act as a surrogate marker of surgical proficiency by virtue of decreased acetabular reaming.

关键词： Hip Arthroplasty Acetabulum Cup Learning

Prehospital transdermal glyceryl trinitrate for ultra- acute ischaemic stroke: data from the RIgHT- 2 randomised sham- controlled ambulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason Philip Appleton Lisa J woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala Mark Dixon Timothy J England Kailash Krishnan grant Mair Keith w Muir John Potter Christopher I price Marc Randall Thompson g Robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna M wardlaw Nikola Sprigg Philip M Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of Medicine The George Institute for Global HealthSydneyNew South WalesAustralia The george Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Department of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and Medical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East Midlands Ambulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Champion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Department of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Department of Neurology Oslo University HospitalOsloNorway Research and Development Norwegian Air Ambulance FoundationOsloNorway Department of Neurology and Comprehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and graduate Services University of NottinghamNottinghamUK Community and Health Research Unit University of LincolnLincolnUK

Background The effect of transdermal glyceryl trinitrate(gTN,a nitrovasodilator)on clinical outcome when administered before hospital admission in suspected stroke patients is ***,we assess the safety and efficacy of gTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with glyceryl trinitrate in Hypertensive stroke Trial-2(RIgHT-2).Methods RIgHT-2 was an ambulance-based multicentre sham-controlled blinded-endpoint study with patients randomised within 4hours of *** primary outcome was a shift in scores on the modified Rankin scale(mRS)at day *** outcomes included death;a global analysis(wei-Lachin test)containing Barthel Index,EuroQol-5D,mRS,telephone interview for cognitive status-modified and Zung depression scale;and neuroimaging-determined‘brain frailty’*** were reported as n(%),mean(SD),median[IQR],adjusted common OR(acOR),mean difference or Mann-whitney difference(MwD)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaemic stroke;age 75(12)years,premorbid mRS>2107(18%),glasgow Coma Scale 14(2)and time from onset to randomisation 67[45,108]***‘brain frailty’was common:median score 2[2,3](range 0–3).At day 90,gTN did not influence the primary outcome(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(MwD 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting gTN may be associated with more death and dependency in participants randomised within 1hour of symptom onset and in those with more severe *** In patients who had an ischaemic stroke,ultra-acute administration of transdermal gTN in the ambulance did not improve clinical outcomes in a population with more clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOwN ON THIS TOPIC⇒Transdermal glyceryl trinitrate(gTN)was associat-ed with less death and dependency in those w

关键词： glasgow nitrate random

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： Morten S.Hansen Kaja Madsen Maria price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.gorvin Morten Frost Alexander Rauch Molecular Endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and Systems Research(IMSR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and Receptors(COMPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed g-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed g-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/gPR120).Activating C5AR1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFAR4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

Secondary steady-state and time-periodic flows from a basic flow with square array of odd number of vortices

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Applied Mathematics and Mechanics(English Edition) 2023年第3期44卷 447-458页

作者： Zhimin CHEN w.g.price School of Mathematics and Statistics Shenzhen UniversityShenzhen 518060Guangdong ProvinceChina Ship Science University of SouthamptonSouthampton SO171BJU.K.

In a magnetohydrodynamic(MHD)driven fluid cell,a plane non-parallel flow in a square domain satisfying a free-slip boundary condition is *** energy dissipation of the flow is controlled by the viscosity and linear *** latter arises from the influence of the Hartmann bottom boundary layer in a three-dimensional(3D)MHD experiment in a square bottomed *** basic flow in this fluid system is a square eddy flow exhibiting a network of N~2 vortices rotating alternately in clockwise and anticlockwise *** N is odd,the instability of the flow.g.ves rise to secondary steady-state flows and secondary time-periodic flows,exhibiting similar characteristics to those observed when N=*** this reason,this study focuses on the instability of the square eddy flow of nine *** is shown that there exist eight bi-critical values corresponding to the existence of eight neutral eigenfunction ***,there exist non-real neutral eigenfunctions,which produce secondary time-periodic flows exhibiting vortices merging in an oscillatory *** Hopf bifurcation phenomenon has not been observed in earlier investigations.

关键词： two-dimensional(2D)Navier-Stokes equation non-parallel square vortex flow primary bifurcation secondary steady-state flow secondary time-periodic flow

Dissipative free-surface solver for potential flow around hydrofoil distributed with doublets

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Applied Mathematics and Mechanics(English Edition) 2012年第11期33卷 1467-1480页

作者：陈志敏 w. g. price Ship Science University of Southampton

A doublet integral equation is formulated for the two-dimensional dissipative potential flow around a hydrofoil submerged below a free-water surface. The free-water surface is assumed to involve energy dissipation, and thus it is the source of damping. A doublet panel method is developed from incorporation of the dissipative green function approach and the doublet distributions on the hydrofoil surface. Numerical computations are implemented, and the derived numerical results are in good agreement with analytic solutions and experimental measurements.

关键词： panel method potential flow free-surface wave energy dissipation hydro-foil

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乐趣是健康生活的秘诀（英文）

英语画刊(高中版) 2024年第1期 3-5页

作者： Catherine price

你每天都有在享受快乐吗?科学记者凯瑟琳·普莱斯认为:享乐不仅是一种快乐的体验,而且对你的健康和幸福也至关重要。在下面的演讲中,她提出了一个新的关于享乐的定义,并分享了一些简单而又可靠的将乐趣融入日常生活的方法。So in realit...

你每天都有在享受快乐吗?科学记者凯瑟琳·普莱斯认为:享乐不仅是一种快乐的体验,而且对你的健康和幸福也至关重要。在下面的演讲中,她提出了一个新的关于享乐的定义,并分享了一些简单而又可靠的将乐趣融入日常生活的方法。So in reality,fun is not just lighthearted pleasure.

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霉菌毒素如何威胁家禽健康和生产性能

国外畜牧学（猪与禽） 2024年第1期44卷 41-43页

作者： Kayla price Alexandra weaver 蔡霞(译) 范美红(校) 李红(审) 不详

霉菌毒素是霉菌在受到应激或环境刺激时产生的代谢物。霉菌毒素一旦产生,就会非常稳定,在作物的整个收获、储存、加工和饲喂过程中都会残留在饲料中,对蛋鸡、种鸡和肉鸡都会造成危害。不同的霉菌会产生不同的霉菌毒素,这些霉菌毒素会影... 详细信息

霉菌毒素是霉菌在受到应激或环境刺激时产生的代谢物。霉菌毒素一旦产生,就会非常稳定,在作物的整个收获、储存、加工和饲喂过程中都会残留在饲料中,对蛋鸡、种鸡和肉鸡都会造成危害。不同的霉菌会产生不同的霉菌毒素,这些霉菌毒素会影响家禽的健康和生产性能。霉菌毒素污染是可控的,但必须采取从田间到农场的综合方法。

关键词：霉菌霉菌毒素家禽生产性能控制

SOLITON SOLUTIONS OF A CLASS OF gENERALIZED NONLINEAR SCHRODINgER EQUATIONS

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Applied Mathematics(A Journal of Chinese Universities) 1997年第4期12卷 389-398页

作者： CAOQINgJIE ZHANgTIANDE K.DJIDJELI g.w.price E.H.TwIZELL DepartmentofMathematicsandPhysics ShangdongUniversityofTechnologyJinan.Chlna250061 DepartmentoFMathematicsandPhysics ShangdongUniver.~ityo~Tecl~nologyJinan.China250061 DepartmentofShipScience UniversityofSouthamptonSouthamptonSo171BJEngland. DepartmentofShipScience UniversityofSouthamptonSouthamptonSO171BJEngland DepartmentofMathematicsandStatistics BrunelUniversityUxbridgeMiddlesexUB83PHEngland.

Soliton solutions of a class of generalized nonlinear evolution equations are discussed analytically and numerically. This is done by using a travelling wave method to formulate one soliton solution and the finite difference method to the numerical solutions and the interactions between the solitons for the generalized nonlinear Schrdinger equations. The characteristic behavior of the nonlinearity admitted in the system has been investigated and the soliton states of the system in the limit when α→0 and α→∞ have been studied. The results presented show that the soliton phenomenon is characteristics associated with the nonlinearities of the dynamical systems.

关键词： generalized nonlinear Schrodinger equation Soliton solution weighted six-point scheme