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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Return of investment and profitability analysis of bio-fuels production using a modeling approach

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Information Processing in Agriculture 2016年第2期3卷 92-98页

作者： Yangyang Deng prem B.Parajuli Department of Agricultural and Biological Engineering Mississippi State UniversityMississippi StateMS 39762United States

The objectives of this study were to evaluate the return of investment and profitability of a bio-gasification facility using a modeling *** on preliminary market analysis,the results determined that the power facilities driven by biomass gasifiers could be profitable if they consider the most sensitive cost factors such as labor,project investment,and feedstock *** result showed that economic feasibility of bio-gasification facility can significantly affect by its production capacity and operating modes(one shift,two shifts,or three shifts).The cost analysis modeling approach developed in this study could be a good approach for economic analysis of bio-syngas and bio-fuel *** addition,this study demonstrated a unique modeling approach to analyze return of investment and profitability of biofuels production.

关键词： Bio-gasification Modeling Sensitivity analysis Profitability analysis

Theory, simulation and experiment of optical properties of cobalt ferrite(CoFe2O4) nanoparticles

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Journal of Materials Science & Technology 2020年第22期54卷 180-187页

作者： Elham Gharibshahi Brandon D.Young Amar S.bhalla Ruyan Guo Department of Electrical and Computer Engineering University of Texas at San Antonio.One UTSA CircleSan AntonioTX 78249USA

Optical properties of cobalt ferrite(CoFe2O4) nanoparticles are modeled and simulated employing finite element analysis(FEA) and density functional theory(DFT) for different particle sizes. The simulated absorption maxima of electronic excitations is red-shifted from 330 nm to 410 nm using finite element analysis and from 331.27 nm to 409.07 nm using quantum mechanical method, with increasing particle sizes from 40 nm to 50 nm. The measured absorption maxima matched the simulated results reasonably well and red-shifted to longer wavelengths from 315.59 nm to 426.73 nm with the increase in particle sizes from 30 nm to 50 nm. The DFT simulated, FEA simulated and experimentally derived optical band gap energies, Eg, were also acquired and compared. The simulated Egvalues decreased from 3.228 to 2.478 e V and from 3.266 to 2.456 e V, while the experimental Egvalue decreased from 3.473 to 2.697 e V, with increasing the particle sizes. The research demonstrated that the optical absorption of CoFe2O4 nanoparticles can be described with high accuracy using the quantum mechanical interpretation based on DFT. FEA based simulations have shown limitations for smaller(les likely due to the increased surface scattering that prevented a stable solution for simulations beyond the quasistatic limit. The DFT computational tool developed by this study can enable both the low cost computation and highly reliable prediction of optical absorption properties and optical band edges, and thus contribute to understanding and design of CoFe2O4 nanoparticle properties prior to fabrication and functionalization of them, for a wide range of applications especially for sensing and photonic wave modulations.

关键词： Cobalt ferrite(CoFe2O4)nanoparticles Optical properties Band gap energy DFT simulation of nanoparticles COMSOl simulation of nanoparticles

Data with Non-Euclidean Geometry and Its Characterization

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Journal of Artificial Intelligence and Technology 2022年第1期2卷 3-8页

作者： prem Kumar Singh Department of Computer Science and Engineering Gandhi Institute of Technology and Management-VisakhapatnamIndia

Recently,dealing with the non-Euclidean data and its characterization is considered as one of the major issues by *** first problem arises while defining the distinction among Euclidean and non-Euclidean geometry with its *** second problem arises while dealing with the non-Euclidean geometry in true,false,and uncertain *** third problem arises while investigating some patterns in non-Euclidean data *** paper focused on tackling these issues with some real-life examples in data processing,data visualization,knowledge representation,and quantum computing.

关键词： anisotropy Euclidean geometry heteroclinic orbit knowledge representation many-valued attributes non-Euclidean geometry

Four-Way Turiyam Set-Based Human Quantum Cognition Analysis

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Journal of Artificial Intelligence and Technology 2022年第4期2卷 144-151页

作者： prem Kumar Singh Department of Computer Science and Engineering Gandhi Institute of Technology and Management-VisakhapatnamAndhra Pradesh 530045India

Recently, the Turiyam set was introduced for characterization of data sets beyond true, false, and uncertain regionsbased on human cognition. This set is able to represent the unknown, undefined, or conduit metaphor of human quantumcognition precisely. One of the suitable examples is USA–Russia conflicts or Cold war is beyond the characterization of win,draw, or loss. It is totally based on the conduit metaphor of USA and Russia. In this case, a set of countries that may supportRussia (Sr) can be characterized as true regions. A set of countries that does not support Russia (i.e., supporting the USA) can becharacterized as false regions (Su). There is also a set of countries that supports both Russia–USA based on the given *** types of countries and their vote are uncertain. The fourth case is some countries like India, China, and UAE that choosenothing to fulfill their conduit metaphor. It is called Turiyam or four-dimension cognition. The characterization of this typeof four-dimension Turiyam cognition and its representation is one of the crucial tasks for data science researchers. It is indeed arequirement to understand the human quantum cognition and its conduit metaphor. To tackle this issue, the current paper will tryto introduce a method for characterization of this undefined, unknown, or Turiyam cognition via a defined interval set. Theobjective is to provide a way to explore them in known graph (t), not known graph (f), partial graph (i), or unknown graph (l) withan example.

关键词： fourth dimensions knowledge representation non-Euclidean Quaternion Turiyam set unknown

Sound Signal Based Fault Classification System in Motorcycles Using Hybrid Feature Sets and Extreme learning Machine Classifiers

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Sound & Vibration 2020年第1期54卷 57-74页

作者： T.Jayasree R.prem Ananth department of electronics&communication engineering government college of engineeringtirunelvelitamil naduindia department of electronics&communication engineering francis xavier engineering collegetirunelvelitamil naduindia

Vehicles generate dissimilar sound patterns under different working *** generated sound patterns signify the condition of the engines,which in turn is used for diagnosing various *** this paper,the sound signals produced by motorcycles are analyzed to locate various *** important attributes are extracted from the generated sound signals based on time,frequency and wavelet domains which clearly describe the statistical behavior of the ***,various types of faults are classified using the Extreme learning Machine(ElM)classifier from the extracted ***,the improved classification performance is obtained by the combination of feature sets in different *** simulation results clearly demonstrate that the proposed hybrid feature set together with the ElM classifier gives more promising results with higher classification accuracy when compared with the other conventional methods.

关键词： Extreme learning machine wavelet transform feature audio

A New High Performance Realization of Hyperchaotic Modified Canonical Chua Circuit Using JFETs

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Chinese Physics letters 2008年第8期25卷 2803-2805页

作者： prem Bhushan Mital Umesh Kumar R.S. Prasad IEC College of Engineering and Technology GB Nagar Pin-201 306 India Indian Institute of Technology Delhi Pin-110016 India Inderprastha Eng. College Sahibabad Ghaziabad (UP) India

A new implementation of hyperchaotic modified canonical Chua circuit using junction field-effect transistors （JFETs） is proposed. The design is based on a source coupled JFET circuit to approximate a smooth cubic nonlinearity and a two-terminal negative resistance element containing a p-n-p silicon transistor and an n-channel JFET. The realization is supported by Orcad Pspice simulation and numerical MATlAB results. The hyperchaotic nature is confirmed by two positive lyapunov exponents associated with the attractor which is a fractal with a lyapunov dimension between 3 and 4.

关键词： OSCIllATOR

Experimental investigation into the effects of Argemone biodiesel/diesel blends on cyclic variations in a multi-cylinder CRDI engine

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Clean Energy 2023年第2期7卷 363-374页

作者： Abhinav Sharma prem Kumar Sarbjot Singh Sandhu Mandeep Singh Department of Mechanical Engineering Dr B R Ambedkar National Institute of TechnologyJalandhar-144011PunjabIndia

Internal combustion engines suffer from high cyclic variations that result in higher emissions,lower efficiency,higher fuel consump-tion and poor *** purpose of this study is to investigate how Argemone mexicana biodiesel(AGB)/diesel blended fuels affect the cyclic variability of combustion parameters such as maximum cylinder pressure(Pmax)and indicated mean effective pressure(IMEP)in a four-cylinder turbocharged intercooled common-rail direct injection engine under various engine loading *** chemical and physical properties of AGB produced from *** oil were measured and compared according to the ASTM D6751 *** various volumetric ratios,AGB and diesel fuel were blended as D100,AB10(10%AGB+90%D100),AB20(20%AGB+80%D100)and AB30(30%AGB+70%D100).The IMEP and Pmax time-series data were collected over 200 consecutive cycles at low,partial and high engine loads at a constant engine speed of 2000 *** coefficients of variation(COV)of combustion parameters(Pmax and IMEP)were measured for different AGB/diesel blends and found to be within acceptable *** results show that COV_(Pmax) and COV_(IMEP) decrease as the engine load *** was observed that at low load,AB10 has the lowest COV(Pmax,IMEP),and at partial and high load,AB20 has the lowest COV(Pmax,IMEP)among all the blends.

关键词： indicated mean effective pressure cyclic variations biodiesel diesel engine Argemone mexicana biodiesel

Decreased expression of hyperpolarisation-activated cyclic nucleotide-gated channel 3 in Hirschsprung's disease

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World Journal of Gastroenterology 2015年第18期21卷 5635-5640页

作者： Anne Marie O’Donnell David Coyle prem Puri National Children’s Research Centre Our lady’s Children’s Hospital Cnmlin Dublin 12 Ireland

AIM: To determine if hyperpolarisation-activated nucleotide-gated(HCN) channels exist in human colon, and to investigate the expression of HCN channels in Hirschsprung's ***:We investigated HCN1,HCN2,HCN3 and HCN4 protein expression in pull-through specimens from patients with Hirschsprung’s disease(HSCR,n=10)using the proximal-most ganglionic segment and distalmost aganglionic segment,as well as in healthy control specimens obtained at the time of sigmoid colostomy closure in children who had undergone anorectoplasty for imperforate anus(n=10).Fluorescent immunohistochemistry was performed to assess protein distribution,which was then visualized using confocal ***:No HCN1 channel expression was observed in any of the tissues *** HCN2 and HCN4proteins were found to be equally expressed in the aganglionic and ganglionic bowel in HSCR and ***3 channel expression was found to be markedly decreased in the aganglionic colon vs ganglionic colon and ***2-4 channels were seen to be expressed within neurons of the myenteric and submucosal plexus of the ganglionic bowel and normal controls,and also co-localised to interstitial cells of Cajal in all tissues ***:We demonstrate HCN channel expression in human colon for the first *** HCN3expression in aganglionic bowel suggests its potential role in HSCR pathophysiology.

关键词： Hyperpolarisation-activated nucleotide-gated Interstitial cells of Cajal Hirschsprung’s Pacemaker Ih current