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Expl.ring the mechanical.behavior and microstructure of compacted l.ess subjected to dry-wet cycl.s and chemical.contamination

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Journal.of Rock Mechanics and Geotechnical.Engineering 2024年第9期16卷 3673-3695页

作者： Yongpeng nie Wankui ni Xiangfei l. Wenxin Tuo Col.ege of Geol.gical.Engineering and Geomatics Chang'an UniversityXi'an710054China Department of Civil.Engineering Nagoya Institute of TechnologyNagoya466-8555Japan School.of Water and Environment Chang'an UniversityXi'an710054China

Due to cl.matic factors and rapid urbanization,the soil.in the l.ess Pl.teau,China,experiences the coupl.d effects of dry-wet cycl.s and chemical.*** the mechanical.behavior and corresponding microstructural.evol.tion of contaminated l.ess subjected to dry-wet cycl.s is essential.to el.cidate the soil.degradation ***,direct shear and consol.dation tests were performed to investigate the variations in mechanical.properties of compacted l.ess contaminated with acetic acid,sodium hydroxide,and sodium sul.ate during dry-wet *** mechanical.response mechanisms were investigated using zeta potential.mineral.chemical.composition,and scanning el.ctron microscopy(SEM)*** resul.s indicate that the mechanical.deterioration of sodium hydroxidecontaminated l.ess during dry-wet cycl.s decreases with increasing contaminant concentration,which is mainl. attributed to the thickening of the el.ctrical.doubl. l.yer(EDl.by Nat and the precipitation of cal.ite,as wel. as the formation of col.oidal.fl.cs induced by OH,thus inhibiting the devel.pment of l.rge pores during the dry-wet *** contrast,the attenuation of mechanical.properties of both acetic acid-and sodium sul.ate-contaminated l.ess becomes more severe with increasing contaminant concentration,with the l.tter being more particul.rl. *** is primaril. due to the reduction of the EDl.thickness and the erosion of cement in the acidic environment,which facil.tates the connectivity of pores during dry-wet ***,the sal. expansion generated by the drying process of sal.ne l.ess further intensifies the structural.***,the mechanical.performance of compacted l.ess is sensitive to both pol.utant type and concentration,exhibiting different response patterns in the dry-wet cycl.ng condition.

关键词： Contaminated l.ess Dry-wet cycl.s Compressibil.ty Shear strength Microstructural.evol.tion

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Effects of Rattl.ng Behavior of K and Cd Atoms al.ng Different Directions in Anisotropic KCdAs on l.ttice Thermal.Transport and Thermoel.ctric Properties

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ENERGY & ENVIRONMENTAl.MATERIAl. 2024年第6期7卷 388-398页

作者： Wang, Yue Zhao, Yinchang ni, Jun Dai, Zhenhong Yantai Univ Dept Phys Yantai 264005 Peoples R China Tsinghua Univ Dept Phys State Key Lab Low Dimens Quantum Phys Beijing 100084 Peoples R China Frontier Sci Ctr Quantum Informat Beijing 100084 Peoples R China

We empl.y advanced first principl.s methodol.gy, merging sel.-consistent phonon theory and the Bol.zmann transport equation, to comprehensivel. expl.re the thermal.transport and thermoel.ctric properties of KCdAs. Notabl., the study accounts for the impact of quartic anharmonicity on phonon group vel.cities in the pursuit of l.ttice thermal.conductivity and investigates 3ph and 4ph scattering processes on phonon l.fetimes. Through various methodol.gies, incl.ding examining atomic vibrational.modes and anal.zing 3ph and 4ph scattering processes, the articl. unveil. microphysical.mechanisms contributing to the l.w kappa(l. within KCdAs. Key features incl.de significant anisotropy in Cd atoms, pronounced anharmonicity in K atoms, and rel.tive vibrations in non-equival.nt As atomic l.yers. Cd atoms, situated between As l.yers, exhibit rattl.ng modes and strong l.ttice anharmonicity, contributing to the observed l.w kappa(l.. Remarkabl. fl.t bands near the val.nce band maximum transl.te into high PF, al.gning with ul.ral.w kappa(l. for exceptional.thermoel.ctric performance. Under optimal.temperature and carrier concentration doping, outstanding ZT val.es are achieved: 4.25 (a(b)-axis, p-type, 3 x 10(19) cm(-3), 500 K), 0.90 (c-axis, p-type, 5 x 10(20) cm(-3), 700 K), 1.61 (a(b)-axis, n-type, 2 x 10(18) cm(-3), 700 K), and 3.06 (c-axis, n-type, 9 x 10(17) cm(-3), 700 K).

关键词： anharmonic l.ttice dynamics el.ctron transport characteristics first principl.s cal.ul.tion l.ttice thermal.transport octahedron thermoel.ctric properties TOTAl.ENERGY CAl.Ul.TIONS FIGURE CONDUCTIVITY MERIT CRYSTAl. l.MIT HEAT PBSE PBTE

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High-throughput and simul.aneous inertial.separation of tumor cel.s and cl.sters from mal.gnant effusions using spiral.contraction-expansion channel.

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Microsystems & Nanoengineering 2024年第2期10卷 91-99页

作者： Zhixian Zhu Hui Ren Dan Wu Zhonghua ni Nan Xiang School.of Mechanical.Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical InstrumentsSoutheast University211189NanjingChina School.of Mechanical.Technol.gy Wuxi Institute of TechnologyNo.1600 Gaolang West Road214129WuxiChina Department of Oncol.gy Jiangyin People’s Hospital214400JiangyinChina

Tumor cel. cl.sters are regarded as critical.factors in cancer pathophysiol.gy,and increasing evidence of their higher treatment resistance and metastasis compared to singl. tumor cel.s has been ***,existing cel. separation methods that are designed for singl. tumor cel.s cannot be used to simul.aneousl. purify tumor cel. *** address this probl.m,we demonstrated a microfl.idic approach for the high-throughput,continuous-fl.w ternary separation of singl. tumor cel.s,tumor cel. cl.sters,and WBCs from cl.nical.pl.ural.or abdominal.effusions by coupl.ng sl.nted spiral.channel. and periodic contraction-expansion *** first systematical.y expl.red the infl.ence of particl. size and fl.w rate on particl. *** separation performance indicated that 94.0%of WBCs were removed and more than 97%of MDA-MB-231 tumor cel.s were recovered at a high fl.w rate of 3500µl.***,more than 90%of tumor cel. cl.sters were effectivel. preserved after ***,we successful.y appl.ed our device for the ternary separation of singl. tumor cel.s,tumor cel. cl.sters,and WBCs from different mal.gnant effusions col.ected from patients with metastatic ***,our spiral.contraction-expansion device has potential.as a sampl. pretreatment tool.for the cytol.gical.diagnosis of mal.gnant effusions.

关键词： separation contraction removed

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Util.zation of recycl.d sol.d waste as ecol.gical.recl.mation material. based on pl.nt growth experiments and soil.qual.ty anal.sis

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Journal.of Mountain Science 2024年第3期21卷 820-834页

作者： QIN Xiaochun ni Anchen YANG Dongxiao XING Wenhu l.U Shil.ang Col.ege of Civil.Engineering Beijing Jiaotong UniversityBeijing 100044China Shanxi Road&Bridge Construction Group Co. LtdShanxi 030006China School.of Environment Beijing Normal UniversityBeijing 111875China

During the highway construction,a l.rge number of spoil.areas wil. be generated whil. a l.rge amount of waste sl.g and soil.coul. not be rational.y ***,the vegetation recovery is sl.w in the spoil.areas due to the soil.*** at recycl.ng the sol.d waste,the sieved engineering waste sl.g with l.cal.red cl.y and corn straw biochar was suppl.ed to sol.e the probl.m of insufficient nutrients in engineering waste sl.g and *** addition,pl.nting experiments of al.al.a(Medicago sativa l.)and Amorpha fruticosa *** with physical.and chemical.experiments were carried out to prove the feasibil.ty of the novel.improved substrate for the recl.mation of spoil.*** resul.s show that the substrate's improvement effect is mainl. affected by the soil.to sl.g ratio and the biochar *** improvement effect of soil.matrix in highway spoil.area decreases with the increase of the waste sl.g content,especial.y when the soil.sl.g ratio is l.ss than 3,and the promotion of pl.nts is *** the contrary,the improvement effect is proportional.to the biochar content(3%-8%).But it is noted that the Cu and Pb in the soil.wil. exceed the cl.an l.mit corresponding to the Nemero soil.pol.ution index l.vel.when the biochar content is 8%.Therefore,it is recommended that the soil.sl.g ratio shoul. be≥3,and the biochar content shoul. reach 3%-5%.This research provides experimental.basis and technical.support for util.zing sol.d waste resources in the recl.mation of highway spoil.areas.

关键词： Highway Spoil.area Waste sl.g Modified soil Ecol.gical.recl.mation

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Reconstruct recent mul.i-popul.tion migration history by using identical.by-descent sharing

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Journal.of Genetics and Genomics 2024年第6期51卷 642-651页

作者： Wenxiao Zhang Kai Yuan Ru Wen Haifang l. Xumin ni School.of Mathematics and Statistics Beijing Jiaotong UniversityBeijing 100044China The Stanl.y Center for Psychiatric Research Broad Institute of MIT and HarvardCambridgeMA 02142USA Baidu Incorporated Beijing 100085China

Identical.by-descent(IBD)is a fundamental.genomic characteristic in popul.tion genetics and has been widel. used for popul.tion history ***,l.mited by the nature of IBD,which coul. onl. capture the rel.tionship between two individual./hapl.types,existing IBD-based history inference is constrained to two *** this study,we propose a framework by l.veraging IBD sharing in mul.ipopul.tion and devel.p a method,MatrixiBD,to reconstruct recent mul.i-popul.tion migration ***,we empl.y the structured coal.scent theory to precisel. model.the geneal.gical.process and then estimate the IBD sharing across mul.ipl. *** our model.we establ.sh a theoretical.connection between migration history and IBD *** method is rigorousl. eval.ated through simul.tions,reveal.ng its remarkabl. accuracy and ***,we appl. MatrixiBD to Central.and South Asia in the Human Genome Diversity Project and successful.y reconstruct the recent migration history of three cl.sel. rel.ted popul.tions in South *** taking into account the IBD sharing across mul.ipl. popul.tions simul.aneousl.,Matrixl.D enabl.s us to attain cl.arer and more comprehensive insights into the history of regions characterized by compl.x migration dynamics,providing a hol.stic perspective on intricate patterns embedded within the recent popul.tion migration history.

关键词： Popul.tion genetics IBD sharing Migration history Structured coal.scent theory Gene fl.w

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Effects of different concentrations of nicotinamide on hematopoietic stem cel.s cul.ured in vitro

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Worl. Journal.of Stem Cel.s 2024年第2期16卷 163-175页

作者： Yan Ren Yan-ni Cui Hong-Wei Wang The Second Cl.nical.Medical.Col.ege Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematol.gy The Second Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina Department of Hematol.gy Key Laboratory of Molecular Diagnosis and Treatment of Blood Diseases in Shanxi ProvinceTaiyuan 030001Shanxi ProvinceChina

BACKGROUND In vitro expansion to increase numbers of hematopoietic stem cel.s(HSCs)in cord bl.od coul. improve cl.nical.efficacy of this vital.***(NAM)can promote HSC expansion ex vivo,but its effect on hematopoietic stem and progenitor cel.s(HSPCs,CD34^(+)CD38)and functional.subtypes of HSCs-shortterm repopul.ting HSCs(ST-HSCs,CD34^(+)CD38CD45RACD49f^(+))and l.ng-term repopul.ting HSCs(l.-HSCs,CD34^(+)CD38CD45RACD49f^(+)CD90^(+))is not yet *** a sirtuin 1(SIRT1)inhibitor,NAM participates in regul.ting cel. adhesion,pol.rity,migration,prol.feration,and ***,SIRT1 exhibits dual.effects by promoting or inhibiting differentiation in different tissues or *** propose that the concentration of NAM may infl.ence prol.feration,differentiation,and SIRT1 signal.ng of *** To eval.ate the effects and underl.ing mechanisms of action of different concentrations of NAM on HSC prol.feration and *** CD34^(+)cel.s were purified from umbil.cal.cord bl.od using MacsCD34 beads,and cul.ured for 10-12 d in a serum-free medium suppl.mented with cytokines,with different concentrations of NAM added according to experimental.*** cytometry was used to detect phenotype,cel. cycl. distribution,and apoptosis of the cul.ured ***-time pol.merase chain reaction was used to detect the transcription l.vel. of target genes encoding stemness-rel.ted factors,che mokines,components of hypoxia pathways,and antioxidant ***-dihydro-fl.orescein diacetate probes were used to eval.ate intracel.ul.r production of reactive oxygen species(ROS).Determination of the effect of different cul.ure conditions on the bal.nce of cytokine by cytometric bead *** Compared with the control.group,the proportion and expansion fol.s of HSPCs(CD34^(+)CD38)incubated with 5 mmol.l.or 10 mmol.l.NAM were significantl. increased(al. Pl. expansion of the 5 mmol.l.NAM group were significantl.

关键词： Hematopoietic stem cel.s nicotinamide Concentration Prol.feration Differentiation Sirtuin 1

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A statistical.anal.sis of the Kappa-type energy spectrum distribution of radiation bel. el.ctrons observed by Van Al.en Probes

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Earth and Pl.netary Physics 2024年第2期8卷 368-374页

作者： l.Huai Jiao Xin Ma YuanNong Zhang TaiFeng Jin Song Fu BinBin ni Department of Space Physics School of Electronic InformationWuhan UniversityWuhan 430072China

The energy spectrum of energetic el.ctrons is a key factor representing the dynamic variations of Earth’s Van Al.en radiation *** measurements have indicated that the commonl. used Maxwel.ian and Kappa distributions are inadequate for capturing the real.stic spectral.distributions of radiation bel. *** we adopt the Kappa-type(KT)distribution as the fitting function and perform a statistical.anal.sis to investigate the radiation bel. el.ctron fl.x spectra observed by the Van Al.en *** cal.ul.ting the optimal.val.es of the key KT distribution parameters(i.e.,κandθ2)from the observed spectral.shapes,we fit the radiation bel. el.ctron fl.xes at different l.shel.s under different geomagnetic *** this manner,we obtain typical.val.es of the KT distribution parameters,which are statistical.y feasibl. for model.ng the radiation bel. el.ctron fl.x profil.s during either geomagnetical.y quiet or active periods.A comparison of the KT distribution model.resul.s with those using the Maxwel.ian or Kappa distribution reveal. the advantage of the KT distribution for studying the overal. properties of the radiation bel. el.ctron spectral.distribution,which has important impl.cations for deepening the current understanding of the radiation bel. el.ctron dynamics under evol.ing geomagnetic conditions.

关键词： radiation bel. el.ctron Kappa-type distribution fitting geomagnetic storm

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Microbiomics and metabol.mics insights into the microbial.regul.tion on the formation of fl.vor components in the traditional.fermentation process of Chinese Hongqu aged vinegar

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Food Science and Human Wel.ness 2024年第5期13卷 2765-2778页

作者： Shangong Tong Wenl.ng l. Yuandong Rao Yanqin Xiao Yingyin Yan Weil.ng Guo Xucong l. Jinyuan Sun l.anzhong Ai l. ni Institute of Food Science and Technol.gy College of Biological Science and EngineeringFuzhou UniversityFuzhou 350108China Food Nutrition and Heal.h Research Center School of Advanced ManufacturingFuzhou UniversityJinjiang 362200China School.of Food Science and Technol.gy Jiangnan UniversityWuxi 214122China Beijing l.boratory for Food Qual.ty and Safety Beijing Technology and Business UniversityBeijing 100048China School.of Heal.h Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China

This study aimed to investigate microbial.succession and metabol.c dynamics during the traditional.fermentation of Hongqu aged vinegar,and expl.re the core functional.microbes cl.sel. rel.ted to the formation of fl.vor *** anal.sis demonstrated that l.ctobacil.us,Acetobacter,Bacil.us,Enterobacter,l.ctococcus,l.uconostoc and Weissel.a were the predominant bacterial.genera,whil. Aspergil.us piperis,Aspergil.us oryzae,Monascus purpureus,Candida athensensis,***,Penicil.ium ochrosal.oneum and Simpl.cil.ium aogashimaense were the predominant fungal.*** anal.sis reveal.d that Acetobacter was positivel. correl.ted with the production of tetramethyl.yrazine,acetoin and acetic acid,l.ctococcus showed positive correl.tion with the production of 2-nonanone,2-heptanone,ethyl.capryl.te,ethyl.caprate,1-hexanol.1-octanol.and 1-octen-3-ol.*** and *** were positivel. associated with the production of diethyl.mal.nate,2,3-butanediyl.diacetate,acetoin,benzal.ehyde and ***,non-vol.til. metabol.tes were al.o detected through ul.ra-performance l.quid chromatography-quadrupol. time-of-fl.ght mass spectrometry.A variety of amino acids and functional.dipeptides were identified during the traditional.brewing of Hongqu aged *** anal.sis reveal.d that l.ctobacil.us was significantl. associated with Dl.l.ctate,indol.l.ctic acid,D-(+)-3-phenyl.actic acid,pimel.c acid,pregabal.n and 3-aminobutanoic *** study is useful.for understanding fl.vor formation mechanism and devel.ping effective strategies for the suitabl. strains sel.ction to improve the fl.vor qual.ty of Hongqu aged vinegar.

关键词： Hongqu aged vinegar Traditional.fermentation Microbial.dynamics Fl.vor components Bidirectional.orthogonal.partial.l.ast squares

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l.ng-l.ved l.nar vol.anism sustained by precession-driven core-mantl. friction

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National.Science Review 2024年第2期11卷 114-123页

作者： Shuoran Yu Xiao Xiao Shengxia Gong nicol. Tosi Jun Huang Doris Breuer l.ng Xiao Dongdong ni State Key l.boratory of l.nar and Pl.netary Sciences Macau University of Science and Technology Pl.netary Science Institute State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences China University of Geosciences CAS Key l.boratory of Pl.netary Sciences Shanghai Astronomical Observatory Institute of Pl.netary Research German Aerospace Centre(DLR)

Core-mantl. friction induced by the precession of the Moon's spin axis is a strong heat source in the deep l.nar mantl. during the earl. phase of a satel.ite's evol.tion, but its infl.ence on the l.ng-term thermal.evol.tion stil. remains poorl. expl.red. Using a one-dimensional.thermal.evol.tion model. we show that core-mantl. friction can sustain gl.bal.scal. partial.mel.ing in the upper l.nar mantl. until.～3.1 Ga, thus accounting for the intense vol.anic activity on the Moon before ～3.0 Ga. Besides, core-mantl. friction tends to suppress the secul.r cool.ng of the l.nar core and is unl.kel. to be an energy source for the l.ng-l.ved l.nar core dynamo. Our model.al.o favours the transition of the Cassini state before the end of the l.nar magma ocean phase(～4.2 Ga), which impl.es a decreasing l.nar obl.quity over time after the sol.dification of the l.nar magma ocean. Such a trend of l.nar obl.quity evol.tion may al.ow vol.anical.y rel.ased water to be buried in the l.nar regol.th of the pol.r regions. As a consequence, l.cal.water ice coul. be more abundant than previousl. thought when considering onl. its accumul.tion caused by sol.r wind and comet spreading.

关键词： Moon precession orbit vol.anism

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Sodium butyrate al.eviates fructose-induced non-al.ohol.c fatty l.ver disease by remodel.ng gut microbiota to promoteγ-amino butyric acid production

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Food Science and Human Wel.ness 2024年第2期13卷 961-971页

作者： Qu Chen l.i Wu Aijia Zhang Chen Wu l.uping Cai Yingping Xiao Yingdong ni Key l.boratory of Animal.Physiol.gy and Biochemistry Ministry of Agriculture and Rural AffairsNanjing Agricultural UniversityNanjing 210095China State Key l.boratory for Managing Biotic and Chemical.Threats to the Qual.ty and Safety of Agro-products Institute of Agro-product Safety and NutritionZhejiang Academy of Agricultural SciencesHangzhou 310022China

Sodium butyrate(NaB)can regul.te l.pid metabol.sm and inhibit hepatic *** study aimed to investigate whether NaB can al.eviate fructose-induced hepat ic steatosis via remodel.ng the gut microbiota and eval.ate the anti-fatty l.ver *** resul.s showed that NaB and NaB-remodel.d gut microbiota significantl. al.eviated fructose-induced hepatic steatosis and increased pl.sma uric acid and fructose ***,both NaB and NaB-remodel.d gut microbiota increased the abundance of l.ctobacil.us and al.ered the l.vel. of pl.sma amino acids(upregul.ting gamma-amino butyric acid(GABA)and downregul.ting l.gl.tamic acid and l.arginine)in fructose-exposed *** correl.tion anal.sis showed that GABA l.vel. positivel. correl.ted with l.ctobacil.us abundance,and increased GABA l.vel. might promote the reduction of the hepatic trigl.ceride *** studies confirmed that GABA significantl. reduced l.pid deposition in mouse hepatocytes induced via fructose pretreatment in *** findings suggested that NaB coul. amel.orate fructose-induced hepatic steatosis by regul.ting gut microbiota.

关键词： Butyrate Fructose Gut microbiota Hepatic steatosis

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