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Low Thrust Minimum Time Orbit Transfer Nonlinear Optimization Using Impulse Discretization via the Modified Picard–Chebyshev Method

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Computer Modeling in Engineering & Sciences 2016年第1期111卷 1-27页

作者： Darin Koblick Shujing Xu Joshua Fogel praveen shankar California State University-Long Beach CAUSA. Millennium Space Systems Inc. El SegundoCAUSA. Claremont Graduate University CAUSA. University of California-San Diego CAUSA. University of Southern California Los AngelesCAUSA.

The Modified Picard-Chebyshev Method(MPCM)is implemented as an orbit propagation solver for a numerical optimization method that determines minimum time orbit transfer trajectory of a satellite using a series of multiple impulses at intermediate *** waypoints correspond to instantaneous impulses that are determined using a nonlinear constrained optimization routine,SNOPT with numerical force models for both Two-Body and J2 *** is found that using the MPCM increases run-time performance of the discretized lowthrust optimization method when compared to other sequential numerical solvers,such as Adams-Bashforth-Moulton and Gauss-Jackson 8th order methods.

关键词： Low Thrust Picard–Chebyshev Optimization Multi-Impulse Boundary Value Problem.

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Analysis of docosanol using GC/MS:Method development,validation,and application to ex vivo human skin permeation studies

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Journal of Pharmaceutical Analysis 2022年第2期12卷 287-292页

作者： Vijay Kumar shankar Mei Wang Srinivas Ajjarapu praveen Kolimi Bharathi Avula Reena Murthy Ikhlas Khan Sathyanarayana Narasimha Murthy Department of Pharmaceutics and Drug Delivery University of MississippiOxfordMS38677USA Natural Products Utilization Research Unit Agricultural Research ServiceU.S.Department of AgricultureOxfordMS38677USA National Center for Natural Products Research Research Institute of Pharmaceutical SciencesSchool of PharmacyUniversity of MississippiOxfordMS38677USA Topical Products Testing LLC OxfordMS38677USA

Docosanol is the only US Food and Drug Administration(FDA)approved over-the-counter topical product for treating recurrent oral-facial herpes simplex *** analytical methods for docosanol are required to demonstrate the bioequivalence of docosanol topical products.A gas chromatography/selected ion monitoring mode mass spectrometry(GC/SIM-MS)method was developed and validated for docosanol determination in biological *** and isopropyl palmitate(internal standard)were separated on a high-polarity GC capillary column with(88%cyanopropy)aryl-polysiloxane employed as the stationary *** ions of m/z 83 and 256 were selected to monitor docosanol and isopropyl palmitate,respectively;the total run time was 20 *** GC/SIM-MS method was validated in accordance with US FDA guidelines,and the results met the US FDA acceptance *** docosanol calibration standards were linear in the 100-10000 ng/mL concentration range(R^(2)>0.994).The recoveries for docosanol from the receptor fluid and skin homogenates were>93.2%and>95.8%,*** validated method was successfully applied to analyze ex vivo human cadaver skin permeation *** applying Abreva®cream tube and Abreva®cream pump,the amount of docosanol that penetrated human cadaver skin at 48 h was 21.5±7.01 and 24.0±6.95 ng/mg,***,we concluded that the validated GC/SIM-MS was sensitive,specific,and suitable for quantifying docosanol as a quality control *** method can be used for routine analysis as a costeffective alternative to other techniques.

关键词： Docosanol Fatty alcohols Gas chromatography-mass spectrometry Topical formulation Skin permeation

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Influence of Calcium Chloride and Sodium Silicate on Index and Engineering Properties of Bentonite

Influence of Calcium Chloride and Sodium Silicate on Index a...

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International Conference on Computer Graphics,Simulation and Modeling(ICGSM’2012);International Conference on Production,Materials and Automobile Engineering(ICPMAE2012);International Conference on Advances in Transformers and Electronics Engineering(ICATEE’2012);International Conference on Chemical,Environmental Science and Engineering(ICEEBS’2012);International Conference on Business Intelligence and Humanities(ICBEBS’2012);International Conference on Biological,Biomedical and Pharmaceutical Sciences(ICCEPS’2012)

作者： M. Heeralal V. Ramana Murty G.V. praveen S. shankar National Institute of Technology S.R. Engineering College

Bentonite is well known for its suitability as molding material in pottery and utensils, drilling mud to support the vertical sides of bore holes. Despite several favorable properties of bentonite for the above applications, such deposits exhibit large volume changes upon wetting and drying due presence of montmorillonite clay mineral with expandable lattice structure. In view of huge cyclic volumetric changes, these deposits are discouraged for construction activity. However, when it is inevitable to construct structures or run a high way, a canal or a pipe line in their deposits, suitable remedial techniques to combat the damages caused by them are to be adopted. In the present study an attempt has been made to study the influence of CaCl2 and Na2SiO3 on Atterberg limits, swell, strength and consolidation properties of bentonite and the effect of individual and combined influence of chemical additives on the above properties of Bentonite is investigated.

关键词： Bentonite Calcium Chloride consolidation Sodium Silicate strength swell

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