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Severe acute kidney injury due to oxalate crystal induced severe interstitial nephritis:A case report

World Journal of Nephrology 2024年第2期13卷 24-30页

作者： Maulik K Lathiya praveen errabelli Sasmit Roy Neeharik Mareedu Department of Emergency Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Centra Lynchburg General HospitalLynchburgVA 24551United States Department of Nephrology UPMC Western MarylandCumberlandMD 21502United States

BACKGROUND Acute kidney injury(AKI)due to interstitial nephritis is a known condition primarily attributed to various *** medication-induced interstitial nephritis is common,occurrences due to non-pharmacological factors are *** report presents a case of severe AKI triggered by intratubular oxalate crystal deposition,leading to interstitial *** aim is to outline the case and its management,emphasizing the significance of recognizing uncommon causes of interstitial *** SUMMARY A 71-year-old female presented with stroke-like symptoms,including weakness,speech difficulties,and cognitive *** hypertension had been managed with hydrochlorothiazide(HCTZ)for over two *** admis-sion,severe hypokalemia and AKI were noted,prompting discontinuation of HCTZ and initiation of prednisolone for acute interstitial *** investigations,including kidney biopsy,confirmed severe acute interstitial nephritis with oxalate crystal deposits as the underlying *** treatment,initial renal function showed minimal ***,with prednisolone therapy and supportive measures,her condition gradually improved,high-lighting the importance of comprehensive *** This case underscores the importance of a thorough diagnostic approach in identifying and addressing uncommon causes of interstitial *** occurrence of interstitial nephritis due to oxalate crystal deposition,especially without typical risk factors,emphasizes the need for vigilance in clinical practice.

关键词： Acute kidney injury Interstitial nephritis Oxalate crystal Hydrochlorothiazide Hypokalemia Case report

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World Journal of Nephrology 2023年第3期12卷 66-72页

作者： Maulik K Lathiya praveen errabelli Salvatore Mignano Susan M Cullinan Department of Emergency Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Pathology Mayo ClinicRochesterMN 55905United States

BACKGROUND Anaplasmosis is a tick-borne disease with a range of clinical manifestations,from a flu-like illness with fever and myalgias to a severe systemic disease with multisystem organ *** renal involvement is not a common presentation,there have been few cases reporting acute kidney injury from *** SUMMARY We present a 55-year-old female with anaplasmosis who developed acute kidney injury due to membranoproliferative glomerulonephritis(MPGN).The patient originally presented with cough and shortness of *** was admitted to the hospital with a diagnosis of community acquired pneumonia and received *** the hospital course she developed severe acute renal *** serological work up didn’t provide any conclusive ***,she underwent kidney biopsy which showed MPGN pattern suggesting autoimmune,multiple myeloma or infectious *** work up was undertaken which was negative for autoimmune diseases,vasculitis panel,paraproteinemias but tested positive for IgG anaplasma with high titers indicating *** Our case shows a unique presentation of severe acute renal failure from MPGN from tick borne *** is usually seen with autoimmune diseases,hepatitis C virus infections,***,we suggest that tick borne illness should also be considered when evaluating acute renal failure cases in tick borne prevalent regions.

关键词： Acute kidney injury Membranoproliferative glomerulonephritis Tick-borne Anaplasmosis Case report

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Severe hypernatremia in hyperglycemic conditions;managing it effectively:A case report

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World Journal of Critical Care Medicine 2023年第1期12卷 29-34页

作者： Maulik K Lathiya praveen errabelli Susan M Cullinan Emeka J Amadi Department of Emergency Mayo Clinic Health SystemEau ClaireWI 54703United States Department of Nephrology Mayo Clinic Health SystemEau ClaireWI 54703United States Hospital Internal Medicine Mayo Clinic Health SystemEau ClaireWI 54703United States

BACKGROUND Diabetic ketoacidosis(DKA)and hyperglycemic hyperosmolar state(HHS)are common acute complications of diabetes mellitus with a high risk of *** combined with hypernatremia,the complications can be even *** is a rarely associated with DKA and HHS as both are usually accompanied by normal sodium or *** a result,a structured and systematic treatment approach is *** discuss the therapeutic approach and implications of this uncommon *** SUMMARY A 62-year-old man with no known past medical history presented to emergency department with altered mental *** work up in emergency room showed severe hyperglycemia with a glucose level of 1093 mg/dL and severe hypernatremia with a serum sodium level of 169 mEq/*** was admitted to the intensive care unit(ICU)and was started on insulin drip as per DKA *** 12 h of ICU admission,blood sugar was 300 mg/*** his mental status didn’t show much *** was dehydrated and had a corrected serum sodium level of>190 mEq/*** a result,dextrose 5%in water and ringer's lactate were *** was also given free water via an nasogastric(NG)tube and IV Desmopressin to improve his free water deficit,which improved his serum sodium to 140 mEq/*** The combination of DKA,HHS and hypernatremia is rare and extremely challenging to manage,but the most challenging part of this condition is selecting the correct type of fluids to treat these *** case illustrates that desmopressin and free water administration via the NG route can be helpful in this situation.

关键词： Diabetic ketoacidosis Hyperglycemic hyperosmolar state Hypernatremia Hyperglycemia Desmopressin Case repot

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Pile foundation in alternate layered liquefiable and non-liquefiable soil deposits subjected to earthquake loading

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 359-376页

作者： praveen Huded M Suresh R Dash LEA Associates South East Asia Pvt.Ltd. New Delhi 110044India Indian Institute of Technology Bhubaneswar Khurda 752050India

Pile foundations are still the preferred foundation system for high-rise structures in earthquake-prone *** foundations have experienced failures in past earthquakes due to *** on pile foundations in liquefiable soils has primarily focused on the pile foundation behavior in two or three-layered soil ***,in natural occurrence,it may occur in alternative layers of liquefiable and non-liquefiable ***,the experimental and/or numerical studies on the layered effect on pile foundations have not been widely addressed in the *** of the design codes across the world do not explicitly mention the effect of sandwiched non-liquefiable soil layers on the pile *** the present study,the behavior of an end-bearing pile in layered liquefiable and non-liquefiable soil deposit is studied *** study found that the kinematic bending moment is higher and governs the design when the effect of the sandwiched non-liquefied layer is considered in the analysis as opposed to when its effect is ***,ignoring the effect of the sandwiched non-liquefied layer in a liquefiable soil deposit might be a nonconservative design approach.

关键词： pile foundation liquefaction alternately layered soil fixity effect layered effect

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Designing Sustainable Thermal Energy System with Electro-Photo Conversion

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Journal of Thermal Science 2024年第5期33卷 1642-1656页

作者： praveen BARMAVATU Sunil Kumar KOTHAPALLI Abilash RADHAKRISHNAN Dani Jermisha RAILIS Department of Mechanical Engineering Faculty of EngineeringUniversidad Tecnologica MetropolitanaSantiago 7810003Chile SRKR Engineering College BhimavaramWest GodavariAndhra Pradesh 534204India Maria College of Engineering and Technology Attoor629177Tamil NaduIndia

Thermal energy conversion and also storage system is to advance knowledge and develop practical solutions at the intersection of micro and nano-scale engineering,energy conversion,and *** research addresses the challenge of enhancing these critical aspects to ensure prolonged system performance and durability in the context of evolving energy *** research analyses the anti-oxidation and filtration behaviours of micro and nano-scale structures in the context of electro-and photo-thermal energy conversion and also storage systems.A micro multiscale hierarchical structure strategy is presented to fabricate multi-scale double-layer porous wick evaporators with the electrospun nanofibers made of gelatin-polyamide 6(GPA6)and Ti_(3)C_(2)T_(x)MXene/silver nanowire with Cellulose Micro/NanoFibers(CMNF)cryogens by using spark plasma sintering(SPS)based high-pressure hydrothermal treatment *** excellent anti-oxidation effect was offered by coating the film in thermal conditions and the anti-oxidation properties were further examined from 500℃to850℃.The results are analysed using Matlab software to improve the efficiency of energy conversion processes by integrating nanostructures into thermal systems,to increase energy output while minimizing *** silver nanowire is with a heat transfer coefficient of 78%,a mass remaining rate of 98.7%,and an energy storage efficiency of 23.8%.This study enhances energy density and duration by integrating nanostructures into thermal systems while minimizing energy losses,and it not only exhibits excellent anti-oxidation properties but also possesses superior filtration capabilities for designing and engineering multifunctional nanomaterials.

关键词： heat exchanger micro and nano-scale structure electro-and photo-thermal energy conversion and storage system anti-oxidation filtration behaviour

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A survey on automatic dashboard recommendation systems

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Visual Informatics 2024年第1期8卷 67-79页

作者： praveen Soni Cyril de Runz Fatma Bouali Gilles Venturini LIFAT University of Tours64 avenue Jean PortalisTours37200France IUT C University of Lille53 Rue de l’AlmaRoubaix59100France

This paper presents a survey on automatic or semi-automatic recommendation systems that help users create *** starts by showing the important role that dashboards play in data science,and gives an informal definition of dashboards,i.e.,a set of visualizations possibly with linkage,a screen layout and user *** are mainly interested in systems that use a fully or partially automatic mechanism to recommend dashboards to *** automation includes the suggestion of data and visualizations,the optimization of the layout and the use of user *** position our work with respect to existing *** from a set of over 1000 papers,we have selected and analyzed 19 papers/systems along several *** main dimensions were the set of considered visualizations,the suggestion method,the utility/objective functions,the layout,and the user *** conclude by highlighting the main achievements in this domain and by proposing perspectives.

关键词： Automatic visualization Dashboard recommendation Multiple view interfaces

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A Novel Multi-objective Protection Coordination Scheme for a Microgrid with Optimal Deployment of Dual-setting ROCOV Based Relays

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Protection and Control of Modern Power Systems 2024年第4期9卷 23-38页

作者： praveen Kumar Gupta Priyanshul Niranjan Niraj Kumar Choudhary Nitin Singh Ravindra Kumar Singh the Department of Electrical Engineering Motilal Nehru National Institute of Technology AllahabadPrayagraj 211004India

Relay coordination is crucial in electrical power systems to protect against malfunctions and damage caused by unexpected events like short *** address the challenge associated with the reverse direction of fault current,dual-setting(DS)directional over-current relays have evolved but failed to provide proper coordination during changes of load,generation,and *** the meantime,with the increasing number of DS relays,the total relay operating time tends to ***,this paper proposes a protection scheme based on the optimal deployment of conventional and dual-setting rate of change of voltage(DS-ROCOV)relays in distribution *** holds true for varying network topologies and is unaffected by variations in load and *** objective of the proposed scheme is to ensure reliable and efficient protection against faults in distribution systems by minimizing the overall operating time with the optimal number of DS-ROCOV *** proposed protection scheme’s performance is evaluated for different coordination time interval values as well as in different microgrid *** paper outlines the design and implementation of the proposed protection scheme which is validated on the modified IEEE 14-bus system using simulations in Matlab/Simulink.

关键词： Coordination time interval DS-ROCOV relay multi-objective optimization optimal-deployment protection coordination

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DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice

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Genes & Diseases 2024年第4期11卷 368-380页

作者： Dafei Chai Xu Wang praveen Neeli Shan Zhou Xingfang Yu Kanaga Sabapathy Yong Li Department of Medicine Section of Epidemiology and Population SciencesDan L Duncan Comprehensive Cancer CenterBaylor College of MedicineHoustonTX 77030USA Division of Cellular&Molecular Research Humphrey Oei Institute of Cancer ResearchNational Cancer Centre SingaporeSingapore 168583Singapore

tThe tumor suppressor p53 is the most common mutated gene in cancer,with the R175H as the most frequent p53 missense ***,there are currently no approved targeted therapies or immunotherapies against mutant ***,we characterized and inves-tigated a monoclonal antibody(mAb)that recognizes the mutant p53-R175H for its affinity,specificity,and activity against tumor cells in *** then delivered DNA plasmids expres-sing the anti-R175H mAb or a bispecific antibody(BsAb)into mice to evaluate their therapeutic *** results showed that the anti-R175H mAb specifically bound to the p53-R175H an-tigen with a high affinity and recognized the human mutant p53-R175H antigen expressed on HEK293T or MC38 cells,with no cross-reactivity with wild-type *** cultured cells,the anti-R175H mAb showed higher cytotoxicity than the control but did not induce antibody-dependent cellular *** made a recombinant MC38 mouse cell line(MC38-p53-R175H)that overexpressed the human p53-R175H after knocking out the endogenous mutant p53 *** vivo,administration of the anti-R175H mAb plasmid elicited a robust anti-tumor effect against MC38-p53-R175H in *** administration of the anti-R175H BsAb plasmid showed no therapeutic effects,yet potent anti-tumor activity was observed in combination with the anti-PD-1 *** results indicate that targeting specific mutant epitopes using DNA-delivered mAbs or BsAbs presents a form of improved natural immunity derived from tumor-infiltrating B cells and plasma cells against intracellular tumor antigens.

关键词： BsAb Cytotoxicity mAb Mutant p53 PD-1 R175H

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Improving hydrogen evolution reaction efficiency through lattice tuning

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Nano Research 2024年第7期17卷 5907-5913页

作者： Zipeng Zhao Haotian Liu Wenpei Gao praveen Kolla Wang Xue Zeyan Liu Jinghua Guo Sanjeev Mukerjee Xiaoqing Pan Qingying Jia Xiangfeng Duan Yu Huang Department of Materials Science and Engineering University of CaliforniaLos AngelesCalifornia 90095USA Department of Chemical Engineering and Materials Science University of CaliforniaIrvineCalifornia 92697USA Materials Science and Engineering North Carolina State UniversityRaleighNorth Carolina 27695USA Department of Chemistry and Chemical Biology Northeastern UniversityBostonMassachusetts 02115USA Department of Chemistry and Biochemistry University of CaliforniaLos AngelesCalifornia 90095USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720USA Department of Chemistry and Biochemistry University of CaliforniaSanta CruzCalifornia 95064USA Department of Physics and Astronomy University of CaliforniaIrvineCalifornia 92697USA California Nanosystems Institute University of CaliforniaLos AngelesCalifornia 90095USA

The intermittent nature of renewable energy sources sets a requirement for efficient energy storage to mitigate the conflict between energy supply and *** is a promising choice for energy storage due to its high energy ***,the conversion of electrical energy to chemical energy stored in hydrogen through water electrolysis suffers from low efficiency,and the electricity cost dominates the total cost of hydrogen ***,we report the study of improving the hydrogen evolution reaction activity of Pt-based catalysts by building a nanoscale surface NiO and Pt interface,further optimizing the performance via tuning the lattice parameter of the core of nanoparticles,which can be achieved by varying the dealloying annealing *** optimized PtCuNi-O/C and PtNi-O/C catalysts are demonstrated to be one of the best catalysts,with a mass activity(MA)of 9.1 and 8.7 mA/μgPt,which is 9.9-fold and 9.5-fold of that of Pt/C,respectively.

关键词： lattice tuning Pt-based catalyst hydrogen evolution reaction electrocatalysis

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Global lessons on delivery of primary healthcare services for people with non-communicable diseases:convergent mixed methods

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Family Medicine and Community Health 2024年第3期12卷 13-24页

作者： Robert Mash Lisa R Hirschhorn Inayat Singh Kakar Renu John Manushi Sharma Devarsetty praveen Stellenbosch University StellenboschSouth Africa Northwestern University ChicagoIllinoisUSA The George Institute for Global Health New DelhiIndia The George Institute for Global Health HyderabadIndia Manipal Academy of Higher Education ManipalIndia

Objective To extract key lessons on primary healthcare(PHC)service delivery strategies for non-communicable diseases(NCD)from the work of researchers funded by the Global Alliance for Chronic Diseases(GACD).Design A convergent mixed methods study that extracted data using a standardised template from research projects funded by the GACD that focused on *** strategies implemented in these studies were mapped onto the PHC Performance Initiative *** qualitative interviews were conducted with researchers from purposefully selected projects to understand the strategies and contextual factors in more *** PHC contexts from low or middle-income countries(LMIC)as well as vulnerable groups within high-income *** came from all regions of the world,particularly East Asia and Pacific,sub-Saharan Africa,South Asia,Latin America and *** The study extracted data on 84 research projects and interviewed researchers from 16 research *** Research projects came from all regions of the world,and mainly focused on diabetes(35.3%),hypertension(28.3%)and mental health(27.6%).Mapped onto the PHC Performance Initiative framework:49.4%focused on high-quality PHC(particularly the comprehensiveness of NCD care,41.2%);41.2%on the availability of PHC services(particularly the competence of healthcare workers,36.5%);35.3%on population health management(particularly community-based services,35.3%);34.1%on facility organisation and management(particularly team-based care,20.0%)and 31.8%on access(particularly digital technology,23.5%).Most common strategies were task shifting and training to improve the comprehensiveness of NCD care through community-based *** factors related to inputs:infrastructure,equipment and medication,workforce(particularly community health workers),finances,health information systems and digital *** Key strategies and contextual factors to improve PHC service del

关键词： services convergent income

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