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Effect of biosynthesized Silver Nanoparticles on Staphylococcus aureus biofilm Quenching and Prevention of biofilm Formation

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Nano-Micro Letters 2012年第1期4卷 34-39页

作者： pratik R.Chaudhari Shalaka A.Masurkar Vrishali b.Shidore Suresh P.Kamble Center for biotechnology Pravara Institute of Medical Sciences

The development of green experimental processes for the synthesis of nanoparticles is a need in the field of nanotechnology. The synthesis of silver nanoparticles was achieved using bacillus cereus supernatant and1 m M silver nitrate. 100 m M glucose was found to quicken the rate of reaction of silver nanoparticles ***-visible spectrophotometric analysis was carried out to assess the synthesis of silver nanoparticles. The synthesized silver nanoparticles were further characterized by using Nanoparticle Tracking Analyzer(NTA),Transmission Electron Microscope and Energy Dispersive X-ray spectra. These silver nanoparticles showed enhanced quorum quenching activity against Staphylococcus aureus biofilm and prevention of biofilm formation which can be seen under inverted microscope(40 X). The synergistic effect of silver nanoparticles along with antibiotics in biofilm quenching was found to be effective. In the near future, silver nanoparticles could be used in the treatment of infections caused by highly antibiotic resistant biofilm.

关键词： Silver Nanoparticles Green Synthesis bacillus cereus biofilm Quorum Quenching

Effect of vanadium on colonic aberrant crypt loci induced in rats by 1,2 Dimethyl hydrazine

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World Journal of Gastroenterology 2003年第5期9卷 1020-1027页

作者： PSuresh Kanna Cb Mahendrakumar T Chakraborty P Hemalatha pratik b.nerjee M Chatterjee Division of biochemistry Department of Pharmaceutical TechnologyJadavpur UniversityKolkata-700032(Calcutta)India

AIM: To investigate the chemo preventive effects of vanadium on rat colorectal carcinogenesis induced by 1,2-dimethylhydrazine (DMH).METHODS: Male Sprague-Dawley Rats were randomly divided into four groups. Rats in Group A received saline vehicle alone for 16 weeks. Rats in Group b were given DMH injection once a week intraperitoneally for 16 weeks;rats in Group C, with the same DMH treatment as in the Group b, but received 0.5-ppm vanadium in the form ammonium monovanadate ad libitum in drinking water. Rats in the Group D received vanadium alone as in the Group C without DMH ***: Aberrant crypt foci (ACF) were formed in animals in DMH-treated groups at the end of week *** to DMH group, vanadium treated group had less ACF (P＜0.001). At the end of week 32, all rats in DMH group developed large intestinal tumors. Rats treated with vanadium contained significantly few colonic adenomas and carcinomas (P＜0.05) compared to rats administered DMH only. In addition, a significant reduction (P＜0.05) in colon tumor burden (sum of tumor sizes per animal) was also evident in animals of Group C when compared to those in rats of carcinogen control Group b. The results also showed that vanadium significantly lowered PCNA index in ACF (P＜0.005). Furthermore, vanadium supplementation also elevated liver GST and Cyt P-450 activities (P＜0.001 and P＜0.02, respectively).CONCLUSION: Vanadium in the form of ammonium monovanadate supplemented in drinking water ad libitum has been found to be highly effective in reducing tumor incidence and preneoplastic foci on DMH-induced colorectal carcinogenesis. These findings suggest that vanadium administration can suppress colon carcinogenesis in rats.

关键词： 1,2-甲基肼结直肠癌肿瘤抑制结肠异常小囊动物实验肿瘤生成

Meta-analysis of transanal vs laparoscopic total mesorectal excision of low rectal cancer:Importance of appropriate patient selection

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World Journal of Gastrointestinal Surgery 2022年第12期14卷 1397-1410页

作者： pratik bhattacharya Ishaan Patel Noureen Fazili Shahab Hajibandeh Shahin Hajibandeh Department of Surgery Sandwell and West Birmingham Hospitals NHS TrustBirmingham B714HJUnited Kingdom Department of Surgery Queen Elizabeth Hospital BirminghamBirmingham B152GWUnited Kingdom Department of Surgery University Hospital of WalesCardiff CF144XWUnited Kingdom Department of Surgery Royal Stoke University HospitalStoke-on-Trent ST46QGUnited Kingdom

bACKGROUND Achieving a clear resection margins for low rectal cancer is technically *** approach to total mesorectal excision(TME)was introduced in order to address the challenges associated with the laparoscopic approach in treating low rectal ***,previous meta-analyses have included mixed population with mid and low rectal tumours when comparing both approaches which has made the interpretation of the real differences between two approaches in treating low rectal cancer *** To investigate the outcomes of transanal TME(TaTME)and laparoscopic TME(LaTME)in patients with low rectal *** A comprehensive systematic review of comparative studies was performed in line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** and postoperative complications,anastomotic leak,R0 resection,completeness of mesorectal excision,circumferential resection margin(CRM),distal resection margin(DRM),harvested lymph nodes,and operation time were the investigated outcome *** We included twelve comparative studies enrolling 969 patients comparing TaTME(n=969)and LaTME(n=476)in patients with low rectal *** was associated with significantly lower risk of postoperative complications(OR:0.74,P=0.04),anastomotic leak(OR:0.59,P=0.02),and conversion to an open procedure(OR:0.29,P=0.002)in comparison with ***,the rate of R0 resection was significantly higher in the TaTME group(OR:1.96,P=0.03).Nevertheless,TaTME and LaTME were comparable in terms of rate of intraoperative complications(OR:1.87;P=0.23),completeness of mesoractal excision(OR:1.57,P=0.15),harvested lymph nodes(MD:-0.05,P=0.96),DRM(MD:-0.94;P=0.17),CRM(MD:1.08,P=0.17),positive CRM(OR:0.64,P=0.11)and procedure time(MD:-6.99 min,P=0.45).CONCLUSION Our findings indicated that for low rectal tumours,TaTME is associated with better clinical and short term oncological outcomes compared to *** randomised controll

关键词： Total mesorectal excision Laparoscopic Transanal Rectal cancer

Comparison of Scour and Flow Characteristics Around Circular and Oblong bridge Piers in Seepage Affected Alluvial Channels

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Journal of Marine Science and Application 2018年第2期17卷 254-264页

作者： Rutuja Chavan b.Venkataramana pratik Acharya bimlesh Kumar Department of Civil Engineering Indian Institute of Technology GuwahatiGuwahati 781039India

The present study examines scour geometry and turbulent flow characteristics around circular and oblong piers in alluvial channel with downward *** were conducted in plane sand bed of non-uniform sand under no seepage,10%seepage and 15%seepage *** depth at oblong pier is significantly lesser than the scour depth at circular ***,the scour depth at both piers reduces with downward *** measurements show that the velocity and Reynolds stresses are negative near the bed at upstream of piers where the strong reversal *** downstream of oblong pier near the free surface,velocity and Reynolds stresses are less positive;whereas,they are negative at downstream of circular *** streamline shape of oblong pier leads to reduce the strength of wake vortices and consequently reversal flow at downstream of *** application of downward seepage turbulent kinetic energy is *** results show that the wake vortices at oblong pier are weaker than the wake vortices at circular *** strength of wake vortices diminishes with downward *** Strouhal number is lesser for oblong pier and decreases with downward seepage for both oblong and circular piers.

关键词： Downward seepage Oblong pier Scour Strouhal number Turbulent kinetic energy

Outcomes of severe sepsis and septic shock patients after stratifi cation by initial lactate value

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World Journal of Emergency Medicine 2018年第2期9卷 113-117页

作者： Kimberly A. Chambers Adam Y. Park Rosa C. banuelos bryan F. Darge bindu H. Akkanti Annamaria Macaluso Manoj Thangam pratik b. Doshi Department of Emergency Medicine McGovern Medical School at UTHealth Houston TX USA McGovern Medical School at UTHealth Houston TX USA Division of Critical Care Department of Internal Medicine McGovern Medical School at UTHealth Houston TX USA Department of Emergency Medicine University of California San Francisco CA USA Memorial Hermann Hospital - Texas Medical Center Houston TX USA Department of Internal Medicine McGovern Medical School at UTHealth Houston TX USA

bACKGROUND: In the setting of severe sepsis and septic shock, mortality increases when lactate levels are ≥ 4 mmol/L. However, the consequences of lower lactate levels in this population are not well understood. The study aimed to determine the in-hospital mortality associated with severe sepsis and septic shock when initial lactate levels are based on initial lactate values. Group 1 had lactate levels be statistically significant. Multivariate logistic regression demonstrated higher odds of death with higher lactate tier group, however the findings did not reach statistical ***: This study found that only assignment to group 3, initial lactic acid level of ≥ 4 mmol/L, was independently associated with increased mortality after correcting for underlying severity of illness and organ dysfunction. However, rising lactate levels in the other two groups were associated with increased severity of illness and were inversely proportional to prognosis.

关键词： Sepsis Lactic acid Emergency medicine

Cancer Cell：新型药物组合或有望治疗恶性白血病

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现代生物医学进展 2017年第11期17卷 I0003-I0003页

作者： Nidal E. Muvarak Khadiza Chowdhury Limin Xia Carine Robert Eun Yong Choi Yi Cai Marina bellani Ying Zou Zeba N. Singh Vu H. Duong Tyler Rutherford pratik Nagaria S?ren M. bentzen Michael M. Seidman Maria R. baer Rena G. Lapidus Stephen b. baylin Feyruz V. Rassool Van Andel Research Institute Grand Rapids MI 49503

近日，刊登在国际杂志Cancer Cell上的一篇研究报告中，来自马里兰大学医学院等机构的研究人员开发了一种新型药物组合或有望帮助治疗急性髓性白血病（AML），在诊断为该疾病后，舭能在5年内使得几乎四分之三的患者死亡。目前在美国三... 详细信息

近日，刊登在国际杂志Cancer Cell上的一篇研究报告中，来自马里兰大学医学院等机构的研究人员开发了一种新型药物组合或有望帮助治疗急性髓性白血病（AML），在诊断为该疾病后，舭能在5年内使得几乎四分之三的患者死亡。目前在美国三个研究中研究研究人员正在招募研究者进行多中心的临床试验。

关键词：药物组合 Cell 白血病治疗恶性研究人员马里兰大学临床试验